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Angela Hartley Brodie
Angela Hartley Brodie (28 September 1934 – 7 June 2017) was a British biochemist who pioneered development of steroidal aromatase inhibitors in cancer research. Born in Lancashire (now Greater Manchester), Brodie studied chemical pathology to a doctoral level in Sheffield and was awarded a fellowship sponsored by National Institutes of Health. After 17 years of working in Shrewsbury, Massachusetts on oral contraceptives with Harry Brodie, whom she married, she switched focus to the effects of the oestrogen-producing enzyme, aromatase, on breast cancer. Brodie managed to get an aromatase inhibitor into a limited clinical trial in breast cancer patients in London, which had such a profound effect that it led to Novartis-sponsored trials, the development of formestane, the first aromatase inhibitor, eventually marketed in 1994. Brodie's work has been hailed "as among the most important contributions to cancer cure." Early life and education Brodie was born Angela Hartley on ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Oldham
Oldham is a town in Greater Manchester, England. It lies amongst the Pennines on elevated ground between the rivers River Irk, Irk and River Medlock, Medlock, southeast of Rochdale, and northeast of Manchester. It is the administrative centre of the Metropolitan Borough of Oldham, which had a population of 242,003 in 2021. Within the boundaries of the Historic counties of England, historic county of Lancashire, and with little Early modern Britain, early history to speak of, Oldham rose to prominence in the 19th century as an international centre of Textile manufacture during the Industrial Revolution, textile manufacture. It was a boomtown of the Industrial Revolution, and among the first ever Industrialisation, industrialised towns, rapidly becoming "one of the most important centres of cotton and textile industries in England." At its zenith, it was the most productive Spinning (textiles), cotton spinning mill town in the world,. producing more cotton than France and Germ ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Quaker
Quakers are people who belong to the Religious Society of Friends, a historically Protestant Christian set of denominations. Members refer to each other as Friends after in the Bible, and originally, others referred to them as Quakers because the founder of the movement, George Fox, told a judge to "quake before the authority of God". The Friends are generally united by a belief in each human's ability to be guided by the inward light to "make the witness of God" known to everyone. Quakers have traditionally professed a priesthood of all believers inspired by the First Epistle of Peter. They include those with evangelical, holiness, liberal, and traditional Quaker understandings of Christianity, as well as Nontheist Quakers. To differing extents, the Friends avoid creeds and hierarchical structures. In 2017, there were an estimated 377,557 adult Quakers, 49% of them in Africa followed by 22% in North America. Some 89% of Quakers worldwide belong to ''evangelical'' a ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Cornelia Channing
Cornelia "Nina" Channing (1938–1985) was an American professor of physiology at the University of Maryland School of Medicine. Her research focused on endocrinology and fertility; along with longtime collaborators Neena Schwartz and Darrell Ward, she was involved in the discovery of hormones involved in regulating the female reproductive cycle. She died of breast cancer in 1985. Early life and education Channing was born in Boston, Massachusetts in 1938. She received her bachelor's degree from Hood College in 1961 and her PhD in biochemistry from Harvard Medical School in 1965, advised by Claude Villee. She worked as a postdoctoral fellow in Cambridge. Academic career Channing returned to the US to serve as an instructor and later an assistant professor at the University of Pittsburgh, where she spent seven years in total. In 1973 she moved to the University of Maryland as an associate professor and was promoted to full professor in 1976. Channing served on the board of direct ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Steroidal Aromatase Inhibitor
Steroidal aromatase inhibitors are a class of drugs that are mostly used for treating breast cancer in postmenopausal women. High levels of estrogen in breast tissue increases the risk of developing breast cancer and the enzyme aromatase is considered to be a good Biological target, therapeutic target when treating breast cancer due to it being involved in the final step of estrogen biosynthetic pathway and also its inhibition will not affect production of other steroids. Aromatase Inhibitors are classified into two categories based on their structure, nonsteroidal and steroidal; the latter resemble the structure of 4-Androstenedione, androstenedione. Steroidal aromatase inhibitors irreversibly inhibit the enzyme by binding covalently to the binding site of aromatase so the substrate cannot access it. History Collaboration leading to discovery In 1944 the Worcester Foundation for Biomedical Research, Worcester Foundation for Experimental Biology (WFEB) was established. The foundati ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Harold Brodie
Harold may refer to: People * Harold (given name), including a list of persons and fictional characters with the name * Harold (surname), surname in the English language * András Arató, known in meme culture as "Hide the Pain Harold" Arts and entertainment * ''Harold'' (film), a 2008 comedy film * ''Harold'', an 1876 poem by Alfred, Lord Tennyson * ''Harold, the Last of the Saxons'', an 1848 book by Edward Bulwer-Lytton, 1st Baron Lytton * ''Harold or the Norman Conquest'', an opera by Frederic Cowen * ''Harold'', an 1885 opera by Eduard Nápravník * Harold, a character from the cartoon ''The Grim Adventures of Billy & Mandy'' *Harold & Kumar, a US movie; Harold/Harry is the main actor in the show. Places ;In the United States * Alpine, Los Angeles County, California, an erstwhile settlement that was also known as Harold * Harold, Florida, an unincorporated community * Harold, Kentucky, an unincorporated community * Harold, Missouri, an unincorporated community ; ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Oral Contraceptive Pill
Oral contraceptives, abbreviated OCPs, also known as birth control pills, are medications taken by mouth for the purpose of birth control. The introduction of the birth control pill ("the Pill") in 1960 revolutionized the options for contraception, sparking vibrant discussion in the scientific and social science literature and in the media. Much attention focused on issues of women's rights, including ethics and personal choice. But these medications also introduced new questions about risk. Female Two types of female oral contraceptive pill, taken once per day, are widely available: * The combined oral contraceptive pill contains estrogen and a progestin; colloquially known as "the Pill". * The progestogen-only pill, colloquially known as "minipill". For perfect use it is 99% effective and typical use is 91% effective. Side effects of the pill include headache, dizziness, nausea, sore breasts, spotting, mood changes, acne, bloating, etc. One pill offers the benefit of only havin ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Brandeis University
Brandeis University () is a Private university, private research university in Waltham, Massachusetts, United States. It is located within the Greater Boston area. Founded in 1948 as a nonsectarian, non-sectarian, coeducational university, Brandeis was established on the site of the former Middlesex University (Massachusetts), Middlesex University. The university is named after Louis Brandeis, a former Justice of the Supreme Court of the United States, Justice of the U.S. Supreme Court. Brandeis is Carnegie Classification of Institutions of Higher Education, classified among "R1: Doctoral Universities – Very high research activity" and is Higher education accreditation in the United States, accredited by the New England Commission of Higher Education. The university has been a member of the Association of American Universities (AAU) since 1985. In 2018, it had a total enrollment of 5,820 students on a campus of . The university has a liberal arts focus. List of Brandeis Univ ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Clark University
Clark University is a private research university in Worcester, Massachusetts, United States. Founded in 1887 with a large endowment from its namesake Jonas Gilman Clark, a prominent businessman, Clark was one of the first modern research universities in the United States. Originally an all-graduate institution, Clark's first undergraduates entered in 1902 and women were first enrolled in 1942. The university offers 46 majors, minors, and concentrations in the humanities, social sciences, natural sciences, and engineering and allows students to design specialized majors and engage in pre-professional programs. It is a member of the Higher Education Consortium of Central Massachusetts, which enables students to cross-register at other Worcester institutions including the Worcester Polytechnic Institute and the College of the Holy Cross. Clark is classified among "R2: Doctoral Universities – High research activity". It was a founding member of the Association of American ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Aldosterone
Aldosterone is the main mineralocorticoid steroid hormone produced by the zona glomerulosa of the adrenal cortex in the adrenal gland. It is essential for sodium conservation in the kidney, salivary glands, sweat glands, and colon. It plays a central role in the homeostatic regulation of blood pressure, plasma sodium (Na+), and potassium (K+) levels. It does so primarily by acting on the mineralocorticoid receptors in the distal tubules and collecting ducts of the nephron. It influences the reabsorption of sodium and excretion of potassium (from and into the tubular fluids, respectively) of the kidney, thereby indirectly influencing water retention or loss, blood pressure, and blood volume.Marieb Human Anatomy & Physiology 9th edition, chapter:16, page:629, question number:14 When dysregulated, aldosterone is pathogenic and contributes to the development and progression of cardiovascular and kidney disease. Aldosterone has exactly the opposite function of the atrial nat ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
University Of Manchester
The University of Manchester is a public university, public research university in Manchester, England. The main campus is south of Manchester city centre, Manchester City Centre on Wilmslow Road, Oxford Road. The University of Manchester is considered a red brick university, a product of the civic university movement of the late 19th century. The current University of Manchester was formed in 2004 following the merger of the University of Manchester Institute of Science and Technology (UMIST) and the Victoria University of Manchester. This followed a century of the two institutions working closely with one another. Additionally, the university owns and operates major cultural assets such as the Manchester Museum, The Whitworth art gallery, the John Rylands Library, the Tabley House, Tabley House Collection and the Jodrell Bank Observatory – a UNESCO World Heritage Site. The University of Manchester Institute of Science and Technology had its origins in the Manchester Mechan ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Estrogen-dependent Condition
An estrogen-dependent condition can be that relating to the differentiation in the steroid sex hormone that is associated with the female reproductive system and sex characteristics. These conditions can fall under the umbrella of hypoestrogenism, hyperestrogenim, or any sensitivity to the presence of estrogen in the body. Estrogen Estrogen is a critical sex hormone for women (in conjunction with progesterone). Estrogen is responsible for all different functions in a female body, but is also seen in any gender. These functions are seen in body tracts such as the skeletal system, liver, brain and breasts. There are three different formulations of estrogen: estrone, estradiol, and estriol. These are commonly referred to as E1, E2, and E3, following the listing stated prior. These three formulations have different functions in a women's life. Estradiol (E2) is seen in the reproductive time period. Estriol (E3) is seen primarily during pregnancy. Finally, estrone (E1) is the form the b ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Christie Hospital
The Christie, formerly known as Christie Hospital and The Christie Hospital and Holt Radium Institute, is a specialist National Health Service, National Health Service (NHS) single site cancer centre in Manchester, United Kingdom. The hospital is managed by The Christie NHS Foundation Trust, which had a turnover of £472 million and around 3,500 staff. Its work is supported by The Christie Charity. The hospital was established in 1890 by Richard Copley Christie, after whom, along with his wife Mary, it is named. Initially situated off Oxford Road, Manchester, Oxford Road in Manchester, the centre moved to a purpose-built facility in Withington in 1932 and became part of the National Health Service, NHS in 1948. Treatments and facilities The Christie is the largest single site cancer centre in Europe, and during the 2023–24 period provided 102,000 fractions of radiotherapy and treated more than 60,000 patients. It is the largest radiotherapy provider in the NHS, and similarly c ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
