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MacFarlan Smith
MacFarlan Smith is a pharmaceutical manufacturing company based in Edinburgh, Scotland, founded in 1815. After its sale from Johnson Matthey in June 2022 to Altaris Capital Partners, Macfarlan Smith rebranded as Veranova. Veranova is a CDMO specialising in the development and manufacturing of specialist and complex active pharmaceutical ingredients, or APIs. It has facilities across Europe and North America. Background J.F. Macfarlan J.F. Macfarlan Ltd was founded in 1780 as an apothecary supplier. In 1815 John Fletcher Macfarlan, licentiate of the Royal College of Surgeons, became the owner of the family business, and acquired an apothecary's shop in Edinburgh. He immediately began to manufacture laudanum, a medicine based on opium. In 1830 Macfarlan began a partnership with his former apprentice David Rennie Brown, and so incorporated the business as J.F. Macfarlan and Co Ltd. In 1832 the company began manufacture of the medicinal version of heroin and morphine hydrochlorid ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Subsidiary
A subsidiary, subsidiary company, or daughter company is a company (law), company completely or partially owned or controlled by another company, called the parent company or holding company, which has legal and financial control over the subsidiary company. Unlike regional branches or divisions, subsidiaries are considered to be distinct entities from their parent companies; they are required to follow the laws of where they are incorporated, and they maintain their own executive leadership. Two or more subsidiaries primarily controlled by same entity/group are considered to be sister companies of each other. Subsidiaries are a common feature of modern business, and most multinational corporations organize their operations via the creation and purchase of subsidiary companies. Examples of holding companies are Berkshire Hathaway, Jefferies Financial Group, The Walt Disney Company, Warner Bros. Discovery, and Citigroup, which have subsidiaries involved in many different Industry (e ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Chloroform
Chloroform, or trichloromethane (often abbreviated as TCM), is an organochloride with the formula and a common solvent. It is a volatile, colorless, sweet-smelling, dense liquid produced on a large scale as a precursor to refrigerants and polytetrafluoroethylene (PTFE). Chloroform was once used as an inhalational anesthetic between the 19th century and the first half of the 20th century. It is miscible with many solvents but it is only very slightly soluble in water (only 8 g/L at 20°C). Structure and name The molecule adopts a tetrahedral molecular geometry with C3v symmetry. The chloroform molecule can be viewed as a methane molecule with three hydrogen atoms replaced with three chlorine atoms, leaving a single hydrogen atom. The name "chloroform" is a portmanteau of ''terchloride'' (tertiary chloride, a trichloride) and ''formyle'', an obsolete name for the methylylidene radical (CH) derived from formic acid. Natural occurrence Many kinds of seaweed produce chlor ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
British Army
The British Army is the principal Army, land warfare force of the United Kingdom. the British Army comprises 73,847 regular full-time personnel, 4,127 Brigade of Gurkhas, Gurkhas, 25,742 Army Reserve (United Kingdom), volunteer reserve personnel and 4,697 "other personnel", for a total of 108,413. The British Army traces back to 1707 and the Acts of Union 1707, formation of the united Kingdom of Great Britain which joined the Kingdoms of Kingdom of England, England and Kingdom of Scotland, Scotland into a Political union, single state and, with that, united the English Army and the Scots Army as the British Army. The Parliament of England, English Bill of Rights 1689 and Convention of the Estates, Scottish Claim of Right Act 1689 require parliamentary consent for the Crown to maintain a peacetime standing army. Members of the British Army swear allegiance to the Charles III, monarch as their commander-in-chief. The army is administered by the Ministry of Defence (United Kingd ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
James Young Simpson
Sir James Young Simpson, 1st Baronet (7 June 1811 – 6 May 1870) was a Scottish obstetrician and a significant figure in the history of medicine. He was the first physician to demonstrate the anaesthetic properties of chloroform in humans and helped to popularize its use in medicine. Simpson's intellectual interests ranged from archaeology to an almost taboo subject at the time: hermaphroditism. He was an early advocate of the use of midwives in the hospital environment. Many prominent women also consulted him for their gynaecological problems. Simpson wrote ''Homœopathy, its Tenets and Tendencies,'' refuting the ideas put forward by Hahnemann. His services as an early founder of gynaecology and proponent of hospital reform were rewarded with a knighthood, and by 1847 he had been appointed as physician to the Queen in Scotland. Queen Victoria also used anaesthesia for her childbirth, resulting in a significant increase of popularity in anaesthesia. Simpson was a close fr ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Chloroform
Chloroform, or trichloromethane (often abbreviated as TCM), is an organochloride with the formula and a common solvent. It is a volatile, colorless, sweet-smelling, dense liquid produced on a large scale as a precursor to refrigerants and polytetrafluoroethylene (PTFE). Chloroform was once used as an inhalational anesthetic between the 19th century and the first half of the 20th century. It is miscible with many solvents but it is only very slightly soluble in water (only 8 g/L at 20°C). Structure and name The molecule adopts a tetrahedral molecular geometry with C3v symmetry. The chloroform molecule can be viewed as a methane molecule with three hydrogen atoms replaced with three chlorine atoms, leaving a single hydrogen atom. The name "chloroform" is a portmanteau of ''terchloride'' (tertiary chloride, a trichloride) and ''formyle'', an obsolete name for the methylylidene radical (CH) derived from formic acid. Natural occurrence Many kinds of seaweed produce chlor ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Lactucarium
Lactucarium is the milky fluid secreted by several species of lettuce, especially ''Lactuca virosa'', usually from the base of the stems. It is known as lettuce opium because of its sedative and analgesic properties. It has also been reported to promote a mild sensation of euphoriant, euphoria. Because it is a latex, lactucarium physically resembles opium, in that it is excreted as a white fluid and can be reduced to a thick smokable solid. Although the effect is not that comparable, with opium being so much more potent, it still is effective in people who have no opioid tolerance. History "Lettuce opium" was used by the ancient Egyptians, and was introduced as a drug in the United States as early as 1799. The drug was prescribed and studied extensively in Poland during the nineteenth century, and was viewed as an alternative to opium, weaker but lacking side effects, such as not being highly addictive, and in some cases preferable. However, early efforts to isolate an act ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
James Duncan (surgeon)
James Duncan FRSE FRCS FRCSE (2 November 1810 – 16 August 1866) was a Scottish surgeon and manufacturing chemist responsible for much of the British supply of chloroform in the mid-19th century. From 1839 to 1866 he was Director of Duncan Flockhart & Co one of Scotland’s largest chemical manufacturers. Life He was born in Perth on 2 November 1810, the son of John Duncan (b. 1780) founder of Duncan Flockhart & Co. and his wife, Elizabeth Morison. He was educated at Perth Academy then sent to the High School in Edinburgh to be educated. In 1833 his father’s company moved from Perth to Edinburgh, with premises at 52 North Bridge with the family living at 1 Blenheim Place at the top of Leith Walk. Meanwhile Duncan was completing his medical studies at the University of Edinburgh, graduating with an MD in 1834. He was taught surgery by Robert Liston. Due to his rich father his postgraduate studies leading to his MD included studies in France, Germany, Austria and Italy. ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
William Flockhart
William Flockhart, L.R.C.S.E. (1808 – 1871) was a Scottish chemist, a pharmacist who provided chloroform to Doctor (later Sir) James Young Simpson for his anaesthesia experiment at 52 Queen Street, Edinburgh on 4 November 1847. This was the first use of this chemical on humans when Simpson tried it on himself and a few friends, and then used it for pain relief in obstetrics, and surgery. This changed medical practice for over a century, according to the British Medical Journal. Career Flockhart had joined John Duncan (also from Kinrosshire, who was 28 years his senior), as a partner in 1833, having started as an apprentice surgeon-apothecary and qualifying as a licenciate of the Royal College of Surgeons Edinburgh in 1830, when he was 22 years old. He did not practise as a surgeon, but with Duncan, worked closely with other doctors in Edinburgh on experimental drugs, which they then refined to improve in purity, following the medical experiments' results. They were both amo ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Perth, Scotland
Perth (; ) is a centrally located Cities of Scotland, Scottish city, on the banks of the River Tay. It is the administrative centre of Perth and Kinross council area and is the historic county town of Perthshire. It had a population of about in . There has been a settlement at Perth since prehistory, prehistoric times. It is a natural mound raised slightly above the flood plain of the Tay. The area surrounding the modern city is known to have been occupied ever since the arrival of Mesolithic hunter-gatherers. Nearby Neolithic standing stones and circles date from about 4,000 Anno Domini, BC, a period that followed the introduction of farming into the area. Close to Perth is Scone Abbey, which formerly housed the Stone of Scone (also known as the Stone of Destiny), on which the King of Scots were traditionally crowned. This enhanced the early importance of the city, and Perth became known as a "capital" of Scotland due to the frequent residence there of the royal court. Royal ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Kinross
Kinross (, ) is a burgh in Perth and Kinross, Scotland, around south of Perth, Scotland, Perth and around northwest of Edinburgh. It is the traditional county town of the Counties of Scotland, historic county of Kinross-shire. History Kinross's origins are connected with the nearby Loch Leven and its islands whose history goes back to the 5th century AD. Kinross developed as a staging post on the Great North Road from North Queensferry to Perth, Scotland, Perth. In time, local industry developed and by the early 18th century the town had grown to a population of around 600 people. By the mid-19th century, a thriving wool weaving industry had emerged. Kinross Town Hall was completed in 1841. Location and transport The site of the original Pre-Reformation parish church (building), church and churchyard is down a small wynd overlooking Loch Leven (Kinross), Loch Leven, a little away from the town. The church was dedicated to St. Serf and was under control of Dunfermline Abbey. ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Strychnine
Strychnine (, , American English, US chiefly ) is a highly toxicity, toxic, colorless, bitter, crystalline alkaloid used as a pesticide, particularly for killing small vertebrates such as birds and rodents. Strychnine, when inhaled, swallowed, or absorbed through the eyes or mouth, causes Strychnine poisoning, poisoning which results in muscular convulsions and eventually death through asphyxia. While it is no longer used medicinally, it was used historically in small doses to strengthen muscle contractions, such as a heart and bowel stimulant and performance-enhancing drug. The most common source is from the seeds of the ''Strychnos nux-vomica'' tree. Biosynthesis Strychnine is a terpene indole alkaloid belonging to the ''Strychnos'' family of ''Corynanthe'' alkaloids, and it is derived from tryptamine and secologanin. The biosynthesis of strychnine was solved in 2022. The enzyme, strictosidine synthase, catalyzes the condensation of tryptamine and secologanin, followed by ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Northfield, Edinburgh
Northfield is a suburb of Edinburgh, the capital of Scotland. It lies east of the city centre and west of Portobello, Scotland, Portobello. The area was laid out at low densities as local authority housing but the city employed private architects for its design - Reginald Fairlie and Reid and Forbes. It was laid out from 1921 and took around three years to complete. Due to the high quality of the buildings it was a very popular area for tenants to purchase under the "Right to Buy" scheme and the area is now largely in private ownership. The quality is also reflected in that several of the groups are now listed buildings. History The area was planned out from 1921 following Edinburgh's reorganisation of its boundaries to controversially encompass Portobello, the fiercely independent Leith, Scotland, Leith and certain areas of Midlothian in 1920. This area was laid out very generously at very low densities, an attitude seemingly derivative of Edinburgh having gained the lan ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
