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Tabernaemontana
''Tabernaemontana'' is a genus of flowering plants in the family Apocynaceae. It has a pan-tropical distribution, found in Asia, Africa, Australia, North America, South America, and a wide assortment of oceanic islands. These plants are evergreen shrubs and small trees growing to 1–15 m tall. The leaves are opposite, 3–25 cm long, with milky sap; hence it is one of the diverse plant genera commonly called "milkwood". The flowers are fragrant, white, 1–5 cm in diameter. The cultivar '' T. divaricata'' cv. 'Plena', with doubled-petaled flowers, is a popular houseplant. Some members of the genus ''Tabernaemontana'' are used as additives to some versions of the psychedelic drink ayahuasca; the genus is known to contain ibogaine (e.g. in bëcchëte, ''T. undulata''), conolidine (present in minor concentration in ''T. divaricata'') and voacangine ('' T. alba'', '' T. arborea'', '' T. africana''). Because of presence of coronaridine and voacangine in Mexican ''Tabern ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Tabernaemontana Divaricata
''Tabernaemontana divaricata'', commonly called pinwheel flower, crape jasmine, East India rosebay, and Nero's crown, is an evergreen shrub or small tree native to South Asia, Southeast Asia and China. In zones where it is not hardy it is grown as a house/glasshouse plant for its attractive flowers and foliage. The stem exudes a milky latex when broken, whence the name milk flower. Description The plant generally grows to a height of and is dichotomously branched. The large shiny leaves are deep green and about in length and in width. The waxy blossoms are found in small clusters on the stem tips. The (single) flowers have the characteristic 'pinwheel' shape also seen in other genera in the family Apocynaceae such as ''Vinca'' and '' Nerium''. Both single and double-flowered forms are cultivated, the flowers of both forms being white. The plant blooms in spring but flowers appear sporadically all year. The flowers have a pleasing fragrance. More than 66 alkaloids are found ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Tabernaemontana Sananho
''Tabernaemontana sananho'' is a tropical tree species in the family Apocynaceae known as lobo sanango. Lobo sanango grows in the Amazon Basin of northern South America. Chemical composition The plant is reported to contain coronaridine, 3-hydroxycoronaridine, (-)-heyneanine, (-)-ibogamine and voacangine. Traditional use In Amazonian traditional medicine, preparations of the leaves, pulp, bark, and latex are either applied topically or taken internally to treat various conditions. Extracts from the tree are antiinflammatory and effective against the protozoan ''Leishmania''. In Peru, this tree is sometimes known by the Spanish–Quechua name lobo sanango ("wolf plant") or simply as sanango. Throughout the Amazon the species has numerous other aliases in several languages. The Secoya people of Ecuador call this plant and put the sticky liquid from the fruit into dogs' noses so they can "smell far in hunting." They also eat the fruit of baĩ su'u. Taxonomy and phylogeny ''T. ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Tabernaemontana Alba
''Tabernaemontana alba'', the white milkwood, is a species of plant in the family Apocynaceae. at www.theplantlist.org. It is found in , , , , and Colombia. References |
Tabernaemontana Africana
''Tabernaemontana africana'' is a species of plant in the Apocynaceae family. It is found in tropical Africa. It is an evergreen perennial shrub with a maximum height of 6 meters. The plant can be used to produce latex Latex is an emulsion (stable dispersion) of polymer microparticles in water. Latexes are found in nature, but synthetic latexes are common as well. In nature, latex is found as a milky fluid found in 10% of all flowering plants (angiosperms ..., soap and dye. at letsplant.org. References africana {{Apocynaceae-stub ...[...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Tabernaemontana Heterophylla
''Tabernaemontana heterophylla'' is a species of plant in the family Apocynaceae. at www.theplantlist.org. It is found in southeastern , and northern and central South America
South America is a continent entirely in the Western Hemisphere and mostly in the Southern Hemisphere, with a relatively small portion in the Northern Hemisphere at the northern tip of the continent. It can also be described as the sou ... .
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Bëcchëte
''Tabernaemontana undulata'', the becchete or bëcchëte (pronounced b'-chéw-teh, a Matis and Matsés word for a medicinal plant) is a plant species in the family Apocynaceae. It occurs in the Amazon rainforest. Effects When applied directly to the eye, becchete is reported by tribes to have the effect of giving the environment greater texture and dimension, making it easier to spot animals during hunting. The effects are reported to be long-term, lasting days or weeks, not just a few hours. In addition to visual enhancement, there is also an increase in energy. On application, the eyes sting, however this would be expected considering that becchete is extracted with Amazonian river water that is high in tannic acid, which on its own would sting and burn the eyes. In the ''Amazonian Ethnobotanical Dictionary'' by James A. Duke and Rodolfo Vásquez, it is reported that Amazonian Indians from the Ticuna tribe mix the latex from a closely related species, ''Tabernaemontana san ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Coronaridine
Coronaridine, also known as 18-carbomethoxyibogamine, is an alkaloid found in ''Tabernanthe iboga'' and related species, including ''Tabernaemontana divaricata'' for which (under the now obsolete synonym ''Ervatamia coronaria'') it was named. Like ibogaine, (''R'')-coronaridine and (''S'')-coronaridine can decrease intake of cocaine and morphine intake in animals and it may have muscle relaxant and hypotensive activity. Chemistry Congeners Coronaridine congers are important in drug discovery and development due to multiple actions on different targets. They have ability to inhibit Cav2.2 channel, modulate and inhibit subunits of nAChr selectively such as α9α10, α3β4 and potentiate GABAA activity. Pharmacology Coronaridine has been reported to bind to an assortment of molecular sites, including: μ-opioid (Ki = 2.0 μM), δ-opioid (Ki = 8.1 μM), and κ-opioid receptors (Ki = 4.3 μM), NMDA receptor (Ki = 6.24 μM) (as an antagonist), and nAChRs (as an antagonist). It ha ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Apocynaceae
Apocynaceae (from ''Apocynum'', Greek for "dog-away") is a family of flowering plants that includes trees, shrubs, herbs, stem succulents, and vines, commonly known as the dogbane family, because some taxa were used as dog poison Members of the family are native to the European, Asian, African, Australian, and American tropics or subtropics, with some temperate members. The former family Asclepiadaceae (now known as Asclepiadoideae) is considered a subfamily of Apocynaceae and contains 348 genera. A list of Apocynaceae genera may be found here. Many species are tall trees found in tropical forests, but some grow in tropical dry (xeric) environments. Also perennial herbs from temperate zones occur. Many of these plants have milky latex, and many species are poisonous if ingested, the family being rich in genera containing alkaloids and cardiac glycosides, those containing the latter often finding use as arrow poisons. Some genera of Apocynaceae, such as '' Adenium'', ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Tabernaemontana Arborea
''Tabernaemontana arborea'' is a species of plant in the family Apocynaceae. at www.theplantlist.org. It is found in southern , , and . References arborea
Arborea is a town and '' comune'' in the province of Oristano, Sardinia, Italy, whose economy is largely ba ...
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Voacangine
Voacangine (12-methoxyibogamine-18-carboxylic acid methyl ester) is an alkaloid found predominantly in the root bark of the '' Voacanga africana'' tree, as well as in other plants such as ''Tabernanthe iboga'', '' Tabernaemontana africana'', ''Trachelospermum jasminoides'', ''Tabernaemontana divaricata'' and ''Ervatamia yunnanensis''. It is an iboga alkaloid which commonly serves as a precursor for the semi-synthesis of ibogaine. It has been demonstrated in animals to have similar anti-addictive properties to ibogaine itself. It also potentiates the effects of barbiturates. Under UV-A and UV-B light its crystals fluoresce blue-green, and it is soluble in ethanol. Pharmacology Pharmacodynamics Voacangine exhibits AChE inhibitory activity. Docking simulation reveals that it has inhibitory effect on VEGF2 kinase and reduces angiogenesis. Like ibogaine, its a potent HERG blocker in vitro. It also acts as antagonist to TRPM8 and TRPV1 receptor but agonist of TRPA1. Pharmacokinetics Th ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Conolidine
Conolidine is an indole alkaloid. Preliminary reports suggest that it could provide analgesic effects with few of the detrimental side-effects associated with opioids such as morphine, though at present it has only been evaluated in mouse models. Conolidine was first isolated in 2004 from the bark of the ''Tabernaemontana divaricata'' (crepe jasmine) shrub which is used in traditional Chinese medicine. The first asymmetric total synthesis of conolidine was developed by Micalizio and coworkers in 2011. This synthetic route allows access to either enantiomer (mirror image) of conolidine via an early enzymatic resolution. Notably, evaluation of the synthetic material resulted in the discovery that both enantiomers of the synthetic compound show analgesic effects. Syntheses The Micalizio route (2011) achieved the end product in 9 steps from a commercially available acetyl-pyridine. Notable reactions include a ,3Still-Wittig rearrangement and a conformationally-controlled int ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Ibogaine
Ibogaine is a naturally occurring psychoactive substance found in plants in the family Apocynaceae such as '' Tabernanthe iboga'', '' Voacanga africana'', and '' Tabernaemontana undulata''. It is a psychedelic with dissociative properties. Preliminary research indicates that it may help counter drug addiction. Its use has been associated with serious side effects and death. Between the years 1990 and 2008, a total of 19 fatalities temporally associated with the ingestion of ibogaine were reported, from which six subjects died of acute heart failure or cardiopulmonary arrest. The total number of subjects who have used it without major side effects during this period remains unknown. It is used as an alternative medicine treatment for drug addiction in some countries. Its prohibition in other countries has slowed scientific research. Ibogaine is also used to facilitate psychological introspection and spiritual exploration. Various derivatives of ibogaine designed to lack psychede ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
