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Hartmann F. Stähelin
Hartmann F. Stähelin (20 October 1925 – 5 July 2011) was a Swiss pharmacologist with an outstanding record in basic and applied cancer and immunology research. He discovered two important drugs: etoposide and ciclosporin. Early life Both Stähelin's parents were medical doctors. After preparatory school and a classical education with the emphasis on Greek and Latin, Stähelin studied medicine in Basel, Zürich and Florence (1944–1950). His first position after graduation was at the Institute of Microbiology of the University of Basel (1951–1954) where he investigated the morphology and sporulation of anthrax bacilli with the help of the then-new phase-contrast microscope. In May 1951, Stähelin was the first to observe naked anthrax bacilli protoplasts, called gymnoplasts, which had left behind their empty cell walls. A year later, during his studies of their osmotic behavior, he discovered and described the occasional fusion of naked protoplasts. This seminal paper in Ger ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Swiss People
The Swiss people (, , , ) are the citizens of the multi-ethnic Swiss Confederation (Switzerland) regardless of ethno-cultural background or people of self-identified Swiss ancestry. The number of Swiss nationals has grown from 1.7 million in 1815 to 8.7 million in 2020. More than 1.5 million Swiss citizens hold multiple citizenship. About 11% of citizens live abroad (0.8 million, of whom 0.6 million hold multiple citizenship). About 60% of those living abroad reside in the European Union (0.46 million). The largest groups of Swiss descendants and nationals outside Europe are found in the United States, Brazil, and Canada. Although the modern state of Switzerland originated in 1848, the period of romantic nationalism, Switzerland is not a nation-state and the Swiss are not a single ethnic group. Rather, Switzerland is a confederacy (') or ' ("nation of will", "nation by choice", that is, a consociational state), a term coined in conscious contrast to "nation" in the conv ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Phagocytosis
Phagocytosis () is the process by which a cell (biology), cell uses its plasma membrane to engulf a large particle (≥ 0.5 μm), giving rise to an internal compartment called the phagosome. It is one type of endocytosis. A cell that performs phagocytosis is called a phagocyte. In a Multicellular organism, multicellular organism's immune system, phagocytosis is a major mechanism used to remove pathogens and cell debris. The ingested material is then digested in the phagosome. Bacteria, dead tissue cells, and small mineral particles are all examples of objects that may be phagocytized. Some protozoa use phagocytosis as means to obtain nutrients. The two main cells that do this are the Macrophages and the Neutrophils of the immune system. Where phagocytosis is used as a means of feeding and provides the organism part or all of its nourishment, it is called phagotrophy and is distinguished from osmotrophy, which is nutrition taking place by absorption. History The history of phag ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Podophyllum
''Podophyllum'' is a genus of flowering plant in the family Berberidaceae, native from Afghanistan to China, and from southeast Canada to the central and eastern United States. The genus was first described by Carl Linnaeus in 1753. Taxonomy The taxonomic status of the genus has varied. Some sources transferred all but ''Podophyllum peltatum'' to other genera, such as ''Dysosma'' and ''Sinopodophyllum''. , Plants of the World Online regarded these genera as synonyms of ''Podophyllum''. Species , Plants of the World Online accepted the following species: *''Podophyllum aurantiocaule'' Hand.-Mazz. *''Podophyllum cymosum'' (Michx.) Christenh. & Byng *''Podophyllum delavayi'' Franch. *''Podophyllum difforme'' Hemsl. & E.H.Wilson *''Podophyllum emeiense'' (J.L.Wu & P.Zhuang) J.M.H.Shaw *''Podophyllum glaucescens'' J.M.H.Shaw *''Podophyllum grayi'' (F.Schmidt) Christenh. & Byng *''Podophyllum guangxiense'' (Y.S.Wang) J.M.H.Shaw *''Podophyllum hemsleyi'' J.M.H.Shaw & Stearn *''Podophyl ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
John F
John is a common English name and surname: * John (given name) * John (surname) John may also refer to: New Testament Works * Gospel of John, a title often shortened to John * First Epistle of John, often shortened to 1 John * Second Epistle of John, often shortened to 2 John * Third Epistle of John, often shortened to 3 John People * John the Baptist (died ), regarded as a prophet and the forerunner of Jesus Christ * John the Apostle (died ), one of the twelve apostles of Jesus Christ * John the Evangelist, assigned author of the Fourth Gospel, once identified with the Apostle * John of Patmos, also known as John the Divine or John the Revelator, the author of the Book of Revelation, once identified with the Apostle * John the Presbyter, a figure either identified with or distinguished from the Apostle, the Evangelist and John of Patmos Other people with the given name Religious figures * John, father of Andrew the Apostle and Saint Peter * Pope Jo ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Novartis
Novartis AG is a Swiss multinational corporation, multinational pharmaceutical company, pharmaceutical corporation based in Basel, Switzerland. Novartis is one of the largest pharmaceutical companies in the world and was the eighth largest by revenue in 2024. Novartis manufactures the drugs clozapine (Clozaril), diclofenac (Voltaren; sold to GlaxoSmithKline in 2015 deal), carbamazepine (Tegretol), valsartan (Diovan), imatinib mesylate (Gleevec/Glivec), cyclosporine (Neoral/Sandimmune), letrozole (Femara), methylphenidate (Ritalin; produced by Sandoz since 2023), terbinafine (Lamisil), deferasirox (Exjade), and others. Novartis was formed in 1996 by the merger of Ciba-Geigy and Sandoz. It was considered the largest corporate merger in history during that time. The pharmaceutical and agrochemical divisions of both companies formed Novartis as an independent entity. The name Novartis was based on the Latin terms, ''novae artes'' (new skills). After the merger, other Ciba-Geigy and ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Sandoz
Sandoz Group AG is a Swiss company that focuses on generic pharmaceuticals and biosimilars. Prior to October 2023, it was part of a division of Novartis that was established in 2003, when Novartis united all of its generics businesses under the name Sandoz. Before this, the company existed as an independent pharmaceutical manufacturer until 1996, when it was merged with Ciba-Geigy to form Novartis. Prior to the merger, it specialized in medicines used in organ transplants, such as Sandimmune, and various antipsychotics and migraine medicines. Its headquarters were in Holzkirchen, Germany and after the spin-off from Novartis, the headquarters moved to Basel, Switzerland, with most of global functions operating from Holzkichen in Germany, Prague in Czechia, and Barcelona in Spain. Sandoz is the global leader in generic pharmaceuticals and biosimilars. History 1886–1995: Formation and initial growth The company was founded in 1886 by Alfred Kern (1850–1893) and Edouard S ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Citation Classic
A citation is a reference to a source. More precisely, a citation is an abbreviated alphanumeric expression embedded in the body of an intellectual work that denotes an entry in the bibliographic references section of the work for the purpose of acknowledging the relevance of the works of others to the topic of discussion at the spot where the citation appears. Generally, the combination of both the in-body citation and the bibliographic entry constitutes what is commonly thought of as a citation (whereas bibliographic entries by themselves are not). Citations have several important purposes. While their uses for upholding intellectual honesty and bolstering claims are typically foregrounded in teaching materials and style guides (e.g.,), correct attribution of insights to previous sources is just one of these purposes. Linguistic analysis of citation-practices has indicated that they also serve critical roles in orchestrating the state of knowledge on a particular topic, ident ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Oxygen
Oxygen is a chemical element; it has chemical symbol, symbol O and atomic number 8. It is a member of the chalcogen group (periodic table), group in the periodic table, a highly reactivity (chemistry), reactive nonmetal (chemistry), nonmetal, and a potent oxidizing agent that readily forms oxides with most elements as well as with other chemical compound, compounds. Oxygen is abundance of elements in Earth's crust, the most abundant element in Earth's crust, making up almost half of the Earth's crust in the form of various oxides such as water, carbon dioxide, iron oxides and silicates.Atkins, P.; Jones, L.; Laverman, L. (2016).''Chemical Principles'', 7th edition. Freeman. It is abundance of chemical elements, the third-most abundant element in the universe after hydrogen and helium. At standard temperature and pressure, two oxygen atoms will chemical bond, bind covalent bond, covalently to form dioxygen, a colorless and odorless diatomic gas with the chemical formula ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Boston
Boston is the capital and most populous city in the Commonwealth (U.S. state), Commonwealth of Massachusetts in the United States. The city serves as the cultural and Financial centre, financial center of New England, a region of the Northeastern United States. It has an area of and a population of 675,647 as of the 2020 United States census, 2020 census, making it the third-largest city in the Northeastern United States after New York City and Philadelphia. The larger Greater Boston metropolitan statistical area has a population of 4.9 million as of 2023, making it the largest metropolitan area in New England and the Metropolitan statistical area, eleventh-largest in the United States. Boston was founded on Shawmut Peninsula in 1630 by English Puritans, Puritan settlers, who named the city after the market town of Boston, Lincolnshire in England. During the American Revolution and American Revolutionary War, Revolutionary War, Boston was home to several seminal events, incl ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Harvard Medical School
Harvard Medical School (HMS) is the medical school of Harvard University and is located in the Longwood Medical and Academic Area, Longwood Medical Area in Boston, Massachusetts. Founded in 1782, HMS is the third oldest medical school in the United States. It provides patient care, medical education, and research training through its 15 clinical affiliates and research institutes, including Massachusetts General Hospital (MGH), Boston Children's Hospital, Dana–Farber Cancer Institute, Brigham and Women's Hospital, Beth Israel Deaconess Medical Center, Mount Auburn Hospital, McLean Hospital, Cambridge Health Alliance, The Baker Center for Children and Families, Spaulding Rehabilitation Hospital, and others. Harvard Medical School also partners with newer entities such as Harvard Catalyst, Broad Institute , Broad Institute of MIT and Harvard, Harvard Stem Cell Institute, the Center for Primary Care, and Wyss Institute for Biologically Inspired Engineering. History Harvard ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Manfred L
''Manfred: A dramatic poem'' is a Closet drama, closet drama written in 1816–1817 by Lord Byron. It contains supernatural elements, in keeping with the popularity of the ghost story in England at the time. It is a typical example of Gothic fiction. Byron commenced this work in late 1816, a few months after the famous ghost-story sessions with Percy Bysshe Shelley and Mary Shelley that provided the initial impetus for ''Frankenstein, Frankenstein; or, The Modern Prometheus''. The supernatural references are made clear throughout the poem. ''Manfred'' was adapted musically by Robert Schumann in 1848–1849, in a composition entitled ''Manfred (Schumann), Manfred: Dramatic Poem with Music in Three Parts'', and in 1885 by Pyotr Ilyich Tchaikovsky in his ''Manfred Symphony''. Friedrich Nietzsche was inspired by the poem's depiction of a super-human being to compose a piano score in 1872 based on it, "Manfred Meditation". Background Byron wrote this "metaphysical drama", as he c ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Leucocyte
White blood cells (scientific name leukocytes), also called immune cells or immunocytes, are cells of the immune system that are involved in protecting the body against both infectious disease and foreign entities. White blood cells are generally larger than red blood cells. They include three main subtypes: granulocytes, lymphocytes and monocytes. All white blood cells are produced and derived from multipotent cells in the bone marrow known as hematopoietic stem cells. Leukocytes are found throughout the body, including the blood and lymphatic system. All white blood cells have nuclei, which distinguishes them from the other blood cells, the anucleated red blood cells (RBCs) and platelets. The different white blood cells are usually classified by cell lineage ( myeloid cells or lymphoid cells). White blood cells are part of the body's immune system. They help the body fight infection and other diseases. Types of white blood cells are granulocytes (neutrophils, eosinophils, a ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
