2C-I is a

psychedelic Psychedelics are a subclass of hallucinogenic drugs whose primary effect is to trigger non-ordinary states of consciousness (known as psychedelic experiences or "trips").Pollan, Michael (2018). ''How to Change Your Mind: What the New Science o ...

phenethylamine Phenethylamine (PEA) is an organic compound, natural monoamine alkaloid, and trace amine, which acts as a central nervous system stimulant in humans. In the brain, phenethylamine regulates monoamine neurotransmission by binding to trace am ...

of the 2C family. It was first synthesized by

Alexander Shulgin Alexander Theodore "Sasha" Shulgin (June 17, 1925 – June 2, 2014) was an American medicinal chemist, biochemist, organic chemist, pharmacologist, psychopharmacologist, and author. He is credited with introducing 3,4-methylenedioxymetha ...

and described in his 1991 book '' PiHKAL'' (''Phenethylamines I Have Known and Loved''). The drug has been used recreationally as psychedelic and other reported effects and was sometimes confused with the more potent chemical cousin

25I-NBOMe 25I-NBOMe (2C-I-NBOMe, Cimbi-5, Smiles and also shortened to "25I") is a synthetic hallucinogen that is used in biochemistry research for mapping the brain's usage of the type 2A serotonin receptor; it is also sometimes used for recreational p ...

, nicknamed "Smiles," in the media.Weiss, Piper (September 20, 2012)
2C-I or 'Smiles': The New Killer Drug Every Parent Should Know About.
''

Yahoo! News Yahoo! News is a news website that originated as an internet-based news aggregator by Yahoo!. The site was created by a Yahoo! software engineer named Brad Clawsie in August 1996. Articles originally came from news services such as the Associate ...

''Mackin, Teresa (October 9, 2012)
Dangerous synthetic drug making its way across the country.

WISH-TV WISH-TV (channel 8) is a television station in Indianapolis, Indiana, United States, affiliated with The CW. It is locally owned by Circle City Broadcasting alongside Marion-licensed MyNetworkTV affiliate WNDY-TV (channel 23) and low-power, C ...

Recreational use

In the early 2000s, 2C-I was sold in Dutch

smart shop A smart shop (or smartshop) is a retail establishment that specializes in the sale of psychoactive substances, usually including psychedelics, as well as related literature and paraphernalia. The name derives from the name " smart drugs", a clas ...

s after the drug

2C-B 2C-B (4-Bromo-2,5-dimethoxyphenethylamine) is a psychedelic drug of the 2C family. It was first synthesized by Alexander Shulgin in 1974. In Shulgin's book '' PiHKAL'', the dosage range is listed as 12–24 mg. As a recreational drug, 2C-B is so ...

was banned. According to the US

Drug Enforcement Administration The Drug Enforcement Administration (DEA; ) is a United States federal law enforcement agency under the U.S. Department of Justice tasked with combating drug trafficking and distribution within the U.S. It is the lead agency for domestic en ...

, 2C-I is taken orally or snorted in a powder form.Reuters (March 20, 2011)
Synthetic drug, subject of proposed bans, kill teen.
/ref>

Drug prohibition laws

European Union

In December 2003, the

European Council The European Council (informally EUCO) is a collegiate body that defines the overall political direction and priorities of the European Union. It is composed of the heads of state or government of the EU member states, the President of the ...

issued a binding order compelling all EU member states to ban 2C-I within three months.

Canada

As of October 31, 2016, 2C-I is a controlled substance (Schedule III) in Canada.

Australia

2C-I is a schedule 9 prohibited substance in Australia under the Poisons Standard (October 2015).Poisons Standard October 2015
/ref> A schedule 9 drug is outlined in the Poisons Act 1964 as "Substances which may be abused or misused, the manufacture, possession, sale or use of which should be prohibited by law except when required for medical or scientific research, or for analytical, teaching or training purposes with approval of the CEO".

Sweden

''Sveriges riksdag'' added 2C-I to schedule I (''"substances, plant materials and fungi which normally do not have medical use"'') as a narcotic on March 16, 2004, published by the ''Medical Products Agency'' in their regulation LVFS 2004:3.

United Kingdom

In the United Kingdom, 2C-I is controlled as a Class A substance.

United States

As of July 9, 2012, in the

United States The United States of America (U.S.A. or USA), commonly known as the United States (U.S. or US) or America, is a country Continental United States, primarily located in North America. It consists of 50 U.S. state, states, a Washington, D.C., ...

2C-I is a Schedule I substance under the Synthetic Drug Abuse Prevention Act of 2012, making possession, distribution and manufacture illegal. A previous bill, introduced in March 2011, that would have done the same passed the House of Representatives, but was not passed by the Senate.

Analogues and derivatives

DOI

References

External links

Erowid 2C-I Vault

Una experiencia con 2C-I de los Shulgin
(In Spanish)
2C-I Entry in PiHKAL

2C-I Entry in PiHKAL • info
{{Phenethylamines 2C (psychedelics) Designer drugs Iodoarenes O-methylated phenols