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2C (psychedelics)
2C (2C-''x'') is a general name for the family of psychedelic drug, psychedelic substituted phenethylamine, phenethylamines containing Methoxy, methoxy groups on the 2 and 5 carbon, positions of a benzene ring. Most of these compounds also carry lipophilic substituents at the 4 position, usually resulting in more potent and more metabolism, metabolically stable and longer acting compounds. Most of the currently known 2C compounds were first synthesized by Alexander Shulgin in the 1970s and 1980s and published in his book ''PiHKAL'' (''Phenethylamines i Have Known And Loved''). Shulgin also coined the term 2C, being an acronym for the 2 carbon atoms between the benzene ring and the amino group. 2C-B is the most popular of the 2C drugs. Use The 2C drugs are oral administration, orally active, are used at oral doses of 6 to 150mg depending on the drug, and have duration of action, durations of 3 to 48hours depending on the drug. However, many have doses in the range of 10 to 60mg an ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
2C-Bu
2C-Bu, also known as 2,5-dimethoxy-4-butylphenethylamine, is a chemical compound of the phenethylamine and 2C families. It has been said by Daniel Trachsel to be completely unknown. 2C-Bu is the 2C analogue of the DOx derivative DOBU, which is active but does not appear to have psychedelic-type effects in either animals or humans. 2C-Bu has several notable skeletal isomers, including 2C-iBu, 2C-tBu, and 2C-sBu. 2C-iBu and 2C-tBu are both active and produce hallucinogen-type effects in animals and/or humans. This is in spite of 2C-tBu being predicted to be inactive and DOTB (the DOx analogue of 2C-tBu) being inactive as a hallucinogen in animals and humans. 2C-iBu may have reduced hallucinogenic potency than other 2C drugs and is being developed as a potential anti-inflammatory Anti-inflammatory is the property of a substance or treatment that reduces inflammation, fever or swelling. Anti-inflammatory drugs, also called anti-inflammatories, make up about half of ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
2C-iBu
2,5-Dimethoxy-4-isobutylphenethylamine (2C-iBu or 2C-IB), also known by its developmental code name ELE-02, is a serotonin 5-HT2A receptor agonist, serotonergic psychedelic, and anti-inflammatory drug which is under development for the treatment of inflammation. It is a member of the phenethylamine and 2C families of compounds. The drug is being developed as a topical eye drop for treatment of inflammatory eye conditions. There is also interest in 2C-iBu and related drugs for treatment of systemic inflammation and neuroinflammation. 2C-iBu was not assessed or discovered by Alexander Shulgin and was not described in ''PiHKAL'' (''Phenethylamines I Have Known and Loved'') (1991). However, he did include 2C-iBu (as "2C-IB") as a DOM analogue in a table in '' The Shulgin Index, Volume One: Psychedelic Phenethylamines and Related Compounds'' (2011). In addition, he stated in a footnote that a 5mg oral dose of 2C-iBu produces threshold activity and has a long duration of a ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
2C-I
2C-I, also known as 2,5-dimethoxy-4-iodophenethylamine, is a phenethylamine of the 2C family with psychedelic effects. It was first synthesized by Alexander Shulgin, and is described in Shulgin's book ''PiHKAL'' (1991). The substance is consumed as a recreational drug, and is circulated in the drug market in a powder form. 2C-I is sometimes confused with other related chemical substances such as 25I-NBOMe (2C-I-NBOMe), nicknamed "Smiles" and "N-bomb" in the media.Weiss, Piper (September 20, 2012)2C-I or 'Smiles': The New Killer Drug Every Parent Should Know About.'' Yahoo! News'' WISH-TV Use In the early 2000s, 2C-I was sold in Dutch smart shops as a recreational drug after the drug 2C-B was banned. According to the US Drug Enforcement Administration, 2C-I is taken orally or snorted in a powder form.Reuters (March 20, 2011)Synthetic drug, subject of proposed bans, kill teen./ref> Interactions 2C-I is metabolized by the monoamine oxidase (MAO) enzymes MAO-A and MA ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
2C-H
2C-H, also known as 2,5-dimethoxyphenethylamine (2,5-DMPEA), is a lesser-known drug of the phenethylamine and 2C (4-substituted 2,5-dimethoxyphenethylamine) families. It is the parent compound of the 2C drugs. Use and effects There is no record of 2C-H trials in humans, as it would likely be destroyed by monoamine oxidase enzymes before causing any significant psychoactive effects. In the book ''PiHKAL'', Alexander Shulgin lists both the dosage and duration of 2C-H effects as unknown. Very little data exists about the pharmacological properties, metabolism, and toxicity of 2C-H. Pharmacology 2C-H acts as a partial agonist of the serotonin 5-HT2A, 5-HT2B, and 5-HT2C receptors, albeit with far lower potency than other 2C drugs. It also shows affinity for the serotonin 5-HT1A receptor, higher than that of any other 2C drug. The drug exhibits agonist activity ''in vitro'' at the human trace amine associated receptor 1 (TAAR1). 2C-H produces visual and auditory cha ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
2C-G-5
2C-G is a psychedelic phenethylamine of the 2C-series. First synthesized by Alexander Shulgin, it is sometimes used as an entheogen. It has structural and pharmacodynamic properties similar to 2C-D and Ganesha. Like many of the phenethylamines in ''PiHKAL'', 2C-G and its homologs have only been taken by Shulgin and a small test group, making it difficult to ensure completeness when describing effects. Chemistry 2C-G is 3,4-dimethyl-2,5-dimethoxyphenethylamine, with the formula . Dosage and effects In Shulgin's book ''PiHKAL'', the dosage range is listed as 20 to 35 mg. Effects are similar to the related Ganesha, and are extremely long lasting; the duration is 18–30 hours. Visual effects are muted or absent, and it is described in ''PiHKAL'' as an "insight-enhancer". Unlike other members of the 2C-series, 2C-G is nearly as potent as its amphetamine form. Homologs Several homologs of 2C-G were also synthesized by Shulgin. These include 2C-G-3, 2C-G-5, and 2C-G-N. S ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
2C-F
2C-F (4-fluoro-2,5-dimethoxyphenethylamine) is a lesser-known psychedelic drug of the 2C family. It was first synthesized by Alexander Shulgin. In his book ''PiHKAL'', the minimum dosage is listed as 250 mg. 2C-F may be found as a brownish freebase oil, or as a white crystalline hydrochloride salt. Effects At a dose of 250 milligrams, 2C-F produces modest closed-eye visuals accompanied by lethargy Lethargy is a state of tiredness, sleepiness, weariness, fatigue, sluggishness, or lack of energy. It can be accompanied by depression, decreased motivation, or apathy. Lethargy can be a normal response to inadequate sleep, overexertion, overw .... Pharmacology Very little data exists about the pharmacological properties, metabolism, and toxicity of 2C-F. Legal status Canada As of October 31, 2016, 2C-F is a controlled substance (Schedule III) in Canada. References {{DEFAULTSORT:2c-F 2C (psychedelics) Fluorobenzene derivatives Methoxy compounds ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
2C-EF
2C-EF is a lesser-known psychedelic drug. It was originally named by Alexander Shulgin as described in his book PiHKAL (Phenethylamines i Have Known And Loved), but he never synthesised it himself, though it has been synthesised and its activity tested in subsequent years by others such as Daniel Trachsel. It is a hallucinogen Hallucinogens, also known as psychedelics, entheogens, or historically as psychotomimetics, are a large and diverse class of psychoactive drugs that can produce altered states of consciousness characterized by major alterations in thought, mo ... and is orally active at doses of 6 to 12mg with a duration of 12hours. See also * 2C-T-21 * 2C-TFM * 2C-TFE * DOEF References 5-HT2A agonists 2,5-Dimethoxyphenethylamines 2C (psychedelics) Entheogens Fluoroethyl compounds {{psychoactive-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
2C-E
2C-E is a Psychedelic drug, psychedelic phenethylamines, phenethylamine of the 2C (psychedelics), 2C family. It was first synthesized by Alexander Shulgin and documented in his book ''PiHKAL''. Like the other substances in its family, it produces sensory and cognitive effects in its physical reactions with living organisms. Use and dosage Shulgin gives the dose range of 2C-E as 10 to 25mg. He describes 2C-E as having a steep dose–response curve, such that a small increase in dose can result in an unexpectedly large increase in effects. Effects According to Shulgin, the duration of action, duration of 2C-E's effects is 8 to 12hours. 2C-E's effects are often described as "neutral", in comparison with other psychedelic chemicals and even other 2C (psychedelics), 2C-x related molecules. In ''PiHKAL'', Shulgin states: :"Here is another of the magical half-dozen. The range is purposefully broad. At 10 milligrams there have been some pretty rich +++Shulgin's +/- rating scale, per ''P ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
2C-D
2C-D, also known as 2C-M or as 2,5-dimethoxy-4-methylphenethylamine, is a psychedelic drug of the 2C family that is sometimes used as an entheogen. It was first synthesized in 1970 by a team from the Texas Research Institute of Mental Sciences, and its activity was subsequently investigated in humans by Alexander Shulgin. Use and effects Not much information is known about the toxicity of 2C-D, as no major studies have been conducted. In his book ''PiHKAL'', Shulgin lists the dosage range as being from 20 to 60 mg. Lower doses of 10 mg or less have been explored for microdosing. According to Shulgin, the effects of 2C-D typically last for 4–6 hours. Shulgin himself referred to this substance as a “pharmacological tofu,” meaning that when mixed with other substances, it can extend or potentiate their effects without coloring the experience too much, in a manner similar to how tofu absorbs the flavors of sauces or spices it is cooked with. Hanscarl Leuner, working in Ge ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
