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Tracy (sheep)
Tracy (1990 – 1997) was a Genetically modified organism, transgenically modified sheep created by scientists at Scotland's Roslin Institute to produce the human protein alpha 1-antitrypsin, a substance regarded in the 1990s as a potential pharmaceutical for the treatments of cystic fibrosis and emphysema. Notably, she is the first transgenic farm mammal ever created. Alpha 1-antitrypsin comprised 50% of the total protein in Tracy's milk, a remarkably high level maintained after lactation. Similar levels were detected in the milk produced by her granddaughters. A deficiency in this protein in humans can produce lung diseases, and its artificial creation was thought to be a potential success in the diseases' treatment. Clinical trials for the engineered protein in 1998 revealed that it developed breathing problems in patients, and research for the milk as a remedy for the diseases has not continued since then.{{cite book, last1=Newton PhD, first1=David E., title=DNA Technology: A R ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
At The Science Museum, London 2025 115
AT or at may refer to: Geography Austria * Austria (ISO 2-letter country code) * .at, Internet country code top-level domain United States * Atchison County, Kansas (county code) * The Appalachian Trail (A.T.), a 2,180+ mile long mountainous trail in the Eastern United States Elsewhere * Antigua and Barbuda, World Meteorological Organization country code * Ashmore and Cartier Islands (FIPS 10-4 territory code, and obsolete NATO country code) * At, Bihar, village in Aurangabad district of Bihar, India * Province of Asti, Italy (ISO 3166-2:IT code) * Australia, LOC MARC code Politics * Awami Tahreek a left-wing Pakistani political party Science and technology Computing * @ (or "at sign"), the punctuation symbol now typically used in e-mail addresses and tweets) * at (command), used to schedule tasks or other commands to be performed or run at a certain time * IBM Personal Computer/AT ** AT (form factor) for motherboards and computer cases ** AT connector, a five-pin D ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Genetically Modified Organism
A genetically modified organism (GMO) is any organism whose genetic material has been altered using genetic engineering techniques. The exact definition of a genetically modified organism and what constitutes genetic engineering varies, with the most common being an organism altered in a way that "does not occur naturally by mating and/or natural Recombination (biology), recombination". A wide variety of organisms have been genetically modified (GM), including animals, plants, and microorganisms. Genetic modification can include the introduction of new genes or enhancing, altering, or Gene knockout, knocking out endogenous genes. In some genetic modifications, genes are transferred Cisgenesis, within the same species, across species (creating transgenic organisms), and even across Kingdom (biology), kingdoms. Creating a genetically modified organism is a multi-step process. Genetic engineers must isolate the gene they wish to insert into the host organism and combine it with o ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Roslin Institute
The Roslin Institute is an animal sciences research institute at Easter Bush, Midlothian, Scotland, part of the University of Edinburgh, and is funded by the Biotechnology and Biological Sciences Research Council. It is best known for creating Dolly the sheep in 1996, the first mammal to be successfully cloned from an adult cell. History Institute of Animal Genetics (1917–1980) The Roslin Institute has its roots in the University of Edinburgh's Institute of Animal Genetics (IAG), which was founded in 1917 under the direction of Francis Albert Eley Crew. Poultry Research Centre (1947–1986) The Poultry Research Centre (PRC) was founded in 1947 by the Agricultural Research Council (ARC). The new institute used expertise and material from the IAG, and its laboratories were located adjacent to the IAG's building on the university's King's Buildings campus. A second site housing larger experiments was located on the Bush Estate, south of Edinburgh. In 1971, the institute's ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Alpha 1-antitrypsin
Alpha-1 antitrypsin or α1-antitrypsin (A1AT, α1AT, A1A, or AAT) is a protein belonging to the serpin superfamily. It is encoded in humans by the ''SERPINA1'' gene. A protease inhibitor, it is also known as alpha1–proteinase inhibitor (A1PI) or alpha1-antiproteinase (A1AP) because it inhibits various proteases (not just trypsin). As a type of enzyme inhibitor, it protects tissues from enzymes of inflammatory cells, especially neutrophil elastase. When the blood contains inadequate or defective A1AT (as in alpha-1 antitrypsin deficiency), neutrophil elastase can excessively break down elastin, leading to the loss of elasticity in the lungs. This results in respiratory issues, such as chronic obstructive pulmonary disease, in adults. Normally, A1AT is produced in the liver and enters the systemic circulation. However, defective A1AT may accumulate in the liver, potentially causing cirrhosis in both adults and children. A1AT not only binds to neutrophil elastase from in ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Cystic Fibrosis
Cystic fibrosis (CF) is a genetic disorder inherited in an autosomal recessive manner that impairs the normal clearance of Sputum, mucus from the lungs, which facilitates the colonization and infection of the lungs by bacteria, notably ''Staphylococcus aureus''. CF is a rare genetic disorder that affects mostly the lungs, but also the pancreas, liver, kidneys, and intestine. The hallmark feature of CF is the accumulation of thick mucus in different organs. Long-term issues include Shortness of breath, difficulty breathing and coughing up mucus as a result of frequent pneumonia, lung infections. Other signs and symptoms may include Sinusitis, sinus infections, failure to thrive, poor growth, Steatorrhea, fatty stool, Nail clubbing, clubbing of the fingers and toes, and infertility in most males. Different people may have different degrees of symptoms. Cystic fibrosis is inherited in an autosomal recessive manner. It is caused by the presence of mutations in both copies (alleles) ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Emphysema
Emphysema is any air-filled enlargement in the body's tissues. Most commonly emphysema refers to the permanent enlargement of air spaces (alveoli) in the lungs, and is also known as pulmonary emphysema. Emphysema is a lower respiratory tract disease, characterised by enlarged air-filled spaces in the lungs, that can vary in size and may be very large. The spaces are caused by the breakdown of the Alveolar wall, walls of the Pulmonary alveolus, alveoli, which replace the spongy Parenchyma#Lungs, lung tissue. This reduces the total alveolar surface available for gas exchange leading to a reduction in oxygen supply for the blood. Emphysema usually affects the middle aged or Old age, older population because it takes time to develop with the effects of tobacco smoking and other risk factors. Alpha-1 antitrypsin deficiency is a genetic risk factor that may lead to the condition presenting earlier. When associated with significant airflow limitation, emphysema is a Chronic obstructive ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Dolly (sheep)
Dolly (5 July 1996 – 14 February 2003) was a female Finn-Dorset sheep and the first mammal that was cloned from an adult somatic cell. She was cloned by associates of the Roslin Institute in Scotland, using the process of nuclear transfer from a cell taken from a mammary gland. Her cloning proved that a cloned organism could be produced from a mature cell from a specific body part. Contrary to popular belief, she was not the first animal to be cloned. The employment of adult somatic cells in lieu of embryonic stem cells for cloning emerged from the foundational work of John Gurdon, who cloned African clawed frogs in 1958 with this approach. The successful cloning of Dolly led to widespread advancements within stem cell research, including the discovery of induced pluripotent stem cells. Dolly lived at the Roslin Institute throughout her life and produced several lambs. She was euthanized at the age of six years due to a progressive lung disease. No cause which linked the d ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Pharming (genetics)
Pharming, a portmanteau of ''farming'' and ''pharmaceutical'', refers to the use of genetic engineering to insert genes that code for useful pharmaceuticals into host animals or plants that would otherwise not express those genes, thus creating a genetically modified organism (GMO). Pharming is also known as molecular farming, molecular pharming, or biopharming. The products of pharming are recombinant proteins or their metabolic products. Recombinant proteins are most commonly produced using bacteria or yeast in a bioreactor, but pharming offers the advantage to the producer that it does not require expensive infrastructure, and production capacity can be quickly scaled to meet demand, at greatly reduced cost. History The first Recombinant DNA, recombinant plant-derived protein (PDP) was human serum albumin, initially produced in 1990 in transgenic tobacco and potato plants. Open field growing trials of these crops began in the United States in 1992 and have taken place every y ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Genetically Modified Organisms
A genetically modified organism (GMO) is any organism whose genetic material has been altered using genetic engineering techniques. The exact definition of a genetically modified organism and what constitutes genetic engineering varies, with the most common being an organism altered in a way that "does not occur naturally by mating and/or natural Recombination (biology), recombination". A wide variety of organisms have been genetically modified (GM), including animals, plants, and microorganisms. Genetic modification can include the introduction of new genes or enhancing, altering, or Gene knockout, knocking out endogenous genes. In some genetic modifications, genes are transferred Cisgenesis, within the same species, across species (creating transgenic organisms), and even across Kingdom (biology), kingdoms. Creating a genetically modified organism is a multi-step process. Genetic engineers must isolate the gene they wish to insert into the host organism and combine it with o ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Cloned Sheep
Cloning is the process of producing individual organisms with identical genomes, either by natural or artificial means. In nature, some organisms produce clones through asexual reproduction; this reproduction of an organism by itself without a mate is known as parthenogenesis. In the field of biotechnology, cloning is the process of creating cloned organisms of cells and of DNA fragments. The artificial cloning of organisms, sometimes known as reproductive cloning, is often accomplished via somatic-cell nuclear transfer (SCNT), a cloning method in which a viable embryo is created from a somatic cell and an egg cell. In 1996, Dolly the sheep achieved notoriety for being the first mammal cloned from a somatic cell. Another example of artificial cloning is molecular cloning, a technique in molecular biology in which a single living cell is used to clone a large population of cells that contain identical DNA molecules. In bioethics, there are a variety of ethical positions reg ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
1990 Animal Births
Year 199 ( CXCIX) was a common year starting on Monday of the Julian calendar. At the time, it was sometimes known as year 952 ''Ab urbe condita''. The denomination 199 for this year has been used since the early medieval period, when the Anno Domini calendar era became the prevalent method in Europe for naming years. Events By place Roman Empire * Mesopotamia is partitioned into two Roman provinces divided by the Euphrates, Mesopotamia and Osroene. * Emperor Septimius Severus lays siege to the city-state Hatra in Central-Mesopotamia, but fails to capture the city despite breaching the walls. * Two new legions, I Parthica and III Parthica, are formed as a permanent garrison. China * Battle of Yijing: Chinese warlord Yuan Shao defeats Gongsun Zan. Korea * Geodeung succeeds Suro of Geumgwan Gaya, as king of the Korean kingdom of Gaya (traditional date). By topic Religion * Pope Zephyrinus succeeds Pope Victor I, as the 15th pope. Births Valerian Roman ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
1997 Animal Deaths
Events January * January 1 – The Emergency Alert System is introduced in the United States. * January 11 – Turkey threatens Cyprus on account of a deal to buy Russian S-300 missiles, prompting the Cypriot Missile Crisis. * January 16 – Murder of Ennis Cosby: Near Interstate 405 (California) on a Los Angeles freeway, Bill Cosby's son Ennis is shot in the head in a failed robbery attempt. * January 17 – A Delta II rocket carrying a military GPS payload explodes, shortly after liftoff from Cape Canaveral. * January 18 – In northwest Rwanda, Hutu militia members kill 6 Spanish aid workers and three soldiers, and seriously wound another. * January 19 – Yasser Arafat returns to Hebron after more than 30 years, and joins celebrations over the handover of the last Israeli-controlled West Bank city. (→ Hebron Agreement) * January 23 – Madeleine Albright becomes the first female Secretary of State of the United States, after confirmation by the United States Senate ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
