|
ARCT-154
ARCT-154, also known as VBC-COV19-154 in Vietnam, is a COVID-19 vaccine candidate developed by Arcturus Therapeutics. For its development, Arcturus collaborated with Vinbiocare, a Vietnamese company, for support with clinical trials and manufacturing. The vaccine was authorised in Japan in November 2023, and the European Union in February 2025. Medical uses The vaccine requires two doses, the second one being administered 28 days after the first shot. It is a self-amplifying mRNA vaccine. Manufacturing The vaccine candidate can be made in a lyophilized powder form, allowed it to be shipped and stored between . In August 2021, Arcturus Therapeutics entered a partnership with Vinbiocare, a unit of Vingroup to conduct clinical trials of ARCT-154 COVID-19 vaccine, developed created using Arcturus’ STARR mRNA technology, in Vietnam and establish a manufacturing facility a factory in Hòa Lạc Hi-tech Park, Hanoi, which requires an estimated investment of $200 million ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Self-amplifying RNA
Self-amplifying RNA (saRNA), also termed self-replicating RNA (srRNA), is a type of mRNA molecule engineered to replicate itself within host cells, enhancing protein expression and boosting the immune response, making it a promising tool for MRNA vaccine#Amplification, vaccines and other therapeutic applications. As a "next-generation" mRNA, saRNA is designed to achieve greater protein expression with a reduced dose compared to conventional mRNA. Unlike conventional mRNA, which has a Messenger RNA#Degradation, short half-life and limited ability to express proteins for an extended time, saRNA can sustain protein expression for longer periods. saRNA are based on positive single stranded RNA viruses most commonly alphaviruses such as Venezuelan equine encephalitis virus. Conventional messenger RNA (mRNA) vaccines only produce a finite amount of protein due to the short mRNA half-life. saRNA extends the kinetics of expression by a second ORF encoding the protein machinery necessary f ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Arcturus Therapeutics
Arcturus Therapeutics Holdings Inc. is an American RNA medicines biotechnology company focused on the discovery, development and commercialization of therapeutics for rare diseases and infectious diseases. Arcturus has developed proprietary lipid nanoparticle RNA therapeutics for nucleic acid medicines including small interfering RNA (siRNA), messenger RNA (mRNA), gene editing RNA, DNA, antisense oligonucleotides, and microRNA. The company develops RNA therapeutics for the treatment of rare diseases such as ornithine transcarbamylase deficiency, and respiratory diseases such as cystic fibrosis. Vaccine medicines include a vaccine candidate for COVID-19 and an influenza vaccine in the preclinical development phase. The vaccine for COVID-19 was authorised in Japan in 2023 and the European Union in 2025. History Founded in 2013 by Joseph Payne and Pad Chivukula, Arcturus Therapeutics is headquartered in San Diego, California, USA. Initially, they developed a proprietary lipid nanop ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
RNA Vaccines
An mRNA vaccine is a type of vaccine that uses a copy of a molecule called messenger RNA (mRNA) to produce an immune response. The vaccine delivers molecules of antigen-encoding mRNA into cells, which use the designed mRNA as a blueprint to build foreign protein that would normally be produced by a pathogen (such as a virus) or by a cancer cell. These protein molecules stimulate an adaptive immune response that teaches the body to identify and destroy the corresponding pathogen or cancer cells. The mRNA is delivered by a co-formulation of the RNA encapsulated in lipid nanoparticles that protect the RNA strands and help their absorption into the cells. Reactogenicity, the tendency of a vaccine to produce adverse reactions, is similar to that of conventional non-RNA vaccines. People susceptible to an autoimmune response may have an adverse reaction to messenger RNA vaccines. The advantages of mRNA vaccines over traditional vaccines are ease of design, speed and lower cost of ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
SARS-CoV-2 Gamma Variant
The Gamma variant (P.1) was one of the variants of SARS-CoV-2, the virus that causes COVID-19. This variant of SARS-CoV-2 has been named lineage P.1 and has 17 amino acid substitutions, ten of which in its spike protein, including these three designated to be of particular concern: N501Y, E484K and K417T. It was first detected by the National Institute of Infectious Diseases (NIID) of Japan, on 6 January 2021 in four people who had arrived in Tokyo having visited Amazonas, Brazil, four days earlier. It was subsequently declared to be in circulation in Brazil. Under the simplified naming scheme proposed by the World Health Organization, P.1 was labeled Gamma variant, and was considered a variant of concern until March 2022, when it was largely displaced by the delta and omicron variants. Gamma caused widespread infection in early 2021 in the city of Manaus, the capital of Amazonas, although the city had already experienced widespread infection in May 2020, with a study i ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Clinical Trials Related To COVID-19
Clinical may refer to: Healthcare * Of or about a clinic, a healthcare facility * Of or about the practice of medicine Other uses * ''Clinical'' (film), a 2017 American horror thriller See also * * * Clinical chemistry, the analysis of bodily fluids for diagnostic and therapeutic purposes * Clinical death, the cessation of blood circulation and breathing * Clinical formulation, a theoretically-based explanation of information obtained from clinical assessment * Clinical governance, a systematic approach to maintaining and improving the quality of patient care * Clinical linguistics, linguistics applied to speech-language pathology * Clinical psychology, the understanding, preventing, and relieving psychologically-based distress or dysfunction * Clinical research, to determine the safety and effectiveness of medications etc. * Clinical significance, the practical importance of a treatment effect * Clinical trial, experiments or observations done in clinical research * Clinical w ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
American COVID-19 Vaccines
American(s) may refer to: * American, something of, from, or related to the United States of America, commonly known as the "United States" or "America" ** Americans, citizens and nationals of the United States of America ** American ancestry, people who self-identify their ancestry as "American" ** American English, the set of varieties of the English language native to the United States ** Native Americans in the United States, indigenous peoples of the United States * American, something of, from, or related to the Americas, also known as "America" ** Indigenous peoples of the Americas * American (word), for analysis and history of the meanings in various contexts Organizations * American Airlines, U.S.-based airline headquartered in Fort Worth, Texas * American Athletic Conference, an American college athletic conference * American Recordings (record label), a record label that was previously known as Def American * American University, in Washington, D.C. Sports teams S ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Equivalence Test
Equivalence tests are a variety of hypothesis tests used to draw statistical inferences from observed data. In these tests, the null hypothesis is defined as an effect large enough to be deemed interesting, specified by an equivalence bound. The alternative hypothesis is any effect that is less extreme than said equivalence bound. The observed data are statistically compared against the equivalence bounds. If the statistical test indicates the observed data is surprising, assuming that true effects are at least as extreme as the equivalence bounds, a Neyman-Pearson approach to statistical inferences can be used to reject effect sizes larger than the equivalence bounds with a pre-specified Type 1 error rate. Equivalence testing originates from the field of clinical trials. One application, known as a non-inferiority trial, is used to show that a new drug that is cheaper than available alternatives works as well as an existing drug. In essence, equivalence tests consist of calculat ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Hanoi
Hanoi ( ; ; ) is the Capital city, capital and List of cities in Vietnam, second-most populous city of Vietnam. The name "Hanoi" translates to "inside the river" (Hanoi is bordered by the Red River (Asia), Red and Black River (Asia), Black Rivers). As a Municipalities of Vietnam, municipality, Hanoi consists of 12 List of urban districts of Vietnam, urban districts, 17 Huyện, rural districts, and 1 District-level town (Vietnam), district-level town. The city encompasses an area of . and as of 2024 has a population of 8,718,000. Hanoi had the second-highest gross regional domestic product of all Vietnamese provinces and municipalities at US$51.4 billion in 2022, behind only Ho Chi Minh City. In the third century BCE, the Cổ Loa Citadel, Cổ Loa Capital Citadel of Âu Lạc was constructed in what is now Hanoi. Âu Lạc then Vietnam under Chinese rule, fell under Chinese rule for a thousand years. In 1010, under the Lý dynasty, Vietnamese emperor Lý Thái Tổ established ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Ministry Of Health (Vietnam)
The Ministry of Health (MOH, ) is the government ministry responsible for the governance and guidance of the health, healthcare and health industry of Vietnam. In conjunction with other ministries and the prime minister's office, the Ministry is responsible for creating and promulgating long-term health policy programs such as the "National Strategy on Nutrition for the 2001 - 2010 period" and the "National Policy on Injury Prevention 2002 - 2010". Its main offices are located in Ba Đình District, Hanoi. History The Ministry of Health was one of the first 13 Ministries of the Provisional Revolutionary Government of the Democratic Republic of Vietnam, established on August 28, 1945 and introduced to the people for the first time on September 2, 1945. The first Minister was Doctor Pham Ngoc Thach. On March 2, 1946, the Government of the Resistance Coalition merged the Ministry of Health, the Ministry of Labor and the Ministry of Social Relief into the Ministry of Social Af ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
