Mithridate, also known as mithridatium, mithridatum, or mithridaticum, is a semi-mythical remedy with as many as 65 ingredients, used as an

antidote An antidote is a substance that can counteract a form of poisoning. The term ultimately derives from the Greek term φάρμακον ἀντίδοτον ''(pharmakon antidoton)'', "(medicine) given as a remedy". An older term in English which is ...

for

poison A poison is any chemical substance that is harmful or lethal to living organisms. The term is used in a wide range of scientific fields and industries, where it is often specifically defined. It may also be applied colloquially or figurati ...

ing, and said to have been created by Mithridates VI Eupator of Pontus in the 1st century BC. It was one of the most complex and highly sought-after drugs during the

Middle Ages In the history of Europe, the Middle Ages or medieval period lasted approximately from the 5th to the late 15th centuries, similarly to the post-classical period of global history. It began with the fall of the Western Roman Empire and ...

and the

Renaissance The Renaissance ( , ) is a Periodization, period of history and a European cultural movement covering the 15th and 16th centuries. It marked the transition from the Middle Ages to modernity and was characterized by an effort to revive and sur ...

, particularly in Italy and France, where it was in continual use for centuries. An updated recipe called theriac ( Theriacum Andromachi) was known well into the 19th century.Mithridate
. Mithridate takes its name from its inventor, Mithridates VI, king of the ancient Anatolian

Kingdom of Pontus Pontus ( ) was a Hellenistic kingdom centered in the historical region of Pontus in modern-day Turkey, and ruled by the Mithridatic dynasty of Persian origin, which may have been directly related to Darius the Great of the Achaemenid dynasty. ...

(134 to 63 BC), who is said to have so fortified his body against poisons with antidotes and preservatives that when he tried to kill himself, he could not find any poison that would have an effect, and, according to some legends, had to ask a soldier to run him through with a sword. The recipe for the reputed antidote was found in his cabinet, written with his own hand, and was carried to Rome by

Pompey Gnaeus Pompeius Magnus (; 29 September 106 BC – 28 September 48 BC), known in English as Pompey ( ) or Pompey the Great, was a Roman general and statesman who was prominent in the last decades of the Roman Republic. ...

. It was translated into Latin by Pompey's freedman Lenaeus, and later improved upon by

Nero Nero Claudius Caesar Augustus Germanicus ( ; born Lucius Domitius Ahenobarbus; 15 December AD 37 – 9 June AD 68) was a Roman emperor and the final emperor of the Julio-Claudian dynasty, reigning from AD 54 until his ...

's physician Andromachus and

Marcus Aurelius Marcus Aurelius Antoninus ( ; ; 26 April 121 – 17 March 180) was Roman emperor from 161 to 180 and a Stoicism, Stoic philosopher. He was a member of the Nerva–Antonine dynasty, the last of the rulers later known as the Five Good Emperors ...

' physician

Galen Aelius Galenus or Claudius Galenus (; September 129 – AD), often Anglicization, anglicized as Galen () or Galen of Pergamon, was a Ancient Rome, Roman and Greeks, Greek physician, surgeon, and Philosophy, philosopher. Considered to be one o ...

. It likely underwent considerable alterations since the time of Mithridates. After realizing the anti-toxic effects of

snake Snakes are elongated limbless reptiles of the suborder Serpentes (). Cladistically squamates, snakes are ectothermic, amniote vertebrates covered in overlapping scales much like other members of the group. Many species of snakes have s ...

meat, Andromachus made Faroug antidote with changes in the previous formulas.Theriac: medicine and antidote
. In the

, mithridate was also used as part of a regimen to ward off potential threats of plague. According to Simon Kellwaye (1593), one should "take a great Onyon, make a hole in the myddle of him, then fill the place with Mitridat or Triacle, and some leaues of

Rue ''Ruta graveolens'', commonly known as rue, common rue or herb-of-grace, is a species of the genus '' Ruta'' grown as an ornamental plant and herb. It is native to the Mediterranean. It is grown throughout the world in gardens, especially for i ...

". Until as late as 1786, physicians in London were officially prescribing mithridate.''

Nature Nature is an inherent character or constitution, particularly of the Ecosphere (planetary), ecosphere or the universe as a whole. In this general sense nature refers to the Scientific law, laws, elements and phenomenon, phenomena of the physic ...

''. 14 September 1989. 115/1. According to historian Christopher Hill,

Oliver Cromwell Oliver Cromwell (25 April 15993 September 1658) was an English statesman, politician and soldier, widely regarded as one of the most important figures in British history. He came to prominence during the Wars of the Three Kingdoms, initially ...

took a large dose of mithridate as a precaution against the plague and found it cured his

acne Acne ( ), also known as ''acne vulgaris'', is a long-term Cutaneous condition, skin condition that occurs when Keratinocyte, dead skin cells and Sebum, oil from the skin clog hair follicles. Typical features of the condition include comedo, ...

. The term ''mithridate'' has come to refer to any generally all-purpose antidote.

Origins

Mithridates' father was assassinated by poisoning, according to some at his mother's orders. After this, Mithridates's mother held regency over Pontus until a male heir was of age. Mithridates was in competition with another brother, whom his mother favored, for the throne. Supposedly during his youth he began to suspect plots against him at his mother's orders and was aware of her likely connection with his father's death. He then, supposedly, began to notice pains during his meals, and suspected his mother had ordered small amounts of poison to be added to his food in order to cause his health to deteriorate while avoiding notice of intent to kill him slowly. After other assassination attempts, he fled into the wilderness. While in the wild it is said that he began consuming non-lethal levels of poisons and mixing many into a remedy to make him immune to many poisons. In keeping with most medical practices of his era, Mithridates' anti-poison routines included a religious component supervised by ''Agari'', or

Scythia Scythia (, ) or Scythica (, ) was a geographic region defined in the ancient Graeco-Roman world that encompassed the Pontic steppe. It was inhabited by Scythians, an ancient Eastern Iranian equestrian nomadic people. Etymology The names ...

shaman Shamanism is a spiritual practice that involves a practitioner (shaman) interacting with the spirit world through altered states of consciousness, such as trance. The goal of this is usually to direct spirits or spiritual energies into ...

s who never left his side.

Formulation

Aulus Cornelius Celsus Aulus Cornelius Celsus ( 25 BC 50 AD) was a Roman encyclopedist, known for his extant medical work, '' De Medicina'', which is believed to be the only surviving section of a much larger encyclopedia. The ''De Medicina'' is a primary source on ...

details one version of the antidote in '' De Medicina'' (ca. AD 30). A recent translation is as follows: "But the most famous antidote is that of Mithridates, which that king is said to have taken daily and by it to have rendered his body safe against danger from poison". It contained: * costmary, 1–66 grams * sweet flag, 20 grams *

hypericum ''Hypericum'' is a genus of flowering plants in the family (biology), family Hypericaceae (formerly considered a subfamily of Clusiaceae). The genus has a nearly worldwide distribution, missing only from tropical lowlands, deserts and polar re ...

, 8 grams *

Natural gum Natural gums are polysaccharides of natural origin, capable of causing a large increase in a solution's viscosity, even at small concentrations. They are mostly gum (botany), botanical gums, found in the woody elements of plants or in seed coati ...

, 8 grams * sagapenum, 8 grams *

acacia ''Acacia'', commonly known as wattles or acacias, is a genus of about of shrubs and trees in the subfamily Mimosoideae of the pea family Fabaceae. Initially, it comprised a group of plant species native to Africa, South America, and Austral ...

juice, 8 grams *Illyrian iris (probably ''I. germanica''), 8 grams *

cardamom Cardamom (), sometimes cardamon or cardamum, is a spice made from the seeds of several plants in the genus (biology), genera ''Elettaria'' and ''Amomum'' in the family Zingiberaceae. Both genera are native to the Indian subcontinent and Indon ...

, 8 grams *

anise Anise (; '), also called aniseed or rarely anix, is a flowering plant in the family Apiaceae native to the eastern Mediterranean region and Southwest Asia. The flavor and aroma of its seeds have similarities with some other spices and herbs, ...

, 12 grams *Gallic nard ('' Valeriana italica''), 16 grams *

gentian ''Gentiana'' () is a genus of flowering plants belonging to the gentian family ( Gentianaceae), the tribe Gentianeae, and the monophyletic subtribe Gentianinae. With over 300 species, it is considered a large genus. Gentians are notable for thei ...

root, 16 grams *dried

rose A rose is either a woody perennial plant, perennial flowering plant of the genus ''Rosa'' (), in the family Rosaceae (), or the flower it bears. There are over three hundred Rose species, species and Garden roses, tens of thousands of cultivar ...

leaves, 16 grams *

poppy A poppy is a flowering plant in the subfamily Papaveroideae of the family Papaveraceae. Poppies are herbaceous plants, often grown for their colourful flowers. One species of poppy, '' Papaver somniferum'', is the source of the narcotic drug ...

-tears (''

Papaver rhoeas ''Papaver rhoeas'', with common names including common poppy, corn poppy, corn rose, field poppy, Flanders poppy, red poppy, and Odai, is an annual herbaceous species of flowering plant in the poppy family Papaveraceae. It is native to north Afr ...

'', a wild poppy with low opiate content),Stata Norton, Molecular Interventions 6:60–66, 2006
/ref> 17 grams *

parsley Parsley, or garden parsley (''Petroselinum crispum''), is a species of flowering plant in the family Apiaceae that is native to Greece, Morocco and the former Yugoslavia. It has been introduced and naturalisation (biology), naturalized in Eur ...

, 17 grams * cassia, 20–66 grams *

saxifrage ''Saxifraga'' is the largest genus in the family Saxifragaceae, containing about 473 species of holarctic perennial plants, known as saxifrages or rockfoils. The Latin word ''saxifraga'' means literally "stone-breaker", from Latin ' ("rock" or " ...

, 20–66 grams * darnel, 20–66 grams *

long pepper Long pepper (''Piper longum''), sometimes called Indian long pepper or ''pippali'', is a flowering vine in the family Piperaceae, cultivated for its fruit, which is usually dried and used as a spice and seasoning. Long pepper has a taste sim ...

, 20–66 grams *

storax Storax (; , ''stúrax''), often commercially sold as styrax, is a natural fragrant resin isolated from the wounded bark of ''Liquidambar orientalis'' Mill. (Asia Minor) and ''Liquidambar styraciflua'' L. (Eastern US, Mexico, Central America) (A ...

, 21 grams *

castoreum Castoreum is a yellowish exudate from the castor sacs of mature beavers used in combination with urine to territorial marking, scent mark their territory. Both beaver sexes have a pair of castor sacs and a pair of anal glands, located in two c ...

, 24 grams *

frankincense Frankincense, also known as olibanum (), is an Aroma compound, aromatic resin used in incense and perfumes, obtained from trees of the genus ''Boswellia'' in the family (biology), family Burseraceae. The word is from Old French ('high-quality in ...

, 24 grams * hypocistis juice, 24 grams *

myrrh Myrrh (; from an unidentified ancient Semitic language, see '' § Etymology'') is a gum-resin extracted from a few small, thorny tree species of the '' Commiphora'' genus, belonging to the Burseraceae family. Myrrh resin has been used ...

, 24 grams * opopanax, 24 grams * malabathrum leaves, 24 grams *flower of round rush, 24–66 grams *

turpentine Turpentine (which is also called spirit of turpentine, oil of turpentine, terebenthine, terebenthene, terebinthine and, colloquially, turps) is a fluid obtainable by the distillation of resin harvested from living trees, mainly pines. Principall ...

-resin, 24–66 grams * galbanum, 24–66 grams *Cretan carrot seeds, 24–66 grams * nard, 25 grams * opobalsam, 25 grams * shepherd's purse, 25 grams *

rhubarb Rhubarb is the fleshy, edible stalks ( petioles) of species and hybrids (culinary rhubarb) of ''Rheum'' in the family Polygonaceae, which are cooked and used for food. The plant is a herbaceous perennial that grows from short, thick rhizomes. ...

root, 28 grams *

saffron Saffron () is a spice derived from the flower of '' Crocus sativus'', commonly known as the "saffron crocus". The vivid crimson stigma and styles, called threads, are collected and dried for use mainly as a seasoning and colouring agent ...

, 29 grams *

ginger Ginger (''Zingiber officinale'') is a flowering plant whose rhizome, ginger root or ginger, is widely used as a spice and a folk medicine. It is an herbaceous perennial that grows annual pseudostems (false stems made of the rolled bases of l ...

, 29 grams *

cinnamon Cinnamon is a spice obtained from the inner bark of several tree species from the genus ''Cinnamomum''. Cinnamon is used mainly as an aromatic condiment and flavouring additive in a wide variety of cuisines, sweet and savoury dishes, biscuits, b ...

, 29 grams The ingredients are then "pounded and taken up in

honey Honey is a sweet and viscous substance made by several species of bees, the best-known of which are honey bees. Honey is made and stored to nourish bee colonies. Bees produce honey by gathering and then refining the sugary secretions of pl ...

. Against poisoning, a piece the size of an

almond The almond (''Prunus amygdalus'', Synonym (taxonomy)#Botany, syn. ''Prunus dulcis'') is a species of tree from the genus ''Prunus''. Along with the peach, it is classified in the subgenus ''Amygdalus'', distinguished from the other subgenera ...

is given in wine. In other affections an amount corresponding in size to an Egyptian bean is sufficient." Of these ingredients, Illyrian iris, darnel, and rhubarb were not commonly found in other versions of the antidote. However, Celsus' formulation, written 100 years after the death of Mithridates, was one of the first published. Galen called the antidote "

theriac Theriac or theriaca is a medical concoction originally labelled by the Greeks in the 1st century AD and widely adopted in the ancient world as far away as Persia, China and India via the trading links of the Silk Route. It was an alexipharmic, ...

" and presented versions by Aelius (used by Julius Caesar), Andromachus (physician to Nero), Antipater, Nicostratus, and Damocratis. The Andromachus formulation closely resembles that of Celsus. The manufacture of antidotes called mithridate or

(English "treacle") continued into the nineteenth century. Ephraim Chambers, in his 1728 Cyclopaedia, says "Mithridate is one of the capital Medicines in the Apothecaries Shops, being composed of a vast Number of Drugs, as

Opium Opium (also known as poppy tears, or Lachryma papaveris) is the dried latex obtained from the seed Capsule (fruit), capsules of the opium poppy ''Papaver somniferum''. Approximately 12 percent of opium is made up of the analgesic alkaloid mor ...

Myrrh Myrrh (; from an unidentified ancient Semitic language, see '' § Etymology'') is a gum-resin extracted from a few small, thorny tree species of the '' Commiphora'' genus, belonging to the Burseraceae family. Myrrh resin has been used ...

Agaric An agaric () is a type of fungal fruiting body characterized by the presence of a pileus (cap) that is clearly differentiated from the stipe (stalk), with lamellae (gills) on the underside of the pileus. It is a type of mushroom (or toadstool) ...

Saffron Saffron () is a spice derived from the flower of '' Crocus sativus'', commonly known as the "saffron crocus". The vivid crimson stigma and styles, called threads, are collected and dried for use mainly as a seasoning and colouring agent ...

Ginger Ginger (''Zingiber officinale'') is a flowering plant whose rhizome, ginger root or ginger, is widely used as a spice and a folk medicine. It is an herbaceous perennial that grows annual pseudostems (false stems made of the rolled bases of l ...

Cinnamon Cinnamon is a spice obtained from the inner bark of several tree species from the genus ''Cinnamomum''. Cinnamon is used mainly as an aromatic condiment and flavouring additive in a wide variety of cuisines, sweet and savoury dishes, biscuits, b ...

, Spikenard,

Frankincense Frankincense, also known as olibanum (), is an Aroma compound, aromatic resin used in incense and perfumes, obtained from trees of the genus ''Boswellia'' in the family (biology), family Burseraceae. The word is from Old French ('high-quality in ...

, Castor, Pepper,

Gentian ''Gentiana'' () is a genus of flowering plants belonging to the gentian family ( Gentianaceae), the tribe Gentianeae, and the monophyletic subtribe Gentianinae. With over 300 species, it is considered a large genus. Gentians are notable for thei ...

, &c. It is accounted a Cordial,

Opiate An opiate is an alkaloid substance derived from opium (or poppy straw). It differs from the similar term ''opioid'' in that the latter is used to designate all substances, both natural and synthetic, that bind to opioid receptors in the brain ( ...

, Sudorific, and Alexipharmic".

Petrus Andreas Matthiolus Pietro Andrea Gregorio Mattioli (; 12 March 1501– ) was a doctor and Natural history, naturalist born in Siena. His most important work was a commentary on the medicinal plants of Pedanius Dioscorides first published in 1544 which was translate ...

considered it more effectual against poisons than Venice treacle, and easier to make. Late versions of the antidote incorporated dried blood or the dried flesh of lizards or

viper Vipers are snakes in the family Viperidae, found in most parts of the world, except for Antarctica, Australia, Hawaii, Madagascar, New Zealand, Ireland, and various other isolated islands. They are venomous and have long (relative to non-vipe ...

s or Malabathrum. Dunglison, Robley. 1848. ''Medical lexicon. A dictionary of medical science''.

Criticism

Pliny (''

Natural History Natural history is a domain of inquiry involving organisms, including animals, fungi, and plants, in their natural environment, leaning more towards observational than experimental methods of study. A person who studies natural history is cal ...

'', XXIX.24–25, ca. AD 77) was skeptical of mithridate and other such

s (panacea potions), with their numerous ingredients:

In literature

A. E. Housman Alfred Edward Housman (; 26 March 1859 – 30 April 1936) was an English classics, classical scholar and poet. He showed early promise as a student at the University of Oxford, but he failed his final examination in ''literae humaniores'' and t ...

's collection of poetry titled '' A Shropshire Lad'' published in 1896, there is a poem about King Mithridates and his antidote's amazing abilities: In the Diary of

Samuel Pepys Samuel Pepys ( ; 23 February 1633 – 26 May 1703) was an English writer and Tories (British political party), Tory politician. He served as an official in the Navy Board and Member of Parliament (England), Member of Parliament, but is most r ...

, entry for 9th April 1664; Pepys writes at the end of the day “by the help of mithridate slept very well” having been unwell the previous night and also having vomited during the day.

References

{{Opioidergics Traditional medicine Lost inventions Mithridates VI Eupator

Origins

Formulation

Criticism

In literature

See also

References