Andrew D. Ellington
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Andrew D. Ellington
Andrew D. Ellington (born 1956) is an American biochemist and synthetic biologist who is a professor at the University of Texas at Austin. He holds the Wilson M. and Kathryn Fraser Professorship in Biochemistry at UT Austin and was selected as a Howard Hughes Medical Institute (HHMI) Professor in 2017. Ellington is best known for his work on in vitro selection techniques and is credited with coining the term "aptamer" to describe nucleic acid molecules that bind specific targets. His laboratory's research spans directed evolution, nucleic acid engineering, and synthetic biology, including the development of aptamers, ribozymes, and diagnostic biosensors. Early life and education Ellington was born in 1956 in Missouri. He developed an early interest in science and went on to attend Michigan State University, where he earned a B.S. in biochemistry in 1981. He then pursued graduate studies at Harvard University, receiving his Ph.D. in biochemistry and molecular biology in 1988. Du ...
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University Of Texas At Austin
The University of Texas at Austin (UT Austin, UT, or Texas) is a public university, public research university in Austin, Texas, United States. Founded in 1883, it is the flagship institution of the University of Texas System. With 53,082 students as of fall 2023, it is also the largest institution in the system. The university is a major center for academic research, with research expenditures totaling $1.06 billion for the 2023 fiscal year. It joined the Association of American Universities in 1929. The university houses seven museums and seventeen libraries, including the Lyndon Baines Johnson Library and Museum, Lyndon B. Johnson Presidential Library and the Blanton Museum of Art, and operates various auxiliary research facilities, such as the J. J. Pickle Research Campus and McDonald Observatory. UT Austin's athletics constitute the Texas Longhorns. The Longhorns have won four NCAA Division I National Football Championships, six NCAA Division I National Baseball Champions ...
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Ebola
Ebola, also known as Ebola virus disease (EVD) and Ebola hemorrhagic fever (EHF), is a viral hemorrhagic fever in humans and other primates, caused by ebolaviruses. Symptoms typically start anywhere between two days and three weeks after infection. The first symptoms are usually fever, sore throat, muscle pain, and headaches. These are usually followed by vomiting, diarrhoea, rash and decreased liver and kidney function, at which point some people begin to bleed both internally and externally. It kills between 25% and 90% of those infected – about 50% on average. Death is often due to shock from fluid loss, and typically occurs between 6 and 16 days after the first symptoms appear. Early treatment of symptoms increases the survival rate considerably compared to late start.Ebola in Uganda: An Ebola vaccine was approved by the US FDA in December 2019. The virus spreads through direct contact with body fluids, such as blood from infected humans or other animals, o ...
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Harvard University Alumni
The list of Harvard University alumni includes notable graduates, professors, and administrators affiliated with Harvard University. For a list of notable non-graduates of Harvard, see the list of Harvard University non-graduate alumni. For a list of Harvard's presidents, see President of Harvard University. Eight Presidents of the United States have graduated from Harvard University: John Adams, John Quincy Adams, Rutherford B. Hayes, John F. Kennedy, Franklin Delano Roosevelt, Theodore Roosevelt, George W. Bush, and Barack Obama. Bush graduated from Harvard Business School, Hayes and Obama from Harvard Law School, and the others from Harvard College. Over 150 Nobel Prize winners have been associated with the university as alumni, researchers or faculty. Nobel laureates Pulitzer Prize winners ...
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Michigan State University Alumni
Michigan ( ) is a peninsular U.S. state, state in the Great Lakes region, Great Lakes region of the Upper Midwest, Upper Midwestern United States. It shares water and land boundaries with Minnesota to the northwest, Wisconsin to the west, Indiana and Illinois to the southwest, Ohio to the southeast, and the Canadian Provinces and territories of Canada, province of Ontario to the east, northeast and north. With a population of 10.14 million and an area of , Michigan is the List of U.S. states and territories by population, 10th-largest state by population, the List of U.S. states and territories by area, 11th-largest by area, and the largest by total area east of the Mississippi River.''i.e.'', including water that is part of state territory. Georgia (U.S. state), Georgia is the largest state by land area alone east of the Mississippi and Michigan the second-largest. The state capital is Lansing, Michigan, Lansing, while its most populous city is Detroit. The Metro Detroit r ...
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21st-century American Biochemists
File:1st century collage.png, From top left, clockwise: Jesus is crucified by Roman authorities in Judaea (17th century painting). Four different men ( Galba, Otho, Vitellius, and Vespasian) claim the title of Emperor within the span of a year; The Great Fire of Rome (18th-century painting) sees the destruction of two-thirds of the city, precipitating the empire's first persecution against Christians, who are blamed for the disaster; The Roman Colosseum is built and holds its inaugural games; Roman forces besiege Jerusalem during the First Jewish–Roman War (19th-century painting); The Trưng sisters lead a rebellion against the Chinese Han dynasty (anachronistic depiction); Boudica, queen of the British Iceni leads a rebellion against Rome (19th-century statue); Knife-shaped coin of the Xin dynasty., 335px rect 30 30 737 1077 Crucifixion of Jesus rect 767 30 1815 1077 Year of the Four Emperors rect 1846 30 3223 1077 Great Fire of Rome rect 30 1108 1106 2155 Boudican re ...
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1956 Births
Events January * January 1 – The Anglo-Egyptian Sudan, Anglo-Egyptian Condominium ends in Sudan after 57 years. * January 8 – Operation Auca: Five U.S. evangelical Christian Missionary, missionaries, Nate Saint, Roger Youderian, Ed McCully, Jim Elliot and Pete Fleming, are killed for trespassing by the Waorani people of Ecuador, shortly after making contact with them. * January 16 – Egyptian leader Gamal Abdel Nasser vows to reconquer Palestine (region), Palestine. * January 25–January 26, 26 – Finnish troops reoccupy Porkkala, after Soviet Union, Soviet troops vacate its military base. Civilians can return February 4. * January 26 – The 1956 Winter Olympics open in Cortina d'Ampezzo, Italy. February * February 2 – Austria and Israel establish diplomatic Austria–Israel relations, relations. * February 11 – British Espionage, spies Guy Burgess and Donald Maclean (spy), Donald Maclean resurface in the Soviet Union, after being missing for 5 years. * ...
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Living People
Purpose: Because living persons may suffer personal harm from inappropriate information, we should watch their articles carefully. By adding an article to this category, it marks them with a notice about sources whenever someone tries to edit them, to remind them of WP:BLP (biographies of living persons) policy that these articles must maintain a neutral point of view, maintain factual accuracy, and be properly sourced. Recent changes to these articles are listed on Special:RecentChangesLinked/Living people. Organization: This category should not be sub-categorized. Entries are generally sorted by family name In many societies, a surname, family name, or last name is the mostly hereditary portion of one's personal name that indicates one's family. It is typically combined with a given name to form the full name of a person, although several give .... Maintenance: Individuals of advanced age (over 90), for whom there has been no new documentation in the last ten ...
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Multidrug-resistant Tuberculosis
Multidrug-resistant tuberculosis (MDR-TB) is a form of tuberculosis (TB) infection caused by bacteria that are resistant to treatment with at least two of the most powerful first-line anti-TB medications (drugs): isoniazid and rifampicin. Some forms of TB are also resistant to second-line medications, and are called extensively drug-resistant TB ( XDR-TB). Tuberculosis is caused by infection with the bacterium ''Mycobacterium tuberculosis''. Almost one in four people in the world are infected with TB bacteria. Only when the bacteria become active do people become ill with TB. Bacteria become active as a result of anything that can reduce the person's immunity, such as HIV, advancing age, diabetes or other immunocompromising illnesses. TB can usually be treated with a course of four standard, or first-line, anti-TB drugs (i.e., isoniazid, rifampicin, pyrazinamide and ethambutol). However, beginning with the first antibiotic treatment for TB in 1943, some strains of t ...
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Synthetic Biology
Synthetic biology (SynBio) is a multidisciplinary field of science that focuses on living systems and organisms. It applies engineering principles to develop new biological parts, devices, and systems or to redesign existing systems found in nature. It is a branch of science that encompasses a broad range of methodologies from various disciplines, such as biochemistry, biotechnology, biomaterials, Materials science, material science/engineering, genetic engineering, molecular biology, molecular engineering, systems biology, Model lipid bilayer, membrane science, biophysics, Biological engineering, chemical and biological engineering, Electrical engineering, electrical and computer engineering, control engineering and evolutionary biology. It includes designing and constructing BioBrick, biological modules, biological systems, and biological machines, or re-designing existing biological systems for useful purposes. Additionally, it is the branch of science that focuses on the ne ...
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Howard Hughes Medical Institute
The Howard Hughes Medical Institute (HHMI) is an American non-profit medical research organization headquartered in Chevy Chase, Maryland with additional facilities in Ashburn, Virginia. It was founded in 1953 by Howard Hughes, an American business magnate, investor, record-setting pilot, engineer, film director, and philanthropist, known during his lifetime as one of the most financially successful individuals in the world. It is one of the largest private funding organizations for biological and medical research in the United States. HHMI spends about $1 million per HHMI Investigator per year, which amounts to annual investment in biomedical research of about $825 million. The institute has an endowment of $22.6 billion, making it the second-wealthiest philanthropic organization in the United States and the second-best-endowed medical research foundation in the world. HHMI is the former owner of the Hughes Aircraft Company, an American aerospace firm that was divested to vari ...
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Directed Evolution
Directed evolution (DE) is a method used in protein engineering that mimics the process of natural selection to steer proteins or nucleic acids toward a user-defined goal. It consists of subjecting a gene to iterative rounds of mutagenesis (creating a library of variants), selection (expressing those variants and isolating members with the desired function) and amplification (generating a template for the next round). It can be performed ''in vivo'' (in living organisms), or ''in vitro'' (in cells or free in solution). Directed evolution is used both for protein engineering as an alternative to rationally designing modified proteins, as well as for experimental evolution studies of fundamental evolutionary principles in a controlled, laboratory environment. History Directed evolution has its origins in the 1960s with the evolution of RNA molecules in the "Spiegelman's Monster" experiment. The concept was extended to protein evolution via evolution of bacteria under selec ...
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Indiana University Bloomington
Indiana University Bloomington (IU Bloomington, Indiana University, IU, IUB, or Indiana) is a public university, public research university in Bloomington, Indiana, United States. It is the flagship university, flagship campus of Indiana University and its largest campus, with over 48,000 students. Established as the state's seminary in 1820, the name was changed to "Indiana College" in 1829 and to "Indiana University" in 1838. Indiana University is a member of the Association of American Universities and is Carnegie Classification of Institutions of Higher Education, classified among "R1: Doctoral Universities – Very high research activity". Its schools and programs include the Jacobs School of Music, Kelley School of Business, Indiana University School of Education, School of Education, Indiana University School of Informatics, Luddy School of Informatics, O'Neill School of Public and Environmental Affairs, Indiana University School of Public Health-Bloomington, School of Pu ...
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