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Cetoniacytone A
Cetoniacytone A is a secondary metabolite classified in the family of C7N aminocyclitols which include other natural products such as Validamycin, validamycin A, acarbose, and epoxyquinomicin. Cetoniacytone A was first identified from a culture of ''Actinomyces'' sp. (strain Lu 9419), an endosymbiotic Gram-positive bacteria, Gram-positive bacillus found in the intestines of a rose chafer (''Cetonia aurata, Cetonia aureata''). Preliminary feeding studies with [U-13C3]glycerol identified the core moiety, cetoniacytone, to be derived via the pentose phosphate pathway. Although agar plate diffusion assay studies of cetoniacytone A showed no antimicrobial activity against Gram-positive and Gram-negative bacteria, cetoniacytone A has demonstrated a significant growth inhibitory effect against human cancer cell lines including hepatocellular carcinoma (HEP G2) and breast adenocarcinoma (MCF 7). Biosynthesis Feeding experiments conducted by Zeeck and co-workers established the synthesis ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Secondary Metabolite
Secondary metabolites, also called ''specialised metabolites'', ''secondary products'', or ''natural products'', are organic compounds produced by any lifeform, e.g. bacteria, archaea, fungi, animals, or plants, which are not directly involved in the normal cell growth, growth, Biological development, development, or reproduction of the organism. Instead, they generally mediate ecological biological interaction, interactions, which may produce a Natural selection, selective advantage for the organism by increasing its survivability or fecundity. Specific secondary metabolites are often restricted to a narrow set of species within a phylogenetic group. Secondary metabolites often play an important role in plant defense against herbivory and other interspecies defenses. Humans use secondary metabolites as medicines, flavourings, pigments, and recreational drugs. The term secondary metabolite was first coined by Albrecht Kossel, the 1910 Nobel Prize laureate for medicine and physio ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
