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Seco-LSD
Seco-LSD is an structural analog, analogue of LSD with one or more covalent bond, bonds removed and may refer to: * 3,5-Seco-LSD (also known as DEIMDHPCA) * 8,10-Seco-LSD (also known as NDTDI) * 10,11-Seco-LSD Additional seco-LSD compounds with more bonds removed include DEMPDHPCA, N-DEAOP-NMT, ''N''-DEAOP-NMT, and N-DEAOP-NMPEA, ''N''-DEAOP-NMPEA. See also * Secoergoline * Partial ergoline * Secosteroid {{Chemistry index Partial ergolines ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
10,11-Seco-LSD
10,11-Seco-LSD is a partial lysergamide and cyclized tryptamine related to lysergic acid diethylamide (LSD). It is the seco structural analog, analogue of LSD in which the covalent bond, bond between the 10 and 11 positions of the ergoline ring system (chemistry), ring system has been broken. 10,11-Seco-LSD was described in a patent by David E. Olson and colleagues at Delix Therapeutics in 2021. Its pharmacology was not described. See also * Partial lysergamide * Seco-LSD * Secoergoline * NDTDI (8,10-seco-LSD) * DEIMDHPCA (3,5-seco-LSD) References Carboxamides Diethylamino compounds N,N-Dialkyltryptamines Partial ergolines Tetrahydropyridines {{Hallucinogen-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Partial Ergoline
Partial or simplified ergolines and lysergamides are structural analog, analogues of ergolines and substituted lysergamide, lysergamides like LSD in which one or more atoms or covalent bond, bonds, for instance within the ergoline ring system (chemistry), ring system, have been removed. Additional chemical substituent, substitutions may also be added, for instance on the A ring of the ergoline nucleus. It is notable that the ergoline ring system contains embedded substituted tryptamine, tryptamine and substituted phenethylamine, phenethylamine moiety (chemistry), moieties within its chemical structure, structure, and so some partial ergolines are simple tryptamines, cyclized tryptamines, simple phenethylamines, and/or cyclized phenethylamines. In terms of pharmacology, partial lysergamides include serotonin receptor agonist, serotonin and dopamine receptor agonists. Some, like NDTDI, DEMPDHPCA, DEIMDHPCA, and LPH-5 (drug), LPH-5, are serotonin 5-HT2A receptor, 5-HT2A receptor agon ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
3,5-Seco-LSD
DEIMDHPCA, also known as 3,5-seco-LSD, is an indole derivative and a "partial" or simplified ergoline which is closely related to the highly potent serotonergic psychedelic lysergic acid diethylamide (LSD). It is specifically the analogue of LSD in which one of LSD's carbon atoms in the ergoline ring system, the carbon at position 4, has been removed. This in turn renders the DEIMDHPCA molecule more flexible and makes it a partially rigid indolic phenethylamine-containing compound rather than an ergoline. DEIMDHPCA is known to be a highly potent serotonin 5-HT2 receptor agonist similarly to LSD and to produce psychoplastogenic effects. Pharmacology Like LSD, the drug is known to be a highly potent serotonin 5-HT2A and 5-HT2C receptor agonist ''in vitro''. Its affinities () are in the ranges of 10–100nM for the serotonin 5-HT2A receptor and 100–1,000nM for the serotonin 5-HT2C receptor, while its activational potencies () are less than 10nM for the serotonin 5-HT ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
8,10-Seco-LSD
NDTDI, also known as 8,10-seco-LSD, is a tricyclic tryptamine derivative which is thought to act as a serotonin receptor agonist, though its pharmacology has not been studied in detail. It is a structurally simplified analogue of the psychedelic drug lysergic acid diethylamide (LSD) and is reported to retain similar effects, though with many times lower potency. NDTDI is specifically the analogue of LSD in which the carbon atom at position 9 of the ergoline ring system has been removed. It has been sold as a designer drug since 2016 and was first identified by a forensic laboratory in Slovenia in 2017. NDTDI was made illegal in Latvia in March 2017. The simplified analogue of NDTDI and LSD in which the carbons at positions 9 and 10 of the ergoline ring system have been removed, resulting in a fully non-rigid tryptamine derivative, is ''N''-DEAOP-NMT. See also * Partial lysergamide * List of miscellaneous 5-HT2A receptor agonists * Seco-LSD * RU-27849 * Bay R 1531 * DEIMDH ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Secoergoline
Secoergoline is an structural analog, analogue of ergoline with one or more bonds removed and may refer to: * 3,5-Secoergoline (also known as RU-27251) * 8,10-Secoergoline (e.g., 8,10-seco-LSD also known as NDTDI) * 10,11-Secoergoline (e.g., 10,11-seco-LSD, CT-5252) Other secoergolines include partial clavines like chanoclavine and paliclavine. See also * Seco-LSD * Partial ergoline * Ergoline * Secosteroid {{Chemistry index Partial ergolines ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Structural Analog
A structural analog, also known as a chemical analog or simply an analog, is a chemical compound, compound having a chemical structure, structure similar to that of another compound, but differing from it in respect to a certain component. It can differ in one or more atoms, functional groups, or substructures, which are replaced with other atoms, groups, or substructures. A structural analog can be imagined to be formed, at least theoretically, from the other compound. Structural analogs are often isoelectronicity, isoelectronic. Despite a high chemical similarity, structural analogs are not necessarily functional analog (chemistry), functional analogs and can have very different physical, chemical, biochemical, or pharmacological properties. In drug discovery, either a large series of structural analogs of an initial lead compound are created and tested as part of a structure–activity relationship study or a database is virtual screening, screened for structural analogs of a ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Covalent Bond
A covalent bond is a chemical bond that involves the sharing of electrons to form electron pairs between atoms. These electron pairs are known as shared pairs or bonding pairs. The stable balance of attractive and repulsive forces between atoms, when they share electrons, is known as covalent bonding. For many molecules, the sharing of electrons allows each atom to attain the equivalent of a full valence shell, corresponding to a stable electronic configuration. In organic chemistry, covalent bonding is much more common than ionic bonding. Covalent bonding also includes many kinds of interactions, including σ-bonding, π-bonding, metal-to-metal bonding, agostic interactions, bent bonds, three-center two-electron bonds and three-center four-electron bonds. The term "covalence" was introduced by Irving Langmuir in 1919, with Nevil Sidgwick using "co-valent link" in the 1920s. Merriam-Webster dates the specific phrase ''covalent bond'' to 1939, recognizing its first known ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
DEMPDHPCA
DEMPDHPCA is a serotonin 5-HT2 receptor agonist and a cyclized phenethylamine and simplified or partial ergoline that is structurally related to the serotonergic psychedelic lysergic acid diethylamide (LSD). It is the analogue of LSD in which the carbon and nitrogen atoms at positions 1 through 4 of the ergoline ring system have been removed. Pharmacology DEMPDHPCA produces gross behavioral effects very similar to those of psychedelics like LSD in rodents and has been assumed to act as a hallucinogen likewise. However, the drug has not been tested in humans. DEMPDHPCA is much less potent than LSD in rodents, which was active at a dose of 0.16μmol/kg by intraperitoneal injection, whereas DEMPDHPCA was active at doses of 10 to 35μmol/kg. On the other hand, DEMPDHPCA was more potent than dimethyltryptamine (DMT) and is more potent than mescaline. Like LSD, the drug has been found to act as a potent serotonin 5-HT2A and 5-HT2C receptor agonist ''in vitro''. The affinitie ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
N-DEAOP-NMT
''N''-(3-Diethylamino-3-oxopropyl)-''N''-methyltryptamine (''N''-DEAOP-NMT) is a substituted tryptamine, tryptamine chemical derivative, derivative and a "partial" or simplified ergoline which is closely related to the highly potency (pharmacology), potent serotonergic psychedelic lysergic acid diethylamide (LSD). It is the structural analog, analogue of LSD in which two of LSD's carbon atoms in the ergoline ring (chemistry), ring, those at positions 9 and 10, have been removed. This in turn renders the ''N''-DEAOP-NMT molecule flexible and makes it a conformational constraint, non-rigid tryptamine rather than an ergoline. The compound is pharmacology, pharmacologically active, as are a number of its analogues and derivatives, with activities of the compounds including serotonin 5-HT2A receptor, 5-HT2A receptor agonist, agonism and LSD- or hallucinogen-like effects. Pharmacology ''N''-DEAOP-NMT has been found to produce quantifiable oxytocic effects in animals. However, in co ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
N-DEAOP-NMPEA
''N''-(3-Diethylamino-3-oxopropyl)-''N''-methyltryptamine (''N''-DEAOP-NMT) is a tryptamine derivative and a "partial" or simplified ergoline which is closely related to the highly potent serotonergic psychedelic lysergic acid diethylamide (LSD). It is the analogue of LSD in which two of LSD's carbon atoms in the ergoline ring, those at positions 9 and 10, have been removed. This in turn renders the ''N''-DEAOP-NMT molecule flexible and makes it a non-rigid tryptamine rather than an ergoline. The compound is pharmacologically active, as are a number of its analogues and derivatives, with activities of the compounds including serotonin 5-HT2A receptor agonism and LSD- or hallucinogen-like effects. Pharmacology ''N''-DEAOP-NMT has been found to produce quantifiable oxytocic effects in animals. However, in contrast to other lysergamides such as lysergic acid and ergonovine (ergometrine), ''N''-DEAOP-NMT was said to not possess significant oxytocic activity relative to clini ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Secosteroid
A secosteroid () is a type of steroid with a "broken" ring. The word ''secosteroid ''derives from the Latin verb ''secare'' meaning "to cut", and 'steroid'. Secosteroids are described as a subclass of steroids under the IUPAC nomenclature. Some sources instead describe them as compounds derived from steroids. Types or subclasses of secosteroids are defined by the carbon atoms of the parent steroid skeleton where the ring cleavage has taken place. For example, 9,10-secosteroids are derived from cleavage of the bond between carbon atoms C9 and C10 of the steroid B-ring (similarly 5,6-secosteroids, 13,14-secosteroids, etc.). The prototypical secosteroid is cholecalciferol Cholecalciferol, also known as vitamin D3, colecalciferol or calciol, is a type of vitamin D that is produced by the skin when exposed to UV light, UVB light; it is found in certain foods and can be taken as a dietary supplement. Cholecalcife ... (vitamin D3). Its IUPAC systematic is "(5''Z'',7''E'')-(3'' ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
