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ARCT-021
ARCT-021, also known as LUNAR-COV19, is a COVID-19 vaccine candidate developed by Arcturus Therapeutics. Medical uses It requires the intramuscular injection with a single dose. Pharmacology ARCT-021 is an self-amplifying mRNA vaccine. History Arcturus Therapeutics partnered with Singapore's Duke–NUS Medical School to develop a COVID-19 vaccine. The company also partnered with Catalent, a contract development and manufacturing organization, to manufacture multiple batches of Arcturus' COVID-19 mRNA vaccine An mRNA vaccine is a type of vaccine that uses a copy of a molecule called messenger RNA (mRNA) to produce an immune response. The vaccine delivers molecules of antigen-encoding mRNA into cells, which use the designed mRNA as a blueprint to b ... candidate. Clinical trials LUNAR-COV19 clinical trials in humans began in July 2020. On 4 January 2021, Arcturus Therapeutics started Phase-2 clinical trials. Economics Arcturus has entered into development an ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Arcturus Therapeutics
Arcturus Therapeutics Holdings Inc. is an American RNA medicines biotechnology company focused on the discovery, development and commercialization of therapeutics for rare diseases and infectious diseases. Arcturus has developed proprietary lipid nanoparticle RNA therapeutics for nucleic acid medicines including small interfering RNA (siRNA), messenger RNA (mRNA), gene editing RNA, DNA, antisense oligonucleotides, and microRNA. The company develops RNA therapeutics for the treatment of rare diseases such as ornithine transcarbamylase deficiency, and respiratory diseases such as cystic fibrosis. Vaccine medicines include a vaccine candidate for COVID-19 and an influenza vaccine in the preclinical development phase. The vaccine for COVID-19 was authorised in Japan in 2023 and the European Union in 2025. History Founded in 2013 by Joseph Payne and Pad Chivukula, Arcturus Therapeutics is headquartered in San Diego, California, USA. Initially, they developed a proprietary lipid nanop ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Severe Acute Respiratory Syndrome Coronavirus 2
Severe acute respiratory syndrome coronavirus 2 (SARS‑CoV‑2) is a strain of coronavirus that causes COVID-19, the respiratory illness responsible for the COVID-19 pandemic. The virus previously had the Novel coronavirus, provisional name 2019 novel coronavirus (2019-nCoV), and has also been called human coronavirus 2019 (HCoV-19 or hCoV-19). First identified in the city of Wuhan, Hubei, China, the World Health Organization designated the outbreak a public health emergency of international concern from January 30, 2020, to May 5, 2023. SARS‑CoV‑2 is a positive-sense single-stranded RNA virus that is Contagious disease, contagious in humans. SARS‑CoV‑2 is a strain of the species ''Betacoronavirus pandemicum'' (SARSr-CoV), as is SARS-CoV-1, the virus that caused the 2002–2004 SARS outbreak. There are animal-borne coronavirus strains more closely related to SARS-CoV-2, the most closely known relative being the BANAL-52 bat coronavirus. SARS-CoV-2 is of Zoonosis, z ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Intramuscular Injection
Intramuscular injection, often abbreviated IM, is the medical injection, injection of a substance into a muscle. In medicine, it is one of several methods for parenteral, parenteral administration of medications. Intramuscular injection may be preferred because muscles have larger and more numerous blood vessels than subcutaneous tissue, leading to faster absorption than subcutaneous injection, subcutaneous or intradermal injections. Medication administered via intramuscular injection is not subject to the first-pass metabolism effect which affects oral medications. Common sites for intramuscular injections include the deltoid muscle of the upper arm and the gluteal muscle of the buttock. In infants, the vastus lateralis muscle of the thigh is commonly used. The injection site must be cleaned before administering the injection, and the injection is then administered in a fast, darting motion to decrease the discomfort to the individual. The volume to be injected in the muscle is ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
COVID-19 Vaccine
A COVID19 vaccine is a vaccine intended to provide acquired immunity against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the virus that causes coronavirus disease 2019 ( COVID19). Knowledge about the structure and function of previous coronaviruses causing diseases like severe acute respiratory syndrome ( SARS) and Middle East respiratory syndrome ( MERS) accelerated the development of various vaccine platforms in early 2020. In 2020, the first COVID19 vaccines were developed and made available to the public through emergency authorizations and conditional approvals. However, immunity from the vaccines wanes over time, requiring people to get booster doses of the vaccine to maintain protection against COVID19. The COVID19 vaccines are widely credited for their role in reducing the spread of COVID19 and reducing the severity and death caused by COVID19. Many countries implemented phased distribution plans that prioritized those at highest risk of comp ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Intramuscular Injection
Intramuscular injection, often abbreviated IM, is the medical injection, injection of a substance into a muscle. In medicine, it is one of several methods for parenteral, parenteral administration of medications. Intramuscular injection may be preferred because muscles have larger and more numerous blood vessels than subcutaneous tissue, leading to faster absorption than subcutaneous injection, subcutaneous or intradermal injections. Medication administered via intramuscular injection is not subject to the first-pass metabolism effect which affects oral medications. Common sites for intramuscular injections include the deltoid muscle of the upper arm and the gluteal muscle of the buttock. In infants, the vastus lateralis muscle of the thigh is commonly used. The injection site must be cleaned before administering the injection, and the injection is then administered in a fast, darting motion to decrease the discomfort to the individual. The volume to be injected in the muscle is ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Self-amplifying RNA
Self-amplifying RNA (saRNA), also termed self-replicating RNA (srRNA), is a type of mRNA molecule engineered to replicate itself within host cells, enhancing protein expression and boosting the immune response, making it a promising tool for MRNA vaccine#Amplification, vaccines and other therapeutic applications. As a "next-generation" mRNA, saRNA is designed to achieve greater protein expression with a reduced dose compared to conventional mRNA. Unlike conventional mRNA, which has a Messenger RNA#Degradation, short half-life and limited ability to express proteins for an extended time, saRNA can sustain protein expression for longer periods. saRNA are based on positive single stranded RNA viruses most commonly alphaviruses such as Venezuelan equine encephalitis virus. Conventional messenger RNA (mRNA) vaccines only produce a finite amount of protein due to the short mRNA half-life. saRNA extends the kinetics of expression by a second ORF encoding the protein machinery necessary f ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
MRNA Vaccine
An mRNA vaccine is a type of vaccine that uses a copy of a molecule called messenger RNA (mRNA) to produce an immune response. The vaccine delivers molecules of antigen-encoding mRNA into cells, which use the designed mRNA as a blueprint to build foreign protein that would normally be produced by a pathogen (such as a virus) or by a cancer cell. These protein molecules stimulate an adaptive immune response that teaches the body to identify and destroy the corresponding pathogen or cancer cells. The mRNA is delivered by a co-formulation of the RNA encapsulated in lipid nanoparticles that protect the RNA strands and help their absorption into the cells. Reactogenicity, the tendency of a vaccine to produce adverse reactions, is similar to that of conventional non-RNA vaccines. People susceptible to an autoimmune response may have an adverse reaction to messenger RNA vaccines. The advantages of mRNA vaccines over traditional vaccines are ease of design, speed and lower cost ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Duke–NUS Medical School
The Duke–NUS Medical School (Duke–NUS) is a graduate medical school in Singapore. Established in April 2005 as the Duke–NUS Graduate Medical School, it is Singapore's second medical school (after the NUS Yong Loo Lin School of Medicine and before the NTU Lee Kong Chian School of Medicine). The school is a collaboration between Duke University in the United States and the National University of Singapore in Singapore. Duke–NUS follows the American model of post-baccalaureate medical education, in which students begin their medical studies after earning a bachelor's degree. Students are awarded degrees from both Duke University and the National University of Singapore. Outram campus The construction of Duke–NUS Medical School's primary facility, the Khoo Teck Puat Building, started in December 2006. In May 2009, the School shifted from its first campus at Jalan Bukit Merah into the Outram campus of Singapore General Hospital, next to the College of Medicine Building. ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
The Straits Times
''The Straits Times'' (also known informally by its abbreviation ''ST'') is a Singaporean daily English-language newspaper owned by the SPH Media Trust. Established on 15 July 1845, it is the most-widely circulated newspaper in the country and has a significant regional audience. The newspaper is published in the broadsheet format and online, the latter of which was launched in 1994. It is regarded as the newspaper of record for Singapore. Print and digital editions of ''The Straits Times'' and ''The Sunday Times'' had a daily average circulation of 364,134 and 364,849 respectively in 2017, as audited by Audit Bureau of Circulations Singapore. In 2014, country-specific editions were published for residents in Brunei and Myanmar, with newsprint circulations of 2,500 and 5,000 respectively. History Early years The original conception for ''The Straits Times'' has been debated by historians of Singapore. Prior to 1845, the only English-language newspaper in Singapore was ''The ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Catalent
Catalent, Inc. (Catalent Pharma Solutions), is an American multinational company, and a subsidiary of Novo Holdings A/S since 2024. It is headquartered in Somerset, New Jersey. It is a provider of drug delivery technologies, drug development, drug manufacturing, biologics, gene therapy, and consumer health products. It has over 50 facilities on four continents and has supported more than half the products approved by the Food and Drug Administration in the last ten years. Annually, it produces 70 billion doses for 8,000 products. The company's major customers include Bayer, Bristol-Myers Squibb, GlaxoSmithKline, Haleon, Novo Nordisk, Moderna, Pfizer, and Sarepta Therapeutics. History Before 2007 In 1996, Cardinal Health acquired PCI of Philadelphia, Pennsylvania, a pharmaceutical contract packing service for commercial and clinical packaging. In 1998, Cardinal Health acquired R.P. Scherer Corporation of Troy, Michigan for $2.2 billion; it was founded by Robert Pauli Sche ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Economic Development Board
The Economic Development Board (EDB) is a statutory board under the Ministry of Trade and Industry of the government of Singapore that plans and executes strategies to sustain Singapore as a leading global hub for business and investment. History 1957–1961: Singapore Industrial Promotion Board In 1957, the Singapore Industrial Promotion Board (SIPB) was formed through the passage of the Singapore Industrial Promotion Bill, to empower the Singapore Government in establishing, developing, and financing industrial undertakings. It had a capital of $1 million, and had received requests from local companies for loans totalling up to $500,000 at its formation. However, SIPB was criticised by political opposition as being slow, not transparent, and ineffective in aiding local businesses. The board was hamstrung by the limited capital that it had with the Minister of Commerce and Industry, J. M. Jumabhoy, blaming on the activities of extreme left-wing politicians on the lack of co ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Ministry Of Health (Israel)
The Ministry of Health (, translit. ''Misrad HaBri'ut'') is a ministry in the Israeli government, responsible for formulating health policies. The ministry plans, supervises, licenses, and coordinates the country's health care services. In addition to overseeing health services provided by Kupat Holim and family health centers such as Tipat Halav, the ministry maintains general hospitals, psychiatric hospitals, mental health clinics, treatment programs for substance abuse, and facilities for the chronically ill. As of late 2023, the current Minister of Health is Uriel Buso. History In January 2021, the ministry entered a collaborative agreement with Pfizer granting the company access to Israel citizens' personal electronic medical records in order to observe the real-world safety and efficacy of the BNT162b2 COVID-19 vaccine product. In February 2022, the ministry banned medical professionals in Israel from providing conversion therapy. List of ministers Deputy minister ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
