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4-Chlorobutyronitrile
4-Chlorobutyronitrile is the organic compound with the formula ClCH2CH2CH2CN. With both chloro and cyano functional groups, it is a bifunctional molecule. It is a colorless liquid. Synthesis It is prepared by the reaction of potassium cyanide with 1-Bromo-3-chloropropane, 1-bromo-3-chloropropane. Cyclopropyl cyanide is prepared by reaction of 4-chlorobutyronitrile with sodium amide in liquid ammonia. However an increased yield was reported when the base/solvent mixture was changed to NaOH/DMSO. Drug use 4-Chlorobutyronitrile is a precursor to the drugs buflomedil and buspirone. Precursor 4-Chlorobutyronitrile has been used as a starting material to prepare 2-phenylpyrrolidine [registry number 1006-64-0]. This in turn is a chief precursor to a family of compounds called pyrroloisoquinolines. These are valuable agents in medicinal chemistry that are endowed with BAT substrate reuptake inhibitor properties, elevating the synaptic concentration of serotonin and/or catecholamines. ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
3-Chloropropionitrile
3-Chloropropionitrile is an organic compound with the formula ClCH2CH2CN. A colorless liquid, it is prepared by the reaction of hydrogen chloride with acrylonitrile. It is used commercially as a precursor to the drug famotidine. It is an alkylating agent, as illustrated by its reaction with imidazoles to give the cyanoethylated imidazolium salts. Similarly, it alkylates thiourea Thiourea () is an organosulfur compound with the formula and the structure . It is structurally similar to urea (), with the oxygen atom replaced by sulfur atom (as implied by the '' thio-'' prefix). The properties of urea and thiourea differ s ..., en route to 3-mercaptopropionitrile. References Nitriles {{Polymer-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
1-Bromo-3-chloropropane
1-Bromo-3-chloropropane is an organohalogen compound with the formula Br(CH2)3Cl. It is a colorless liquid, produced by free-radical addition of hydrogen bromide to allyl chloride. It is used as an alkylating agent Alkylation is a chemical reaction that entails transfer of an alkyl group. The alkyl group may be transferred as an alkyl carbocation, a free radical, a carbanion, or a carbene (or their equivalents). Alkylating agents are reagents for effecting ... to install the –(CH2)3Cl and –(CH2)3– groups. For example, it is a precursor to 4-chlorobutyronitrile. References {{DEFAULTSORT:Bromo-3-chloropropane, 1- Bromochloroalkanes ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Cyclopropyl Cyanide
Cyclopropyl cyanide is an organic compound consisting of a nitrile group as a substituent on a cyclopropane ring. It is the smallest cyclic compound containing a nitrile. Structure The structure of cyclopropyl cyanide has been determined by a variety of experiments, including microwave spectroscopy, rotational spectroscopy and photodissociation. In 1958, cyclopropyl cyanide was first studied for its rotational spectra, by Friend and Dailey. An additional experiment involving cyclopropyl cyanide was the determination of the molecular dipole moment through spectroscopy experiments, by Carvalho in 1967. Production Cyclopropyl cyanide is prepared by the reaction of 4- chlorobutyronitrile with a strong base, such as sodium amide in liquid ammonia. Reactions Hydrolysis gives cyclopropane carboxylic acid]. Cyclopropyl cyanide, when heated to 660-760K and under pressure of 2-89torr, becomes cis and trans crotonitrile and allyl cyanide Allyl cyanide is an organic compound with the ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Maryanoff
Maryanoff is a surname. Notable people with the surname include: *Bruce E. Maryanoff Bruce Eliot Maryanoff Fellow of the Royal Society of Chemistry, FRSC (born February 26, 1947, in Philadelphia, Pennsylvania) is an American medicinal and organic chemist. Background and contributions Maryanoff received a Bachelor of Science, B.S ... (born 1947), American chemist * Cynthia A. Maryanoff (born 1949), American chemist {{Short pages monitor ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
McN 4612-z
MCN may refer to: Media * ''MCN'' (journal), a peer-reviewed journal of obstetrical and neonatal nursing * Multi-channel network, a type of organization working with video platforms to assist their owners * Metro Chinese Network, a Rockville, Maryland Chinese-language TV station * Music Center the Netherlands, promotes and archives Dutch professional music * ''Motor Cycle News'', a British motorcycling newspaper * ''Motorcycle Consumer News'', American motorcycling monthly Organizations Government * Muscogee (Creek) Nation, a federally recognized Native American tribe based in the U.S. state of Oklahoma Military * Military Counseling Network, a free source of information for U.S military concerning regulations and discharges * Mountain Corps Norway, a German army unit during World War II * Multinational Corps Northeast, military group in Szczecin, Poland Computing and technology * Melbourne Centre for Nanofabrication, nanotechnology headquarters in Victoria, Australia * Microcom ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Mcn 5707
MCN may refer to: Media * ''MCN'' (journal), a peer-reviewed journal of obstetrical and neonatal nursing * Multi-channel network, a type of organization working with video platforms to assist their owners * Metro Chinese Network, a Rockville, Maryland Chinese-language TV station * Music Center the Netherlands, promotes and archives Dutch professional music * ''Motor Cycle News'', a British motorcycling newspaper * ''Motorcycle Consumer News'', American motorcycling monthly Organizations Government * Muscogee (Creek) Nation, a federally recognized Native American tribe based in the U.S. state of Oklahoma Military * Military Counseling Network, a free source of information for U.S military concerning regulations and discharges * Mountain Corps Norway, a German army unit during World War II * Multinational Corps Northeast, military group in Szczecin, Poland Computing and technology * Melbourne Centre for Nanofabrication, nanotechnology headquarters in Victoria, Australia * Microcom ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
McN5652
McN5652 is a molecule that can be radiolabeled and then used as a radioligand in positron emission tomography (PET) studies. The [11C]-(+)-McN5652 enantiomer binds to the serotonin transporter. The radioligand is used for molecular neuroimaging and for imaging of the lungs. It was developed by Johnson & Johnson's McNeil Laboratories. According to McNeil, McN5652 was among the strongest SRI ever reported at the time of its discovery (sub nM Ki). However, it is not completely 5-HT selective: the racemate has 5-HT=0.68, NA=2.9, and D=36.8nM, whereas (+)-enantiomer has 5-HT=0.39, NA=1.8, and D=23.5 nM. Paroxetine was listed as 5-HT=0.44 nM, NA=20, and DA=460nM in the same paper by the same authors. Derivatives McN5652 and related structures have been analyzed for QSAR in terms of binding to the MAT receptor binding site. See also * DASB DASB, also known as 3-amino-4-(2-dimethylaminomethylphenylsulfanyl)-benzonitrile, is a compound that binds to the serotonin transport ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
