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Clavine
Ergoline is a core structure in many alkaloids and their synthetic derivatives. Ergoline alkaloids were first characterized in ergot. Some of these are implicated in the condition of ergotism, which can take a convulsive form or a gangrenous form. Even so, many ergoline alkaloids have been found to be clinically useful. Annual world production of ergot alkaloids has been estimated at 5,000–8,000 kg of all ergopeptines and 10,000–15,000 kg of lysergic acid, used primarily in the manufacture of semi-synthetic derivatives. Others, such as lysergic acid diethylamide, better known as LSD, a semi-synthetic derivative, and ergine, a natural derivative found in ''Argyreia nervosa'', ''Ipomoea tricolor'' and related species, are known psychedelic substances. Natural occurrence Ergoline alkaloids are found in fungi such as Claviceps purpurea, Claviceps paspali, and the related Periglandula, which have a permanent, symbiotic bond with numerous flowering vines, most notably, ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Argyreia Nervosa
''Argyreia nervosa'' is a perennial climbing vine native to the Indian subcontinent and introduced to numerous areas worldwide, including Hawaii, Africa, and the Caribbean. Though it can be invasive, it is often prized for its aesthetic and medicinal value. Common names include Hawaiian baby woodrose, adhoguda अधोगुडा or vidhara विधारा (Sanskrit), elephant creeper and woolly morning glory. Its seeds are known for their powerful entheogenic properties, greater or similar to those of Ipomoea species, with users reporting significant psychedelic and spiritual experiences. The two botanical varieties are ''Argyreia nervosa'' var. ''nervosa'' described here, and ''Argyreia nervosa'' var. ''speciosa'', the roots of which are used in Ayurvedic medicine. ''Argyreia nervosa'' contains various ergoline alkaloids such as ergine. A study reported stereoisomers of ergine to be found in the seeds at a concentration of 0.325% of dry weight. Two modern studies from a ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Ergine
Ergine, also known as lysergic acid amide (LSA or LAA) as well as LA-111, is a psychoactive compound of the ergoline and lysergamide families related to lysergic acid diethylamide (LSD). Ergine is an ergoline alkaloid found in fungi such as '' Claviceps paspali'' (ergot) and '' Periglandula'' species such as '' Periglandula clandestina'', which are permanently connected with many morning glory vines. Ergine induces relatively mild psychedelic effects as well as pronounced sedative effects. The most common sources of ergine for use as a drug are the seeds of morning glory species including ''Ipomoea tricolor'' (tlitliltzin), '' Ipomoea corymbosa'' (ololiuhqui), and '' Argyreia nervosa'' (Hawaiian baby woodrose). Morning glory seeds have a history of entheogenic use in Mesoamerica dating back at least hundreds of years. They have also since been used by many Westerners. In addition to ergine, morning glory seeds contain other ergolines such as lysergic acid hydroxyethylamid ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Isoergine
Isoergine, also known as isolysergic acid amide (iso-LSA or iso-LA-819), isolysergamide, or erginine, is a serotonergic psychedelic of the ergoline and lysergamide families related to ergine (lysergic acid amide; LSA) and lysergic acid diethylamide (LSD). It is the epimer of ergine inverted at the 8 position. Along with ergine and other ergolines, isoergine occurs naturally in morning glories. It is thought to be primarily responsible for the hallucinogenic effects of morning glory seeds. Use and effects Isoergine occurs naturally in morning glory species, including ''Ipomoea tricolor'' (tlitliltzin), ''Ipomoea corymbosa'' (ololiuhqui), and '' Argyreia nervosa'' (Hawaiian baby woodrose). It has been found to constitute 8 to 35% of total alkaloid content relative to 5 to 58% for ergine. Albert Hofmann, the discoverer of LSD's psychedelic effects, tried 2mg isoergine orally and experienced feelings of unreality, detachment from the outside world, feelings of mental emptiness ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Ergometrine
Ergonovine, also known as ergometrine and lysergic acid propanolamide, is a medication used to cause contractions of the uterus to treat heavy vaginal bleeding after childbirth. It can be used either by mouth, by injection into a muscle, or injection into a vein. Common side effects include high blood pressure, vomiting, seizures, headache, and low blood pressure. Other serious side effects include ergotism. Ergonovine was discovered in 1932. It is on the World Health Organization's List of Essential Medicines. Ergonovine is controlled in some countries because it can be used to make the psychedelic drug lysergic acid diethylamide (LSD). It is also known to produce psychedelic effects itself at high doses. Medical uses Ergonovine has a medical use in obstetrics to facilitate delivery of the placenta and to prevent bleeding after childbirth by causing smooth muscle tissue in the blood vessel walls to narrow, thereby reducing blood flow. It is usually combined with oxyto ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Alkaloid
Alkaloids are a broad class of natural product, naturally occurring organic compounds that contain at least one nitrogen atom. Some synthetic compounds of similar structure may also be termed alkaloids. Alkaloids are produced by a large variety of organisms including bacteria, fungus, fungi, Medicinal plant, plants, and animals. They can be purified from crude extracts of these organisms by acid-base extraction, or solvent extractions followed by silica-gel column chromatography. Alkaloids have a wide range of pharmacology, pharmacological activities including antimalarial medication, antimalarial (e.g. quinine), asthma, antiasthma (e.g. ephedrine), chemotherapy, anticancer (e.g. omacetaxine mepesuccinate, homoharringtonine), cholinomimetic (e.g. galantamine), vasodilation, vasodilatory (e.g. vincamine), Antiarrhythmic agent, antiarrhythmic (e.g. quinidine), analgesic (e.g. morphine), antibacterial (e.g. chelerythrine), and anti-diabetic, antihyperglycemic activities (e.g. berb ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Lysergic Acid Hydroxyethylamide
Lysergic acid hydroxyethylamide (LSH or LAH), also known as lysergic acid ''N''-(α-hydroxyethyl)amide, is an ergoamide and an ergoline. It is perhaps the main constituent of the parasitic fungus, '' Claviceps paspali''; and found in trace amounts in ''Claviceps purpurea''. ''C. paspali'' and ''C. purpurea'' are ergot-spreading fungi. ''Periglandula'', ''Clavicipitacepus'' fungi, are permanently symbiotically connected to an estimated 450species of ''Convolvulaceae'' and thus generate LAH in some of them (42 generate ergolines, by Eckart Eich's review). The most well-known ones are ''Ipomoea tricolor'' (“morning glory”), ''Turbina corymbosa'' (''coaxihuitl''), and '' Argyreia nervosa'' (Hawaiian baby woodrose). LAH is structurally similar to ergonovine, which is also known as lysergic acid hydroxymethylethylamide. The more well-known analog, lysergic acid amide (syn. ''ergine''), is more prominent in analytical results because LAH easily decomposes to ergine. Ergine is only ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Ipomoea Tricolor
''Ipomoea tricolor'', the Mexican morning glory or just morning glory, is a species of flowering plant in the family (biology), family Convolvulaceae, native plant, native to the tropics of the Americas, and widely cultivated and naturalisation (biology), naturalised elsewhere. Alkaloids ''Ipomoea tricolor'' seeds contains Lysergic acid amide, LSA and Lysergic acid hydroxyethylamide, LSH among other alkaloids due to the presence of a symbiotic fungus ''Periglandula ipomoeae'', which produces them. Description It is an herbaceous plant, herbaceous annual plant, annual or perennial plant, perennial twining liana growing to tall. The leaf, leaves are spirally arranged, long with a long petiole. The flowers are trumpet-shaped, in diameter, most commonly blue with a white to golden yellow centre. I. tricolor and many rarer species of morning glory, contain ergoline, ergoline alkaloids, predominantly ergine. Some supermarkets have stopped carrying ''I. tricolor'' seeds because ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Ergot
Ergot ( ) or ergot fungi refers to a group of fungi of the genus ''Claviceps''. The most prominent member of this group is '' Claviceps purpurea'' ("rye ergot fungus"). This fungus grows on rye and related plants, and produces alkaloids that can cause ergotism in humans and other mammals who consume grains contaminated with its fruiting structure (called ''ergot sclerotium''). ''Claviceps'' includes about 50 known species, mostly in the tropical regions. Economically significant species include ''C. purpurea'' (parasitic on grasses and cereals), ''C. fusiformis'' (on pearl millet, buffel grass), '' C. paspali'' (on dallis grass), ''C. africana'' (on sorghum) and ''C. lutea'' (on paspalum). ''C. purpurea'' most commonly affects outcrossing species such as rye (its most common host), as well as triticale, wheat and barley. It affects oats only rarely. ''C. purpurea'' has at least three races or varieties, which differ in their host specificity: *G1 – land grasses of op ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Turbina Corymbosa
''Ipomoea corymbosa'' (''Rivea corymbosa'', ''Turbina corymbosa'') is a species of morning glory, native throughout Latin America from Mexico as far south as Peru and widely naturalised elsewhere. Its common names include Christmasvine, Christmaspops, and snakeplant. Description and names Known to natives of north and central Mexico by its Nahuatl name, coaxihuitl and by the south eastern natives as xtabentún (in Mayan), it is a perennial climbing vine with white flowers, often grown as an ornamental plant. Its flowers secrete copious amount of nectar, and the honey that bees make from it is very clear and aromatic. It also grows in Cuba, where it usually blooms from early December to February. It is considered one of the main honey plants of the island. This plant is often used for purposes other than recreation, as natives of Mexico consider the flour produced from its seeds (distinguished as ''ololiuhqui'' (''ololiúqui'', "round things")) a tool for divination and communi ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Albert Hofmann
Albert Hofmann (11 January 1906 – 29 April 2008) was a Swiss chemist known for being the first to synthesize, ingest, and learn of the psychedelic effects of lysergic acid diethylamide (LSD). Hofmann's team also isolated, named and synthesized the principal psychedelic mushroom compounds psilocybin and psilocin. He authored more than 100 scientific articles and numerous books, including ''LSD: Mein Sorgenkind'' (''LSD: My Problem Child''). In 2007, he shared first place with Tim Berners-Lee on a list of the 100 greatest living geniuses published by ''The Daily Telegraph'' newspaper. Early life and education Albert Hofmann was born in Baden, Switzerland, on 11 January 1906. He was the first of four children to factory toolmaker Adolf Hofmann and Elisabeth ( Schenk) and was baptized Protestant. When his father became ill, Hofmann obtained a position as a commercial apprentice in concurrence with his studies. Owing to his father's low income, Albert's godfather paid for his e ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
