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Raymond L. Rodriguez
Raymond L. Rodriguez (born 1947) is an American professor of biology, specializing in molecular biology, genomics and biotechnology. His current research interests include diet-genome interactions, plant-made pharmaceuticals and the food/brain axis. Rodriguez is also an inventor, and entrepreneur. His research at the University of California, San Francisco in the 1970s helped lay the foundation for the biotechnology industry. He also holds several issued US patents. He is involved in programs that promote diversity, equity and inclusion for women and underrepresented minorities in science, technology, engineering, and mathematics (STEM) disciplines. Early life and education The son of migrant farm workers, Rodriguez was born in 1947 in Fresno, California and raised in San Joaquin and Kerman, California. In 1965, he graduated from Kerman Union High School. After graduating from Fresno City College, he received a Bachelor of Science degree in biology from California State Univer ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Fresno, California
Fresno () is a major city in the San Joaquin Valley of California, United States. It is the county seat of Fresno County and the largest city in the greater Central Valley region. It covers about and had a population of 542,107 in 2020, making it the fifth-most populous city in California, the most populous inland city in California, and the 34th-most populous city in the nation. The Metro population of Fresno is 1,008,654 as of 2022. Named for the abundant ash trees lining the San Joaquin River, Fresno was founded in 1872 as a railway station of the Central Pacific Railroad before it was incorporated in 1885. It has since become an economic hub of Fresno County and the San Joaquin Valley, with much of the surrounding areas in the Metropolitan Fresno region predominantly tied to large-scale agricultural production. Fresno is near the geographic center of California, approximately north of Los Angeles, south of the state capital, Sacramento, and southeast of San Fran ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
University Of California San Francisco Medical Center
The University of California, San Francisco Medical Center is a research and teaching hospital in San Francisco, California and is the medical center of the University of California, San Francisco. It is affiliated with the UCSF School of Medicine. In 2022–23, it was ranked as the 12th-best overall hospital in the United States and one of the top three hospital in California by '' U.S. News & World Report''. It was founded in 1907 at the site of Parnassus Heights, on Mount Sutro, following the 1906 earthquake, and it was the first hospital in the University of California system. The university acquired Mount Zion Hospital in 1990, which became the second major clinical site and since 1999 has hosted the first comprehensive cancer center in Northern California. Beginning in 2001, the university expanded in the Mission Bay neighborhood and added a new medical center with three new hospitals. History The UCSF medical center opened as a hospital in 1907 with 75 beds, after th ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
University Of California, Davis
The University of California, Davis (UC Davis, UCD, or Davis) is a public land-grant research university near Davis, California. Named a Public Ivy, it is the northernmost of the ten campuses of the University of California system. The institution was first founded as an agricultural branch of the system in 1905 and became the seventh campus of the University of California in 1959. The university is classified among "R1: Doctoral Universities – Very high research activity". The UC Davis faculty includes 23 members of the National Academy of Sciences, 30 members of the American Academy of Arts and Sciences, 17 members of the American Law Institute, 14 members of the Institute of Medicine, and 14 members of the National Academy of Engineering. Among other honors that university faculty, alumni, and researchers have won are two Nobel Prizes, one Fields Medal, a Presidential Medal of Freedom, three Pulitzer Prizes, three MacArthur Fellowships, and a National Medal of ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Joachim Messing
Joachim Wilhelm "Jo" Messing (September 10, 1946 – September 13, 2019) was a German-American biologist who was a professor of molecular biology and the fourth director of the Waksman Institute of Microbiology at Rutgers University. Upon his arrival at Rutgers in 1985, Jo Messing initiated research activity on computational and structural biology and further emphasis on molecular genetics of the regulation of gene expression and biomolecular interactions. In the eighties, he provided incubator space for two Biotechnology centers at Rutgers, one in Medicine and one in Agriculture. Subsequently, he also founded two new departments at Rutgers and served as the first chair, the Department of Molecular Biology and Biochemistry and the Department of Genetics. Messing was also involved in the Plant Genome Initiative at Rutgers, which has contributed to the sequencing of the maize, sorghum, and the rice genome. Besides maize, sorghum, and rice, they have also contributed to the sequenci ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
PUC19
pUC19 is one of a series of plasmid cloning vectors created by Joachim Messing and co-workers. The designation "pUC" is derived from the classical "p" prefix (denoting "plasmid") and the abbreviation for the University of California, where early work on the plasmid series had been conducted. It is a circular double stranded DNA and has 2686 base pairs. pUC19 is one of the most widely used vector molecules as the recombinants, or the cells into which foreign DNA has been introduced, can be easily distinguished from the non-recombinants based on color differences of colonies on growth media. pUC18 is similar to pUC19, but the MCS region is reversed. Components Notably, it has an N-terminal fragment of β-galactosidase ('' lacZ'') gene of '' E. coli''. The multiple cloning site (MCS) region is split into codons 6-7 of the lacZ gene, providing for many restriction endonucleases restriction sites. In addition to β-galactosidase, pUC19 also encodes for an ampicillin resistance gene ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Plasmid Vector
A plasmid is a small, extrachromosomal DNA molecule within a cell that is physically separated from chromosomal DNA and can replicate independently. They are most commonly found as small circular, double-stranded DNA molecules in bacteria; however, plasmids are sometimes present in archaea and eukaryotic organisms. In nature, plasmids often carry genes that benefit the survival of the organism and confer selective advantage such as antibiotic resistance. While chromosomes are large and contain all the essential genetic information for living under normal conditions, plasmids are usually very small and contain only additional genes that may be useful in certain situations or conditions. Artificial plasmids are widely used as vectors in molecular cloning, serving to drive the replication of recombinant DNA sequences within host organisms. In the laboratory, plasmids may be introduced into a cell via transformation. Synthetic plasmids are available for procurement over the interne ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Proinsulin
Proinsulin is the prohormone precursor to insulin made in the beta cells of the islets of Langerhans, specialized regions of the pancreas. In humans, proinsulin is encoded by the ''INS'' gene. The islets of Langerhans only secrete between 1% and 3% of proinsulin intact. However, because proinsulin has a longer half life than insulin, it can account for anywhere from 5–30% of the insulin-like structures circulating in the blood. There are higher concentrations of proinsulin after meals and lower levels when a person is fasting. Additionally, while proinsulin and insulin have structural differences, proinsulin does demonstrate some affinity for the insulin receptor. Due to the relative similarities in structure, proinsulin can produce between 5% and 10% of the metabolic activity similarly induced by insulin. Proinsulin is the final single chain protein structure secreted by cells before cleavage into mature insulin. Proinsulin was discovered by Professor Donald F. Steiner of the Un ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Somatostatin
Somatostatin, also known as growth hormone-inhibiting hormone (GHIH) or by several other names, is a peptide hormone that regulates the endocrine system and affects neurotransmission and cell proliferation via interaction with G protein-coupled somatostatin receptors and inhibition of the release of numerous secondary hormones. Somatostatin inhibits insulin and glucagon secretion. Somatostatin has two active forms produced by the alternative cleavage of a single preproprotein: one consisting of 14 amino acids (shown in infobox to right), the other consisting of 28 amino acids. Among the vertebrates, there exist six different somatostatin genes that have been named ''SS1, SS2, SS3, SS4, SS5'' and ''SS6''. Zebrafish have all six. The six different genes, along with the five different somatostatin receptors, allow somatostatin to possess a large range of functions. Humans have only one somatostatin gene, ''SST''. Nomenclature Synonyms of "somatostatin" include: * growth ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Peptide Hormone
Peptide hormones or protein hormones are hormones whose molecules are peptide, or proteins, respectively. The latter have longer amino acid chain lengths than the former. These hormones have an effect on the endocrine system of animals, including humans. Most hormones can be classified as either amino acid–based hormones (amine, peptide, or protein) or steroid hormones. The former are water-soluble and act on the surface of target cells via second messengers; the latter, being lipid-soluble, move through the plasma membranes of target cells (both cytoplasmic and nuclear) to act within their nuclei. Like all peptides and proteins, peptide hormones and protein hormones are synthesized in cells from amino acids according to mRNA transcripts, which are synthesized from DNA templates inside the cell nucleus. Preprohormones, peptide hormone precursors, are then processed in several stages, typically in the endoplasmic reticulum, including removal of the N-terminal signal seque ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
National Institute Of Health
The National Institutes of Health, commonly referred to as NIH (with each letter pronounced individually), is the primary agency of the United States government responsible for biomedical and public health research. It was founded in the late 1880s and is now part of the United States Department of Health and Human Services. The majority of NIH facilities are located in Bethesda, Maryland, and other nearby suburbs of the Washington metropolitan area, with other primary facilities in the Research Triangle Park in North Carolina and smaller satellite facilities located around the United States. The NIH conducts its own scientific research through the NIH Intramural Research Program (IRP) and provides major biomedical research funding to non-NIH research facilities through its Extramural Research Program. , the IRP had 1,200 principal investigators and more than 4,000 postdoctoral fellows in basic, translational, and clinical research, being the largest biomedical research institu ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
PBR322
pBR322 is a plasmid and was one of the first widely used '' E. coli'' cloning vectors. Created in 1977 in the laboratory of Herbert Boyer at the University of California, San Francisco, it was named after Francisco Bolivar Zapata, the postdoctoral researcher and Raymond L. Rodriguez. The p stands for "plasmid," and BR for "Bolivar" and "Rodriguez." pBR322 is 4361 base pairs in length and has two antibiotic resistance genes – the gene '' bla'' encoding the ampicillin resistance (AmpR) protein, and the gene ''tetA'' encoding the tetracycline resistance (TetR) protein. It contains the origin of replication of pMB1, and the '' rop'' gene, which encodes a restrictor of plasmid copy number. The plasmid has unique restriction sites for more than forty restriction enzymes. Eleven of these forty sites lie within the TetR gene. There are two sites for restriction enzymes HindIII and ClaI within the promoter of the TetR gene. There are six key restriction sites inside the AmpR gene.T ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
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