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6-Hydroxytryptamine
6-Hydroxytryptamine (6-HT or 6-HO-T) is a serotonin receptor modulator of the substituted tryptamine, tryptamine family related to serotonin. It is a positional isomer of serotonin (5-hydroxytryptamine; 5-HT) and of 4-hydroxytryptamine (4-HT). Pharmacology 6-Hydroxytryptamine shows dramatically reduced affinity (pharmacology), affinity for serotonin receptors, including the serotonin 5-HT1A receptor, 5-HT1A, 5-HT1B receptor, 5-HT1B, 5-HT2A receptor, 5-HT2A, and 5-HT2C receptor, 5-HT2C receptors (Ki = 1,590nM, 5,890nM, 11,500nM, and 5,500nM, respectively), compared to serotonin, 4-hydroxytryptamine, 5-methoxytryptamine, and certain other tryptamines. It did not produce hyperlocomotion in rodents but did partially reverse reserpine-induced hypoactivity. 6-Hydroxytryptamine appears to be less susceptible to drug metabolism, metabolism by monoamine oxidase (MAO) than serotonin. History 6-Hydroxytryptamine was first described in the scientific literature by the 1950s. Derivatives Cer ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Substituted β-carboline
A substituted β-carboline is a chemical compound featuring a β-carboline moiety (chemistry), moiety with one or more chemical substituent, substitutions. β-Carbolines include more than one hundred alkaloids and synthetic compounds. The effects of these substances depend on their respective substituent. Natural β-carbolines primarily influence brain functions but can also exhibit antioxidant effects. Synthetically designed β-carboline Derivative (chemistry), derivatives have recently been shown to have Neuroprotection, neuroprotective, Neuroenhancement, cognitive enhancing and anti-cancer properties. β-Carbolines are indole alkaloids featuring a fused pyridine and indole ring structure similar to tryptamine, forming a three-ringed system with variable saturation in the third ring. β-Carboline alkaloids naturally occur widely in prokaryotes, plants, animals, certain marine tunicates, and foods like coffee and smoked meats, and are also responsible for the fluorescence of sco ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
