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Angela Koehler
Angela N. Koehler is an American biochemist who is the Karl Van Tassel (1925) Career Development Professor of Chemical Biology at the Broad Institute. Her research considers the development of chemical tools to understand transcriptional regulation, and the design of next-generation pharmaceuticals. Early life and education Koehler was an undergraduate student in biochemistry at Reed College. She worked on structural studies of proteins that recognize nucleic acids, including transfer RNA and DNA. She moved to Harvard University as a doctoral researcher, where she worked alongside Stuart Schreiber on strategies to understand the interactions between proteins and molecules. Research and career Koehler joined the chemical biology program at the Broad Institute, where she was made group leader for chemical genetics. Koehler develops time-sensitive chemical tools to understand the dynamics of transcriptional regulation. Before the work of Koehler it was understood that transcrip ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
California Institute Of Technology
The California Institute of Technology (branded as Caltech) is a private research university in Pasadena, California, United States. The university is responsible for many modern scientific advancements and is among a small group of institutes of technology in the United States that are devoted to the instruction of pure and applied sciences. The institution was founded as a preparatory and vocational school by Amos G. Throop in 1891 and began attracting influential scientists such as George Ellery Hale, Arthur Amos Noyes, and Robert Andrews Millikan in the early 20th century. The vocational and preparatory schools were disbanded and spun off in 1910, and the college assumed its present name in 1920. In 1934, Caltech was elected to the Association of American Universities, and the antecedents of NASA's Jet Propulsion Laboratory, which Caltech continues to manage and operate, were established between 1936 and 1943 under Theodore von Kármán. Caltech has six academic divisi ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Broad Institute
The Eli and Edythe L. Broad Institute of MIT and Harvard (IPA: , pronunciation respelling: ), often referred to as the Broad Institute, is a biomedical and genomic research center located in Cambridge, Massachusetts, United States. The institute is independently governed and supported as a 501(c)(3) nonprofit research organization under the name Broad Institute Inc., and it partners with the Massachusetts Institute of Technology, Harvard University, and the five Harvard teaching hospitals. History The Broad Institute evolved from a decade of research collaborations among MIT and Harvard scientists. One cornerstone was the Center for Genome Research of Whitehead Institute at MIT. Founded in 1982, the Whitehead became a major center for genomics and the Human Genome Project. As early as 1995, scientists at the Whitehead started pilot projects in genomic medicine, forming an unofficial collaborative network among young scientists interested in genomic approaches to cancer and ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Harvard University
Harvard University is a Private university, private Ivy League research university in Cambridge, Massachusetts, United States. Founded in 1636 and named for its first benefactor, the History of the Puritans in North America, Puritan clergyman John Harvard (clergyman), John Harvard, it is the oldest institution of higher learning in the United States. Its influence, wealth, and rankings have made it one of the most prestigious universities in the world. Harvard was founded and authorized by the Massachusetts General Court, the governing legislature of Colonial history of the United States, colonial-era Massachusetts Bay Colony. While never formally affiliated with any Religious denomination, denomination, Harvard trained Congregationalism in the United States, Congregational clergy until its curriculum and student body were gradually secularized in the 18th century. By the 19th century, Harvard emerged as the most prominent academic and cultural institution among the Boston B ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Reed College
Reed College is a Private college, private Liberal arts colleges in the United States, liberal arts college in Portland, Oregon, United States. Founded in 1908, Reed is a residential college with a campus in the Eastmoreland, Portland, Oregon, Eastmoreland neighborhood, Tudor style architecture, Tudor-Gothic Revival architecture, Gothic style architecture, and a forested canyon nature preserve at its center. Reed List of Reed College people, alumni include 123 Fulbright Scholars, 73 Thomas J. Watson Fellowship, Watson Fellows, and three Churchill Scholarship, Churchill Scholars. Its 32 Rhodes Scholars are the second-most for a liberal arts college. Reed is ranked fourth in the United States for the percentage of its graduates who earn a PhD. History The Reed Institute (the legal name of the college) was founded in 1908 and held its first classes in 1911. Reed is named for Oregon pioneers Simeon Gannett Reed (1830–1895) and Amanda Reed (died 1904). Simeon was an entrepreneur in ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Stuart Schreiber
Stuart Schreiber (born February 6, 1956) is an American chemist who is the Morris Loeb Research Professor at Harvard University, a co-founder of the Broad Institute, Howard Hughes Medical Institute Investigator, Emeritus, and a member of the National Academy of Sciences and National Academy of Medicine. He currently leads Arena BioWorks. His work integrates chemical biology and human biology to advance the science of therapeutics. Key advances include the discovery that small molecules can function as “molecular glues” that promote protein–protein interactions, the co-discovery of mTOR and its role in nutrient-response signaling, the discovery of histone deacetylases and (with Michael Grunstein and David Allis) the demonstration that chromatin marks regulate gene expression, the development and application of diversity-oriented synthesis to microbial therapeutics, and the discovery of vulnerabilities of cancer cells linked to genetic, lineage and cell-state features, inclu ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Transfer RNA
Transfer ribonucleic acid (tRNA), formerly referred to as soluble ribonucleic acid (sRNA), is an adaptor molecule composed of RNA, typically 76 to 90 nucleotides in length (in eukaryotes). In a cell, it provides the physical link between the genetic code in messenger RNA (mRNA) and the amino acid sequence of proteins, carrying the correct sequence of amino acids to be combined by the protein-synthesizing machinery, the ribosome. Each three-nucleotide codon in mRNA is complemented by a three-nucleotide anticodon in tRNA. As such, tRNAs are a necessary component of translation, the biological synthesis of new proteins in accordance with the genetic code. Overview The process of translation starts with the information stored in the nucleotide sequence of DNA. This is first transformed into mRNA, then tRNA specifies which three-nucleotide codon from the genetic code corresponds to which amino acid. Each mRNA codon is recognized by a particular type of tRNA, which docks to it along ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Koch Institute For Integrative Cancer Research
The Koch Institute for Integrative Cancer Research at MIT ( ; also referred to as the Koch Institute or KI) is a cancer research center affiliated with the Massachusetts Institute of Technology (MIT) located in Cambridge, Massachusetts, United States. The institute is one of seven National Cancer Institute-designated basic laboratory cancer centers in the United States. The institute was launched in October 2007 with a $100 million grant from David H. Koch and the research facility opened in December 2010, replacing the MIT Center for Cancer Research (CCR). The institute is affiliated with 29 MIT faculty members in both the Schools of Engineering and Science. History In 1974, the Center for Cancer Research was founded by 1969 Nobel laureate Salvador Luria to study basic biological processes related to cancer. The center researches the genetic and molecular basis of cancer, how alterations in cellular processes affect cell growth and behavior, and how the immune system develo ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
National Academy Of Sciences
The National Academy of Sciences (NAS) is a United States nonprofit, NGO, non-governmental organization. NAS is part of the National Academies of Sciences, Engineering, and Medicine, along with the National Academy of Engineering (NAE) and the National Academy of Medicine (NAM). As a national academy, new members of the organization are elected annually by current members, based on their distinguished and continuing achievements in original research. Election to the National Academy is one of the highest honors in the scientific field in the United States. Member of the National Academy of Sciences, Members of the National Academy of Sciences serve ''pro bono'' as "advisers to the nation" on science, engineering, and medicine. The group holds a congressional charter under Title 36 of the United States Code. Congress legislated and President Abraham Lincoln signed an Act of Congress (1863) establishing the National Academy of Sciences as an independent, trusted nongovernmen ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
National Science Foundation CAREER Award
The National Science Foundation CAREER award is the most prestigious award presented by the National Science Foundation (NSF) of the United States Federal Government to support junior faculty who exemplify the role of teacher-scholars through research and education, and the integration of these endeavors in the context of their organizations' missions. The awards, presented once each year, include a federal grant of minimum $400,000 for research and education activities for five-year period. On 30 May 2025, the Trump administration requested a budget that eliminated the CAREER award. History The Presidential Young Investigators (PYI) program was initiated in 1983 during the presidency of Ronald Reagan, and remained active until the NSF New Young Investigators (NYI) program replaced it in 1992. Both programs were research-oriented and funded an average of 200 faculty members per year. Another, more selective program began in 1992, when the White House asked NSF to institute the P ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Reed College Alumni
Reed or Reeds may refer to: Science, technology, biology, and medicine * Reed bird (other) * Reed pen, writing implement in use since ancient times * Reed (plant), one of several tall, grass-like wetland plants of the order Poales * Reed reaction, in chemistry * Reed receiver, an outdated form of multi-channel signal decoding * Reed relay, one or more reed switches controlled by an electromagnet * Reed switch, an electrical switch operated by an applied magnetic field * Reed valve, restricts the flow of fluids to a single direction * Reed (weaving), a comb like tool for beating the weft when weaving * Reed's law, describes the utility of large networks, particularly social networks * Reed–Solomon error correction, a systematic way of building codes that can be used to detect and correct multiple random symbol errors * Reed–Sternberg cell, related to Hodgkin's disease Organizations * Reed (company), offering employment-related services (UK) * Reed and Stem, former ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Harvard Graduate School Of Arts And Sciences Alumni
Harvard University is a private Ivy League research university in Cambridge, Massachusetts, United States. Founded in 1636 and named for its first benefactor, the Puritan clergyman John Harvard, it is the oldest institution of higher learning in the United States. Its influence, wealth, and rankings have made it one of the most prestigious universities in the world. Harvard was founded and authorized by the Massachusetts General Court, the governing legislature of colonial-era Massachusetts Bay Colony. While never formally affiliated with any denomination, Harvard trained Congregational clergy until its curriculum and student body were gradually secularized in the 18th century. By the 19th century, Harvard emerged as the most prominent academic and cultural institution among the Boston elite. Following the American Civil War, under Harvard president Charles William Eliot's long tenure from 1869 to 1909, Harvard developed multiple professional schools, which transform ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Massachusetts Institute Of Technology Faculty
Massachusetts ( ; ), officially the Commonwealth of Massachusetts, is a U.S. state, state in the New England region of the Northeastern United States. It borders the Atlantic Ocean and the Gulf of Maine to its east, Connecticut and Rhode Island to its south, New Hampshire and Vermont to its north, and New York (state), New York to its west. Massachusetts is the List of U.S. states and territories by area, sixth-smallest state by land area. With a 2024 U.S. Census Bureau-estimated population of 7,136,171, its highest estimated count ever, Massachusetts is the most populous state in New England, the List of U.S. states and territories by population, 16th-most-populous in the United States, and the List of states and territories of the United States by population density, third-most densely populated U.S. state, after New Jersey and Rhode Island. Massachusetts was a site of early British colonization of the Americas, English colonization. The Plymouth Colony was founded in 16 ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
