|
Veranova
Veranova, L.P. (formally Johnson Matthey Health) is an American multinational contract development and manufacturing organization (CDMO) based in Devens, MA, with operations in North America and Europe. The company focuses on the process, development, and manufacturing of active pharmaceutical ingredients (APIs), particularly specialty and highly regulated, complex chemistries. It has two divisions, Generics and Originators. Its specialized drug development and manufacturing technologies and expertise in the pharmaceutical and biotechnology industries span the drug development lifecycle. Johnson Matthey Health was purchased in 2022 by Altaris Capital Partners for £325 million (JM retaining 30% equity) and rebranded to become Veranova; the name originates from the combined Latin words ‘vērus’, meaning ‘true’, and ‘nŏvus’, meaning ‘new’. History 19th Century J.F. Macfarlan, Duncan Flockhart, and T&S Smith Through its original founding companies, the ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
MacFarlan Smith
MacFarlan Smith is a pharmaceutical manufacturing company based in Edinburgh, Scotland, founded in 1815. After its sale from Johnson Matthey in June 2022 to Altaris Capital Partners, Macfarlan Smith rebranded as Veranova. Veranova is a CDMO specialising in the development and manufacturing of specialist and complex active pharmaceutical ingredients, or APIs. It has facilities across Europe and North America. Background J.F. Macfarlan J.F. Macfarlan Ltd was founded in 1780 as an apothecary supplier. In 1815 John Fletcher Macfarlan, licentiate of the Royal College of Surgeons, became the owner of the family business, and acquired an apothecary's shop in Edinburgh. He immediately began to manufacture laudanum, a medicine based on opium. In 1830 Macfarlan began a partnership with his former apprentice David Rennie Brown, and so incorporated the business as J.F. Macfarlan and Co Ltd. In 1832 the company began manufacture of the medicinal version of heroin and morphine hydrochlorid ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Limited Partnership
A limited partnership (LP) is a type of partnership with general partners, who have a right to manage the business, and limited partners, who have no right to manage the business but have only limited liability for its debts. Limited partnerships are distinct from limited liability partnerships in which all partners have limited liability. The general partners (GPs) are, in all major respects, in the same legal position as partners in a conventional firm: they have management control, share the right to use partnership property, share the profits of the firm in predefined proportions, and have joint and several liability for the debts of the partnership. As in a general partnership, the GPs have actual authority, as agency law, agents of the firm, to bind the partnership in contracts with third parties that are in the ordinary course of the partnership's business. As with a general partnership, "an act of a general partner which is not apparently for carrying on in the ordinary ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Joseph Lister
Joseph Lister, 1st Baron Lister, (5 April 1827 – 10 February 1912) was a British surgeon, medical scientist, experimental pathologist and pioneer of aseptic, antiseptic surgery and preventive healthcare. Joseph Lister revolutionised the Surgical technique, craft of surgery in the same manner that John Hunter (surgeon), John Hunter revolutionised the science of surgery. From a technical viewpoint, Lister was not an exceptional surgeon, but his research into bacteriology and infection in wounds revolutionised surgery throughout the world. Lister's contributions were four-fold. Firstly, as a surgeon at the Glasgow Royal Infirmary, he introduced carbolic acid (modern-day phenol) as a sterilization (microbiology), steriliser for surgical instruments, patients' skins, surgical suture, sutures, surgeons' hands, and wards, promoting the principle of antiseptics. Secondly, he researched the role of inflammation and tissue perfusion in the healing of wounds. Thirdly, he advanced diag ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Medicines And Healthcare Products Regulatory Agency
The Medicines and Healthcare products Regulatory Agency (MHRA) is an executive agency of the Department of Health and Social Care in the United Kingdom which is responsible for ensuring that medicines and medical devices work and are acceptably safe. The MHRA was formed in 2003 with the merger of the Medicines Control Agency (MCA) and the Medical Devices Agency (MDA). In April 2013, it merged with the National Institute for Biological Standards and Control (NIBSC) and was rebranded, with the MHRA identity being used solely for the regulatory centre within the group. The agency employs more than 1,200 people in London, York and South Mimms, Hertfordshire. Structure The MHRA is divided into three main centres: * MHRA Regulatory – the regulator for the pharmaceutical and medical devices industries * Clinical Practice Research Datalink – licences anonymised health care data to pharmaceutical companies, academics and other regulators for research * National Institute for ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Biocatalysis
Biocatalysis refers to the use of living (biological) systems or their parts to speed up ( catalyze) chemical reactions. In biocatalytic processes, natural catalysts, such as enzymes, perform chemical transformations on organic compounds. Both enzymes that have been more or less isolated and enzymes still residing inside living cells are employed for this task. Modern biotechnology, specifically directed evolution, has made the production of modified or non-natural enzymes possible. This has enabled the development of enzymes that can catalyze novel small molecule transformations that may be difficult or impossible using classical synthetic organic chemistry. Utilizing natural or modified enzymes to perform organic synthesis is termed chemoenzymatic synthesis; the reactions performed by the enzyme are classified as chemoenzymatic reactions. History Biocatalysis underpins some of the oldest chemical transformations known to humans, for brewing predates recorded history. The old ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
London Stock Exchange
The London Stock Exchange (LSE) is a stock exchange based in London, England. the total market value of all companies trading on the LSE stood at US$3.42 trillion. Its current premises are situated in Paternoster Square close to St Paul's Cathedral. Since 2007, it has been part of the London Stock Exchange Group (LSEG, which the exchange also lists (ticker symbol LSEG)). Despite a post-Brexit exodus of stock listings from the LSE, it was the most valued stock exchange in Europe as of 2023. According to the 2020 Office for National Statistics report, approximately 12% of UK-resident individuals reported having investments in stocks and shares. According to a 2020 Financial Conduct Authority report, approximately 15% of British adults reported having investments in stocks and shares. History Coffee House The Royal Exchange, London, Royal Exchange had been founded by the English financier Thomas Gresham and Sir Richard Clough on the model of the The Belgian bourse of Antwerp, An ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Michigan State University
Michigan State University (Michigan State or MSU) is a public university, public Land-grant university, land-grant research university in East Lansing, Michigan, United States. It was founded in 1855 as the Agricultural College of the State of Michigan, the first of its kind in the country. After the introduction of the Morrill Land-Grant Acts, Morrill Act in 1862, the state designated the college a land-grant institution in 1863, making it the first of the land-grant colleges in the United States. The college became coeducational in 1870. Today, Michigan State has facilities all across the state and over 634,000 alumni. Michigan State is a member of the Association of American Universities and is Carnegie Classification of Institutions of Higher Education, classified among "R1: Doctoral Universities – Very high research activity". The university's campus houses the Facility for Rare Isotope Beams, the W. J. Beal Botanical Garden, the Abrams Planetarium, the Wharton Center f ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Cisplatin
Cisplatin is a chemical compound with chemical formula, formula ''cis''-. It is a coordination complex of platinum that is used as a chemotherapy medication used to treat a number of cancers. These include testicular cancer, ovarian cancer, cervical cancer, bladder cancer, head and neck cancer, esophageal cancer, lung cancer, mesothelioma, brain tumors and neuroblastoma. It is given by intravenous, injection into a vein. Common side effects include bone marrow suppression, hearing problems including severe hearing loss, nephrotoxicity, kidney damage, and vomiting. Other serious side effects include numbness, trouble walking, allergic reactions, electrolyte problems, and heart disease. Use during pregnancy can cause harm to the developing fetus. Cisplatin is in the platinum-based antineoplastic family of medications. It works in part by binding to DNA and inhibiting DNA replication, its replication. Cisplatin was first reported in 1845 and licensed for medical use in 1978 an ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
GSK Plc
GSK plc (an acronym from its former name GlaxoSmithKline plc) is a British Multinational corporation, multinational Pharmaceutics, pharmaceutical and biotechnology company with headquarters in London. It was established in 2000 by a Mergers and acquisitions, merger of Glaxo Wellcome and SmithKline Beecham, which was itself a merger of a number of pharmaceutical companies around the Smith, Kline & French firm. GSK is the tenth largest pharmaceutical company and No. 294 on the 2022 Fortune Global 500, ''Fortune'' Global 500, ranked behind other pharmaceutical companies China Resources, Sinopharm (company), Sinopharm, Johnson & Johnson, Pfizer, Roche, AbbVie, Novartis, Bayer, and Merck & Co., Merck Sharp & Dohme. The company has a primary listing on the London Stock Exchange and is a constituent of the FTSE 100 Index. As of February 2024, it had a Market capitalization, market capitalisation of £69 billion, the eighth largest on the London Stock Exchange. The company developed ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Denatonium
Denatonium, usually available as denatonium benzoate (under trade names such as Denatrol, BITTERANT-b, BITTER+PLUS, Bitrex, Bitrix, and Aversion) and as denatonium saccharinate (BITTERANT-s), is the bitterest chemical compound known, with bitterness thresholds of 0.05 ppm for the benzoate and 0.01 ppm for the saccharinate. It was discovered in 1958 during research on local anesthetics by T. & H. Smith of Edinburgh, Scotland, and registered under the trademark Bitrex. Dilutions of as little as 10 ppm are unbearably bitter to most people. Denatonium salts are usually colorless and odorless solids, but are often traded as solutions. They are used as aversive agents (bitterants) to prevent inappropriate ingestion. Denatonium is used in denatured alcohol, antifreeze, preventive nail biting preparations, respirator mask fit-testing, animal repellents, liquid soaps, shampoos, and Nintendo Switch game cards to prevent accidental swallowing or choking by children. It ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Gauze
Gauze is a thin, translucent Textile, fabric with a wikt:loose, loose open Weaving, weave. In technical terms, "gauze" is a weave structure in which the weft yarns are arranged in pairs and are crossed before and after each Warp (weaving), warp yarn, keeping the weft firmly in place. This weave structure is used to add stability to the fabric, which is important when using fine yarns loosely spaced. However, this weave structure can be used with any weight of yarn, and can be seen in some rustic textiles made from coarse hand-spun plant fiber yarns. Gauze is widely used for medical dressings. Gauze can also be made of non-woven fabric. Etymology and history The word ''gauze'' came into English in the 16th century via French ''gaze'', beyond which its history is uncertain. Most scholars trace ''gauze'' to a Persian language, Persian word for thin cloth or an Arabic word for raw silk. The Philip III, Bishop of Fermo#Hungary, 1279 Council of Baden banned clergy from wearing " ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Morphine
Morphine, formerly also called morphia, is an opiate that is found naturally in opium, a dark brown resin produced by drying the latex of opium poppies (''Papaver somniferum''). It is mainly used as an analgesic (pain medication). There are multiple methods used to administer morphine: oral; sublingual administration, sublingual; via inhalation; intramuscular, injection into a muscle, Subcutaneous injection, injection under the skin, or injection into the spinal cord area; transdermal; or via rectal administration, rectal suppository. It acts directly on the central nervous system (CNS) to induce analgesia and alter perception and emotional response to pain. Physical and psychological dependence and tolerance may develop with repeated administration. It can be taken for both acute pain and chronic pain and is frequently used for pain from myocardial infarction, kidney stones, and during Childbirth, labor. Its maximum effect is reached after about 20 minutes when administ ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
