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BANP
Protein BANP is a protein that can be found in humans, it is encoded by the ''BANP'' gene. It is a member of the human gene family, " BEN-domain containing", which includes eight other genes: BEND2, BEND3, BEND4, BEND5, BEND6, BEND7, NACC1 (BEND8), and NACC2 (BEND9). BANP is a protein coding gene that is located in the Nucleoplasm. Its official name is BTG3 associated with nuclear protein. It plays a role in DNA binding, chromatin regulation, repressor, transcription regulation and the cell cycle process. In recombination BANP protein represses T-cell receptors to control recombination during transcription. As a tumor suppressor BANP negatively regulates p53 transcription in recombination. It can be expressed in various tissues in the body including the testis, spleen, and the placenta. Function This gene encodes a protein that binds to matrix attachment regions. The protein functions as a tumor suppressor and cell cycle The cell cycle, or cell-division cycle, is the s ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
BEN Domain
In molecular biology, the BEN domain is a protein domain which is found in diverse proteins including: * SMAR1 (Scaffold/Matrix attachment region-binding protein 1; also known as BANP), a tumour-suppressor MAR-binding protein that down-regulates Cyclin D1 expression by recruiting HDAC1-mSin3A co-repressor Protein complex, complex at Cyclin D1 promoter locus; SMAR1 is the target of prostaglandin A2 (PGA2) induced growth arrest. * NACC1, a novel member of the POZ/BTB (Pox virus and Zinc finger/Bric-a-bracTramtrack Broad complex), but which varies from other protein Proteins are large biomolecules and macromolecules that comprise one or more long chains of amino acid residues. Proteins perform a vast array of functions within organisms, including catalysing metabolic reactions, DNA replication, respon ...s of this class in that it lacks the characteristic DNA-binding protein motif, motif. * Mod(mdg4) isoform C, the modifier of the mdg4 locus (genetics), locus in ''Drosophila ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
BEND2 (protein)
BEND2 is a protein that in humans is encoded by the ''BEND2'' gene. It is also found in other vertebrates, including mammals, birds, and reptiles. The expression of BEND2 in ''Homo sapiens'' is regulated and occurs at high levels in the skeletal muscle tissue of the male Testicle, testis and in the bone marrow. The presence of the BEN domains in the BEND2 protein indicates that this protein may be involved in Chromatin remodeling, chromatin modification and regulation. Gene Common aliases BEND2 stands for BEN domain containing 2 and is also known as CXorf20 (HGNC ID28509. Locus and size The locus for BEND2 is on the minus strand of the X chromosome at Xp22.13. The gene is approximately 58 kilobases in length. mRNA Alternative splicing BEND2 contains 14 exons which undergo alternative splicing to create five transcript variants that vary from 4,720 Base pair, base pairs (bp) to 2,144 bp in the mature mRNA. The longest and most complete transcript of the gene, variant ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Protein
Proteins are large biomolecules and macromolecules that comprise one or more long chains of amino acid residues. Proteins perform a vast array of functions within organisms, including catalysing metabolic reactions, DNA replication, responding to stimuli, providing structure to cells and organisms, and transporting molecules from one location to another. Proteins differ from one another primarily in their sequence of amino acids, which is dictated by the nucleotide sequence of their genes, and which usually results in protein folding into a specific 3D structure that determines its activity. A linear chain of amino acid residues is called a polypeptide. A protein contains at least one long polypeptide. Short polypeptides, containing less than 20–30 residues, are rarely considered to be proteins and are commonly called peptides. The individual amino acid residues are bonded together by peptide bonds and adjacent amino acid residues. The sequence of amino acid resid ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Gene
In biology, the word gene (from , ; "... Wilhelm Johannsen coined the word gene to describe the Mendelian units of heredity..." meaning ''generation'' or ''birth'' or ''gender'') can have several different meanings. The Mendelian gene is a basic unit of heredity and the molecular gene is a sequence of nucleotides in DNA that is transcribed to produce a functional RNA. There are two types of molecular genes: protein-coding genes and noncoding genes. During gene expression, the DNA is first copied into RNA. The RNA can be directly functional or be the intermediate template for a protein that performs a function. The transmission of genes to an organism's offspring is the basis of the inheritance of phenotypic traits. These genes make up different DNA sequences called genotypes. Genotypes along with environmental and developmental factors determine what the phenotypes will be. Most biological traits are under the influence of polygenes (many different genes) as well as g ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
NACC1
Nucleus accumbens-associated protein 1 is a protein that in humans is encoded by the ''NACC1'' gene. References l External links * PDBe-KBprovides an overview of all the structure information available in the PDB for Human Nucleus accumbens-associated protein 1 (BTBD14B) Further reading * * * * * * * * {{gene-19-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
T-cell Receptor
The T-cell receptor (TCR) is a protein complex found on the surface of T cells, or T lymphocytes, that is responsible for recognizing fragments of antigen as peptides bound to major histocompatibility complex (MHC) molecules. The binding between TCR and antigen peptides is of relatively low affinity and is degenerate: that is, many TCRs recognize the same antigen peptide and many antigen peptides are recognized by the same TCR. The TCR is composed of two different protein chains (that is, it is a hetero dimer). In humans, in 95% of T cells the TCR consists of an alpha (α) chain and a beta (β) chain (encoded by ''TRA'' and ''TRB'', respectively), whereas in 5% of T cells the TCR consists of gamma and delta (γ/δ) chains (encoded by '' TRG'' and '' TRD'', respectively). This ratio changes during ontogeny and in diseased states (such as leukemia). It also differs between species. Orthologues of the 4 loci have been mapped in various species. Each locus can produce a ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Tumor Suppressor
A tumor suppressor gene (TSG), or anti-oncogene, is a gene that regulates a cell during cell division and replication. If the cell grows uncontrollably, it will result in cancer. When a tumor suppressor gene is mutated, it results in a loss or reduction in its function. In combination with other genetic mutations, this could allow the cell to grow abnormally. The loss of function for these genes may be even more significant in the development of human cancers, compared to the activation of oncogenes. TSGs can be grouped into the following categories: caretaker genes, gatekeeper genes, and more recently landscaper genes. Caretaker genes ensure stability of the genome via DNA repair and subsequently when mutated allow mutations to accumulate. Meanwhile, gatekeeper genes directly regulate cell growth by either inhibiting cell cycle progression or inducing apoptosis. Lastly landscaper genes regulate growth by contributing to the surrounding environment, when mutated can cause an e ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
