Walthard cell rests, sometimes called Walthard cell nests, are a benign cluster of
epithelial
Epithelium or epithelial tissue is one of the four basic types of animal tissue, along with connective tissue, muscle tissue and nervous tissue. It is a thin, continuous, protective layer of compactly packed cells with a little intercellu ...
cells most commonly found in the
connective tissue
Connective tissue is one of the four primary types of animal tissue, along with epithelial tissue, muscle tissue, and nervous tissue. It develops from the mesenchyme derived from the mesoderm the middle embryonic germ layer. Connective tissue ...
of the
Fallopian tubes
The fallopian tubes, also known as uterine tubes, oviducts or salpinges (singular salpinx), are paired tubes in the human female that stretch from the uterus to the ovaries. The fallopian tubes are part of the female reproductive system. In ...
, but also seen in the
mesovarium,
mesosalpinx and
ovarian hilus.
Appearance
They appear as white/yellow cysts or nodules that can reach a size of 2 millimeters. They typically have elliptical nuclei with a long groove (along the major axis) – so-called "coffee bean" nuclei.
Pathology
It has been suggested that these cell rests are the
histogenetic origins of
Brenner tumors, due to the
histological
Histology,
also known as microscopic anatomy or microanatomy, is the branch of biology which studies the microscopic anatomy of biological tissues. Histology is the microscopic counterpart to gross anatomy, which looks at larger structures vis ...
similarity of the
epithelium of Walthard cell rests and Brenner tumors to the
urothelium
Transitional epithelium also known as urothelium is a type of stratified epithelium. Transitional epithelium is a type of tissue that changes shape in response to stretching (stretchable epithelium). The transitional epithelium usually appears ...
of the lower
urinary tract
The urinary system, also known as the urinary tract or renal system, consists of the kidneys, ureters, bladder, and the urethra. The purpose of the urinary system is to eliminate waste from the body, regulate blood volume and blood pressure, ...
. Also, it has been proposed that Brenner tumors and Walthard cell rests signify urothelial differentiation within the female genital tract.
Eponym
They are named after Swiss
gynecologist
Gynaecology or gynecology (see spelling differences) is the area of medicine that involves the treatment of women's diseases, especially those of the reproductive organs. It is often paired with the field of obstetrics, forming the combined ar ...
Max Walthard (1867–1933), who provided a comprehensive description of them in 1903.
Additional images
Image:Brenner tumour high mag.jpg, High magnification micrograph
A micrograph or photomicrograph is a photograph or digital image taken through a microscope or similar device to show a magnify, magnified image of an object. This is opposed to a macrograph or photomacrograph, an image which is also taken ...
of a Brenner tumor showing the characteristic ''coffee bean
A coffee bean is a seed of the '' Coffea'' plant and the source for coffee. It is the pip inside the red or purple fruit often referred to as a coffee cherry. Just like ordinary cherries, the coffee fruit is also a so-called stone fruit. Even tho ...
'' nuclei which are also seen in Walthard cell rests. H&E stain
Hematoxylin and eosin stain ( or haematoxylin and eosin stain or hematoxylin-eosin stain; often abbreviated as H&E stain or HE stain) is one of the principal tissue stains used in histology. It is the most widely used stain in medical diagnos ...
.
References
Pathology Outline, Fallopian Tubes*
Histology
Gynaecology
{{Oncology-stub