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BOx (psychedelics)
BOx, also known as β-hydroxy- or -methoxy- and ring-substituted phenethylamines, are a group of psychedelic and other psychoactive drugs of the phenethylamine family. They have either a hydroxy group or methoxy group at the β position of the alkyl side chain as well as additional substitutions at the 2 through 5 positions of the phenyl ring. The BOx drugs were synthesized and tested by Alexander Shulgin and reported in his 1991 book ''PiHKAL'' (''Phenethylamines I Have Known and Loved''). List of BOx drugs The BOx drugs include the following, with their effects as reported by Shulgin also specified: * BOB (4-bromo-2,5,β-trimethoxyphenethylamine) – methoxy BOx analogue of 2C-B – altered state of consciousness, tinnitus, tingling, sense of awareness * BOH-2C-B (β-OH-2C-B) – hydroxy BOx analogue of 2C-B – encountered as a novel designer drug and presumably a psychedelic * BOD (4-methyl-2,5,β-trimethoxyphenethylamine) – methoxy BOx analogue of 2C-D – mild open-e ...
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4-methyl-2,5,beta-trimethoxy-phenethylamine
BOD (4-methyl-2,5,β-trimethoxyphenethylamine) is a lesser-known psychedelic drug of the BOx group. It is the beta-methoxy analog of 2C-D and was first synthesized by Alexander Shulgin. In his book ''PiHKAL'', the dosage range is listed as 15–25 mg with a duration of 8–16 hours. Its reported effects include mild open-eye and moderate closed-eye alterations in visual perception, enhancement of conversation and sense of humor, and unpleasant physical effects such as nausea and lethargy. Very little data exists about the pharmacological properties, metabolism, and toxicity of BOD. Legality United States BOD is unscheduled in the United States, but purchase, sale, or possession for human consumption could be prosecuted under the Federal Analogue Act. United Kingdom This substance is a Class A drug in the Drugs controlled by the UK Misuse of Drugs Act. See also * BOB * BOH * BOHD BOHD (4-methyl-2,5-dimethoxy-beta-hydroxyphenethylamine) is a lesser-known drug of the BOx ...
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BOB (psychedelic)
BOB, also known as 4-bromo-2,5,β-trimethoxyphenethylamine, is a lesser-known psychedelic drug of the substituted phenethylamine, phenethylamine and BOx families. It is the β-methoxy group, methoxy analog (chemistry), analogue of 2C-B. BOB was first synthesized by Alexander Shulgin. In his book ''PiHKAL'', the dosage range is listed as 10 to 20mg, and the duration listed as 10 to 20hours. BOB produces an altered state of consciousness, tinnitus, a pleasant Paresthesia, tingling throughout the body, and a sense of awareness. Very little data exists about the pharmacological properties, metabolism, and toxicity of BOB. Legal status United Kingdom This substance is a Class A drug in the Drugs controlled by the UK Misuse of Drugs Act#Class A drugs, Drugs controlled by the UK Misuse of Drugs Act. See also * BOD (psychedelic), BOD * BOH (psychedelic), BOH * BOHD (psychedelic), BOHD * Bk-2C-B * β-Methyl-2C-B * 2C-B-aminorex * Phenethylamine External links BOB Entry at ''PiHKAL''· ...
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3,4-dimethoxyamphetamine
3,4-Dimethoxyamphetamine (3,4-DMA), or simply dimethoxyamphetamine (DMA), is a psychedelic drug of the phenethylamine and amphetamine families. It is one of the dimethoxyamphetamine (DMA) series of positional isomers. The drug has been assessed in various biochemical and preclinical studies. It has been tried in humans at doses of up to 700mg intravenously, with mescaline-like effects reported. 3,4-DMA is also orally active and has produced sympathomimetic effects at a dose of 160mg. Its duration of action is unknown. Its affinity (Ki) for the rat serotonin 5-HT2A receptor has been assessed and was found to be 43,300nM. For comparison, the affinity of ''para''-methoxyamphetamine (PMA) was 33,600nM, of 2,5-dimethoxyamphetamine (2,5-DMA) was 5,200nM, and of 2,5-dimethoxy-4-methylamphetamine (DOM) was 100nM in the same study. 3,4-DMA also showed affinity for the 5-HT1 receptor (Ki = 64,600nM). The drug has additionally been found to be a monoamine oxidase inhibitor (MAOI), wit ...
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DME (drug)
DME, also known as 3,4-dimethoxy-β-hydroxyphenethylamine, is a lesser-known psychoactive drug of the BOx family. It is the β- hydroxy derivative of 3,4-dimethoxyphenethylamine. DME was first synthesized by Alexander Shulgin. In his book ''PiHKAL'', the minimum dosage is listed as 115 mg, and the duration unknown. DME produces few to no effects. Very little data exists about the pharmacological properties, metabolism, and toxicity of DME. Legality United Kingdom This substance is a Class A drug in the Drugs controlled by the UK Misuse of Drugs Act. See also * Phenethylamine * Psychedelics, dissociatives and deliriants Hallucinogens, also known as psychedelics, entheogens, or historically as psychotomimetics, are a large and diverse class of psychoactive drugs that can produce altered states of consciousness characterized by major alterations in thought, mo ... References 2,5-Dimethoxyphenethylamines BOx (psychedelics) Phenylethanolamines {{Psychoact ...
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Mescaline
Mescaline, also known as mescalin or mezcalin, and in chemical terms 3,4,5-trimethoxyphenethylamine, is a natural product, naturally occurring psychedelic drug, psychedelic alkaloid, protoalkaloid of the substituted phenethylamine class, found in Cactus, cacti like peyote (''Lophophora williamsii'') and San Pedro cactus, San Pedro (certain species of the Echinopsis genus) and known for its Serotonin, serotonergic Hallucinogen, hallucinogenic effects. Mescaline is typically taken orally and used recreationally, spiritually, and medically, with psychedelic effects occurring at doses from 100 to 1,000 mg, including microdosing below 75 mg, and it can be consumed in pure form or via mescaline-containing cacti. Mescaline induces a psychedelic experience characterized by vivid visual patterns, altered perception of time and self, synesthesia, and spiritual effects, with an onset of 0.5–0.9 hours and a duration that increases with dose, ranging from about 6 to 14 hours. Mescaline h ...
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BOM (drug)
BOM (3,4,5,beta-tetramethoxyphenethylamine) is a lesser-known drug of the BOx group. It is the β-methoxy derivative of mescaline. BOM was first synthesized by Alexander Shulgin. In his book ''PiHKAL'', the minimum dosage is listed as 200 mg, and the duration unknown. BOM produces few to no effects. Very little data exists about its pharmacological properties, metabolism, and toxicity. Legality United Kingdom This substance is a Class A drug in the Drugs controlled by the UK Misuse of Drugs Act The Misuse of Drugs Act 1971 (c. 38) is an act of the Parliament of the United Kingdom. It represents action in line with treaty commitments under the Single Convention on Narcotic Drugs, the Convention on Psychotropic Substances, and the Un .... References BOx (psychedelics) Phenylethanolamine ethers Scalines {{Psychoactive-stub ...
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Shulgin Rating Scale
The Shulgin Rating Scale (or "quantitative potency scale") is a simple scale for reporting the subjective effect of psychoactive substances at a given dosage, and at a given time. The system was developed for research purposes by the American biochemist Alexander Shulgin, and published with co-authors Ann Shulgin and Peyton Jacob, III, in a 1986 issue of the journal ''Methods and Findings in Experimental and Clinical Pharmacology''. It was later described in the Shulgins' popular 1991 book ''PIHKAL: A Chemical Love Story''. ''PIHKAL'' Glossary excerpts Usage ''Shulgin Ratings'' typically include three components. An identification of the chemical being ingested, a dosage, and a descriptive narrative including the ratings themselves used to describe various moments in time. The chemical itself must be clearly identified, preferably using chemical nomenclature, as opposed to popular or "street" names. The dosage must be known and communicated, as substances may result in wildly d ...
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MDPEA
3,4-Methylenedioxyphenethylamine, also known as 3,4-MDPEA, MDPEA, and homopiperonylamine, is a substituted phenethylamine formed by adding a methylenedioxy group to phenethylamine. It is structurally similar to MDA, but without the methyl group at the alpha position. According to Alexander Shulgin in his book ''PiHKAL'', MDPEA appears to be biologically inactive. This is likely because of extensive first-pass metabolism by the enzyme monoamine oxidase. However, if MDPEA were either used in high enough of doses (e.g., 1-2 grams), or in combination with a monoamine oxidase inhibitor (MAOI), it is probable that it would become sufficiently active, though it would likely have a relatively short duration of action. This idea is similar in concept to the use of selective MAOA inhibitors and selective MAOB inhibitors in augmentation of dimethyltryptamine (DMT) and phenethylamine (PEA), respectively. MDPEA produces sympathomimetic effects when administered intravenously in d ...
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BOH (drug)
BOH, also known as 3,4-methylenedioxy-β-methoxyphenethylamine, is a drug of the phenethylamine and BOx families. It is the β-methoxy analog of methylenedioxyphenethylamine (MDPEA) and is also more distantly related to methylone. On account of its similarity to norepinephrine, the effects of BOH may be of a purely adrenergic nature. BOH was first synthesized by Alexander Shulgin. In his book PiHKAL ''PiHKAL: A Chemical Love Story'' is a book by Alexander Shulgin and Ann Shulgin published in 1991. The subject of the work is Psychoactive drug, psychoactive phenethylamine Derivative (chemistry), chemical derivatives, notably those that act ..., the dosage range is listed as 80–120 mg, and the duration listed as 6–8 hours. Shulgin reports that BOH causes slight warmth, mydriasis, anorexia (symptom), anorexia, mild nausea, and cold feet, with no psychedelic drug, psychedelic, entactogen, or euphoriant effects. He gives it a ++ on the Shulgin Rating Scale. Legality ...
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BOHD (psychedelic)
BOHD (4-methyl-2,5-dimethoxy-beta-hydroxyphenethylamine) is a lesser-known drug of the BOx group. It is the beta- hydroxy derivative of 2C-D. BOHD was first synthesized by Alexander Shulgin. In his book ''PiHKAL'', the minimum dosage is listed as 50 mg, and the duration unknown. BOHD produces a marked drop in blood pressure. Very little data exists about the pharmacological properties, metabolism, and toxicity of BOHD. Legality United Kingdom This substance is a Class A drug under the UK Misuse of Drugs Act 1971 The Misuse of Drugs Act 1971 (c. 38) is an act of the Parliament of the United Kingdom. It represents action in line with treaty commitments under the Single Convention on Narcotic Drugs, the Convention on Psychotropic Substances, and the .... United States In the U.S., this substance is a Schedule 1 isomer of Mescaline. See also * BOB * BOD * BOH References BOx (psychedelics) Methoxyphenethylamines Phenylethanolamines {{Psychoactiv ...
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2C-D
2C-D, also known as 2C-M or as 2,5-dimethoxy-4-methylphenethylamine, is a psychedelic drug of the 2C family that is sometimes used as an entheogen. It was first synthesized in 1970 by a team from the Texas Research Institute of Mental Sciences, and its activity was subsequently investigated in humans by Alexander Shulgin. Use and effects Not much information is known about the toxicity of 2C-D, as no major studies have been conducted. In his book ''PiHKAL'', Shulgin lists the dosage range as being from 20 to 60 mg. Lower doses of 10 mg or less have been explored for microdosing. According to Shulgin, the effects of 2C-D typically last for 4–6 hours. Shulgin himself referred to this substance as a “pharmacological tofu,” meaning that when mixed with other substances, it can extend or potentiate their effects without coloring the experience too much, in a manner similar to how tofu absorbs the flavors of sauces or spices it is cooked with. Hanscarl Leuner, working in Ge ...
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BOD (psychedelic)
BOD (4-methyl-2,5,β-trimethoxyphenethylamine) is a lesser-known psychedelic drug of the BOx group. It is the beta-methoxy analog of 2C-D and was first synthesized by Alexander Shulgin. In his book ''PiHKAL'', the dosage range is listed as 15–25 mg with a duration of 8–16 hours. Its reported effects include mild open-eye and moderate closed-eye alterations in visual perception, enhancement of conversation and sense of humor, and unpleasant physical effects such as nausea and lethargy. Very little data exists about the pharmacological properties, metabolism, and toxicity of BOD. Legality United States BOD is unscheduled in the United States, but purchase, sale, or possession for human consumption could be prosecuted under the Federal Analogue Act. United Kingdom This substance is a Class A drug in the Drugs controlled by the UK Misuse of Drugs Act. See also * BOB * BOH * BOHD BOHD (4-methyl-2,5-dimethoxy-beta-hydroxyphenethylamine) is a lesser-known drug of the BOx ...
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