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Roslin Institute
The Roslin Institute is an animal sciences research institute at Easter Bush, Midlothian, Scotland, part of the University of Edinburgh, and is funded by the Biotechnology and Biological Sciences Research Council. It is best known for creating Dolly the sheep in 1996, the first mammal to be successfully cloned from an adult cell. History Institute of Animal Genetics (1917–1980) The Roslin Institute has its roots in the University of Edinburgh's Institute of Animal Genetics (IAG), which was founded in 1917 under the direction of Francis Albert Eley Crew. Poultry Research Centre (1947–1986) The Poultry Research Centre (PRC) was founded in 1947 by the Agricultural Research Council (ARC). The new institute used expertise and material from the IAG, and its laboratories were located adjacent to the IAG's building on the university's King's Buildings campus. A second site housing larger experiments was located on the Bush Estate, south of Edinburgh. In 1971, the institute's ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Midlothian
Midlothian (; ) is registration county, lieutenancy areas of Scotland, lieutenancy area and one of 32 council areas of Scotland used for local government. Midlothian lies in the east-central Lowlands, bordering the City of Edinburgh council area, East Lothian and the Scottish Borders. The modern council area was formed in 1975 when the Midlothian (historic), historic county of Midlothian, also known as Edinburghshire, was altered substantially as part of local government reforms; its southern part formed a new Midlothian Districts of Scotland, District within the Local government areas of Scotland 1973 to 1996, Region of Lothian, whilst areas on the peripheries were assigned to other districts and the city of Edinburgh, which had always been autonomous to an extent, was formally separated as the Edinburgh (district), City of Edinburgh District. In 1996 Midlothian became a unitary authority area, using the same name and territory as in 1975. History Midlothian County Council w ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Babraham Institute
The Babraham Institute is a life sciences research institution focussing on healthy ageing. The Babraham Institute is based on the Babraham Research Campus, partly occupying a former manor house, but also laboratory and science facility buildings on the campus, surrounded by an extensive parkland estate, just south of Cambridge, England. It is an independent and charitable organization which is involved in biomedical research, including healthy aging and molecular biology. The director is Dr Simon Cook who also leads the Institute's signalling research programme. The Babraham Institute is a member of EU-LIFE, an alliance of leading life sciences research centres in Europe. It is also a partner organisation of the University of Cambridge History The institute is located on the historic Babraham Hall Estate (now called the Babraham Research Campus), situated six miles south-east of Cambridge University, near the Gog Magog Hills. It is close to where the ancient Roman Via De ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Grahame Bulfield
Grahame Bulfield, CBE, FRSE, Hon FRASE (born 1941) is an English geneticist, vice-principal and Emeritus Professor of Genetics at the University of Edinburgh. He was the director and chief executive of the Roslin Institute, Edinburgh, when in 1996 the research group led by Ian Wilmut first cloned a mammal from an adult somatic cell, a Finnish Dorset lamb named Dolly. Early life and education Grahame Bulfield was born in 1941 in Leeds, was educated in Cheshire, where his interest in agriculture and farming started to grow. In 1959 he enrolled at the University of Leeds, reading for a BSc in Agriculture with Honours in animal production. His curiosity for genetics fully blossomed and he took to completion his honours project on the subject of "Beef Sire Performance and Progeny Test". Upon recommendation by a lecturer, with the support of a scholarship from the Ministry of Agriculture, in 1964 he enlisted the Institute of Animal Genetics in Edinburgh, studying for a Diploma in ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Alan William Greenwood
Alan William Greenwood Order of the British Empire, CBE FRSE (29 June 1897 – 4 May 1981) was an Australian zoologist and geneticist, who helped pave the way to creating Dolly (sheep), Dolly the Sheep. He served as director of the Roslin Institute, Poultry Research Centre from 1947 until 1962. Life He was born in Melbourne in Australia on 29 June 1897 and attended Wesley College (Victoria), Wesley College in Melbourne. He then won a place at Melbourne University graduating BSc in Chemistry and Biology in 1920. He continued as a postgraduate, gaining an MSc in 1923 then travelling to Scotland to study for a PhD at the University of Edinburgh under the supervision of James Cossar Ewart. Here he also began work at the Animal Breeding Research Department (later renamed to the Institute of Animal Genetics). His colleagues included the geneticist Janet Scott Salmon Blyth, with whom he would go on to collaborate with for many years, and the pharmacist John Michael Robson who joine ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Genetically Modified Organism
A genetically modified organism (GMO) is any organism whose genetic material has been altered using genetic engineering techniques. The exact definition of a genetically modified organism and what constitutes genetic engineering varies, with the most common being an organism altered in a way that "does not occur naturally by mating and/or natural Recombination (biology), recombination". A wide variety of organisms have been genetically modified (GM), including animals, plants, and microorganisms. Genetic modification can include the introduction of new genes or enhancing, altering, or Gene knockout, knocking out endogenous genes. In some genetic modifications, genes are transferred Cisgenesis, within the same species, across species (creating transgenic organisms), and even across Kingdom (biology), kingdoms. Creating a genetically modified organism is a multi-step process. Genetic engineers must isolate the gene they wish to insert into the host organism and combine it with o ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Quantitative Genetics
Quantitative genetics is the study of quantitative traits, which are phenotypes that vary continuously—such as height or mass—as opposed to phenotypes and gene-products that are Categorical variable, discretely identifiable—such as eye-colour, or the presence of a particular biochemical. Both of these branches of genetics use the frequencies of different alleles of a gene in breeding populations (gamodemes), and combine them with concepts from simple Mendelian inheritance to analyze inheritance patterns across generations and descendant lines. While population genetics can focus on particular genes and their subsequent metabolic products, quantitative genetics focuses more on the outward phenotypes, and makes only summaries of the underlying genetics. Due to the continuous distribution of phenotypic values, quantitative genetics must employ many other statistical methods (such as the ''effect size'', the ''mean'' and the ''variance'') to link phenotypes (attributes) to gen ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Polly And Molly
Polly and Molly (born 1997), two ewes, were the first mammals to have been successfully cloned from an adult somatic cell and to be transgenic animals at the same time. This is not to be confused with Dolly the Sheep, the first animal to be successfully cloned from an adult somatic cell where there wasn’t modification carried out on the adult donor nucleus. Polly and Molly, like Dolly the Sheep, were cloned at the Roslin Institute in Edinburgh, Scotland. The creation of Polly and Molly built on the somatic nuclear transfer experiments that led to the cloning of Dolly the Sheep. The crucial difference was that in creating Polly and Molly, scientists used cells into which a new gene had been inserted. The gene chosen was a therapeutic protein to demonstrate the potential of such recombinant DNA technology combined with animal cloning. This could hopefully be used to produce pharmacological and therapeutic proteins to treat human diseases. The protein in question was the human b ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Keith Campbell (biologist)
Keith Henry Stockman Campbell (23 May 1954 – 5 October 2012) was a British biologist who was a member of the team at Roslin Institute that in 1996 first cloned a mammal, a Finnish Dorset lamb named Dolly, from fully differentiated adult mammary cells. He was Professor of Animal Development at the University of Nottingham. In 2008, he received the Shaw Prize for Medicine and Life Sciences jointly with Ian Wilmut and Shinya Yamanaka for "their works on the cell differentiation in mammals". Education Campbell was born in Birmingham, England, to an English mother and Scottish father. He started his education in Perth, Scotland, but, when he was eight years old, his family returned to Birmingham, where he attended King Edward VI Camp Hill School for Boys. He obtained his Bachelor of Science degree in microbiology from the Queen Elizabeth College, University of London (now part of King's College London). In 1983 Campbell was awarded the Marie Curie Research Scholarship, which ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Ian Wilmut
Sir Ian Wilmut (7 July 1944 – 10 September 2023) was a British embryologist and the chair of the Scottish Centre for Regenerative Medicine at the University of Edinburgh. He was the leader of the research group that in 1996 first cloned a mammal from an adult somatic cell, a Finnish Dorset lamb named Dolly. Wilmut was appointed OBE in 1999 for services to embryo development and knighted in the 2008 New Year Honours. He, Keith Campbell and Shinya Yamanaka jointly received the 2008 Shaw Prize for Medicine and Life Sciences for their work on cell differentiation in mammals. Early life and education Wilmut was born in Hampton Lucy, Warwickshire, England, on 7 July 1944. Wilmut's father, Leonard Wilmut, was a mathematics teacher who suffered from diabetes for fifty years, which eventually caused him to become blind. The younger Wilmut attended the Boys' High School in Scarborough, where his father taught. His early desire was to embark on a naval career, but he was unabl ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Eleanor Riley
Eleanor Mary Riley was Director of the Roslin Institute, Dean of Research at the Royal (Dick) School of Veterinary Studies, and professor of Immunology at the University of Edinburgh. Her research focusses on understanding the immune response of the host to malaria and other diseases using human data and mouse models. Education Riley gained her bachelor's degree in cell biology and veterinary science from the University of Bristol, before reading for a postgraduate diploma in veterinary disease from Cornell University and studying her PhD in immunology and parasitology at the University of Liverpool. Her thesis entitled '''The immunology of experimental Echinoccus granulosus'' ic''infection in mice was accepted in 1985. Career Riley worked for five years at the MRC Unit The Gambia. Riley joined the University of Edinburgh initially as a research fellow in 1990, before moving to the London School of Hygiene & Tropical Medicine (LSHTM) in 1998 as a professor of infectious d ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Royal (Dick) School Of Veterinary Studies
The Royal (Dick) School of Veterinary Studies, commonly referred to as the Dick Vet, is the University of Edinburgh's vet school. It is part of the College of Medicine and Veterinary Medicine. In a joint submission to the latest UK Research Excellence Framework exercise, research at the Royal (Dick) School of Veterinary Studies and Scotland's Rural College (SRUC) was ranked number one in the UK for agriculture, food and veterinary sciences by combining Times Higher Education's ratings for each institution. The judgement, based on the quality and breadth of research, maintains the R(D)SVS and SRUC's position as the strongest provider in these subject areas. The institutions' research environment was classified to be 100 per cent world leading or internationally excellent for agriculture, food and veterinary sciences research. The joint submission was also assessed as being 100 per cent world leading or internationally excellent in terms of the impact the research work has on w ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
