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25D-NM-NDEAOP
25D-NM-NDEAOP, or 25D-NM-NDEPA, is a chemical compound of the substituted phenethylamine, phenethylamine and 2C (psychedelics), 2C families. It is a partial lysergamide, simplified or partial lysergamide and is a chemical derivative, derivative of 2C-D with a lysergic acid diethylamide (LSD)-like ''N''-(3-diethylamino-3-oxopropyl)- chemical substituent, substitution. The compound was assessed and found to inhibit prolactin secretion in rat pituitary glands ''in vitro'' at high concentrations, suggesting that it may possess weak dopamine receptor agonist activity. However, it was subsequently assessed in rats ''in vivo'' and, in contrast to LSD, was found to not significantly inhibit prolactin secretion. Other possible activities of 25D-NM-NDEAOP, such as serotonin receptor interactions and associated effects, were not evaluated or reported. 25D-NDEAOP was first described in the scientific literature in 1974. The compound is a "PEA-NDEPA" and is similar in structure to other PEA- ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Partial Lysergamide
Partial or simplified ergolines and lysergamides are analogues of ergolines and lysergamides like LSD in which one or more atoms or bonds, for instance within the ergoline ring system, have been removed. Additional substitutions may also be added, for instance on the A ring of the ergoline nucleus. It is notable that the ergoline ring system contains embedded tryptamine and phenethylamine moieties within its structure, and so some partial ergolines are simple tryptamines, cyclized tryptamines, simple phenethylamines, and/or cyclized phenethylamines. In terms of pharmacology, partial lysergamides include serotonin and dopamine receptor agonists. Some, like NDTDI, DEMPDHPCA, DEIMDHPCA, and LPH-5, are serotonin 5-HT2A receptor agonists and have psychedelic-like and/or psychoplastogenic effects. Some, like 8-OH-DPAT and LY-178210, are selective serotonin 5-HT1A receptor agonists. Others, like rotigotine, nolomirole, and RU-28251, are dopamine D2-like receptor agonists. Par ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
2C (psychedelics)
2C (2C-''x'') is a general name for the family of psychedelic drug, psychedelic substituted phenethylamine, phenethylamines containing Methoxy, methoxy groups on the 2 and 5 carbon, positions of a benzene ring. Most of these compounds also carry lipophilic substituents at the 4 position, usually resulting in more potent and more metabolism, metabolically stable and longer acting compounds. Most of the currently known 2C compounds were first synthesized by Alexander Shulgin in the 1970s and 1980s and published in his book ''PiHKAL'' (''Phenethylamines i Have Known And Loved''). Shulgin also coined the term 2C, being an acronym for the 2 carbon atoms between the benzene ring and the amino group. 2C-B is the most popular of the 2C drugs. Use The 2C drugs are oral administration, orally active, are used at oral doses of 6 to 150mg depending on the drug, and have duration of action, durations of 3 to 48hours depending on the drug. However, many have doses in the range of 10 to 60mg an ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
25B-NAcPip
25B-NAcPip is a chemical compound related to the 25-NB family of psychedelic drugs. It has been described in patents published by psychedelic pharmaceutical companies like Betterlife Pharma and Mindstate Design Labs. Uniquely among 25-NB compounds, 25B-NAcPip is similar to simplified/partial lysergamides and has elements of the chemical structure of LSD and related psychedelic lysergamides like LSD-Pip within its structure. See also * Partial lysergamide * List of miscellaneous 5-HT2A receptor agonists * 25D-NM-NDEAOP * DEMPDHPCA-2C-D DEMPDHPCA-2C-D is a possible serotonergic psychedelic of the phenethylamine and 2C families. It is a cyclized phenethylamine and a partial or simplified lysergamide. More specifically, the compound is a derivative of 2C-D in which the β positi ... References External links 25B-NAcPip - Isomer Design 25-NB (psychedelics) Bromoarenes Carboxamides Partial ergolines Piperidines Methoxy compounds {{Hallucinogen-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
DOTFM-NDEPA
DOTFM-NDEPA is a chemical compound of the phenethylamine, DOx, and NDEPA families. It is the ''N''-(''N'',''N''-diethylpropylamide) (NDEPA) derivative of the psychedelic drug DOTFM. The drug can also be thought of as a derivative of DOTFM with an LSD-like ''N'',''N''-diethylamide moiety. A quantitative structure–activity relationship (QSAR) predicted that DOTFM-NDEPA would bind with high affinity to the serotonin 5-HT2A receptor. Its predicted affinity (Ki) was 22nM. DOTFM-NDEPA was first described in the scientific literature by 1999. See also * Substituted methoxyphenethylamine * Partial lysergamide * DOB-NDEPA * DOI-NDEPA * 25D-NM-NDEAOP * ''N''-DEAOP-NMPEA * DEMPDHPCA-2C-D DEMPDHPCA-2C-D is a possible serotonergic psychedelic of the phenethylamine and 2C families. It is a cyclized phenethylamine and a partial or simplified lysergamide. More specifically, the compound is a derivative of 2C-D in which the β positi ... References Amides Diethylamino compou ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
DOI-NDEPA
DOI-NDEPA is a chemical compound of the phenethylamine, DOx, and NDEPA families. It is the ''N''-(''N'',''N''-diethylpropylamide) (NDEPA) derivative of the psychedelic drug DOI. The drug can also be thought of as a derivative of DOI with an LSD-like ''N'',''N''-diethylamide moiety. A quantitative structure–activity relationship (QSAR) predicted that DOI-NDEPA would bind with high affinity to the serotonin 5-HT2A receptor. Its predicted affinity (Ki) was 3.2nM. DOI-NDEPA was first described in the scientific literature by 1999. See also * Substituted methoxyphenethylamine * Partial lysergamide * DOB-NDEPA * DOTFM-NDEPA * 25D-NM-NDEAOP * ''N''-DEAOP-NMPEA * DEMPDHPCA-2C-D DEMPDHPCA-2C-D is a possible serotonergic psychedelic of the phenethylamine and 2C families. It is a cyclized phenethylamine and a partial or simplified lysergamide. More specifically, the compound is a derivative of 2C-D in which the β positi ... References Amides Iodobenzene derivatives Di ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
DOB-NDEPA
DOB-NDEPA is a chemical compound of the phenethylamine, DOx, and NDEPA families. It is the ''N''-(''N'',''N''-diethylpropylamide) (NDEPA) derivative of the psychedelic drug DOB. The drug can also be thought of as a derivative of DOB with an LSD-like ''N'',''N''-diethylamide moiety. A quantitative structure–activity relationship (QSAR) predicted that DOB-NDEPA would bind with high affinity to the serotonin 5-HT2A receptor. Its predicted affinity (Ki) was 4.6nM. DOB-NDEPA was first described in the scientific literature by 1999. See also * Substituted methoxyphenethylamine * Partial lysergamide * DOI-NDEPA * DOTFM-NDEPA * 25D-NM-NDEAOP * ''N''-DEAOP-NMPEA * DEMPDHPCA-2C-D DEMPDHPCA-2C-D is a possible serotonergic psychedelic of the phenethylamine and 2C families. It is a cyclized phenethylamine and a partial or simplified lysergamide. More specifically, the compound is a derivative of 2C-D in which the β positi ... References Amides Bromobenzene derivatives Die ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Substituted Methoxyphenethylamine
Methoxyphenethylamines (MPEAs), as well as methoxyamphetamines (MAs) in the case of the amphetamine (α-methylphenethylamine) homologues, are substituted phenethylamines with one or more methoxy groups. In some cases, one or more of the methoxy groups may also be extended to form other alkoxy and related groups such as ethoxy or propoxy. Methoxyphenethylamines may have additional substitutions as well. Many methoxyphenethylamines that have multiple methoxy groups in the 2- through 5-positions of the phenyl ring, for instance mescaline, 2C-B, TMA, DOM, and 25I-NBOMe, are serotonin 5-HT2A receptor agonists and serotonergic psychedelics. Other methoxyphenethylamines, particularly monomethoxyamphetamines like ''para''-methoxyamphetamine (PMA), are monoamine releasing agents of serotonin, norepinephrine, and/or dopamine, with stimulant and/or entactogen-related effects. Compounds closely related to methoxyphenethylamines include methylenedioxyphenethylamines (MDxx) like M ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Serotonin
Serotonin (), also known as 5-hydroxytryptamine (5-HT), is a monoamine neurotransmitter with a wide range of functions in both the central nervous system (CNS) and also peripheral tissues. It is involved in mood, cognition, reward, learning, memory, and physiological processes such as vomiting and vasoconstriction. In the CNS, serotonin regulates mood, appetite, and sleep. Most of the body's serotonin—about 90%—is synthesized in the gastrointestinal tract by enterochromaffin cells, where it regulates intestinal movements. It is also produced in smaller amounts in the brainstem's raphe nuclei, the skin's Merkel cells, pulmonary neuroendocrine cells, and taste receptor cells of the tongue. Once secreted, serotonin is taken up by platelets in the blood, which release it during clotting to promote vasoconstriction and platelet aggregation. Around 8% of the body's serotonin is stored in platelets, and 1–2% is found in the CNS. Serotonin acts as both a vasoconstrictor and vas ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
List Of Miscellaneous 5-HT2A Receptor Agonists
This is a list of miscellaneous agonists of the serotonin receptor subtype 5-HT2A (and other 5-HT2 subtypes to a varying extent) that fall outside the common structural classes. Most agonists at this receptor are either substituted phenethylamine derivatives from the 2C, DOx and 25-NB groups, or substituted tryptamines and related compounds along with more complex derivatives of these such as lysergamides and iboga-type alkaloids. There are however numerous 5-HT2A receptor agonists which do not fall within any of these groups, some representative examples of which are listed below. Ki and EC50 values vary depending on the assay conditions used and so may not be directly comparable between sources. Many of these compounds have been designed to be non-psychoactive derivatives for medical applications, and it should not be assumed that a compound which acts as a 5-HT2A agonist will necessarily be psychedelic in nature. See also * Partial lysergamide * DPCPX * LY-341,495 * Ro ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Preclinical Research
In drug development, preclinical development (also termed preclinical studies or nonclinical studies) is a stage of research that begins before clinical trials (testing in humans) and during which important feasibility, iterative testing and drug safety data are collected, typically in laboratory animals. The main goals of preclinical studies are to determine a starting, safe dose for first-in-human study and assess potential toxicity of the product, which typically include new medical devices, prescription drugs, and diagnostics. Companies use stylized statistics to illustrate the risks in preclinical research, such as that on average, only one in every 5,000 compounds that enters drug discovery to the stage of preclinical development becomes an approved drug. Types Each class of product may undergo different types of preclinical research. For instance, drugs may undergo pharmacodynamics (what the drug does to the body) (PD), pharmacokinetics (what the body does to t ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
