Vebreltinib (also known as bozitinib) is a pharmaceutical drug used for the treatment of cancer. Vebreltinib selectively binds to

c-Met Hepatocyte growth factor receptor (HGF receptor) is a protein that in humans is encoded by the ''MET'' gene. The protein possesses tyrosine kinase activity. The primary single chain precursor protein is post-translationally cleaved to produce t ...

, preventing its

phosphorylation In biochemistry, phosphorylation is described as the "transfer of a phosphate group" from a donor to an acceptor. A common phosphorylating agent (phosphate donor) is ATP and a common family of acceptor are alcohols: : This equation can be writ ...

and thereby disrupting c-Met

signal transduction Signal transduction is the process by which a chemical or physical signal is transmitted through a cell as a biochemical cascade, series of molecular events. Proteins responsible for detecting stimuli are generally termed receptor (biology), rece ...

pathways. In China, it is approved for the treatment of

non-small-cell lung cancer Non-small-cell lung cancer (NSCLC), or non-small-cell lung carcinoma, is any type of epithelial lung cancer other than small-cell lung cancer (SCLC). NSCLC accounts for about 85% of all lung cancers. As a class, NSCLCs are relatively insensitiv ...

(NSCLC) with MET exon 14 skipping mutations.

References

Antineoplastic and immunomodulating drugs Kinase inhibitors Indazoles Cyclopropyl compounds Pyrazoles Fluoroarenes {{antineoplastic-drug-stub