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Bioprospecting
Bioprospecting (also known as biodiversity prospecting) is the exploration of natural sources for small molecules, macromolecules and biochemical and genetic information that could be developed into commercialization, commercially valuable products for the agricultural, aquaculture, bioremediation, cosmetics, nanotechnology, or pharmaceutical industries. In the pharmaceutical industry, for example, almost one third of all small-molecule drugs approved by the U.S. Food and Drug Administration (FDA) between 1981 and 2014 were either natural products or compounds derived from natural products. Terrestrial plants, fungi and Actinomycetota, actinobacteria have been the focus of many past bioprospecting programs, but interest is growing in less explored ecosystems (e.g. seas and oceans, caves and Polar regions of Earth, polar regions) and organisms (e.g. extremophiles, tropical corals and necrophages) as a means of identifying new molecules with novel Biological activity, biological ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Biopiracy
Biopiracy (also known as scientific colonialism ) is the unauthorized appropriation of knowledge and genetic resources of farming and indigenous communities by individuals or institutions seeking exclusive monopoly control through patents or intellectual property. While bioprospecting is the act of exploring natural resources for undiscovered chemical compounds with medicinal or anti-microbial properties, commercial success from bioprospecting leads to the company's attempt at protecting their intellectual property rights on indigenous medicinal plants, seeds, genetic resources, and traditional medicines. Moreover, if biological resources and traditional knowledge are taken from indigenous or marginalized groups, the commercialization of their natural resource can harm communities. Despite the medicinal and innovative benefits of bioprospecting and biochemical research, the expropriation of indigenous land for their genetic resources without fair compensation inevitably leads to ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Natural Product
A natural product is a natural compound or substance produced by a living organism—that is, found in nature. In the broadest sense, natural products include any substance produced by life. Natural products can also be prepared by chemical synthesis (both semisynthesis and total synthesis and have played a central role in the development of the field of organic chemistry by providing challenging synthetic targets). The term ''natural product'' has also been extended for commercial purposes to refer to cosmetics, dietary supplements, and foods produced from natural sources without added artificial ingredients. Within the field of organic chemistry, the definition of natural products is usually restricted to organic compounds isolated from natural sources that are produced by the pathways of primary or secondary metabolism. Within the field of medicinal chemistry, the definition is often further restricted to secondary metabolites. Secondary metabolites (or specialized meta ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Metformin
Metformin, sold under the brand name Glucophage, among others, is the main first-line medication for the treatment of type2 diabetes, particularly in people who are overweight. It is also used in the treatment of polycystic ovary syndrome, and is sometimes used as an off-label adjunct to lessen the risk of metabolic syndrome in people who take antipsychotic medication. It has been shown to inhibit inflammation, and is not associated with weight gain. Metformin is taken by mouth. Metformin is generally well tolerated. Common adverse effects include diarrhea, nausea, and abdominal pain. It has a small risk of causing low blood sugar. High blood lactic acid level (acidosis) is a concern if the medication is used in overly large doses or prescribed in people with severe kidney problems. Metformin is a biguanide anti- hyperglycemic agent. It works by decreasing glucose production in the liver, increasing the insulin sensitivity of body tissues, and increasing GDF15 s ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Polar Regions Of Earth
The polar regions, also called the frigid zones or polar zones, of Earth are Earth's polar ice caps, the regions of the planet that surround its geographical poles (the North and South Poles), lying within the polar circles. These high latitudes are dominated by floating sea ice covering much of the Arctic Ocean in the north, and by the Antarctic ice sheet on the continent of Antarctica and the Southern Ocean in the south. Definitions The Arctic has various definitions, including the region north of the Arctic Circle (currently Epoch 2010 at 66°33'44" N), or just the region north of 60° north latitude, or the region from the North Pole south to the timberline. The Antarctic is usually defined simply as south of 60° south latitude, or the continent of Antarctica. The 1959 Antarctic Treaty uses the former definition. The two polar regions are distinguished from the other two climatic and biometric belts of Earth, a tropics belt near the equator, and two middle latitude ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Exploitation Of Natural Resources
The exploitation of natural resources describes using natural resources, often non-renewable or limited, for economic growth or development. Environmental degradation, human insecurity, and social conflict frequently accompany natural resource exploitation. The impacts of the depletion of natural resources include the decline of economic growth in local areas; however, the abundance of natural resources does not always correlate with a country's material prosperity. Many resource-rich countries, especially in the Global South, face distributional conflicts, where local bureaucracies mismanage or disagree on how resources should be used. Foreign industries also contribute to resource exploitation, where raw materials are outsourced from developing countries, with the local communities receiving little profit from the exchange. This is often accompanied by negative effects of economic growth around the affected areas such as inequality and pollution The exploitation of natural res ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Indigenous Knowledge
Traditional knowledge (TK), indigenous knowledge (IK), folk knowledge, and local knowledge generally refers to knowledge systems embedded in the cultural traditions of regional, indigenous, or local communities. Traditional knowledge includes types of knowledge about traditional technologies of areas such as subsistence (e.g. tools and techniques for hunting or agriculture), midwifery, ethnobotany and ecological knowledge, traditional medicine, celestial navigation, craft skills, ethnoastronomy, climate, and others. These systems of knowledge are generally based on accumulations of empirical observation of and interaction with the environment, transmitted orally across generations. The World Intellectual Property Organization (WIPO) and the United Nations (UN) include traditional cultural expressions (TCE) in their respective definitions of indigenous knowledge. Traditional knowledge systems and cultural expressions exist in the forms of culture, stories, legends, folklo ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Genomic
Genomics is an interdisciplinary field of molecular biology focusing on the structure, function, evolution, mapping, and editing of genomes. A genome is an organism's complete set of DNA, including all of its genes as well as its hierarchical, three-dimensional structural configuration. In contrast to genetics, which refers to the study of ''individual'' genes and their roles in inheritance, genomics aims at the collective characterization and quantification of ''all'' of an organism's genes, their interrelations and influence on the organism. Genes may direct the production of proteins with the assistance of enzymes and messenger molecules. In turn, proteins make up body structures such as organs and tissues as well as control chemical reactions and carry signals between cells. Genomics also involves the sequencing and analysis of genomes through uses of high throughput DNA sequencing and bioinformatics to assemble and analyze the function and structure of entire genomes. Advanc ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Historical
History is the systematic study of the past, focusing primarily on the human past. As an academic discipline, it analyses and interprets evidence to construct narratives about what happened and explain why it happened. Some theorists categorize history as a social science, while others see it as part of the humanities or consider it a hybrid discipline. Similar debates surround the purpose of history—for example, whether its main aim is theoretical, to uncover the truth, or practical, to learn lessons from the past. In a more general sense, the term ''history'' refers not to an academic field but to the past itself, times in the past, or to individual texts about the past. Historical research relies on primary and secondary sources to reconstruct past events and validate interpretations. Source criticism is used to evaluate these sources, assessing their authenticity, content, and reliability. Historians strive to integrate the perspectives of several sources to devel ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Ethnomedical
Ethnomedicine is a study or comparison of the traditional medicine based on bioactive compounds in plants and animals and practiced by various ethnic groups, especially those with little access to western medicines, e.g., indigenous peoples. The word ''ethnomedicine'' is sometimes used as a synonym for ''traditional medicine''.Acharya, Deepak and Shrivastava Anshu: ''Indigenous Herbal Medicines: Tribal Formulations and Traditional Herbal Practices''. Aavishkar Publishers Distributor, Jaipur / India 2008, , p. 440. Ethnomedical research is interdisciplinary; in its study of traditional medicines, it applies the methods of ethnobotany and medical anthropology. Often, the medicine traditions it studies are preserved only by oral tradition. In addition to plants, some of these traditions constitute significant interactions with insects on the Indian Subcontinent, in Africa, or elsewhere around the globe. Scientific ethnomedical studies constitute either anthropological research o ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Ethnobiology
] Ethnobiology is the multidisciplinary field of study of relationships among peoples, biota, and environments integrating many perspectives, from the social, biological, and medical sciences; along with application to conservation and sustainable development. The diversity of perspectives in ethnobiology allows for examining complex, dynamic interactions between human and natural systems. History Beginnings (15th century–19th century) Biologists have been interested in local biological knowledge since the time Europeans started colonising the world, from the 15th century onwards. Paul Sillitoe wrote that: Local biological knowledge, collected and sampled over these early centuries significantly informed the early development of modern biology: * during the 17th century, Georg Eberhard Rumphius benefited from local biological knowledge in producing his catalogue, ''"Herbarium Amboinense"'', covering more than 1,200 species of the plants in Indonesia; * during the 18t ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Ecological
Ecology () is the natural science of the relationships among living organisms and their environment. Ecology considers organisms at the individual, population, community, ecosystem, and biosphere levels. Ecology overlaps with the closely related sciences of biogeography, evolutionary biology, genetics, ethology, and natural history. Ecology is a branch of biology, and is the study of abundance, biomass, and distribution of organisms in the context of the environment. It encompasses life processes, interactions, and adaptations; movement of materials and energy through living communities; successional development of ecosystems; cooperation, competition, and predation within and between species; and patterns of biodiversity and its effect on ecosystem processes. Ecology has practical applications in fields such as conservation biology, wetland management, natural resource management, and human ecology. The word ''ecology'' () was coined in 1866 by the German scientist Ern ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Biological Activity
In pharmacology, biological activity or pharmacological activity describes the beneficial or adverse effects of a drug on living matter. When a drug is a complex chemical mixture, this activity is exerted by the substance's active ingredient or pharmacophore but can be modified by the other constituents. Among the various properties of chemical compounds, pharmacological/biological activity plays a crucial role since it suggests uses of the compounds in the medical applications. However, chemical compounds may show some adverse and toxic effects which may prevent their use in medical practice. Biological activity is usually measured by a bioassay and the activity is generally dosage-dependent, which is investigated via dose-response curves. Further, it is common to have effects ranging from beneficial to adverse for one substance when going from low to high doses. Activity depends critically on fulfillment of the ADME criteria. To be an effective drug, a compound not only ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
