The calphostins are a class of closely related chemical compounds isolated from the fungus ''
Cladosporium cladosporioides
''Cladosporium cladosporioides'' is a darkly pigmented mold that occurs world-wide on a wide range of materials both outdoors and indoors.
It is known for its role in the decomposition of organic matter and its presence in indoor and outdoor en ...
''.
The known calphostins include calphostin A, calphostin B,
calphostin C
Calphostin C is a natural chemical compound. It is one of the calphostins, isolated from the fungus ''Cladosporium cladosporioides''. Calphostin C is a potent inhibitor of protein kinase C
In cell biology, protein kinase C, commonly abbreviat ...
, calphostin D, and calphostin I. The calphostins are
inhibitors of
protein kinase C
In cell biology, protein kinase C, commonly abbreviated to PKC (EC 2.7.11.13), is a family of protein kinase enzymes that are involved in controlling the function of other proteins through the phosphorylation of hydroxyl groups of serine and t ...
(PKC).
The most potent member of the series, calphostin C,
has found use as a biochemical tool because of this activity.
Calphostin C
Calphostin C is a potent
inhibitor
Inhibitor or inhibition may refer to:
Biology
* Enzyme inhibitor, a substance that binds to an enzyme and decreases the enzyme's activity
* Reuptake inhibitor, a substance that increases neurotransmission by blocking the reuptake of a neurotransmi ...
of
protein kinase C
In cell biology, protein kinase C, commonly abbreviated to PKC (EC 2.7.11.13), is a family of protein kinase enzymes that are involved in controlling the function of other proteins through the phosphorylation of hydroxyl groups of serine and t ...
(PKC).
References
External links
*{{Commonscat-inline, Calphostins
O-methylated natural phenols
Cladosporium
3-Hydroxypropenals within hydroxyquinones