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Inverse Agonist
In pharmacology, an inverse agonist is a drug that binds to the same receptor as an agonist but induces a pharmacological response opposite to that of the agonist. A neutral antagonist has no activity in the absence of an agonist or inverse agonist but can block the activity of either; they are in fact sometimes called ''blockers'' (examples include alpha blockers, beta blockers, and calcium channel blockers). Inverse agonists have opposite actions to those of agonists but the effects of both of these can be blocked by antagonists. A prerequisite for an inverse agonist response is that the receptor must have a constitutive (also known as intrinsic or basal) level of activity in the absence of any ligand. An agonist increases the activity of a receptor above its basal level, whereas an inverse agonist decreases the activity below the basal level. The efficacy of a full agonist is by definition 100%, a neutral antagonist has 0% efficacy, and an inverse agonist has < 0% (i.e., n ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] [Amazon] |
Inverse Agonist 3
Inverse or invert may refer to: Science and mathematics * Inverse (logic), a type of conditional sentence which is an immediate inference made from another conditional sentence * Additive inverse, the inverse of a number that, when added to the original number, yields zero * Compositional inverse, a function that "reverses" another function * Inverse element * Inverse function, a function that "reverses" another function **Generalized inverse, a matrix that has some properties of the inverse matrix but not necessarily all of them * Multiplicative inverse (reciprocal), a number which when multiplied by a given number yields the multiplicative identity, 1 ** Inverse matrix of an Invertible matrix Other uses * Invert level, the base interior level of a pipe, trench or tunnel * ''Inverse'' (website), an online magazine * An outdated term for an LGBT person; see Sexual inversion (sexology) See also * Inversion (other) * Inverter (other) * Opposite (disambiguation ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] [Amazon] |
