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Active Pharmaceutical Ingredient
An active ingredient is any ingredient that provides biological activity, biologically active or other direct effect in the diagnosis, cure, mitigation, treatment, or prevention of disease or to affect the structure or any function of the body of humans or animals. The similar terms active pharmaceutical ingredient (abbreviated as API) and bulk active are also used in medicine. The term active substance may be used to describe the effective chemical used to control bacteria or pests. Some medication products can contain more than one active ingredient. The traditional word for the active pharmaceutical agent is pharmacon or pharmakon (from , adapted from ''pharmacos'') which originally denoted a Potion, magical substance or drug. The terms active constituent or active principle are often chosen when referring to the active chemical substance, substance of interest in a plant (such as salicylic acid in willow bark or arecoline in areca nuts), since the word "ingredient" can be tak ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Ingredient
In a general sense, an ingredient is a substance which forms part of a mixture. In cooking, recipes specify which ingredients are used to prepare a dish, and the term may also refer to a specific food item in relation to its use in different recipes. Many commercial products contain secret ingredients purported to make them better than competing products. In the pharmaceutical industry, an active ingredient is the ingredient in a Pharmaceutical formulation, formulation which invokes biological activity. National laws usually require prepared food products to display a list of ingredients and specifically require that certain food additive, additives be listed. Law typically requires that ingredients be listed according to their relative weight within the product. Etymology From Middle French , from Latin , present participle of ('to go or enter into or onto'). Artificial ingredient An artificial ingredient usually refers to an ingredient which is wikt:artificial, artifici ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
MedicineNet
''MedicineNet'' is an American healthcare information website launched in 1996. The website provides a medical dictionary and information about diseases, conditions, medications and general health. In partnership with Veritas Medicine, it connects site users with appropriate clinical trials. For those seeking general information, MedicineNet (www.medicinenet.com) is an extensive site from Information Network that provides a medical dictionary; databases on pharmaceuticals and their side effects, and diseases and treatments. In the "ask the experts," section you can query online physicians. Personnel Dr. William C. Shiel co-founded MedicineNet to provide the public with current, comprehensive medical information, written in easy-to-understand language. He was Chief Editor until July 2020 and authored or edited over 15,000 articles for the website. He continues as Chief Medical Editor/Author on the site's medical editorial board. Dr. Melissa Stöppler also serves on th ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Regulation Of Therapeutic Goods
The regulation of therapeutic goods, defined as drugs and therapeutic devices, varies by jurisdiction. In some countries, such as the United States, they are regulated at the national level by a single agency. In other jurisdictions they are regulated at the state level, or at both state and national levels by various bodies, as in Australia. The role of therapeutic goods regulation is designed mainly to protect the health and safety of the population. Regulation is aimed at ensuring the safety, quality, and efficacy of the therapeutic goods which are covered under the scope of the regulation. In most jurisdictions, therapeutic goods must be registered before they are allowed to be sold. There is usually some degree of restriction on the availability of certain therapeutic goods, depending on their risk to consumers. History Modern drug regulation has historical roots in the response to the proliferation of universal antidotes which appeared in the wake of Mithridates' death. ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Pharmakos
A pharmakós (, plural ''pharmakoi'') in Ancient Greek religion was the ritualistic sacrifice or exile of a human scapegoat or victim. Ritual A slave, a cripple, or a criminal was chosen and expelled from the community at times of disaster (famine, invasion or plague) or at times of calendrical crisis. It was believed that this would bring about purification. On the first day of the Thargelia, a festival of Apollo at Athens, two men, the ''pharmakoi'', were led out as if to be sacrificed as an expiation. Some scholia state that ''pharmakoi'' were actually sacrificed (thrown from a cliff or burned), but many modern scholars reject this, arguing that the earliest source for the ''pharmakos'' (the iambic satirist Hipponax) shows the ''pharmakoi'' being beaten and stoned, but not executed. A more plausible explanation would be that sometimes they were executed and sometimes not, depending on the attitude of the victim. For instance, a deliberate unrepentant murderer would most likely ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Medication
Medication (also called medicament, medicine, pharmaceutical drug, medicinal product, medicinal drug or simply drug) is a drug used to medical diagnosis, diagnose, cure, treat, or preventive medicine, prevent disease. Drug therapy (pharmacotherapy) is an important part of the medicine, medical field and relies on the science of pharmacology for continual advancement and on pharmacy for appropriate management. Drugs are Drug class, classified in many ways. One of the key divisions is by level of controlled substance, control, which distinguishes prescription drugs (those that a pharmacist dispenses only on the medical prescription) from over-the-counter drugs (those that consumers can order for themselves). Medicines may be classified by mode of action, route of administration, biological system affected, or therapeutic effects. The World Health Organization keeps a list of essential medicines. Drug discovery and drug development are complex and expensive endeavors undertake ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Formulation
Formulation is a term used in various senses in various applications, both the material and the abstract or formal. Its fundamental meaning is the putting together of components in appropriate relationships or structures, according to a formula. Etymologically ''formula'' is the diminutive of the Latin ''forma'', meaning shape. In that sense a ''formulation'' is created according to the standard for the product. Abstract applications Disciplines in which one might use the word ''formulation'' in the abstract sense include logic, mathematics, linguistics, legal theory, and computer science. For details, see the related articles. Material applications In more material senses the concept of ''formulation'' appears in the physical sciences, such as physics, chemistry, and biology. It also is ubiquitous in industry, engineering and medicine, especially pharmaceutics. Pharmacy In pharmacy, a formulation is a mixture or a structure such as a capsule, tablet, or an emulsion ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Hyperforin
Hyperforin is a phytochemical produced by some of the members of the plant genus ''Hypericum'', notably ''Hypericum perforatum'' (St John's wort). Hyperforin may be involved in the pharmacology, pharmacological effects of St. John's wort, specifically in its antidepressant effects. Meta-analysis, Meta-analyses of Clinical trial, clinical trials suggest that ''H. perforatum'' is as effective as Selective serotonin reuptake inhibitor, SSRIs for treating mild to moderate Depression (mood), depression and is better tolerated, although findings are limited by short study durations. Hyperforin is found in significant amounts only in ''H. perforatum'', where it accumulates as a probable Plant defense against herbivory, plant defense compound, with modern Carbon dioxide, CO₂ extraction methods used to isolate it from mixtures containing related compounds like adhyperforin. Occurrence Hyperforin has only been found in significant amounts in ''Hypericum perforatum'' with other related s ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Antidepressant
Antidepressants are a class of medications used to treat major depressive disorder, anxiety disorders, chronic pain, and addiction. Common side effects of antidepressants include Xerostomia, dry mouth, weight gain, dizziness, headaches, akathisia, sexual dysfunction, and emotional blunting. There is an increased risk of Suicidal ideation, suicidal thinking and Suicide, behavior when taken by children, adolescents, and young adults. Antidepressant discontinuation syndrome, Discontinuation syndrome, which resembles recurrent Depression (mood), depression in the case of the Selective serotonin reuptake inhibitor, SSRI class, may occur after stopping the intake of any antidepressant. Research regarding the effectiveness of antidepressants for depression in adults is controversial and has found both benefits and drawbacks. Meanwhile, evidence of benefit in children and adolescents is unclear, even though antidepressant use has considerably increased in children and adolescents in th ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Hypericin
Hypericin is a carbopolycyclic compound derived from bisanthene with antidepressant properties, found in various ''Hypericum'' species, and is being studied for treating cutaneous T-cell lymphoma. Opinions differ on the extent to which hypericin exhibits antidepressant effects. According to some scholars, hypericin, along with other active compounds in ''Hypericum perforatum'' (St. John’s wort), contributes to the antidepressant effects of the total plant extract. According to others, hypericin does not significantly inhibit monoamine oxidase and thus is unlikely to account for the antidepressant effects of ''Hypericum'' extract. While another hypericin shows affinity mainly for NMDA receptors, suggesting that other plant constituents likely play a more significant role in its antidepressant effects. Hypericin is a structurally complex phenanthroperylene quinone with potential Evidence-based medicine, medical and photoreceptive applications. It is red-colored, photosensiti ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Hypericum Perforatum
''Hypericum perforatum'', commonly known as St. John's wort (sometimes perforate St. John's wort or common St. John's wort), is a flowering plant in the family Hypericaceae. It is a hairless, Perennial, perennial herb with woody Root, roots, yellow Flower, flowers marked by black glands, and leaves that appear Perforation, perforated due to translucent glands, producing thousands of seeds per plant. ''H. perforatum'' is the type species of its genus, known for its historical use in folklore and traditional medicine. Probably a Hybrid (biology), hybrid between the closely related ''Hypericum attenuatum, H. attenuatum'' and ''Hypericum maculatum, H. maculatum'' (imperforate St. John's wort) that originated in Siberia, the species has Cosmopolitan distribution, spread worldwide. It can further hybridize with related species due to its Polyploidy, allopolyploid nature. It is native to much of Europe, West Asia, West and Central Asia, and parts of Africa and China and has been wide ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Biomarker
In biomedical contexts, a biomarker, or biological marker, is a measurable indicator of some biological state or condition. Biomarkers are often measured and evaluated using blood, urine, or soft tissues to examine normal biological processes, pathogenic processes, or pharmacologic responses to a therapeutic intervention. as cited in Biomarkers are used in many scientific fields. Medicine Biomarkers used in the medical field, are a part of a relatively new clinical toolset categorized by their clinical applications. The four main classes are molecular, physiologic, histologic and radiographic biomarkers. All four types of biomarkers have a clinical role in narrowing or guiding treatment decisions and follow a sub-categorization of being either predictive, prognostic, or diagnostic. Predictive Predictive molecular, cellular, or imaging biomarkers that pass validation can serve as a method of predicting clinical outcomes. Predictive biomarkers are used to help optimize ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Standardization
Standardization (American English) or standardisation (British English) is the process of implementing and developing technical standards based on the consensus of different parties that include firms, users, interest groups, standards organizations and governments. Standardization can help maximize compatibility, interoperability, safety, repeatability, efficiency, and quality. It can also facilitate a normalization of formerly custom processes. In social sciences, including economics, the idea of ''standardization'' is close to the solution for a coordination problem, a situation in which all parties can realize mutual gains, but only by making mutually consistent decisions. Divergent national standards impose costs on consumers and can be a form of non-tariff trade barrier. History Early examples Standard weights and measures were developed by the Indus Valley civilization.Iwata, Shigeo (2008), "Weights and Measures in the Indus Valley", ''Encyclopaedia of the History ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
