Sheila Sherlock
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Sheila Sherlock
Dame Sheila Patricia Violet Sherlock DBE, FRCP FRCPE FRS HFRSE FMGA FCRGA (31 March 1918 – 30 December 2001) was a British physician and medical educator who is considered the major 20th-century contributor to the field of hepatology (the study of the liver). Early life Sheila Sherlock was born in Dublin on 31 March 1918, the only daughter of Violet Mary Catherine (''née'' Beckett) and Samuel Philip Sherlock, an army officer then serving as a lieutenant in the 1st Cavalry Reserve. Her family moved from Ireland to London soon after her birth and she attended private schools in the city until her family moved in 1929 to the village of Sandgate, Kent. In Kent, she was educated at the Folkestone County School for Girls. In the early part of the twentieth-century female applicants to medical schools were at a great disadvantage, and from 1935 to 1936 Sherlock attempted to enter several English medical schools but was rejected. In 1936 she was accepted for a place to study me ...
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Dame
''Dame'' is an honorific title and the feminine form of address for the honour of damehood in many Christian chivalric orders, as well as the Orders, decorations, and medals of the United Kingdom, British honours system and those of several other Commonwealth realms, such as Australia and New Zealand, with the masculine form of address being ''Sir''. It is the female equivalent for knighthood, which is traditionally granted to males. Dame is also style used by baronetesses Suo jure, in their own right. A woman appointed to the grades of the Dame Commander or Dame Grand Cross of the Order of Saint John (Bailiwick of Brandenburg), Order of Saint John, Equestrian Order of the Holy Sepulchre, Most Honourable Order of the Bath, the Most Distinguished Order of Saint Michael and Saint George, the Royal Victorian Order, or the Most Excellent Order of the British Empire becomes a dame. A Central European order in which female members receive the rank of Dame is the Order of St. George (H ...
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Edinburgh
Edinburgh ( ; gd, Dùn Èideann ) is the capital city of Scotland and one of its 32 council areas. Historically part of the county of Midlothian (interchangeably Edinburghshire before 1921), it is located in Lothian on the southern shore of the Firth of Forth. Edinburgh is Scotland's second-most populous city, after Glasgow, and the seventh-most populous city in the United Kingdom. Recognised as the capital of Scotland since at least the 15th century, Edinburgh is the seat of the Scottish Government, the Scottish Parliament and the highest courts in Scotland. The city's Palace of Holyroodhouse is the official residence of the British monarchy in Scotland. The city has long been a centre of education, particularly in the fields of medicine, Scottish law, literature, philosophy, the sciences, and engineering. It is the second-largest financial centre in the United Kingdom, and the city's historical and cultural attractions have made it the UK's second-most visited tourist d ...
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UCL Medical School
UCL Medical School is the medical school of University College London (UCL) and is located in London, United Kingdom. The School provides a wide range of undergraduate and postgraduate medical education programmes and also has a medical education research unit and an education consultancy unit. It is internationally renowned and is currently ranked 7th in the world by the QS World University Rankings 2022. UCL has offered education in medicine since 1834. The currently configured and titled medical school was established in 2008 following mergers between UCLH Medical School and the medical school of the Middlesex Hospital (in 1987) and The Royal Free Hospital Medical School (in 1998). The School's clinical teaching is primarily conducted at University College Hospital, The Royal Free Hospital and the Whittington Hospital, with other associated teaching hospitals including the Great Ormond Street Hospital, Moorfields Eye Hospital, the National Hospital for Neurology and Neuros ...
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Hammersmith Hospital
Hammersmith Hospital, formerly the Military Orthopaedic Hospital, and later the Special Surgical Hospital, is a major teaching hospital in White City, West London. It is part of Imperial College Healthcare NHS Trust in the London Borough of Hammersmith and Fulham, and is associated with the Imperial College Faculty of Medicine. Confusingly the hospital is not in Hammersmith but is located in White City adjacent to Wormwood Scrubs and East Acton. History Origins The hospital's origins begin in 1902, when the Hammersmith Poor Law Guardians decided to erect a new workhouse and infirmary on a site at the north side of Du Cane Road somewhat to the north of Shepherd's Bush. The land, adjacent to Wormwood Scrubs Prison, was purchased for £14,500 from the Ecclesiastical Commissioners. A temporary corrugated iron building was erected on the site in 1902 to provide care for victims of a smallpox epidemic that had taken place in the winter of 1901–2. The buildings were designed ...
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Rockefeller Foundation
The Rockefeller Foundation is an American private foundation and philanthropy, philanthropic medical research and arts funding organization based at 420 Fifth Avenue, New York City. The second-oldest major philanthropic institution in America, after the Carnegie Corporation, the foundation was ranked as the List of wealthiest charitable foundations, 39th largest U.S. foundation by total giving as of 2015. By the end of 2016, assets were tallied at $4.1 billion (unchanged from 2015), with annual grants of $173 million. According to the OECD, the foundation provided US$103.8 million for development in 2019. The foundation has given more than $14 billion in current dollars. The foundation was started by Standard Oil magnate John D. Rockefeller ("Senior") and son "John D. Rockefeller Jr., Junior", and their primary business advisor, Frederick Taylor Gates, on May 14, 1913, when its charter was granted by New York State Legislature, New York. The foundation has had an international re ...
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Yale School Of Medicine
The Yale School of Medicine is the graduate medical school at Yale University, a private research university in New Haven, Connecticut. It was founded in 1810 as the Medical Institution of Yale College and formally opened in 1813. The primary teaching hospital for the school is Yale New Haven Hospital. The school is home to the Harvey Cushing/John Hay Whitney Medical Library, one of the largest modern medical libraries which is known for its historical collections. The faculty includes 70 National Academy of Sciences members, 47 National Academy of Medicine members, and 13 Howard Hughes Medical Institute investigators. '' U.S. News & World Report'' currently ranks the Yale School of Medicine 10th in the country for research and 59th in primary care. The MD program is highly selective; for the class of 2022, the school received 4,968 applications to fill 104 seats. The median GPA for the class was 3.89, and the median MCAT was 521. Education The School of Medicine offers th ...
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Ascites
Ascites is the abnormal build-up of fluid in the abdomen. Technically, it is more than 25 ml of fluid in the peritoneal cavity, although volumes greater than one liter may occur. Symptoms may include increased abdominal size, increased weight, abdominal discomfort, and shortness of breath. Complications can include spontaneous bacterial peritonitis. In the developed world, the most common cause is liver cirrhosis. Other causes include cancer, heart failure, tuberculosis, pancreatitis, and blockage of the hepatic vein. In cirrhosis, the underlying mechanism involves high blood pressure in the portal system and dysfunction of blood vessels. Diagnosis is typically based on an examination together with ultrasound or a CT scan. Testing the fluid can help in determining the underlying cause. Treatment often involves a low-salt diet, medication such as diuretics, and draining the fluid. A transjugular intrahepatic portosystemic shunt (TIPS) may be placed but is associated with ...
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Hepatic Encephalopathy
Hepatic encephalopathy (HE) is an altered level of consciousness as a result of liver failure. Its onset may be gradual or sudden. Other symptoms may include movement problems, changes in mood, or changes in personality. In the advanced stages it can result in a coma. Hepatic encephalopathy can occur in those with acute or chronic liver disease. Episodes can be triggered by infections, GI bleeding, constipation, electrolyte problems, or certain medications. The underlying mechanism is believed to involve the buildup of ammonia in the blood, a substance that is normally removed by the liver. The diagnosis is typically based on symptoms after ruling out other potential causes. It may be supported by blood ammonia levels, an electroencephalogram, or a CT scan of the brain. Hepatic encephalopathy is possibly reversible with treatment. This typically involves supportive care and addressing the triggers of the event. Lactulose is frequently used to decrease ammonia levels. ...
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Portal Hypertension
Portal hypertension is abnormally increased portal venous pressure – blood pressure in the portal vein and its branches, that drain from most of the intestine to the liver. Portal hypertension is defined as a hepatic venous pressure gradient greater than 5 mmHg. Cirrhosis (a form of chronic liver failure) is the most common cause of portal hypertension; other, less frequent causes are therefore grouped as non-cirrhotic portal hypertension. When it becomes severe enough to cause symptoms or complications, treatment may be given to decrease portal hypertension itself or to manage its complications. Signs and symptoms Signs and symptoms of portal hypertension include: * Ascites (free fluid in the peritoneal cavity), ** Abdominal pain or tenderness (when bacteria infect the ascites, as in spontaneous bacterial peritonitis). * Increased spleen size ( splenomegaly), which may lead to lower platelet counts ( thrombocytopenia) * Anorectal varices * Swollen veins on the anterior a ...
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Doctor Of Medicine
Doctor of Medicine (abbreviated M.D., from the Latin ''Medicinae Doctor'') is a medical degree, the meaning of which varies between different jurisdictions. In the United States, and some other countries, the M.D. denotes a professional degree. This generally arose because many in 18th-century medical professions trained in Scotland, which used the M.D. degree nomenclature. In England, however, Bachelor of Medicine, Bachelor of Surgery was used and eventually in the 19th century became the standard in Scotland too. Thus, in the United Kingdom, Ireland and other countries, the M.D. is a research doctorate, honorary doctorate or applied clinical degree restricted to those who already hold a professional degree (Bachelor's/Master's/Doctoral) in medicine. In those countries, the equivalent professional degree to the North American, and some others use of M.D., is still typically titled Bachelor of Medicine, Bachelor of Surgery ( M.B.B.S.). History The first medical degrees were a ...
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Beit Memorial Fellowships For Medical Research
The Beit Memorial Medical Fellowships were one of the most prestigious and competitive fellowships for post-doctoral or medical degree research in medicine in the United Kingdom. The Fellowships were founded in 1909 by Sir Otto Beit, a German-born British financier, philanthropist and art connoisseur, in memory of his brother Alfred Beit. Beit Memorial Fellows have been awarded a number of prestigious prizes with seven Nobel Prizes including two for Frederick Sanger (1944) and the 2012 prize for medicine for John Gurdon. Nobel laureates who have held Beit fellowships are Alexander R. Todd (chemistry, 1957), Fred Sanger (chemistry, 1958 and 1980), Macfarlane Burnet (physiology or medicine, 1960), Bernard Katz (physiology or medicine, 1970) and Tim Hunt (physiology or medicine, 2001). The first female member of the Royal Society in 1945 was Marjory Stephenson (1914 Beit fellowship) an early recipient of the fellowship. The Beit Memorial Medical Fellowships were replaced by the pres ...
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Medical Research Council (UK)
The Medical Research Council (MRC) is responsible for co-coordinating and funding medical research in the United Kingdom. It is part of United Kingdom Research and Innovation (UKRI), which came into operation 1 April 2018, and brings together the UK's seven research councils, Innovate UK and Research England. UK Research and Innovation is answerable to, although politically independent from, the Department for Business, Energy and Industrial Strategy. The MRC focuses on high-impact research and has provided the financial support and scientific expertise behind a number of medical breakthroughs, including the development of penicillin and the discovery of the structure of DNA. Research funded by the MRC has produced 32 Nobel Prize winners to date. History The MRC was founded as the Medical Research Committee and Advisory Council in 1913, with its prime role being the distribution of medical research funds under the terms of the National Insurance Act 1911. This was a consequen ...
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