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4-HO-MPMI
4-HO-MPMI (also known as 4-Hydroxy-''N''-methyl-(α,''N''-trimethylene)-tryptamine or lucigenol) is a tryptamine derivative that is a psychedelic drug. It was developed by the team led by David Nichols from Purdue University in the late 1990s. This compound produces hallucinogen-appropriate responding in animal tests with a similar potency to the amphetamine- derived psychedelic DOI, and has two enantiomer In chemistry, an enantiomer (Help:IPA/English, /ɪˈnænti.əmər, ɛ-, -oʊ-/ Help:Pronunciation respelling key, ''ih-NAN-tee-ə-mər''), also known as an optical isomer, antipode, or optical antipode, is one of a pair of molecular entities whi ...s, with only the (''R'')-enantiomer being active. The binding affinity for 5-HT2A receptor is 13 ± 2 nM (Ki 25IOI). It is reported at doses starting at 0.5 mg and 1.0-1.5 mg seem to be psychedelic doses. The duration it is reported between six and eight hours. Available (anecdotal) data on subjective effects report ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Pyrrolidinylmethylindoles
3-(N-methylpyrrolidin-3-ylmethyl)indole (MPMI) is a tryptamine derivative which acts as a serotonin receptor agonist. It has been studied as an analogue and trace impurity of the anti-migraine drug eletriptan but is otherwise little known. See also * α,N,N-Trimethyltryptamine * Dimethyltryptamine * 4-HO-MPMI * 5F-MPMI * 5-MeO-MPMI * NTBT * 10,11-Secoergoline (α,''N''-Pip-T) * Pyr-T * SN-22 SN-22 is a chemical compound which acts as a moderately selective agonist at the 5-HT2 family of serotonin receptors, with a Ki of 19 nM at 5-HT2 subtypes versus 514 nM at 5-HT1A receptors. Many related derivatives are known, most of ... References Alpha-Alkyltryptamines Designer drugs N,N-Dialkyltryptamines Psychedelic tryptamines Pyrrolidinylmethylindoles Serotonin receptor agonists {{nervous-system-drug-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
4-HO-McPeT
4-HO-McPeT (4-hydroxy-''N''-methyl-''N''-cyclopentyltryptamine) is a tryptamine derivative which has serotonergic effects. See also * 4-HO-DSBT * 4-HO-McPT * 4-HO-MPMI 4-HO-MPMI (also known as 4-Hydroxy-''N''-methyl-(α,''N''-trimethylene)-tryptamine or lucigenol) is a tryptamine derivative that is a psychedelic drug. It was developed by the team led by David Nichols from Purdue University in the late 1990s. ... * 4-HO-pyr-T * 4-HO-DMT (Psilocin) * PiPT References Cyclopentyl compounds N,N-Dialkyltryptamines 4-Hydroxytryptamines {{psychoactive-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
MPMI (drug)
3-(N-methylpyrrolidin-3-ylmethyl)indole (MPMI) is a tryptamine derivative which acts as a serotonin receptor agonist. It has been studied as an analogue and trace impurity of the anti-migraine drug eletriptan but is otherwise little known. See also * α,N,N-Trimethyltryptamine * Dimethyltryptamine * 4-HO-MPMI * 5F-MPMI * 5-MeO-MPMI * NTBT * 10,11-Secoergoline (α,''N''-Pip-T) * Pyr-T * SN-22 SN-22 is a chemical compound which acts as a moderately selective agonist at the 5-HT2 family of serotonin receptors, with a Ki of 19 nM at 5-HT2 subtypes versus 514 nM at 5-HT1A receptors. Many related derivatives are known, most of ... References Alpha-Alkyltryptamines Designer drugs N,N-Dialkyltryptamines Psychedelic tryptamines Pyrrolidinylmethylindoles Serotonin receptor agonists {{nervous-system-drug-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
CP-135,807
CP-135807 is a drug which acts as a potent and selective agonist for the 5-HT1D serotonin receptor, and is used to study the function of this receptor subtype. See also * 4-HO-MPMI * 5-MeO-MPMI * Eletriptan * LY-334370 LY-334370 is a selective 5-HT1F receptor agonist which was under development by Eli Lilly and Company for the treatment of migraine headaches. The drug showed efficacy in a phase II clinical trial but further development was halted due to toxic ... References Disubstituted pyridines Alpha-Alkyltryptamines N,N-Dialkyltryptamines Nitroarenes Pyrrolidinylmethylindoles Serotonin receptor agonists {{nervous-system-drug-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
5-MeO-MPMI
5-MeO-MPMI (also known as 5-Methoxy-''N''-methyl-(α,''N''-trimethylene)tryptamine) is a tryptamine derivative that is a psychedelic drug. It was first developed by the team led by JE Macor in 1992, and subsequently investigated by the team led by David Nichols from Purdue University in the late 1990s. This compound produces psychedelic-appropriate responding in animal tests with a similar potency to the amphetamine- derived psychedelic DOI, and has two enantiomer In chemistry, an enantiomer (Help:IPA/English, /ɪˈnænti.əmər, ɛ-, -oʊ-/ Help:Pronunciation respelling key, ''ih-NAN-tee-ə-mər''), also known as an optical isomer, antipode, or optical antipode, is one of a pair of molecular entities whi ...s, with only the (''R'')-enantiomer being active. See also * 5-MeO-pyr-T * 5F-MPMI * 4-HO-MPMI * 4-HO-pyr-T * CP-135,807 * MPMI References {{Tryptamines Alpha-Alkyltryptamines Designer drugs N,N-Dialkyltryptamines 5-Methoxytryptamines Pyrrolidinylmethyli ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
5F-MPMI
5F-MPMI is a tryptamine derivative which acts as a serotonin receptor agonist, selective for the 5-HT2 subtypes but with similar affinity to all three receptors, having strongest activity at 5-HT2B and weakest at 5-HT2A. Retrieved 2025-05-14 See also * 4-HO-MPMI * 5-MeO-MPMI 5-MeO-MPMI (also known as 5-Methoxy-''N''-methyl-(α,''N''-trimethylene)tryptamine) is a tryptamine derivative that is a psychedelic drug. It was first developed by the team led by JE Macor in 1992, and subsequently investigated by the team led ... * MPMI References Designer drugs N,N-Dialkyltryptamines Fluoroarenes 5-Halotryptamines Pyrrolidinylmethylindoles Serotonin receptor agonists {{psychoactive-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
2,5-dimethoxy-4-iodoamphetamine
2,5-Dimethoxy-4-iodoamphetamine (DOI) is a psychedelic drug of the amphetamine and 4-substituted-2,5-dimethoxyamphetamine (DOx) families. It is relatively little-used as a recreational drug but is frequently used in scientific research in the study of psychedelics and serotonin receptors. DOI acts as a potent serotonin 5-HT2 receptor agonist, including of the serotonin 5-HT2A and 5-HT2C receptors. The compound has a stereocenter, and ''R''-(−)-DOI is the more active stereoisomer. 125I">sup>125I''R''-(−)-DOI is used as a radioligand and indicator of the presence of serotonin 5-HT2A receptors in studies. DOI's effects have been compared to LSD, although there are differences that experienced users can distinguish. Besides the longer duration of DOI compared to LSD, the trip tends to be more energetic than an LSD trip, with more body load and a different subjective visual experience. The after effects include residual stimulation and difficulty sleeping, which, dep ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Enantiomer
In chemistry, an enantiomer (Help:IPA/English, /ɪˈnænti.əmər, ɛ-, -oʊ-/ Help:Pronunciation respelling key, ''ih-NAN-tee-ə-mər''), also known as an optical isomer, antipode, or optical antipode, is one of a pair of molecular entities which are mirror images of each other and non-superposable. Enantiomer molecules are like right and left hands: one cannot be superposed onto the other without first being converted to its mirror image. It is solely a relationship of chirality (chemistry), chirality and the permanent three-dimensional relationships among molecules or other chemical structures: no amount of re-orientation of a molecule as a whole or conformational isomerism, conformational change converts one chemical into its enantiomer. Chemical structures with chirality rotate plane-polarized light. A mixture of equal amounts of each enantiomer, a ''racemic mixture'' or a ''racemate'', does not rotate light. Stereoisomers include both enantiomers and diastereomers. Diaste ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
4-HO-pyr-T
4-HO-pyr-T, also known as 4-hydroxy-''N'',''N''-tetramethylenetryptamine, is a serotonin receptor modulator of the tryptamine family. It is the 4-hydroxyl analogue of pyr-T and the analogue of psilocin (4-HO-DMT) and 4-HO-DET in which the ''N'',''N''-dialkyl moiety has been cyclized into a pyrrolidine ring. Use and effects In his book ''TiHKAL'', Shulgin gives the dose as ≥20mg orally, its duration as unknown, and its onset as about 3hours. It was described as quite unlike psilocin and bordering on bizarre. There were minimal visual disturbances and no alterations in colors or objects. It was however said to heighten the intellectual process. The drug was said to be more "stimulant-like" than hallucinogenic or psychedelic. 4-HO-pyr-T was described as very unpleasant. Pharmacology The drug has been found to interact with serotonin receptors, including the serotonin 5-HT2A, 5-HT2B, and 5-HT2C receptors. Its affinities (Ki) were 429nM for the serotonin 5-HT2A receptor, 4 ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Amphetamine
Amphetamine (contracted from Alpha and beta carbon, alpha-methylphenethylamine, methylphenethylamine) is a central nervous system (CNS) stimulant that is used in the treatment of attention deficit hyperactivity disorder (ADHD), narcolepsy, and obesity; it is also used to treat binge eating disorder in the form of its inactive prodrug lisdexamfetamine. Amphetamine was discovered as a chemical in 1887 by Lazăr Edeleanu, and then as a drug in the late 1920s. It exists as two enantiomers: levoamphetamine and dextroamphetamine. ''Amphetamine'' properly refers to a specific chemical, the Racemic mixture, racemic free base, which is equal parts of the two enantiomers in their pure amine forms. The term is frequently used informally to refer to any combination of the enantiomers, or to either of them alone. Historically, it has been used to treat nasal congestion and depression. Amphetamine is also used as an Performance-enhancing substance, athletic performance enhancer and Nootropic ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Chemical Derivative
In chemistry, a derivative is a compound that is derived from a similar compound by a chemical reaction. In the past, derivative also meant a compound that ''can be imagined to'' arise from another compound, if one atom or group of atoms is replaced with another atom or group of atoms, but modern chemical language now uses the term structural analog for this meaning, thus eliminating ambiguity. The term "structural analogue" is common in organic chemistry. In biochemistry, the word is used for compounds that at least theoretically can be formed from the precursor compound. Chemical derivatives may be used to facilitate analysis. For example, melting point (MP) analysis can assist in identification of many organic compounds. A crystalline derivative may be prepared, such as a semicarbazone or 2,4-dinitrophenylhydrazone (derived from aldehydes or ketones), as a simple way of verifying the identity of the original compound, assuming that a table of derivative MP values is availa ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Purdue University
Purdue University is a Public university#United States, public Land-grant university, land-grant research university in West Lafayette, Indiana, United States, and the flagship campus of the Purdue University system. The university was founded in 1869 after Lafayette, Indiana, Lafayette businessman John Purdue donated land and money to establish a college of science, technology, and agriculture; the first classes were held on September 16, 1874. Purdue University is a member of the Association of American Universities and is Carnegie Classification of Institutions of Higher Education, classified among "R1: Doctoral Universities – Very high research activity". Purdue enrolls the largest student body of any individual university campus in Indiana, as well as the ninth-largest foreign student population of any university in the United States. The university is home to the oldest computer science Purdue University Department of Computer Science, program in the United States. Pur ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
