Protein BANP is a

protein Proteins are large biomolecules and macromolecules that comprise one or more long chains of amino acid residue (biochemistry), residues. Proteins perform a vast array of functions within organisms, including Enzyme catalysis, catalysing metab ...

that can be found in humans, it is encoded by the ''BANP''

gene In biology, the word gene has two meanings. The Mendelian gene is a basic unit of heredity. The molecular gene is a sequence of nucleotides in DNA that is transcribed to produce a functional RNA. There are two types of molecular genes: protei ...

. It is a member of the human gene family, " BEN-domain containing", which includes eight other genes:

BEND2 Bend may refer to: Places Canada * Bend, British Columbia, a railway point United States * Bend, California * Bend, Missouri * Bend, Oregon * Bend, South Dakota * Bend, Texas Science, technology and engineering * Bending, the deformation o ...

, BEND3, BEND4, BEND5, BEND6, BEND7, NACC1 (BEND8), and NACC2 (BEND9). BANP is a protein coding gene that is located in the Nucleoplasm. Its official name is BTG3 associated with nuclear protein. It plays a role in DNA binding, chromatin regulation, repressor, transcription regulation and the cell cycle process. In recombination BANP protein represses

T-cell receptors The T-cell receptor (TCR) is a protein complex, located on the surface of T cells (also called T lymphocytes). They are responsible for recognizing fragments of antigen as peptides bound to major histocompatibility complex (MHC) molecules. ...

to control recombination during transcription. As a tumor suppressor BANP negatively regulates

p53 p53, also known as tumor protein p53, cellular tumor antigen p53 (UniProt name), or transformation-related protein 53 (TRP53) is a regulatory transcription factor protein that is often mutated in human cancers. The p53 proteins (originally thou ...

transcription in recombination. It can be expressed in various tissues in the body including the testis, spleen, and the placenta.

Function

This gene encodes a protein that binds to matrix attachment regions. The protein functions as a

tumor suppressor A tumor suppressor gene (TSG), or anti-oncogene, is a gene that regulates a cell (biology), cell during cell division and replication. If the cell grows uncontrollably, it will result in cancer. When a tumor suppressor gene is mutated, it results ...

and

cell cycle The cell cycle, or cell-division cycle, is the sequential series of events that take place in a cell (biology), cell that causes it to divide into two daughter cells. These events include the growth of the cell, duplication of its DNA (DNA re ...

regulator. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.

Function

References

External links

Further reading