Unibrows
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A unibrow (or jacco brow or monobrow; called synophrys in medicine) is a single eyebrow created when the two
eyebrow An eyebrow is an area of short hairs above each eye that follows the shape of the lower margin of the Supraorbital ridge, brow ridges of some mammals. In humans, eyebrows serve two main functions: first, human communication, communication thro ...
s meet in the middle above the bridge of the
nose A nose is a sensory organ and respiratory structure in vertebrates. It consists of a nasal cavity inside the head, and an external nose on the face. The external nose houses the nostrils, or nares, a pair of tubes providing airflow through the ...
. The
hair Hair is a protein filament that grows from follicles found in the dermis. Hair is one of the defining characteristics of mammals. The human body, apart from areas of glabrous skin, is covered in follicles which produce thick terminal and ...
above the bridge of the nose is of the same color and thickness as the eyebrows, such that they converge to form one uninterrupted line of hair.


History

The word ''monobrow'' first appeared in print in 1968, and the adjectival form ''monobrowed'' followed in 1973, in
Martin Amis Sir Martin Louis Amis (25 August 1949 – 19 May 2023) was an English novelist, essayist, memoirist, screenwriter and critic. He is best known for his novels ''Money'' (1984) and '' London Fields'' (1989). He received the James Tait Black Mem ...
' novel ''
The Rachel Papers ''The Rachel Papers'' is a 1989 British comedy drama film written and directed by Damian Harris, and based on the 1973 novel of the same name by Martin Amis. It stars Dexter Fletcher and Ione Skye with Jonathan Pryce, James Spader, Bill Paters ...
''. The first known use of the word ''unibrow'' was in 1981.


Culture and beauty

Some nations prize the unibrow. It is a sign of beauty among Baluchi
Oman Oman, officially the Sultanate of Oman, is a country located on the southeastern coast of the Arabian Peninsula in West Asia and the Middle East. It shares land borders with Saudi Arabia, the United Arab Emirates, and Yemen. Oman’s coastline ...
is, whose women sometimes draw a black line joining the brows as a part of their routine makeup to fake a unibrow. A study found the prevalence of synophrys to be at 11.87% in the
Oman Oman, officially the Sultanate of Oman, is a country located on the southeastern coast of the Arabian Peninsula in West Asia and the Middle East. It shares land borders with Saudi Arabia, the United Arab Emirates, and Yemen. Oman’s coastline ...
i population. In
Tajikistan Tajikistan, officially the Republic of Tajikistan, is a landlocked country in Central Asia. Dushanbe is the capital city, capital and most populous city. Tajikistan borders Afghanistan to the Afghanistan–Tajikistan border, south, Uzbekistan to ...
, where the unibrow is similarly viewed as attractive, some women dry and extract an herb known locally as ''usma'' and daub it onto their brows to mimic one. Urban women may do the same with a
kohl Kohl may refer to: *Kohl (cosmetics), an ancient eye cosmetic *Kohl (surname), including a list of people with the surname *Kohl's Kohl's Corporation (Kohl's is stylized in all caps) is an American department store retail chain store, chain. ...
liner or a kajal pen. The unibrow has largely been seen as undesirable in the Americas and Europe, with the hairs often plucked, shaved, or waxed away. Exceptions include the artist
Frida Kahlo Magdalena Carmen Frida Kahlo y Calderón (; 6 July 1907 – 13 July 1954) was a Mexican painter known for her many portraits, self-portraits, and works inspired by the nature and artifacts of Mexico. Inspired by Culture of Mexico, the country' ...
, famous for her unibrow, which she often depicted in self-portraits, and the Greek-Cypriot model
Sophia Hadjipanteli Sophia Hadjipanteli (; born 25 May 1997) is a Greek Cypriot model, most notable for her unibrow look. She initially gained public attention in the UK in 2017 and first appeared in fashion shows during London's Fashion week 2020. Early life Hadj ...
. The unibrow is also the trademark of the NBA player
Anthony Davis Anthony Marshon Davis Jr. (born March 11, 1993), nicknamed "AD" and "the Brow", is an American professional basketball player for the Dallas Mavericks of the National Basketball Association (NBA). Davis, a Power forward (basketball), power f ...
, the football player
Marouane Fellaini Marouane Fellaini-Bakkioui (born 22 November 1987) is a Belgian former professional footballer who played as a midfielder. Born in Etterbeek to Moroccan parents, Fellaini played youth football for Anderlecht, R.A.E.C. Mons, Royal Francs Borai ...
, and the YouTuber
ElectroBOOM Mehdi Sadaghdar ( ; , ; born 13 January 1977) is an Iranian-Canadian Electrical/Electronics Designer who hosts the YouTube channel ElectroBOOM. Early life Sadaghdar was born in Iran on 13 January 1977 and resides in Vancouver, British Columbi ...
. The boxer
Roberto Elizondo Roberto Elizondo (born December 28, 1955) is an American former professional boxer of Mexican descent. Elizondo competed in the sport of professional boxing from 1977 to 1987, and he fought for the World Boxing Council's world Lightweight title twi ...
famously sported a unibrow during his professional career.


Medicine


Genetics

The unibrow is a genetic trait. It is associated with the
PAX3 The PAX3 (paired box gene 3) gene encodes a member of the paired box or Pax genes, PAX family of transcription factors. The PAX family consists of nine human (PAX1-PAX9) and nine mouse (Pax1-Pax9) members arranged into four subfamilies. Human PAX ...
gene.


Medical conditions

A unibrow is part of normal human variation, but can also stem from developmental disorders. A unibrow is a recognized feature of
Cornelia De Lange syndrome Cornelia de Lange syndrome (CdLS) is a genetic disorder. People with Cornelia de Lange syndrome experience a range of physical, cognitive, and medical challenges ranging from mild to severe. Cornelia de Lange syndrome has a widely varied phenotype, ...
, a genetic disorder whose main features include moderate to severe learning difficulties, limb abnormalities such as
oligodactyly Oligodactyly () is the presence of fewer than five digits (fingers or toes) on a hand or foot.phocomelia Phocomelia is a congenital condition that involves malformations of human arms and legs which result in a flipper-like appendage. A prominent cause of phocomelia is the mother being prescribed the use of the drug thalidomide during pregnancy; ho ...
(malformed limbs), and facial abnormalities including a long
philtrum The philtrum (, from Ancient Greek , lit. 'love charm') or medial cleft is a vertical indentation in the middle area of the upper lip, common to therian mammals, extending in humans from the nasal septum to the tubercle of the upper lip. Toget ...
(the slight depression/line between the nose and mouth). Other medical conditions associated with a unibrow include: * 3MC syndrome 1 * Acromegaloid facial appearance syndrome *
Acromesomelic dysplasia Acromesomelic dysplasia is a rare skeletal disorder that causes abnormal bone and cartilage development, leading to shortening of the forearms, lower legs, hands, feet, fingers, and toes. Five different genetic mutations have been implicated in t ...
4 *
Amaurosis Amaurosis (Greek meaning ''darkening'', ''dark'', or ''obscure'') is vision loss or weakness that occurs without an apparent lesion affecting the eye. It may result from either a medical condition or excess acceleration, as in flight. The term is t ...
-
hypertrichosis Hypertrichosis (sometimes known as werewolf syndrome) is an abnormal amount of hair growth over the body. The two distinct types of hypertrichosis are generalized hypertrichosis, which occurs over the entire body, and localized hypertrichosis, w ...
syndrome *
Arrhinia Arrhinia (alternatively spelled "arhinia") is the congenital partial or complete absence of the nose at birth. It is an extremely rare condition, with few reported cases in the history of modern medicine. It is generally classified as a craniofac ...
with
choanal atresia Choanal atresia is a congenital disorder where the back of the nasal passage (choana) is blocked, usually by abnormal bony or soft tissue (membranous) due to failed hole development of the nasal fossae during prenatal development. It causes persi ...
and
microphthalmia Microphthalmia (Greek: , ), also referred as microphthalmos, is a developmental disorder of the eye in which one (unilateral microphthalmia) or both (bilateral microphthalmia) eyes are abnormally small and have anatomic malformations. Microphthalm ...
syndrome *
Autosomal recessive In genetics, dominance is the phenomenon of one variant (allele) of a gene on a chromosome masking or overriding the Phenotype, effect of a different variant of the same gene on Homologous chromosome, the other copy of the chromosome. The firs ...
spinocerebellar ataxia Spinocerebellar ataxia (SCA) is a progressive, degenerative, genetic disease with multiple types, each of which could be considered a neurological condition in its own right. An estimated 150,000 people in the United States have a diagnosis of ...
17 * Blepharophimosis-impaired intellectual development syndrome *
Blepharophimosis-ptosis-esotropia-syndactyly-short stature syndrome ''Blepharophimosis-ptosis-esotropia-syndactyly-short stature syndrome'' is a very rare genetic and congenital disorder which is characterized by blepharophimosis, ptosis, V-esotropia, foot syndactyly, extra-ocular and frontal muscles weakness ...
*
Brachycephaly Brachycephaly (derived from the Ancient Greek '' βραχύς'', 'short' and '' κεφαλή'', 'head') is the shape of a skull shorter than average in its species. It is perceived as a cosmetically desirable trait in some domesticated dog and ...
,
trichomegaly Trichomegaly is a condition in which the eyelashes are abnormally long, objectively defined as 12mm or greater in the central area and 8mm in the peripheral. The term was first used by H. Gray in 1944 in a publication in the Stanford Medical Bulle ...
, and
developmental delay The term developmental delay can refer to: *Global developmental delay, an umbrella term used when children are significantly delayed in two or more areas of development *Specific developmental disorder, a classification of disorders characterize ...
* Chromosome 1p36 deletion syndrome * Coffin-Siris syndrome 12 *
Cognitive impairment Cognitive impairment is an inclusive term to describe any characteristic that acts as a barrier to the cognition process or different areas of cognition. Cognition, also known as cognitive function, refers to the mental processes of how a person ...
coarse facies
heart defects A congenital heart defect (CHD), also known as a congenital heart anomaly, congenital cardiovascular malformation, and congenital heart disease, is a defect in the structure of the heart or great vessels that is present at birth. A congenital he ...
obesity Obesity is a medical condition, considered by multiple organizations to be a disease, in which excess Adipose tissue, body fat has accumulated to such an extent that it can potentially have negative effects on health. People are classifi ...
– pulmonary involvement –
short stature Short stature refers to a height of a human which is below typical. Whether a person is considered short depends on the context. Because of the lack of preciseness, there is often disagreement about the degree of shortness that should be called ...
skeletal dysplasia An osteochondrodysplasia,Etymology: . or skeletal dysplasia, is a disorder of the development of bone and cartilage. Osteochondrodysplasias are rare diseases. About 1 in 5,000 babies are born with some type of skeletal dysplasia. Nonetheless, if t ...
syndrome * Congenital muscular hypertrophy-cerebral syndrome *
Cornelia de Lange syndrome Cornelia de Lange syndrome (CdLS) is a genetic disorder. People with Cornelia de Lange syndrome experience a range of physical, cognitive, and medical challenges ranging from mild to severe. Cornelia de Lange syndrome has a widely varied phenotype, ...
1–5 * Corpus callosum agenesis-abnormal genitalia syndrome *
Cortical dysplasia Focal cortical dysplasia (FCD) is a congenital abnormality of brain development where the neurons in an area of the brain failed to migrate in the proper formation ''in utero''. ''Focal'' means that it is limited to a focal zone in any lobe. Foca ...
, complex, with other brain malformations 11 *
Deafness Deafness has varying definitions in cultural and medical contexts. In medical contexts, the meaning of deafness is hearing loss that precludes a person from understanding spoken language, an audiological condition. In this context it is writte ...
,
cataract A cataract is a cloudy area in the lens (anatomy), lens of the eye that leads to a visual impairment, decrease in vision of the eye. Cataracts often develop slowly and can affect one or both eyes. Symptoms may include faded colours, blurry or ...
, impaired
intellectual development Cognitive development is a field of study in neuroscience and psychology focusing on a child's development in terms of information processing, conceptual resources, perceptual skill, language learning, and other aspects of the developed adult bra ...
, and
polyneuropathy Polyneuropathy () is damage or disease affecting peripheral nerves (peripheral neuropathy) in roughly the same areas on both sides of the body, featuring weakness, numbness, and burning pain. It usually begins in the hands and feet and may prog ...
* Deficiency of transaldolase *
DeSanto-Shinawi syndrome DeSanto-Shinawi (DESSH) syndrome is a rare genetic disorder caused by genetic variations (mutations) in a gene called  WW Domain-Containing Adaptor with Coiled-coil Region (the WAC gene). The condition was first described in 2015 in six individua ...
due to WAC
point mutation A point mutation is a genetic mutation where a single nucleotide base is changed, inserted or deleted from a DNA or RNA sequence of an organism's genome. Point mutations have a variety of effects on the downstream protein product—consequences ...
* Developmental and epileptic
encephalopathy Encephalopathy (; ) means any disorder or disease of the brain, especially chronic degenerative conditions. In modern usage, encephalopathy does not refer to a single disease, but rather to a syndrome of overall brain dysfunction; this syndrome ...
23, 66, 83, 84, 85 (with or without midline brain defects), 100, and 105 (with
hypopituitarism Hypopituitarism is the decreased (''hypo'') secretion of one or more of the eight hormones normally produced by the pituitary gland at the base of the brain. If there is decreased secretion of one specific pituitary hormone, the condition is know ...
) *
Developmental delay The term developmental delay can refer to: *Global developmental delay, an umbrella term used when children are significantly delayed in two or more areas of development *Specific developmental disorder, a classification of disorders characterize ...
with variable
intellectual disability Intellectual disability (ID), also known as general learning disability (in the United Kingdom), and formerly mental retardation (in the United States), Rosa's Law, Pub. L. 111-256124 Stat. 2643(2010).Archive is a generalized neurodevelopmental ...
and dysmorphic facies * Developmental delay, impaired speech, and
behavioral abnormalities In psychology, abnormality (also dysfunctional behavior, maladaptive behavior, or deviant behavior) is a behavioral characteristic assigned to those with conditions that are regarded as dysfunctional. Behavior is considered to be abnormal when i ...
* Diamond-Blackfan anemia 21 * Early-onset progressive diffuse
brain atrophy Cerebral atrophy is a common feature of many of the diseases that affect the brain. Atrophy of any tissue means a decrement in the size of the cell, which can be due to progressive loss of cytoplasmic proteins. In brain tissue, atrophy describes ...
-
microcephaly Microcephaly (from Neo-Latin ''microcephalia'', from Ancient Greek μικρός ''mikrós'' "small" and κεφαλή ''kephalé'' "head") is a medical condition involving a smaller-than-normal head. Microcephaly may be present at birth or it m ...
-
muscle weakness Muscle weakness is a lack of muscle strength. Its causes are many and can be divided into conditions that have either true or perceived muscle weakness. True muscle weakness is a primary symptom of a variety of skeletal muscle diseases, includ ...
-
optic atrophy Optic neuropathy is damage to the optic nerve from any cause. The optic nerve is a bundle of millions of fibers in the retina that sends visual signals to the brain. Damage and death of these nerve cells, or neurons, leads to characteristic featu ...
syndrome *
Epilepsy Epilepsy is a group of Non-communicable disease, non-communicable Neurological disorder, neurological disorders characterized by a tendency for recurrent, unprovoked Seizure, seizures. A seizure is a sudden burst of abnormal electrical activit ...
,
X-linked Sex linkage describes the sex-specific patterns of inheritance and expression when a gene is present on a sex chromosome (allosome) rather than a non-sex chromosome ( autosome). Genes situated on the X-chromosome are thus termed X-linked, and ...
2, with or without impaired intellectual development and dysmorphic features * Epilepsy-
telangiectasia Telangiectasias (), also known as spider veins, are small dilated blood vessels that can occur near the surface of the skin or mucous membranes, measuring between 0.5 and 1 millimeter in diameter. These dilated blood vessels can develop anywhere ...
syndrome *
Focal segmental glomerulosclerosis Focal segmental glomerulosclerosis (FSGS) is a histopathologic finding of scarring (sclerosis) of glomeruli and damage to renal podocytes. This process damages the filtration function of the kidney, resulting in protein presence in the urine du ...
and neurodevelopmental syndrome * Fontaine progeroid syndrome * Goldberg-Shprintzen megacolon syndrome *
Growth delay Child development involves the biological, psychological and emotional changes that occur in human beings between birth and the conclusion of adolescence. It is—particularly from birth to five years— a foundation for a prosperous and sustai ...
due to
insulin-like growth factor I Insulin-like growth factor 1 (IGF-1), also called somatomedin C, is a hormone similar in molecular structure to insulin which plays an important role in childhood growth, and has anabolic effects in adults. In the 1950s IGF-1 was called "sulfat ...
resistance * Hajdu-Cheney syndrome * Hennekam lymphangiectasia-lymphedema syndrome 3 *
Holoprosencephaly Holoprosencephaly (HPE) is a cephalic disorder in which the prosencephalon (the forebrain of the embryo) fails to Prenatal development, develop into two Cerebral hemisphere, hemispheres, typically occurring between the 18th and 28th day of gestati ...
5, 7, and 11 *
Hypotonia Hypotonia is a state of low muscle tone (the amount of tension or resistance to stretch in a muscle), often involving reduced muscle strength. Hypotonia is not a specific medical disorder, but it is a potential manifestation of many different dis ...
,
ataxia Ataxia (from Greek α- negative prefix+ -τάξις rder= "lack of order") is a neurological sign consisting of lack of voluntary coordination of muscle movements that can include gait abnormality, speech changes, and abnormalities in e ...
, and delayed development syndrome *
Intellectual developmental disorder Intellectual disability (ID), also known as general learning disability (in the United Kingdom), and formerly mental retardation (in the United States), Rosa's Law, Pub. L. 111-256124 Stat. 2643(2010).Archive is a generalized neurodevelopmental d ...
61 * Intellectual developmental disorder with or without
peripheral neuropathy Peripheral neuropathy, often shortened to neuropathy, refers to damage or disease affecting the nerves. Damage to nerves may impair sensation, movement, gland function, and/or organ function depending on which nerve fibers are affected. Neuropa ...
* Intellectual developmental disorder,
autosomal dominant In genetics, dominance is the phenomenon of one variant (allele) of a gene on a chromosome masking or overriding the Phenotype, effect of a different variant of the same gene on Homologous chromosome, the other copy of the chromosome. The firs ...
64 and 65 * Intellectual developmental disorder, autosomal recessive 68 * Intellectual developmental disorder, X-linked, syndromic, with pigmentary
mosaicism Mosaicism or genetic mosaicism is a condition in which a multicellular organism possesses more than one genetic line as the result of genetic mutation. This means that various genetic lines resulted from a single fertilized egg. Mosaicism is o ...
and coarse facies * Intellectual disability, autosomal dominant 29, 30, 34, 43, 48, and 52 * Intellectual disability, autosomal recessive 5, 13, 16, 45, 46, and 61 * Intellectual disability, X-linked 21, 73, 97, and 106 * Intellectual disability, X-linked, syndromic 33 * Intellectual disability-
brachydactyly Brachydactyly () is a medical term denoting the presence of abnormally short digits (fingers or toes) at birth. The shortness is relative to the length of other long bones and other parts of the body. Brachydactyly is an inherited, dominant t ...
-
Pierre Robin syndrome Pierre Robin sequence (; abbreviated PRS) is a congenital defect observed in humans which is characterized by facial abnormalities. The three main features are micrognathia (abnormally small mandible), which causes glossoptosis (downwardly displ ...
* Intellectual disability-facial dysmorphism syndrome due to SETD5
haploinsufficiency Haploinsufficiency in genetics describes a model of dominant gene action in diploid organisms, in which a single copy of the wild-type allele at a locus in heterozygous combination with a variant allele is insufficient to produce the wild-type ...
*
Joubert syndrome Joubert syndrome is a rare autosomal recessive genetic disorder that affects the cerebellum, an area of the Human brain, brain that controls balance and coordination. Joubert syndrome is one of the many genetic syndromes associated with syndromic ...
35 *
KBG syndrome KBG syndrome is a rare genetic disease that is the result of a mutation in the ANKRD11 gene at location 16q24.3. Only about a hundred known cases have been reported, although it is expected to be under-reported. The syndrome was first described by ...
*
Kleefstra syndrome 9q34 deletion syndrome, now known as Kleefstra syndrome, is a rare genetic disorder. Terminal deletions of chromosome 9q34 have been associated with childhood hypotonia, distinctive facial appearance and intellectual disability. Most individuals fa ...
1 *
Lissencephaly Lissencephaly (, meaning 'smooth brain') is a set of rare brain disorders whereby the whole or parts of the surface of the brain are smooth. It is caused by defective neuronal migration during the 12th to 24th weeks of gestation, resulting in a ...
6 with microcephaly * Macrothrombocytopenia-
lymphedema Lymphedema, also known as lymphoedema and lymphatic edema, is a condition of localized edema, swelling caused by a compromised lymphatic system. The lymphatic system functions as a critical portion of the body's immune system and returns inters ...
-developmental delay-facial dysmorphism-
camptodactyly Camptodactyly is a medical condition that causes one or more Digit (anatomy), digits (fingers or toes) to be permanently bent. It involves fixed Human anatomical terms#Types of movement, flexion deformity of the proximal interphalangeal articulat ...
syndrome * Mandibulofacial dysostosis-macroblepharon-
macrostomia Macrostomia refers to a mouth that is unusually wide. The term is from the Greek prefix ''makro-'' meaning "large" and from Greek στόμα, "mouth".Marshall-Smith syndrome * Microcephaly 4, primary, autosomal recessive * Midface hypoplasia,
hearing impairment Hearing loss is a partial or total inability to Hearing, hear. Hearing loss may be present at birth or acquired at any time afterwards. Hearing loss may occur in one or both ears. In children, hearing problems can affect the ability to Lang ...
,
elliptocytosis Hereditary elliptocytosis, also known as ovalocytosis, is an inherited blood disorder in which an abnormally large number of the person's red blood cells are elliptical rather than the typical biconcave disc shape. Such morphologically distinctiv ...
, and
nephrocalcinosis Nephrocalcinosis, once known as Albright's calcinosis after Fuller Albright, is a term originally used to describe the deposition of poorly soluble calcium salts in the renal parenchyma due to hyperparathyroidism. The term nephrocalcinosis is u ...
* Mitochondrial complex 4 deficiency, nuclear type 20 * Mitochondrial complex III deficiency nuclear type 7 * Mucopolysaccharidosis, MPS-III-A to -D *
Neurodevelopmental disorder Neurodevelopmental disorders are a group of mental conditions negatively affecting the development of the nervous system, which includes the brain and spinal cord. According to the American Psychiatric Association Diagnostic and Statistical Manu ...
with dysmorphic facies and variable
seizure A seizure is a sudden, brief disruption of brain activity caused by abnormal, excessive, or synchronous neuronal firing. Depending on the regions of the brain involved, seizures can lead to changes in movement, sensation, behavior, awareness, o ...
s * Neurodevelopmental disorder with facial dysmorphism, absent language, and pseudo- pelger-huet anomaly * Neurodevelopmental disorder with
growth retardation A delayed milestone, which is also known as a developmental delay, refers to a situation where a child does not reach a particular developmental milestone at the expected age. Developmental milestones refer to a collection of indicators that a chil ...
, dysmorphic facies, and corpus callosum abnormalities * Neurodevelopmental disorder with microcephaly, short stature, and
speech delay Speech delay, also known as alalia, refers to a delay in the development or use of the mechanisms that produce speech. Speech – as distinct from language – is the actual process of making sounds, using such organs and structures as the lungs, ...
* Neurodevelopmental disorder with severe motor impairment and absent language * Neurodevelopmental disorder with
spasticity Spasticity () is a feature of altered skeletal muscle performance with a combination of paralysis, increased tendon reflex activity, and hypertonia. It is also colloquially referred to as an unusual "tightness", stiffness, or "pull" of muscles. ...
and poor growth * Neurodevelopmental disorder with spasticity,
cataract A cataract is a cloudy area in the lens (anatomy), lens of the eye that leads to a visual impairment, decrease in vision of the eye. Cataracts often develop slowly and can affect one or both eyes. Symptoms may include faded colours, blurry or ...
s, and
cerebellar hypoplasia Cerebellar hypoplasia is characterized by reduced cerebellar volume, even though cerebellar shape is (near) normal. It consists of a heterogeneous group of disorders of cerebellum, cerebellar maldevelopment presenting as early-onset Non-progress ...
*
Periventricular nodular heterotopia MRI of a child experiencing seizures. There are small foci of grey matter heterotopia in the corpus callosum, deep to the Cortical dysplasia">dysplastic cortex. (double arrows)">Heterotopia (medicine)">heterotopia in the corpus callosum, deep ...
9 *
Pontocerebellar hypoplasia Pontocerebellar hypoplasia (PCH) is a heterogeneous group of rare neurodegenerative disorders caused by genetic mutations and characterised by progressive atrophy of various parts of the brain such as the cerebellum or brainstem (particularly th ...
type 7, 8, and 10 *
Primrose syndrome Primrose syndrome is a rare, slowly progressive genetic disorder that can vary symptomatically between individual cases, but is generally characterised by ossification of the external ears, learning difficulties, and facial abnormalities. It was f ...
* Severe
feeding difficulties Dysphagia is difficulty in swallowing. Although classified under "symptoms and signs" in ICD-10, in some contexts it is classified as a condition in its own right. It may be a sensation that suggests difficulty in the passage of solids or liq ...
-
failure to thrive Failure to thrive (FTT), also known as weight faltering or faltering growth, indicates insufficient weight gain or absence of appropriate physical growth in children. FTT is usually defined in terms of weight, and can be evaluated either by a low ...
-microcephaly due to
ASXL3 Putative Polycomb group protein ASXL3 is a protein that in humans is encoded by the ''ASXL3'' gene. See also * Bainbridge–Ropers syndrome * Polycomb-group proteins * ASXL1 * ASXL2 Additional sex combs like 2, transcriptional regulator is a ...
deficiency syndrome * Sialuria * Skin creases, congenital symmetric circumferential, 2 * Smith-Magenis syndrome * Spondyloepimetaphyseal dysplasia, Genevieve type *
Spondyloepiphyseal dysplasia Spondyloepiphyseal dysplasia congenita (abbreviated to SED more often than SDC) is a rare disorder of bone growth that results in dwarfism, characteristic skeletal abnormalities, and, in some instances, problems with Visual perception, vision and ...
,
sensorineural hearing loss Sensorineural hearing loss (SNHL) is a type of hearing loss in which the root cause lies in the inner ear, sensory organ (cochlea and associated structures), or the vestibulocochlear nerve (Cranial nerves, cranial nerve VIII). SNHL accounts for a ...
, impaired
intellectual development Cognitive development is a field of study in neuroscience and psychology focusing on a child's development in terms of information processing, conceptual resources, perceptual skill, language learning, and other aspects of the developed adult bra ...
, and
leber congenital amaurosis Leber congenital amaurosis (LCA) is a rare inherited eye disease that appears at birth or in the first few months of life. It affects about 1 in 40,000 newborns. LCA was first described by Theodor Leber in the 19th century. It should not be ...
* Syndromic
X-linked intellectual disability X-linked intellectual disability refers to medical disorders associated with X-linked recessive inheritance that result in intellectual disability. As with most X-linked disorders, males are more heavily affected than females. Females with one a ...
Chudley-Schwartz type * Syndromic X-linked intellectual disability Nascimento type * Syndromic X-linked intellectual disability Siderius type * Syndromic X-linked intellectual disability Snyder type *
Trigonocephaly Trigonocephaly is a congenital condition due to premature Synostosis, fusion of the metopic suture (), leading to a triangular forehead. The premature merging of the two frontal bones leads to transverse growth restriction and parallel growth ex ...
1 * Uruguay Faciocardiomusculoskeletal syndrome *
Waardenburg syndrome Waardenburg syndrome is a group of rare genetic conditions characterised by at least some degree of congenital hearing loss and pigmentation deficiencies, which can include bright blue eyes (or Heterochromia iridum, one blue eye and one brown ey ...
types 1, 2A, and 3 * Wiedemann-Steiner syndrome * Zimmermann-Laband syndrome 1, 2, and 3


See also

*
Glabella The glabella, in humans, is the area of skin between the eyebrows and above the nose. The term also refers to the underlying bone that is slightly depressed, and joins the two brow ridges. It is a cephalometric landmark that is just superior ...


References


External links

* {{Authority control Eyebrow