|
Rumack–Matthew Nomogram
The Rumack–Matthew nomogram, also known as the acetaminophen nomogram, is an acetaminophen toxicity nomogram. It plots serum (blood), serum concentration of acetaminophen against the time since ingestion, in order to predict possible hepatotoxicity, liver toxicity and allow a clinician to decide whether to proceed with N-Acetylcysteine (NAC) treatment. It is a logarithmic graph starting 4 hours after ingestion; at this time the absorption of acetaminophen is considered likely to be complete. This nomogram allows for timely management of an acetaminophen overdose. Generally, a serum plasma concentration (APAP) of 140–150 μg/mL (or mg/L) at 4 hours post-ingestion indicates the need for NAC treatment. This nomogram is not used alone if the patient has altered mental status or if the history is not reliable; rather, an additional line should be drawn and plotted to see if the slope of the line remains at or above the nomogram. Additionally, a formal half-life may also be determin ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Original Nomogram Rumack BH Matthew H, Acetaminophen Pediatrics 1975 (55) 871 - 876
Originality is the aspect of created or invented works that distinguish them from reproductions, clones, forgeries, or substantially derivative works. The modern idea of originality is according to some scholars tied to Romanticism, by a notion that is often called romantic originality.Smith (1924)Waterhouse (1926)Macfarlane (2007) The validity of "originality" as an operational concept has been questioned. For example, there is no clear boundary between "derivative" and "inspired by" or "in the tradition of." The concept of originality is both culturally and historically contingent. For example, unattributed reiteration of a published text in one culture might be considered plagiarism but in another culture might be regarded as a convention of veneration. At the time of Shakespeare, it was more common to appreciate the similarity with an admired classical work, and Shakespeare himself avoided "unnecessary invention".Royal Shakespeare Company (2007) ''The RSC Shakespeare - Will ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Acetaminophen Toxicity
Paracetamol, or acetaminophen, is a non-opioid analgesic and antipyretic agent used to treat fever and mild to moderate pain. It is a widely available over-the-counter drug sold under various brand names, including Tylenol and Panadol. Paracetamol relieves pain in both acute mild migraine and episodic tension headache. At a standard dose, paracetamol slightly reduces fever, though it is inferior to ibuprofen in that respect and the benefits of its use for fever are unclear, particularly in the context of fever of viral origins. The aspirin/paracetamol/caffeine combination also helps with both conditions when the pain is mild and is recommended as a first-line treatment for them. Paracetamol is effective for post-surgical pain, but is inferior to ibuprofen for this purpose. The paracetamol/ibuprofen combination increases the drugs' potency and is superior to either drug alone. The pain relief paracetamol provides in osteoarthritis is small and clinically insignificant. Evidenc ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Nomogram
A nomogram (), also called a nomograph, alignment chart, or abac, is a graphical Analog computer, calculating device, a two-dimensional diagram designed to allow the approximate graphical computation of a Function (mathematics), mathematical function. The field of nomography was invented in 1884 by the French engineer Philbert Maurice d'Ocagne (1862–1938) and used extensively for many years to provide engineers with fast graphical calculations of complicated formulas to a practical precision. Nomograms use a parallel coordinate system invented by d'Ocagne rather than standard Cartesian coordinates. A nomogram consists of a set of n scales, one for each variable in an equation. Knowing the values of n-1 variables, the value of the unknown variable can be found, or by fixing the values of some variables, the relationship between the unfixed ones can be studied. The result is obtained by laying a straightedge across the known values on the scales and reading the unknown value fro ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Serum (blood)
Serum () is the fluid and solvent component of blood which does not play a role in clotting. It may be defined as blood plasma without the clotting factors, or as blood with all cells and clotting factors removed. Serum contains all proteins except clotting factors (involved in blood clotting), including all electrolytes, antibodies, antigens, hormones; and any exogenous substances (e.g., drugs, microorganisms). Serum also does not contain all the formed elements of blood, which include blood cells, white blood cells ( leukocytes, lymphocytes), red blood cells ( erythrocytes), and platelets. The study of serum is serology. Serum is used in numerous diagnostic tests as well as blood typing. Measuring the concentration of various molecules can be useful for many applications, such as determining the therapeutic index of a drug candidate in a clinical trial. To obtain serum, a blood sample is allowed to clot ( coagulation). The sample is then centrifuged to remove th ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Acetaminophen
Paracetamol, or acetaminophen, is a non-opioid analgesic and antipyretic agent used to treat fever and mild to moderate pain. It is a widely available over-the-counter drug sold under various brand names, including Tylenol and Panadol. Paracetamol relieves pain in both acute mild migraine and episodic tension headache. At a standard dose, paracetamol slightly reduces fever, though it is inferior to ibuprofen in that respect and the benefits of its use for fever are unclear, particularly in the context of fever of viral origins. The aspirin/paracetamol/caffeine combination also helps with both conditions when the pain is mild and is recommended as a first-line treatment for them. Paracetamol is effective for post-surgical pain, but is inferior to ibuprofen for this purpose. The paracetamol/ibuprofen combination increases the drugs' potency and is superior to either drug alone. The pain relief paracetamol provides in osteoarthritis is small and clinically insignificant. Eviden ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Hepatotoxicity
Hepatotoxicity (from ''hepatic toxicity'') implies chemical-driven liver damage. Drug-induced liver injury (DILI) is a cause of acute and chronic liver disease caused specifically by medications and the most common reason for a drug to be withdrawn from the market after approval. The liver plays a central role in transforming and clearing chemicals and is susceptible to the toxicity from these agents. Certain medicinal agents, when taken in overdoses (e.g. acetaminophen, paracetamol) and sometimes even when introduced within therapeutic ranges (e.g. halothane), may injure the organ. Other chemical agents, such as those used in laboratories and industries, natural chemicals (e.g., alpha-amanitin), and herbal remedies (two prominent examples being kava, though the causal mechanism is unknown, and comfrey, through pyrrolizidine alkaloid content) can also induce hepatotoxicity. Chemicals that cause liver injury are called hepatotoxins. More than 900 drugs have been implicated ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
N-Acetylcysteine
''N''-acetylcysteine, also known as Acetylcysteine and NAC, is a mucolytics that is used to treat paracetamol (acetaminophen) overdose and to loosen thick mucus in individuals with chronic bronchopulmonary disorders, such as pneumonia and bronchitis. It has been used to treat lactobezoar in infants. It can be taken intravenously, orally (swallowed by mouth), or inhaled as a mist by use of a nebulizer. It is also sometimes used as a dietary supplement. Common side effects include nausea and vomiting when taken orally. The skin may occasionally become red and itchy with any route of administration. A non-immune type of anaphylaxis may also occur. It appears to be safe in pregnancy. For paracetamol overdose, it works by increasing the level of glutathione, an antioxidant that can neutralize the toxic breakdown products of paracetamol. When inhaled, it acts as a mucolytic by decreasing the thickness of mucus. Acetylcysteine was initially patented in 1960 and came into me ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Logarithmic Graph
A logarithmic scale (or log scale) is a method used to display numerical data that spans a broad range of values, especially when there are significant differences among the magnitudes of the numbers involved. Unlike a linear scale where each unit of distance corresponds to the same increment, on a logarithmic scale each unit of length is a multiple of some base value raised to a power, and corresponds to the multiplication of the previous value in the scale by the base value. In common use, logarithmic scales are in base 10 (unless otherwise specified). A logarithmic scale is nonlinear, and as such numbers with equal distance between them such as 1, 2, 3, 4, 5 are not equally spaced. Equally spaced values on a logarithmic scale have exponents that increment uniformly. Examples of equally spaced values are 10, 100, 1000, 10000, and 100000 (i.e., 101, 102, 103, 104, 105) and 2, 4, 8, 16, and 32 (i.e., 21, 22, 23, 24, 25). Exponential growth curves are often depicted on a logar ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Half-life
Half-life is a mathematical and scientific description of exponential or gradual decay. Half-life, half life or halflife may also refer to: Film * Half-Life (film), ''Half-Life'' (film), a 2008 independent film by Jennifer Phang * ''Half Life: A Parable for the Nuclear Age'', a 1985 Australian documentary film Literature * Half Life (Jackson novel), ''Half Life'' (Jackson novel), a 2006 novel by Shelley Jackson * Half-Life (Krach novel), ''Half-Life'' (Krach novel), a 2004 novel by Aaron Krach * Halflife (Michalowski novel), ''Halflife'' (Michalowski novel), a 2004 novel by Mark Michalowski * ''Rozpad połowiczny'' (), a 1988 award-winning dystopia novel by Edmund Wnuk-Lipiński Music *Half Life (3 album), ''Half Life'' (3 album) (2001) *Halflife (EP), ''Halflife'' (EP), an EP by Lacuna Coil and the title track *''Half-Life E.P.'', an EP by Local H * "Half Life", a song by 10 Years from ''The Autumn Effect'' * "Half Life", a song by Come from ''Near-Life Experience'' * "Ha ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Liver Failure
Liver failure is the inability of the liver to perform its normal synthetic and metabolic functions as part of normal physiology. Two forms are recognised, acute and chronic (cirrhosis). Recently, a third form of liver failure known as acute-on-chronic liver failure (ACLF) is increasingly being recognized. Acute Acute liver failure is defined as "the rapid development of hepatocellular dysfunction, specifically coagulopathy and mental status changes (encephalopathy) in a patient without known prior liver disease".:1557 The disease process is associated with the development of a coagulopathy of liver aetiology, and clinically apparent altered level of consciousness due to hepatic encephalopathy. Several important measures are immediately necessary when the patient presents for medical attention. The diagnosis of acute liver failure is based on a physical exam, laboratory findings, patient history, and past medical history to establish mental status changes, coagulopathy, ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Sudbury, Massachusetts
Sudbury is a town in Middlesex County, Massachusetts, United States. At the 2020 census, it had a population of 18,934. The town, located in Greater Boston's MetroWest region, has a colonial history. History Incorporated in 1639, the boundaries of Sudbury included (by 1653) what is now Wayland (which split off in 1780, initially as East Sudbury), and parts of present day Framingham, Marlborough, Stow and Maynard (the latter town splitting off in 1871). Nipmuc Indians lived in what is now Sudbury, including Tantamous, a medicine man, and his son Peter Jethro, who deeded a large parcel of land to Sudbury for settlement in 1684.Gutteridge, William H. (1921)''A Brief History of the Town of Maynard, Massachusetts'' Maynard, MA: Town of Maynard, p. 13-16 The original town center and meetinghouse were located near the Sudbury River at what is now known as Wayland's North Cemetery. For the residents on the west side of the river, it was a treacherous passage in the winter an ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
