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Bette Korber
Bette Korber is an American computational biologist focusing on the molecular biology and population genetics of the HIV virus that causes infection and eventually AIDS. She has contributed heavily to efforts to obtain an effective HIV vaccine. She created a database at Los Alamos National Laboratory that has enabled her to design novel mosaic HIV vaccines, one of which is currently in human testing in Africa. The database contains thousands of HIV genome sequences and related data. Korber is a scientist in theoretical biology and biophysics. at Los Alamos National Laboratory. She has received the Ernest Orlando Lawrence Award, the Department of Energy's highest award for scientific achievement. She has also received several other awards including the Elizabeth Glaser Award for pediatric AIDS research and the Richard Feynman Award for Innovation. Early life and education Bette Korber grew up in Southern California. She earned her B.S. in chemistry in 1981 from California Stat ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Zulu People
Zulu people (; ) are a native people of Southern Africa of the Nguni people, Nguni. The Zulu people are the largest Ethnic groups in South Africa, ethnic group and nation in South Africa, living mainly in the province of KwaZulu-Natal. They originated from Nguni communities who took part in the Bantu migrations over millennia. As the clans integrated, the rulership of Shaka brought success to the Zulu nation due to his improved military tactics and organization. Zulus take pride in their ceremonies such as the Umhlanga (ceremony)#South Africa, Umhlanga, or Reed Dance, and their various forms of beadwork. The art and skill of beadwork take part in the identification of Zulu people and act as a form of communication and dedication to the nation and specific traditions. Today, the Zulu people are predominantly Christian, but have created a Religious syncretism, syncretic religion that is combined with the Zulu's prior belief systems. History of the people of Zulu Origins Th ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Theoretical Biology
Mathematical and theoretical biology, or biomathematics, is a branch of biology which employs theoretical analysis, mathematical models and abstractions of living organisms to investigate the principles that govern the structure, development and behavior of the systems, as opposed to experimental biology which deals with the conduction of experiments to test scientific theories. The field is sometimes called mathematical biology or biomathematics to stress the mathematical side, or theoretical biology to stress the biological side. Theoretical biology focuses more on the development of theoretical principles for biology while mathematical biology focuses on the use of mathematical tools to study biological systems, even though the two terms interchange; overlapping as Artificial Immune Systems of Amorphous Computation. Mathematical biology aims at the mathematical representation and modeling of biological processes, using techniques and tools of applied mathematics. It can ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Harvard School Of Public Health
The Harvard T.H. Chan School of Public Health is the public health school at Harvard University, located in the Longwood Medical Area of Boston, Massachusetts. It was named after Hong Kong entrepreneur Chan Tseng-hsi in 2014 following a US$350 million donation, the largest in Harvard's history at the time. The school grew out of the Harvard– MIT School for Health Officers, the country's first graduate training program in population health, which was founded in 1913 and became the Harvard School of Public Health in 1922. History Harvard's T.H. Chan School of Public Health traces its origins to the Harvard– MIT School for Health Officers, which was founded in 1913. Harvard calls it "the nation's first graduate training program in public health." In 1922, the School for Health Officers became the Harvard School of Public Health. The school was part of Harvard Medical School until 1946, when it became a fully autonomous institution with its own dedicated public health and me ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
HTLV-1
Human T-cell lymphotropic virus type 1 or human T-lymphotropic virus (HTLV-I), also called the adult T-cell lymphoma virus type 1, is a retrovirus of the human T-lymphotropic virus (HTLV) family. Most people with HTLV-1 infection do not appear to develop health conditions that can be directly linked to the infection. However, there is a subgroup of people who experience severe complications. The most well characterized are adult T-cell lymphoma (ATL) and HTLV-I-associated myelopathy/ Tropical spastic paraparesis (HAM/TSP), both of which are only diagnosed in individuals testing positive to HTLV-1 infection. The estimated lifetime risk of ATL among people with HTLV-1 infection is approximately 5%, while that of HAM/TSP is approximately 2%. In 1977, Adult T-cell lymphoma (ATL) was first described in a case series of individuals from Japan. The symptoms of ATL were different from other lymphomas known at the time. The common birthplace shared amongst most of the ATL patients was s ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Molecular Epidemiology
Molecular epidemiology is a branch of epidemiology and medical science that focuses on the contribution of potential genetic and environmental risk factors, identified at the molecular level, to the etiology, distribution and prevention of disease within families and across populations. This field has emerged from the integration of molecular biology into traditional epidemiological research. Molecular epidemiology improves our understanding of the pathogenesis of disease by identifying specific pathways, molecules and genes that influence the risk of developing disease. More broadly, it seeks to establish understanding of how the interactions between genetic traits and environmental exposures result in disease. History The term "molecular epidemiology" was first coined by Edwin D. Kilbourne in a 1973 article entitled "The molecular epidemiology of influenza". The term became more formalized with the formulation of the first book on molecular epidemiology titled ''Molecular Epide ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Myron Essex
Myron Elmer "Max" Essex (born August 17, 1939) is the Mary Woodard Lasker Professor of Health Sciences, emeritus in the department of immunology and infectious diseases at Harvard University, chair of the Harvard T.H. Chan School of Public Health AIDS Initiative (HAI) in the department of immunology and infectious diseases, and chair of the Botswana–Harvard AIDS Institute in Gaborone, Botswana. Essex was one of the first to link animal and human retroviruses to immunosuppressive disease, to suspect that a retrovirus was the cause of AIDS, and to determine that HIV could be transmitted through blood and blood products to hemophiliacs and recipients of blood transfusions. With collaborators, Essex also provided the first evidence that HIV could be transmitted by heterosexual intercourse. In 1984, Essex identified gp120, the virus surface protein that is used worldwide for blood screening, HIV detection, and epidemiological monitoring. With collaborators, including African micr ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Interferon
Interferons (IFNs, ) are a group of signaling proteins made and released by host cells in response to the presence of several viruses. In a typical scenario, a virus-infected cell will release interferons causing nearby cells to heighten their anti-viral defenses. IFNs belong to the large class of proteins known as cytokines, molecules used for communication between cells to trigger the protective defenses of the immune system that help eradicate pathogens. Interferons are named for their ability to "interfere" with viral replication by protecting cells from virus infections. However, virus-encoded genetic elements have the ability to antagonize the IFN response, contributing to viral pathogenesis and viral diseases. IFNs also have various other functions: they activate immune cells, such as natural killer cells and macrophages, and they increase host defenses by up-regulating antigen presentation by virtue of increasing the expression of major histocompatibility compl ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Transplant Rejection
Transplant rejection occurs when transplanted tissue is rejected by the recipient's immune system, which destroys the transplanted tissue. Transplant rejection can be lessened by determining the molecular similitude between donor and recipient and by use of immunosuppressant drugs after transplant. Types Transplant rejection can be classified into three types: hyperacute, acute, and chronic. These types are differentiated by how quickly the recipient's immune system is activated and the specific aspect or aspects of immunity involved. Hyperacute rejection Hyperacute rejection is a form of rejection that manifests itself in the minutes to hours following transplantation. It is caused by the presence of pre-existing antibodies in the recipient that recognize antigens in the donor organ. These antigens are located on the endothelial lining of blood vessels within the transplanted organ and, once antibodies bind, will lead to the rapid activation of the complement system. ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Histocompatibility
Histocompatibility, or tissue compatibility, is the property of having the same, or sufficiently similar, alleles of a set of genes called human leukocyte antigens (HLA), or major histocompatibility complex (MHC). Each individual expresses many unique HLA proteins on the surface of their cells, which signal to the immune system whether a cell is part of the self or an invading organism. T cells recognize foreign HLA molecules and trigger an immune response to destroy the foreign cells. Histocompatibility testing is most relevant for topics related to whole organ, tissue, or stem cell transplants, where the similarity or difference between the donor's HLA alleles and the recipient's triggers the immune system to reject the transplant. The wide variety of potential HLA alleles lead to unique combinations in individuals and make matching difficult. Discovery The discovery of the MHC and role of histocompatibility in transplantation was a combined effort of many scientists in the 20t ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Regulation Of Gene Expression
Regulation of gene expression, or gene regulation, includes a wide range of mechanisms that are used by cells to increase or decrease the production of specific gene products (protein or RNA). Sophisticated programs of gene expression are widely observed in biology, for example to trigger developmental pathways, respond to environmental stimuli, or adapt to new food sources. Virtually any step of gene expression can be modulated, from Transcriptional regulation, transcriptional initiation, to RNA processing, and to the post-translational modification of a protein. Often, one gene regulator controls another, and so on, in a gene regulatory network. Gene regulation is essential for viruses, prokaryotes and eukaryotes as it increases the versatility and adaptability of an organism by allowing the cell to express protein when needed. Although as early as 1951, Barbara McClintock showed interaction between two genetic loci, Activator (''Ac'') and Dissociator (''Ds''), in the color f ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
California State University, Long Beach
California State University, Long Beach (CSULB), also known in athletics as Long Beach State University (LBSU), is a public teaching-focused institution in Long Beach, California, United States. The 322-acre campus is the second largest in the California State University system (CSU). The university enrolls around 35,843 undergraduate students and 5,346 graduate students as of fall 202The graduate programs include master's degrees, credentials, post-baccalaureate certificates, and doctoral programs. CSULB is Carnegie Classification of Institutions of Higher Education, classified as an "R2: Doctoral Universities – High Research Activity". The university offers four doctoral programs: Educational Leadership (Ed.D.), Engineering and Computational Mathematics (Ph.D.), Physical Therapy (DPT) and Nursing Practice (DNP). The university is home to one of the largest publicly funded art schools in the United States. The university is a Hispanic-serving institution (HSI) and is eligib ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Chemistry
Chemistry is the scientific study of the properties and behavior of matter. It is a physical science within the natural sciences that studies the chemical elements that make up matter and chemical compound, compounds made of atoms, molecules and ions: their composition, structure, properties, behavior and the changes they undergo during chemical reaction, reactions with other chemical substance, substances. Chemistry also addresses the nature of chemical bonds in chemical compounds. In the scope of its subject, chemistry occupies an intermediate position between physics and biology. It is sometimes called the central science because it provides a foundation for understanding both Basic research, basic and Applied science, applied scientific disciplines at a fundamental level. For example, chemistry explains aspects of plant growth (botany), the formation of igneous rocks (geology), how atmospheric ozone is formed and how environmental pollutants are degraded (ecology), the prop ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
