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Sanofi Pasteur is the
vaccines A vaccine is a biological preparation that provides active acquired immunity to a particular infectious or malignant disease. The safety and effectiveness of vaccines has been widely studied and verified. A vaccine typically contains an ag ...
division of the French multinational pharmaceutical company
Sanofi Sanofi S.A. is a French Multinational corporation, multinational pharmaceutical and healthcare company headquartered in Paris, France. The corporation was established in 1973 and merged with Synthélabo in 1999 to form Sanofi-Synthélabo. In 200 ...
. Sanofi Pasteur is the largest company in the world devoted entirely to vaccines. It is one of four global producers of the yellow fever vaccine.


History

Since 1992, Sanofi Pasteur has sponsored
Sanofi Biogenius Canada Sanofi Biogenius Canada (SBC), formerly known as the Sanofi BioGENEius Challenge Canada (SBCC), is a national, biotechnology-focused science competition for Canadian high school and CEGEP students. SBC challenges students to initiate and undertake ...
(SBC), a national,
biotechnology Biotechnology is a multidisciplinary field that involves the integration of natural sciences and Engineering Science, engineering sciences in order to achieve the application of organisms and parts thereof for products and services. Specialists ...
-focused science competition for Canadian high school and
CEGEP A CEGEP ( or ; , ; also written CÉGEP and cegep) is a publicly funded college providing general, professional, academic or a mix of programs; they are exclusive to the province of Quebec's education system. A loanword from French, it ori ...
students. Those selected for the SBC work with local mentors, giving students hands-on research experience in a professional lab setting. Participants compile their results and present their findings at regional competitions. Cash prizes are awarded and regional winners advance to the National stage, where they vie for the top spot and the chance to compete in the International BioGENEius Challenge, held at the prestigious BIO International Convention – the largest biotechnology event in the world. In 2004, Aventis merged with and into Sanofi. The new
Sanofi-Aventis Sanofi S.A. is a French multinational pharmaceutical and healthcare company headquartered in Paris, France. The corporation was established in 1973 and merged with Synthélabo in 1999 to form Sanofi-Synthélabo. In 2004, Sanofi-Synthélabo merg ...
Group became the world's 3rd largest pharmaceutical company. Aventis Pasteur, the vaccine division of Sanofi-Aventis Group, changed its name to Sanofi Pasteur. In 2014, Sanofi Pasteur stopped producing its effective Fav-Afrique
antivenom Antivenom, also known as antivenin, venom antiserum, and antivenom immunoglobulin, is a specific treatment for envenomation. It is composed of antibodies and used to treat certain venomous bites and stings. Antivenoms are recommended only if ...
because competition from cheaper though less powerful competitors made it unprofitable.
Doctors Without Borders Doctor, Doctors, The Doctor or The Doctors may refer to: Titles and occupations * Physician, a medical practitioner * Doctor (title), an academic title for the holder of a doctoral-level degree ** Doctorate ** List of doctoral degrees awarded ...
said that it would take two years to develop a similar antivenom, and that existing stocks would run out in June 2016. In the fall of 2011 the Sanofi Pasteur plant flooded, causing problems with mold. The facility, located in Toronto, Ontario, Canada, produced
BCG vaccine The Bacillus Calmette–Guérin (BCG) vaccine is a vaccine primarily used against tuberculosis (TB). It is named after its inventors Albert Calmette and Camille Guérin. In countries where tuberculosis or leprosy is common, one dose is recom ...
products made with the Glaxo 1077 strain, such as a tuberculosis vaccine and ImmuCYST, a BCG immunotherapeutic and bladder cancer drug. By April 2012 the FDA had found dozens of documented problems with sterility at the plant including mold, nesting birds and rusted electrical conduits, as well as numerous procedural safety issues and violations. The resulting closure of the plant for over two years resulted in shortages of bladder cancer and tuberculosis vaccines. On October 29, 2014
Health Canada Health Canada (HC; )Health Canada is the applied title under the Federal Identity Program; the legal title is Department of Health (). is the Structure of the Canadian federal government#Departments, with subsidiary units, department of the Gove ...
gave the permission for Sanofi to resume production of BCG. The Philippine Department of Health began in 2016 a programme in three regions to vaccinate schoolchildren against
dengue fever Dengue fever is a mosquito-borne disease caused by dengue virus, prevalent in tropical and subtropical areas. Asymptomatic infections are uncommon, mild cases happen frequently; if symptoms appear, they typically begin 3 to 14 days after i ...
, using Dengvaxia supplied by Sanofi Pasteur. On 29 November 2017, Sanofi issued a caution stating that new analysis had shown that those vaccinated who had not previously been infected with dengue ran a greater risk of infection causing severe symptoms. On 1 December 2017, the Philippine DOH placed the programme on hold, pending review. Over 700,000 people had received at least one vaccination at that point. Since the announcement by Sanofi, at least 62 children have died, allegedly after receiving a vaccination. The victims' parents blamed the dengue vaccine for the deaths of their children."Anak namin namatay sa Dengvaxia"
(in Tagalog). Archived from th
original
''Pilipino Star Ngayon''. Retrieved December 20, 2017.
In July 2020, Sanofi Pasteur announced that it would begin phase three testing of a
COVID-19 vaccine A COVID19 vaccine is a vaccine intended to provide acquired immunity against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the virus that causes coronavirus disease 2019 ( COVID19). Knowledge about the structure and fun ...
in several countries, including Mexico, and that the cost would be US $7 to $10 per dose. If data are positive, a global phase 3 study could start in Q2 2021. If the vaccine meets clinical requirements on safety and effectiveness, approved by regulatory authorities, a vaccine can expected in the fourth quarter of 2021. One of the vaccines ordered by the
Netherlands , Terminology of the Low Countries, informally Holland, is a country in Northwestern Europe, with Caribbean Netherlands, overseas territories in the Caribbean. It is the largest of the four constituent countries of the Kingdom of the Nether ...
for the mass anti-
coronavirus Coronaviruses are a group of related RNA viruses that cause diseases in mammals and birds. In humans and birds, they cause respiratory tract infections that can range from mild to lethal. Mild illnesses in humans include some cases of the comm ...
vaccination programme in 2021 seems not to work well in elderly people and the development of the vaccine will face delays. In 2021, Sanofi Toronto announced it was seeking to start a new Biosafety level 3 laboratory.


Key dates

* 1897: Marcel Mérieux creates the Mérieux Biological Institute in Lyon. Richard Slee creates the Pocono Biological Laboratories, in Swiftwater, Pennsylvania in the U.S. * 1914: John G. FitzGerald creates Connaught Laboratories, part of the
University of Toronto The University of Toronto (UToronto or U of T) is a public university, public research university whose main campus is located on the grounds that surround Queen's Park (Toronto), Queen's Park in Toronto, Ontario, Canada. It was founded by ...
. * 1968:
Rhône-Poulenc Rhône-Poulenc () was a French chemical and pharmaceutical company founded in 1928. In 1999, it merged with Hoechst AG to form Aventis. As of 2015, the pharmaceutical operations of Rhône-Poulenc are part of Sanofi and the chemicals divisions ...
acquires 51% of the capital of the Institut Mérieux. * 1974:
Pasteur Institute The Pasteur Institute (, ) is a French non-profit private foundation dedicated to the study of biology, micro-organisms, diseases, and vaccines. It is named after Louis Pasteur, who invented pasteurization and vaccines for anthrax and rabies. Th ...
creates Pasteur Production, a subsidiary specializing in manufacturing vaccines. * 1978: Connaught Laboratories in Canada acquires the vaccine manufacturing facility (Merrell-National Laboratories) at Swiftwater, Pennsylvania, U.S. * 1985: Pasteur Production is acquired by the Mérieux Institute, and Pasteur Vaccins is created. * 1989: The Mérieux Institute acquires the Connaught Laboratories in
Canada Canada is a country in North America. Its Provinces and territories of Canada, ten provinces and three territories extend from the Atlantic Ocean to the Pacific Ocean and northward into the Arctic Ocean, making it the world's List of coun ...
and its subsidiaries and becomes a world leader in
human biology Human biology is an interdisciplinary area of academic study that examines humans through the influences and interplay of many diverse fields such as genetics, evolution, physiology, anatomy, epidemiology, anthropology, ecology, nutrition, populat ...
. * 1990: Creation of Pasteur Mérieux Serums & Vaccins. * 1994: Pasteur Mérieux Sérums & Vaccins becomes a wholly owned subsidiary of Rhône-Poulenc. * 1996: Pasteur Mérieux Connaught is the new name of Pasteur Mérieux Serums et Vaccins. * 1999: Rhône-Poulenc and Hoechst unite their Life Sciences activities in a single company, which takes on the name Aventis. Within this group, Pasteur Mérieux Connaught changes its name to Aventis Pasteur. * 2004: merger of Aventis with and into Sanofi. The new Sanofi-Aventis Group becomes the world's 3rd largest pharmaceutical company, behind
Pfizer Pfizer Inc. ( ) is an American Multinational corporation, multinational Pharmaceutical industry, pharmaceutical and biotechnology corporation headquartered at The Spiral (New York City), The Spiral in Manhattan, New York City. Founded in 184 ...
and
GlaxoSmithKline GSK plc (an acronym from its former name GlaxoSmithKline plc) is a British Multinational corporation, multinational Pharmaceutics, pharmaceutical and biotechnology company with headquarters in London. It was established in 2000 by a Mergers an ...
. Aventis Pasteur, the vaccine division of the Sanofi-Aventis Group, changes its name to Sanofi Pasteur. * 2008: Sanofi Pasteur acquires Acambis plc, a biotech company. * 2009: Sanofi Pasteur acquires major stake in Hyderabad-based
Shantha Biotechnics Shantha Biotechnics Limited is an Indian biotechnology company headquartered in Hyderabad, India. It is the first Indian company to develop, manufacture and market Recombinant DNA, recombinant human healthcare products in India. The company is a ...
. * 2020: Sanofi Pasteur and
GlaxoSmithKline GSK plc (an acronym from its former name GlaxoSmithKline plc) is a British Multinational corporation, multinational Pharmaceutics, pharmaceutical and biotechnology company with headquarters in London. It was established in 2000 by a Mergers an ...
have said they are starting clinical trials of their coronavirus vaccine. They hope to have the first results of the trial by December and if it is successful they will move on to further trials by the end of the year.


Key facts & figures in 2012

Sanofi Pasteur * 2012 net sales: €3,897 million (+5.7% over 2011) * Staff: nearly 13,000 employees worldwide * More than 1 billion doses of vaccines produced yearly to immunize more than 500 million people in the world * Largest product range available, against 20 infectious diseases * More than €1 million invested every day in R&D * Nearly €2 billion invested in the last 5 years in production infrastructures. * Headquarters: Lyon, France * 14 production and/or R&D sites located in: **
Marcy-l'Étoile Marcy-l'Étoile () is a Communes of France, commune in the Metropolis of Lyon in Auvergne-Rhône-Alpes Regions of France, region in eastern France. Population See also *Communes of the Metropolis of Lyon *Parc de Lacroix-Laval References

...
and Val-de-Reuil, France ** Swiftwater, Pennsylvania (Sanofi Pasteur's
United States The United States of America (USA), also known as the United States (U.S.) or America, is a country primarily located in North America. It is a federal republic of 50 U.S. state, states and a federal capital district, Washington, D.C. The 48 ...
headquarters),
Cambridge, Massachusetts Cambridge ( ) is a city in Middlesex County, Massachusetts, United States. It is a suburb in the Greater Boston metropolitan area, located directly across the Charles River from Boston. The city's population as of the 2020 United States census, ...
and
Canton, Massachusetts Canton is a town in Norfolk County, Massachusetts, United States. The population was 24,370 at the 2020 United States census, 2020 census. Canton is part of Greater Boston, about southwest of Downtown Boston. History The area that is present ...
,
Orlando, Florida Orlando ( ) is a city in and the county seat of Orange County, Florida, United States. The city proper had a population of 307,573 at the 2020 census, making it the fourth-most populous city in Florida behind Jacksonville, Florida, Jacksonville ...
and
Rockville, Maryland Rockville is a city in and the county seat of Montgomery County, Maryland, United States, and is part of the Washington metropolitan area. The 2020 United States census, 2020 census tabulated Rockville's population at 67,117, making it the fourth ...
, United States **
Toronto, Ontario Toronto ( , locally pronounced or ) is the List of the largest municipalities in Canada by population, most populous city in Canada. It is the capital city of the Provinces and territories of Canada, Canadian province of Ontario. With a p ...
,
Canada Canada is a country in North America. Its Provinces and territories of Canada, ten provinces and three territories extend from the Atlantic Ocean to the Pacific Ocean and northward into the Arctic Ocean, making it the world's List of coun ...
** Pilar, Buenos Aires Province,
Argentina Argentina, officially the Argentine Republic, is a country in the southern half of South America. It covers an area of , making it the List of South American countries by area, second-largest country in South America after Brazil, the fourt ...
**
Shenzhen Shenzhen is a prefecture-level city in the province of Guangdong, China. A Special economic zones of China, special economic zone, it is located on the east bank of the Pearl River (China), Pearl River estuary on the central coast of Guangdong ...
,
China China, officially the People's Republic of China (PRC), is a country in East Asia. With population of China, a population exceeding 1.4 billion, it is the list of countries by population (United Nations), second-most populous country after ...
**
Hyderabad Hyderabad is the capital and largest city of the Indian state of Telangana. It occupies on the Deccan Plateau along the banks of the Musi River (India), Musi River, in the northern part of Southern India. With an average altitude of , much ...
,
India India, officially the Republic of India, is a country in South Asia. It is the List of countries and dependencies by area, seventh-largest country by area; the List of countries by population (United Nations), most populous country since ...
** Ocoyoacac,
Mexico Mexico, officially the United Mexican States, is a country in North America. It is the northernmost country in Latin America, and borders the United States to the north, and Guatemala and Belize to the southeast; while having maritime boundar ...
**
Chachoengsao Chachoengsao (, ) is a town ('' thesaban mueang'') in central Thailand, capital of Chachoengsao Province. It is on the banks of the Bang Pakong River. It includes ''tambon'' Na Mueang and parts of Ban Mai, Bang Tin Pet, Wang Takhian, and Sothon ...
,
Thailand Thailand, officially the Kingdom of Thailand and historically known as Siam (the official name until 1939), is a country in Southeast Asia on the Mainland Southeast Asia, Indochinese Peninsula. With a population of almost 66 million, it spa ...
**
Neuville-sur-Saône Neuville-sur-Saône (, literally ''Neuville on Saône'') is a Communes of France, commune in the Metropolis of Lyon in Auvergne-Rhône-Alpes Regions of France, region in eastern France. Surrounding communes * Genay, Rhône, Genay * Montanay * Fl ...
, France


Vaccines

''This list is for vaccines with trade names; Sanofi Pasteur also produces many generic vaccines which do not have trade names'' *
Cancer vaccine A cancer vaccine, or oncovaccine, is a vaccine that either treats existing cancer or prevents development of cancer. Vaccines that treat existing cancer are known as ''therapeutic'' cancer vaccines or tumor antigen vaccines. Some of the vaccines ...
s **
bladder cancer Bladder cancer is the abnormal growth of cells in the bladder. These cells can grow to form a tumor, which eventually spreads, damaging the bladder and other organs. Most people with bladder cancer are diagnosed after noticing blood in thei ...
: TheraCys * Coronavirus vaccines ** A
COVID-19 vaccine A COVID19 vaccine is a vaccine intended to provide acquired immunity against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the virus that causes coronavirus disease 2019 ( COVID19). Knowledge about the structure and fun ...
is under development by the French pharmaceutical company and the British pharmaceutical company
GlaxoSmithKline GSK plc (an acronym from its former name GlaxoSmithKline plc) is a British Multinational corporation, multinational Pharmaceutics, pharmaceutical and biotechnology company with headquarters in London. It was established in 2000 by a Mergers an ...
. Advanced clinical trials of the vaccine were delayed in December 2020 after it failed to produce a strong immune response in people over the age of 50, most likely due to an insufficient
antigen In immunology, an antigen (Ag) is a molecule, moiety, foreign particulate matter, or an allergen, such as pollen, that can bind to a specific antibody or T-cell receptor. The presence of antigens in the body may trigger an immune response. ...
concentration in the vaccine, delaying the launch of the vaccine to late 2021. * Dengue vaccines ** Dengvaxia, approved in 18 countries *
DPT vaccine The DPT vaccine or DTP vaccine is a class of combination vaccines to protect against three infectious diseases in humans: diphtheria, pertussis (whooping cough), and tetanus (lockjaw). The vaccine components include diphtheria and tetanus t ...
s ** Adacel ** Daptacel ** Tripedia (Trepedia), discontinued, last shipped in 2012 * Haemophilus influenzae type b vaccines ** ActHIB *
Hepatitis A vaccine Hepatitis A vaccine is a vaccine that prevents hepatitis A. It is effective in around 95% of cases and lasts for at least twenty years and possibly a person's entire life. If given, two doses are recommended beginning after the age of one. It ...
s ** Avaxim 160 U (or just Avaxim) *
Hepatitis B vaccine Hepatitis B vaccine is a vaccine that prevents hepatitis B. The first dose is recommended within 24 hours of birth with either two or three more doses given after that. This includes those with poor immune function such as from HIV/AIDS and ...
s ** Genhevac B Pasteur ** Hbvaxpro (5, 10 and 40 μg) *
Influenza vaccine Influenza vaccines, colloquially known as flu shots or the flu jab, are vaccines that protect against infection by influenza viruses. New versions of the vaccines are developed twice a year, as the influenza virus rapidly changes. While their ...
s ** Addigrip ** Flublok Quadrivalent ** Fluzone High-Dose **
Fluzone Influenza vaccines, colloquially known as flu shots or the flu jab, are vaccines that protect against infection by influenza viruses. New versions of the vaccines are developed twice a year, as the influenza virus rapidly changes. While thei ...
(standard-dose; without preservatives; pediatric dose without preservatives) ** Sandovac ** Vaxigrip *
Japanese encephalitis virus Japanese encephalitis (JE) is an infection of the brain caused by the Japanese encephalitis virus (JEV). While most infections result in little or no symptoms, occasional inflammation of the brain occurs. In these cases, symptoms may include he ...
vaccines ** JE-VAX (inactivated) ** IMOJEV ( live, attenuated) *
Measles vaccine Measles vaccine protects against becoming infected with measles. Nearly all of those who do not develop immunity after a single dose develop it after a second dose. When the rate of vaccination within a population is greater than 92%, outbreaks ...
s ** Rouvax *
Meningococcal vaccine Meningococcal vaccine refers to any vaccine used to prevent infection by '' Neisseria meningitidis''. Different versions are effective against some or all of the following types of meningococcus: A, B, C, W-135, and Y. The vaccines are between ...
s ** Menactra, the first meningococcal vaccine approved for use in infants ** Menomune-A/C/Y/W-135 ** Vaccin Meningococcique A+C *
MMR vaccine The MMR vaccine is a vaccine against measles, mumps, and rubella (German measles), abbreviated as ''MMR''. The first dose is generally given to children around 9 months to 15 months of age, with a second dose at 15 months to 6 years of age, w ...
s ** M-M-RVaxPro * Pneumonia vaccines ** Pneumo 23 *
Polio vaccine Polio vaccines are vaccines used to prevent poliomyelitis (polio). Two types are used: an inactivated vaccine, inactivated poliovirus given by injection (IPV) and a attenuated vaccine, weakened poliovirus given by mouth (OPV). The World Healt ...
s ** Imovax Polio ** Ipol ** Polio Salk *
Rabies vaccine The rabies vaccine is a vaccine used to prevent rabies. There are several rabies vaccines available that are both safe and effective. Vaccinations must be administered prior to rabies virus exposure or within the Latent period (epidemiology), l ...
s ** Imovax Rabies (Imovax) ** Imogam Rabies-HT, rabies immune globulin ** Vaccin Rabique Pasteur ** Verorab *
Rubella vaccine Rubella vaccine is a vaccine used to prevent rubella. Effectiveness begins about two weeks after a single dose and around 95% of people become immune. Countries with high rates of immunization no longer see cases of rubella or congenital rubell ...
s ** Rudivax *
Smallpox vaccine The smallpox vaccine is used to prevent smallpox infection caused by the variola virus. It is the first vaccine to have been developed against a contagious disease. In 1796, British physician Edward Jenner demonstrated that an infection with th ...
s ** ACAM 2000 *
Tetanus vaccine Tetanus vaccine, also known as tetanus toxoid (TT), is a toxoid vaccine used to prevent tetanus. During childhood, five doses are recommended, with a sixth given during adolescence. After three doses, almost everyone is initially immune, but ...
s ** Vaccin Tetanique Pasteur *
Tuberculosis vaccines Tuberculosis (TB) vaccines are vaccinations intended for the prevention of tuberculosis. Immunotherapy as a defence against TB was first proposed in 1890 by Robert Koch. As of 2021, the only effective tuberculosis vaccine in common use is the ...
** Mycobax ** Tubersol ** Vaccin Bcg Ssi *
Typhoid fever Typhoid fever, also known simply as typhoid, is a disease caused by '' Salmonella enterica'' serotype Typhi bacteria, also called ''Salmonella'' Typhi. Symptoms vary from mild to severe, and usually begin six to 30 days after exposure. Often th ...
vaccines ** Typhim Vi *
Yellow fever vaccine Yellow fever vaccine is a vaccine that protects against yellow fever. Yellow fever is a viral infection that occurs in Africa and South America. Most people begin to develop immunity within ten days of vaccination and are 99% protected withi ...
s ** Stamaril ** YF-VAX * Diphtheria and tetanus combined vaccines ** DECAVAC ** dT reduct ** D. T. Vax * Diphtheria, tetanus and polio combined vaccines ** Revaxis * DPT, haemophilus combined vaccines ** TriHIBit, a booster vaccine, with DPT and haemophilus influenzae type b vaccines * DPT, polio combined vaccines ** Repevax * DPT, haemophilus, polio combined vaccines ** Pentacel ** Pentavac * DPT, haemophilus, polio, hepatitis B combined vaccines ** Hexavac * Hepatitis A, typhoid fever combined vaccines ** Tyavax


References

{{Authority control Sanofi Vaccine producers 2004 establishments in France Manufacturing companies based in Lyon BSL3 laboratories in Canada COVID-19 vaccine producers