U.S. Route 61 or U.S. Highway 61 (U.S. 61) is a major
United States highway
The United States Numbered Highway System (often called U.S. Routes or U.S. Highways) is an integrated network of roads and highways numbered within a nationwide grid in the contiguous United States. As the designation and numbering of these h ...
that extends between
New Orleans
New Orleans (commonly known as NOLA or The Big Easy among other nicknames) is a Consolidated city-county, consolidated city-parish located along the Mississippi River in the U.S. state of Louisiana. With a population of 383,997 at the 2020 ...
,
Louisiana
Louisiana ( ; ; ) is a state in the Deep South and South Central regions of the United States. It borders Texas to the west, Arkansas to the north, and Mississippi to the east. Of the 50 U.S. states, it ranks 31st in area and 25 ...
and the city of
Wyoming, Minnesota
Wyoming is a city in Chisago County, Minnesota. The population was 7,791 at the time of the 2010 census.
History
Wyoming was platted in 1869 when the St. Paul and Duluth Railroad was extended to that point. The city took its name from Wyomin ...
. The highway generally follows the course of the
Mississippi River
The Mississippi River is the main stem, primary river of the largest drainage basin in the United States. It is the second-longest river in the United States, behind only the Missouri River, Missouri. From its traditional source of Lake Ita ...
and is designated the
Great River Road
The Great River Road is a collection of state and local roads that follow the course of the Mississippi River through ten states of the United States. They are Minnesota, Wisconsin, Iowa, Illinois, Missouri, Kentucky, Tennessee, Arkansas, Miss ...
for much of its route. As of 2004, the highway's northern terminus in Wyoming, Minnesota, is at an intersection with
Interstate 35
Interstate 35 (I-35) is a major Interstate Highway in the central United States. As with most primary Interstates that end in a five, it is a major cross-country, north–south route. It stretches from Laredo, Texas, near the Mexican bo ...
(I-35). Until 1991, the highway extended north on what is now
Minnesota State Highway 61
Minnesota State Highway 61 (MN 61) is a highway in northeast Minnesota, which runs from a junction with Interstate 35 (I-35) in Duluth at 26th Avenue East, and continues northeast to its northern terminus at the Canadian border near Grand Po ...
(MN 61) through
Duluth
Duluth ( ) is a Port, port city in the U.S. state of Minnesota and the county seat of St. Louis County, Minnesota, St. Louis County. Located on Lake Superior in Minnesota's Arrowhead Region, the city is a hub for cargo shipping. The population ...
to the
Canada–U.S. border near
Grand Portage
Grand Portage National Monument is a United States National Monument located on the north shore of Lake Superior in northeastern Minnesota that preserves a vital center of fur trade activity and Anishinaabeg Ojibwe heritage. The area became on ...
, then continued to Thunder Bay, Canada, as Ontario Highway 61. Its southern terminus in New Orleans is at an intersection with
U.S. Route 90
U.S. Route 90 or U.S. Highway 90 (US 90) is an east–west major United States highway in the Southern United States. Despite the "0" in its route number, US 90 never was a full coast-to-coast route. It generally travels near Int ...
(US 90). The route was an important south–north connection in the days before the
interstate highway
The Dwight D. Eisenhower National System of Interstate and Defense Highways, commonly known as the Interstate Highway System, or the Eisenhower Interstate System, is a network of controlled-access highways that forms part of the National Hi ...
system.
The highway is often called the Blues Highway because of its long history in
blues music
Blues is a music genre and musical form that originated among African Americans in the Deep South of the United States around the 1860s. Blues has incorporated spiritual (music), spirituals, work songs, field hollers, Ring shout, shouts, cha ...
; part of the route lies on the
Mississippi Blues Trail
The Mississippi Blues Trail was created by the Mississippi Blues Commission in 2006 to place interpretive markers at the most notable historical sites related to the birth, growth, and influence of the blues throughout (and in some cases beyond) t ...
and is denoted by markers in
Vicksburg and
Tunica. It is also the subject of numerous musical works, with the route inspiring the album ''
Highway 61 Revisited
''Highway 61 Revisited'' is the sixth studio album by the American singer-songwriter Bob Dylan, released on August 30, 1965, by Columbia Records. Dylan continued the musical approach of his previous album ''Bringing It All Back Home'' (1965), usi ...
'' by
Bob Dylan
Bob Dylan (legally Robert Dylan; born Robert Allen Zimmerman, May 24, 1941) is an American singer-songwriter. Described as one of the greatest songwriters of all time, Dylan has been a major figure in popular culture over his nearly 70-year ...
.
Route description
Louisiana

US 61 in
Louisiana
Louisiana ( ; ; ) is a state in the Deep South and South Central regions of the United States. It borders Texas to the west, Arkansas to the north, and Mississippi to the east. Of the 50 U.S. states, it ranks 31st in area and 25 ...
is four-laned from its southern terminus in
New Orleans
New Orleans (commonly known as NOLA or The Big Easy among other nicknames) is a Consolidated city-county, consolidated city-parish located along the Mississippi River in the U.S. state of Louisiana. With a population of 383,997 at the 2020 ...
to the
Mississippi
Mississippi ( ) is a U.S. state, state in the Southeastern United States, Southeastern and Deep South regions of the United States. It borders Tennessee to the north, Alabama to the east, the Gulf of Mexico to the south, Louisiana to the s ...
state line, where the highway continues to
Natchez Natchez may refer to:
Places
* Natchez, Alabama, United States
* Natchez, Indiana, United States
* Natchez, Louisiana, United States
* Natchez, Mississippi, a city in southwestern Mississippi, United States
** Natchez slave market, Mississippi
* ...
as a four-lane highway.
The section of US 61 from New Orleans to
Baton Rouge
Baton Rouge ( ; , ) is the List of capitals in the United States, capital city of the U.S. state of Louisiana. It had a population of 227,470 at the 2020 United States census, making it List of municipalities in Louisiana, Louisiana's second-m ...
is known as the
Airline Highway
Airline Highway is a divided highway in the U.S. state of Louisiana, built in stages between 1925 and 1953 to bypass the older Jefferson Highway. It runs , carrying U.S. Highway 61 from New Orleans northwest to Baton Rouge and U.S. Highw ...
. Although the road fronts the
former terminal of
Louis Armstrong New Orleans International Airport
Louis Armstrong New Orleans International Airport is an international airport under Class B airspace in the City of Kenner, Jefferson Parish, Louisiana, United States. It is owned by the City of New Orleans and is west of downtown New ...
and passes near
Baton Rouge Metropolitan Airport
Baton Rouge Metropolitan Airport , also known as Ryan Field, is a public use airport located four miles (7 km) north of the central business district of Baton Rouge, a city in East Baton Rouge Parish, Louisiana, United States.
The airport w ...
, the name originally referred to the highway's straight route in contrast to that of the winding
Jefferson Highway
The Jefferson Highway was an automobile highway stretching through the central United States from New Orleans, Louisiana, to Winnipeg, Manitoba in Canada. The Jefferson Highway was replaced with the new numbered US Highway system in the late 1920 ...
, which often paralleled the
Mississippi River
The Mississippi River is the main stem, primary river of the largest drainage basin in the United States. It is the second-longest river in the United States, behind only the Missouri River, Missouri. From its traditional source of Lake Ita ...
. Legend has it that former Louisiana Governor
Huey Long
Huey Pierce Long Jr. (August 30, 1893September 10, 1935), nicknamed "The Kingfish", was an American politician who served as the 40th governor of Louisiana from 1928 to 1932 and as a United States senator from 1932 until his assassination i ...
advocated the construction of the "airline" highway to provide him with a quick means of access from the capitol building in Baton Rouge to the bars and other pleasure establishments in New Orleans. On Airline Highway in
Jefferson Parish
Jefferson Parish () is a parish in the U.S. state of Louisiana. As of the 2020 census, the population was 440,781. Its parish seat is Gretna, its largest community is Metairie, and its largest incorporated city is Kenner. Jefferson Parish i ...
in 1987, Baton Rouge televangelist
Jimmy Swaggart
Jimmy Lee Swaggart (; born March 15, 1935) is an American Pentecostal televangelist and gospel artist.
Swaggart is one of the most well-known televangelists in America. During the 1980s, Swaggart's crusades were a major part of his ministry� ...
was confronted by rival preacher Marvin Gorman as Swaggart exited the Travel Inn after seeing a
prostitute
Prostitution is a type of sex work that involves engaging in sexual activity in exchange for payment. The definition of "sexual activity" varies, and is often defined as an activity requiring physical contact (e.g., sexual intercourse, non-pe ...
. This incident increased the area's reputation as a locale of "seedy motels". Partly because of that reputation, the section in Jefferson Parish was later renamed Airline Drive.
Mississippi

US 61 is divided from the
Tennessee
Tennessee (, ), officially the State of Tennessee, is a landlocked U.S. state, state in the Southeastern United States, Southeastern region of the United States. It borders Kentucky to the north, Virginia to the northeast, North Carolina t ...
state line to
U.S. 82 in
Leland. The highway south of
Vicksburg to
Natchez Natchez may refer to:
Places
* Natchez, Alabama, United States
* Natchez, Indiana, United States
* Natchez, Louisiana, United States
* Natchez, Mississippi, a city in southwestern Mississippi, United States
** Natchez slave market, Mississippi
* ...
is mostly divided and four-lane; only short sections through
Port Gibson
Port Gibson is a city and the county seat of Claiborne County, Mississippi, United States. The population was 1,567 at the 2010 United States Census, 2010 census. It is bordered on the west by the Mississippi River.
The first European settlers i ...
are two lane. From Natchez to the
Louisiana
Louisiana ( ; ; ) is a state in the Deep South and South Central regions of the United States. It borders Texas to the west, Arkansas to the north, and Mississippi to the east. Of the 50 U.S. states, it ranks 31st in area and 25 ...
state line, US 61 is now divided and four lanes. The
Mississippi Department of Transportation
The Mississippi Department of Transportation (MDOT) is the organization in charge of developing and maintaining all state and federal roadways in the U.S. state of Mississippi. In addition to highways, the department also has a limited role in s ...
is now widening the highway between Vicksburg and Leland to four lanes, beginning with replacement of the
Yazoo River
The Yazoo River is a river primarily in the U.S. state of Mississippi. It is considered by some to mark the southern boundary of what is called the Mississippi Delta, a broad floodplain that was cultivated for cotton plantations before the Ame ...
bridge at
Redwood
Sequoioideae, commonly referred to as redwoods, is a subfamily of Pinophyta, coniferous trees within the family (biology), family Cupressaceae, that range in the Northern Hemisphere, northern hemisphere. It includes the List of superlative tree ...
in
Warren County.
The road is also known as the Blues Highway because it runs through the
Mississippi Delta
The Mississippi Delta, also known as the Yazoo–Mississippi Delta, or simply the Delta, is the distinctive northwest section of the U.S. state of Mississippi (and portions of Arkansas and Louisiana) that lies between the Mississippi and Yazo ...
country, which was an important source of
blues
Blues is a music genre and musical form that originated among African Americans in the Deep South of the United States around the 1860s. Blues has incorporated spiritual (music), spirituals, work songs, field hollers, Ring shout, shouts, cha ...
music. Highway 61 has been referenced in music by various artists with roots in the region.
The former junction of US 61 and
U.S. 49 in
Clarksdale (North State Street and Desoto Avenue) is designated as the famous crossroads where, according to legend,
Robert Johnson
Robert Leroy Johnson (May 8, 1911August 16, 1938) was an American blues musician and songwriter. His singing, guitar playing and songwriting on his landmark 1936 and 1937 recordings have influenced later generations of musicians. Although his r ...
supposedly
sold his soul to the Devil in exchange for mastery of
the blues
Blues is a music genre and musical form that originated among African Americans in the Deep South of the United States around the 1860s. Blues has incorporated spirituals, work songs, field hollers, shouts, chants, and rhymed simple narra ...
. US 49 and US 61 are currently routed around the city on a freeway bypass. It was on this stretch of highway that blues singer
Bessie Smith
Bessie Smith (April 15, 1892 – September 26, 1937) was an African-American blues singer widely renowned during the Jazz Age. Nicknamed the "Honorific nicknames in popular music, Empress of the Blues" and formerly Queen of the Blues, she was t ...
died as a result of a car crash on September 26, 1937.
Like
Route 66
U.S. Route 66 or U.S. Highway 66 (US 66 or Route 66) is one of the original highways in the United States Numbered Highway System. It was established on November 11, 1926, with road signs erected the following year. The high ...
in the Western U.S., the iconic US 61 sign is so strongly identified with the Clarksdale area that it is used to market different products and services. US 61 is defined in Mississippi Code Annotated § 65-3-3.
Tennessee
US 61 enters
Memphis
Memphis most commonly refers to:
* Memphis, Egypt, a former capital of ancient Egypt
* Memphis, Tennessee, a major American city
Memphis may also refer to:
Places United States
* Memphis, Alabama
* Memphis, Florida
* Memphis, Indiana
* Mem ...
from
Walls
Walls may refer to:
*The plural of wall, a structure
* Walls (surname), a list of notable people with the surname
Places
* Walls, Louisiana, United States
* Walls, Mississippi, United States
*Walls, Ontario
Perry is a township (Canada), ...
as South 3rd Street in South Memphis, continues north to E.H. Crump Boulevard, then turns west, joining
US 64
U.S. Route 64 (US 64) is an east–west United States highway that runs for 2,281 miles (3,672 km) from Nags Head in eastern North Carolina to just southwest of the Four Corners in northeast Arizona. The western terminus is at U.S. Route ...
,
US 70
U.S. Route 70 or U.S. Highway 70 (US 70) is an east–west United States highway that runs for from eastern North Carolina to east-central Arizona. It is a major east–west highway of the Southeastern, Southern and Southwestern United States. ...
, and
US 79
U.S. Route 79 (US 79) is a United States highway in the Southern United States. The route is officially considered and signed as a north–south highway, but its path is actually more of a diagonal northeast–southwest highway. The highway's n ...
, then joins
I-55
Interstate 55 (I-55) is a major Interstate Highway in the central United States. As with most primary Interstates that end in a five, it is a major cross-country, north–south route, connecting the Gulf of Mexico to the Great Lakes. The ...
as they cross the
Mississippi River
The Mississippi River is the main stem, primary river of the largest drainage basin in the United States. It is the second-longest river in the United States, behind only the Missouri River, Missouri. From its traditional source of Lake Ita ...
to
West Memphis
West Memphis is the largest city in Crittenden County, Arkansas, United States. The population was 24,520 at the 2020 census, ranking it as the state's 20th largest city. It is part of the Memphis metropolitan area, and is located directly acro ...
, a distance of approximately .
Arkansas
US 61 runs through the state for from West Memphis to just north of
Blytheville, near the
Missouri
Missouri (''see #Etymology and pronunciation, pronunciation'') is a U.S. state, state in the Midwestern United States, Midwestern region of the United States. Ranking List of U.S. states and territories by area, 21st in land area, it border ...
border.
The route enters
Arkansas
Arkansas ( ) is a landlocked state in the West South Central region of the Southern United States. It borders Missouri to the north, Tennessee and Mississippi to the east, Louisiana to the south, Texas to the southwest, and Oklahoma ...
in a concurrency with
I-55
Interstate 55 (I-55) is a major Interstate Highway in the central United States. As with most primary Interstates that end in a five, it is a major cross-country, north–south route, connecting the Gulf of Mexico to the Great Lakes. The ...
and
US 64,
US 70, and
US 79 near
West Memphis
West Memphis is the largest city in Crittenden County, Arkansas, United States. The population was 24,520 at the 2020 census, ranking it as the state's 20th largest city. It is part of the Memphis metropolitan area, and is located directly acro ...
. The route skirts the northwest edge of the city, briefly meeting
Interstate 40
Interstate 40 (I-40) is a major east–west transcontinental Interstate Highway System, Interstate Highway in the Southeastern United States, southeastern and Southwestern United States, southwestern portions of the United States. At a leng ...
before continuing north with I-55,
US 63 and US 64. US 61 overlaps I-55 until an area near
Turrell, when US 61 branches east but continues to run parallel to I-55. Southbound US 61 appears disconnected after the reconstruction of the
Interstate 555
Interstate 555 (I-555) is an Interstate Highway connecting Interstate 55 in Arkansas, I-55 in Turrell, Arkansas, Turrell with Arkansas Highway 91, Highway 91 in Jonesboro, Arkansas, Jonesboro. It provides a complete freeway corridor be ...
/US 63 interchange in the early 2000s. The old alignment of US 61 between West Memphis and Turrell is currently signed as
Arkansas Highway 77
Highway 77 (AR 77, Ark. 77, and Hwy. 77) is a north–south state highway in Northeast Arkansas. The route of runs from US Highway 70 (US 70) in West Memphis north through small towns and agricultural areas of the Arkansas Delta to ...
. The route runs through many small towns in
Mississippi County, and becomes a city street in
Osceola
Osceola (1804 – January 30, 1838, Vsse Yvholv in Muscogee language, Creek, also spelled Asi-yahola), named Billy Powell at birth, was an influential leader of the Seminole people in Florida. His mother was Muscogee, and his great-grandfa ...
. Continuing north, the route crosses over I-55, south of Blytheville. In the city, US 61 becomes South Division Street until crossing
Main Street (AR 18). The route runs north through the rest of Blytheville and beyond until a junction with
AR 150 near
Yarbro. After this junction, the route continues due north to Missouri.
Missouri
US 61 enters Missouri south of
Steele, passing under
a concrete arch that was constructed by the
Mississippi County,
Arkansas
Arkansas ( ) is a landlocked state in the West South Central region of the Southern United States. It borders Missouri to the north, Tennessee and Mississippi to the east, Louisiana to the south, Texas to the southwest, and Oklahoma ...
highway department in 1924. The alignment of the highway is closely followed by
I-55
Interstate 55 (I-55) is a major Interstate Highway in the central United States. As with most primary Interstates that end in a five, it is a major cross-country, north–south route, connecting the Gulf of Mexico to the Great Lakes. The ...
between there and the
St. Louis
St. Louis ( , sometimes referred to as St. Louis City, Saint Louis or STL) is an independent city in the U.S. state of Missouri. It lies near the confluence of the Mississippi and the Missouri rivers. In 2020, the city proper had a populatio ...
area, with portions of the two highways overlapping. Between
Howardville and
Sikeston
Sikeston () is a city located both in southern Scott County, Missouri, Scott County and northern New Madrid County, Missouri, New Madrid County, in the state of Missouri, United States. It is situated just north of the "Missouri Bootheel", althou ...
, US 61 overlaps with
US 62. At Sikeston, US 61 also meets
US 60. Crossing
Route 32
The following highways are numbered 32:
International
* AH32, Asian Highway 32
* European route E32
Australia
* Great Western Highway
* Barrier Highway
* East Derwent Highway
* Mitchell Highway
Canada
* Alberta Highway 32
* Manitoba Highway 32 ...
at "one of the oldest
French Colonial
French colonial architecture includes several styles of architecture used by the French during colonization. French colonial architecture has a long history, beginning in North America in 1604 and being most active in the Western Hemisphere (Car ...
settlements west of the Mississippi River (1735)",
Ste. Genevieve, the road continues through Ste. Genevieve County. The highway then turns northwest and meets
US 67 at
Festus
Festus may refer to:
People Ancient world
*Porcius Festus, Roman governor of Judea from approximately 58 to 62 AD
*Sextus Pompeius Festus (later 2nd century), Roman grammarian
*Festus (died 305), martyr along with Proculus of Pozzuoli
*Festus (h ...
. The two highways overlap until separating in the St. Louis area in
Ladue
Ladue is an inner-ring suburb of St. Louis, located in St. Louis County, Missouri. As of the 2020 census, the city had a population of 8,989.
Ladue has the highest median household income of any city in Missouri with a population over 1,000.
Ge ...
, where US 61 meets
I-64
Interstate 64 (I-64) is an east–west Interstate Highway in the Eastern United States. Its western terminus is at I-70, U.S. Route 40 (US 40), and US 61 in Wentzville, Missouri. Its eastern terminus is at the Bowers Hill ...
and
US 40. While in the St. Louis area, US 61 is on
Lindbergh Boulevard
Lindbergh Boulevard, named after the aviator, Charles Lindbergh, is a section of U.S. Routes 61 and 67 that extends through Missouri. Lindbergh Boulevard is home to Missouri's only traffic tunnel underneath a runway at Lambert–St. Louis ...
, which goes by the name of Kirkwood Road while in that municipality.
After meeting I-64 and US 40, US 61 turns west with them and its overlap with the
Avenue of the Saints
The Avenue of the Saints is a highway in the Midwestern United States that connects St. Louis, Missouri, and St. Paul, Minnesota.
__TOC__ Route description
Missouri
The southern end of the Avenue of the Saints is at exit 28A on Interstate ...
begins. At
Wentzville
Wentzville is an exurb of St. Louis that is located in western St. Charles County, Missouri, United States. As of the 2023 U.S. Census Bureau estimates, the city had a total population of 47,497, making it the 15th largest city in Missouri. Wentz ...
, the overlap with I-64 and US 40 ends when it meets
I-70
Interstate 70 (I-70) is a major east–west Interstate Highway in the United States that runs from I-15 near Cove Fort, Utah, to I-695 and Maryland Route 570 (MD 570) in Woodlawn, just outside Baltimore, Maryland.
I-70 appr ...
, with the former ending at I-70. It continues in a general northwesterly route, meeting
US 54 at
Bowling Green
A bowling green is a finely laid, close-mown and rolled stretch of turf for playing the game of bowls.
Before 1830, when Edwin Beard Budding of Thrupp, near Stroud, UK, invented the lawnmower, lawns were often kept cropped by grazing sheep ...
and
US 36 and
I-72
Interstate 72 (I-72) is an Interstate Highway in the Midwestern United States. Its western terminus is in Hannibal, Missouri, at an intersection with U.S. Route 61 (US 61); its eastern terminus is at Country Fair Drive in Champa ...
at
Hannibal
Hannibal (; ; 247 – between 183 and 181 BC) was a Punic people, Carthaginian general and statesman who commanded the forces of Ancient Carthage, Carthage in their battle against the Roman Republic during the Second Punic War.
Hannibal's fat ...
, an intersection which is I-72's western terminus. Northwest of Hannibal, US 61 meets
US 24 and the two overlap until they separate at
Taylor
Taylor, Taylors or Taylor's may refer to:
People
* Taylor (surname)
** List of people with surname Taylor
* Taylor (given name), including Tayla and Taylah
* Taylor sept, a branch of Scottish clan Cameron
* Justice Taylor (disambiguation)
...
. US 61 continues north until near
Wayland, where the highway turns east at
Route 27 and the overlap with the Avenue of the Saints ends. Shortly before leaving Missouri, US 61 meets
US 136 and the two overlap until entering
Iowa
Iowa ( ) is a U.S. state, state in the upper Midwestern United States, Midwestern region of the United States. It borders the Mississippi River to the east and the Missouri River and Big Sioux River to the west; Wisconsin to the northeast, Ill ...
. US 61 in Missouri was formerly known as Route 9.
US 61 runs along the western side of the Mississippi River between
Memphis, Tennessee
Memphis is a city in Shelby County, Tennessee, United States, and its county seat. Situated along the Mississippi River, it had a population of 633,104 at the 2020 United States census, 2020 census, making it the List of municipalities in Tenne ...
, and
Dubuque, Iowa
Dubuque (, ) is a city in Dubuque County, Iowa, United States, and its county seat. The population was 59,667 at the 2020 United States census. The city lies along the Mississippi River at the junction of Iowa, Illinois, and Wisconsin, a region ...
, and therefore never enters the state of
Illinois
Illinois ( ) is a U.S. state, state in the Midwestern United States, Midwestern United States. It borders on Lake Michigan to its northeast, the Mississippi River to its west, and the Wabash River, Wabash and Ohio River, Ohio rivers to its ...
.
Iowa
US 61 enters Iowa overlapped with US 136 near
Keokuk. They separate in Keokuk and US 61 turns north there and meets
US 218 in northwestern Keokuk. They overlap for , then US 218 turns northwest. US 61 goes north until crossing
Iowa 2 and becomes a four-lane
freeway
A controlled-access highway is a type of highway that has been designed for high-speed vehicular traffic, with all traffic flow—ingress and egress—regulated. Common English terms are freeway, motorway, and expressway. Other similar terms ...
bypass around
Fort Madison
Fort Madison is a city in and a county seat of Lee County, Iowa, Lee County, Iowa, United States along with Keokuk, Iowa, Keokuk. Of Iowa's 99 counties, Lee County is the only one with two county seats. The population was 10,270 at the time of ...
. US 61 then turns northeast and meets
US 34 in
Burlington. The highway goes north and overlaps
Iowa 92
Iowa Highway 92 (Iowa 92) is a state highway that runs from east to west across the state of Iowa. Iowa 92 is long and is part of a continuous four-state "Highway 92" which begins in Torrington, Wyoming, goes through Nebraska and Iowa an ...
from
Grandview to
Muscatine. At Muscatine, the highway turns east to go towards the
Quad Cities
The Quad Cities is a region of five cities (originally Tri-Cities, later four, see #History, History) in the U.S. states of Iowa and Illinois: Davenport, Iowa, Davenport and Bettendorf, Iowa, Bettendorf (the fifth to be included) in southeaster ...
. At
Davenport
Davenport may refer to:
Places Australia
*Davenport, Northern Territory, a locality
*Hundred of Davenport, cadastral unit in South Australia
**Davenport, South Australia, suburb of Port Augusta
**District Council of Davenport, former local govern ...
, US 61 follows
I-280
Interstate 280 may refer to multiple highways, all of which are or were related to Interstate 80:
* Interstate 280 (California), a north–south freeway running from San Jose to San Francisco
* Interstate 280 (Iowa–Illinois), part of the beltwa ...
and
I-80
Interstate 80 (I-80) is an east–west transcontinental freeway that crosses the United States from San Francisco, California, to Teaneck, New Jersey, in the New York metropolitan area. The highway was designated in 1956 as one of the ori ...
around Davenport and meets Business 61.
After I-80, the highway turns back north as a freeway until
De Witt, which is where it meets
US 30. It continues north from there to Dubuque as an
expressway except for a freeway section in the
Maquoketa area. The highway joins with
US 151 about south of
Dubuque
Dubuque (, ) is a city in Dubuque County, Iowa, United States, and its county seat. The population was 59,667 at the 2020 United States census. The city lies along the Mississippi River at the junction of Iowa, Illinois, and Wisconsin, a region ...
. US 61 and US 151 are joined at the
Southwest Arterial in Dubuque by
US 52, which separates in
Key West
Key West is an island in the Straits of Florida, at the southern end of the U.S. state of Florida. Together with all or parts of the separate islands of Dredgers Key, Fleming Key, Sunset Key, and the northern part of Stock Island, it con ...
. Also in Dubuque, a short connecting highway links US 61 and US 151 with
US 20. Together, US 61 and US 151 continue through Dubuque, where they cross the
Mississippi River
The Mississippi River is the main stem, primary river of the largest drainage basin in the United States. It is the second-longest river in the United States, behind only the Missouri River, Missouri. From its traditional source of Lake Ita ...
and enter Wisconsin via the
Dubuque-Wisconsin Bridge.
A four-lane freeway bypass of
Fort Madison
Fort Madison is a city in and a county seat of Lee County, Iowa, Lee County, Iowa, United States along with Keokuk, Iowa, Keokuk. Of Iowa's 99 counties, Lee County is the only one with two county seats. The population was 10,270 at the time of ...
was completed and opened to traffic in November 2011. A project to widen a segment between the Louisa–Muscatine county line near
Letts and the south junction of Iowa 92 near
Grandview to a four-lane expressway was completed in December 2017. Construction on widening US-61 to a divided highway is under way between
Burlington and
Mediapolis
Mediapolis is a city in Des Moines County, Iowa, United States. Its population was 1,688 at the time of the 2020 census. It is part of the Burlington, IA– IL Micropolitan Statistical Area.
History
Mediapolis was founded in the year ...
. The remaining segments between Iowa 92 and Mediapolis, and between the northern end of the
Keokuk bypass and the Missouri state line have not been programmed yet by the Iowa DOT.
Wisconsin
On the opposite bank of the Mississippi, US 61 and US 151 enter
Grant County Grant County may refer to:
Places
;Australia
* County of Grant, Victoria
;United States
* Grant County, Arkansas
* Grant County, Indiana
* Grant County, Kansas
*Grant County, Kentucky
Grant County is a county located in the northern pa ...
, with US 61 going north through Wisconsin about to
La Crosse
La Crosse ( ) is a city in La Crosse County, Wisconsin, United States, and its county seat. Positioned alongside the Mississippi River, La Crosse is the largest city on Wisconsin's western border. La Crosse's population was 52,680 as of the 20 ...
. US 151 separates from US 61 at
Dickeyville, with US 61 proceeding through
Lancaster
Lancaster may refer to:
Lands and titles
*The County Palatine of Lancaster, a synonym for Lancashire
*Duchy of Lancaster, one of only two British royal duchies
*Duke of Lancaster
*Earl of Lancaster
*House of Lancaster, a British royal dynasty
...
,
Fennimore, and
Boscobel. At
Readstown
Readstown is a village in Vernon County, Wisconsin, Vernon County, Wisconsin, United States. The population was 376 at the 2020 United States census, 2020 census.
Geography
Readstown is located at (43.448544, -90.760708).
According to the Uni ...
US 61 and US 14 join and proceed together to La Crosse.

In 2004, a new two-lane
Mississippi River
The Mississippi River is the main stem, primary river of the largest drainage basin in the United States. It is the second-longest river in the United States, behind only the Missouri River, Missouri. From its traditional source of Lake Ita ...
Bridge opened in La Crosse, creating a four-lane highway from downtown La Crosse to the
Minnesota
Minnesota ( ) is a U.S. state, state in the Upper Midwestern region of the United States. It is bordered by the Canadian provinces of Manitoba and Ontario to the north and east and by the U.S. states of Wisconsin to the east, Iowa to the so ...
state line. The new bridge brings traffic into La Crosse, and is located just south of the old Cass Street Bridge which continues to be used by traffic heading towards
Minnesota
Minnesota ( ) is a U.S. state, state in the Upper Midwestern region of the United States. It is bordered by the Canadian provinces of Manitoba and Ontario to the north and east and by the U.S. states of Wisconsin to the east, Iowa to the so ...
.
Minnesota

The four-lane highway continues north to
La Crescent.
US 61 follows the Mississippi River through southeast Minnesota through the cities of
Winona,
Lake City
Lake City may refer to:
Places
*Lake City, Arkansas
* Lake City, California (disambiguation)
*Lake City, Modoc County, California
* Lake City, Nevada County, California
*Lake City, Colorado
*Lake City, Florida
* Lake City, Georgia
* Lake City, I ...
, and
Red Wing. It crosses the river at
Hastings
Hastings ( ) is a seaside town and Borough status in the United Kingdom, borough in East Sussex on the south coast of England,
east of Lewes and south east of London. The town gives its name to the Battle of Hastings, which took place to th ...
using the
Hastings Bridge and joins
US 10 before entering St. Paul. Within the city, the route follows
I-94 for a short distance, and then follows Mounds Boulevard, East 7th Street, and Arcade Street through the east side of St. Paul.
The section of US 61 from
La Crescent to
Cottage Grove is officially designated the Disabled American Veterans Highway.
The portion of US 61 north of
Duluth
Duluth ( ) is a Port, port city in the U.S. state of Minnesota and the county seat of St. Louis County, Minnesota, St. Louis County. Located on Lake Superior in Minnesota's Arrowhead Region, the city is a hub for cargo shipping. The population ...
is now part of the Minnesota State Highway system, bearing the designation
MN 61 since 1991. Between the city of
Wyoming
Wyoming ( ) is a landlocked U.S. state, state in the Mountain states, Mountain West subregion of the Western United States, Western United States. It borders Montana to the north and northwest, South Dakota and Nebraska to the east, Idaho t ...
and Duluth, the highway has been turned back to local jurisdiction or supplanted by
I-35
Interstate 35 (I-35) is a major Interstate Highway in the central United States. As with most primary Interstates that end in a five, it is a major cross-country, north–south route. It stretches from Laredo, Texas, near the Mexico–Uni ...
.
History
US 61 once ran from
New Orleans
New Orleans (commonly known as NOLA or The Big Easy among other nicknames) is a Consolidated city-county, consolidated city-parish located along the Mississippi River in the U.S. state of Louisiana. With a population of 383,997 at the 2020 ...
through
Duluth
Duluth ( ) is a Port, port city in the U.S. state of Minnesota and the county seat of St. Louis County, Minnesota, St. Louis County. Located on Lake Superior in Minnesota's Arrowhead Region, the city is a hub for cargo shipping. The population ...
,
Minnesota
Minnesota ( ) is a U.S. state, state in the Upper Midwestern region of the United States. It is bordered by the Canadian provinces of Manitoba and Ontario to the north and east and by the U.S. states of Wisconsin to the east, Iowa to the so ...
all the way to the
Canada–US border. The road has been shortened to ending now in the city of
Wyoming
Wyoming ( ) is a landlocked U.S. state, state in the Mountain states, Mountain West subregion of the Western United States, Western United States. It borders Montana to the north and northwest, South Dakota and Nebraska to the east, Idaho t ...
, Minnesota at an intersection with
I-35
Interstate 35 (I-35) is a major Interstate Highway in the central United States. As with most primary Interstates that end in a five, it is a major cross-country, north–south route. It stretches from Laredo, Texas, near the Mexico–Uni ...
.
The northern section of US 61 in Minnesota was separated when I-35 was constructed, and decommissioned in 1991.
Mississippi
The section of US 61 in northwestern
Mississippi
Mississippi ( ) is a U.S. state, state in the Southeastern United States, Southeastern and Deep South regions of the United States. It borders Tennessee to the north, Alabama to the east, the Gulf of Mexico to the south, Louisiana to the s ...
, between the state line and
Clarksdale, has received numerous changes since 1990, when
casino
A casino is a facility for gambling. Casinos are often built near or combined with hotels, resorts, restaurants, retail shops, cruise ships, and other tourist attractions. Some casinos also host live entertainment, such as stand-up comedy, conce ...
s were legalized by the state, in concert with expanding suburban development from Memphis into Mississippi. The resulting boom in casino development in
Tunica County
Tunica County is a county located in the U.S. state of Mississippi. As of the 2020 census, the population was 9,782. Its county seat is Tunica. The county is named for the Tunica Native Americans. Most migrated to central Louisiana during t ...
, coupled with dramatic population and development growth in
DeSoto County south of Memphis has led to relocating most of the highway and expanding to a divided four-lane highway.
Missouri
The present-day course of US 61 south of
St. Louis
St. Louis ( , sometimes referred to as St. Louis City, Saint Louis or STL) is an independent city in the U.S. state of Missouri. It lies near the confluence of the Mississippi and the Missouri rivers. In 2020, the city proper had a populatio ...
largely follows the original course of the Spanish colonial road ''El Camino Real''. In 1776, when the Spanish lieutenant governor recognized that the two principal communities of St. Louis and
Ste. Genevieve needed an overland connection, he wrote his superior requesting permission. Construction then began, with parts of the Spanish road following old Indian trails. The road had been reportedly constructed by 1779, and then extended further south to the provincial posts at
Cape Girardeau
Cape Girardeau ( , ; colloquially referred to as "Cape") is a city in Cape Girardeau and Scott Counties in the U.S. state of Missouri. At the 2020 census, the population was 39,540, making it the 17th-largest in the state. The city is one o ...
and
New Madrid, and extended northwest to the post of
St. Charles. The sole rationale for the ''Camino Real'' was a military road to connect the several district posts for defense and administrative purposes. Much of the road was a simple trace for horses and foot travelers, and by 1796 transport large enough to require the use of wagons was largely being moved up the Mississippi River.
The original Spanish name ''el camino real'' was conferred by Colonel George Morgan in honor of
Charles IV of Spain
Charles IV (; 11 November 1748 – 20 January 1819) was King of Spain and ruler of the Spanish Empire from 1788 to 1808.
The Spain inherited by Charles IV gave few indications of instability, but during his reign, Spain entered a series of disa ...
, the reigning King of Spain (1788-1808). The government road was known as ''le Chemin du Roi'' or ''Rue Royale'' by the local French-speaking population and known as ''King's Highway'' or the old ''King's Trace'' by early American settlers. Because the road led to the French colonial "
Illinois Country
The Illinois Country ( ; ; ), also referred to as Upper Louisiana ( ; ), was a vast region of New France claimed in the 1600s that later fell under Spanish and British control before becoming what is now part of the Midwestern United States. Whi ...
", which also included parts of present-day Missouri, early American settlers sometimes referred to it as the ''Illinois Road''. It is also known as the ''Royal Road of the King's Domain'' in St.Charles County, Missouri. ''King's Highway'' or ''Kingshighway'' continues as street names in present-day St.Charles, St.Louis,
Perryville, Cape Girardeau,
Sikeston
Sikeston () is a city located both in southern Scott County, Missouri, Scott County and northern New Madrid County, Missouri, New Madrid County, in the state of Missouri, United States. It is situated just north of the "Missouri Bootheel", althou ...
and New Madrid.
When it was designated in 1926, US 61 replaced most of Route 9, which had been established in 1922 between Arkansas and Iowa. The only part that did not become part of US 61 was north of
Wayland, where US 61 turned east on
Route 4
Route 4, or Highway 4, may refer to several highways in the following countries:
International
* Asian Highway 4
* European route E04
* European route E004
* Cairo – Cape Town Highway
Albania
* SH-4 road in Albania from Durrës to Kakavi ...
, and Route 9 became
Route 4B (now
Route 81) to the state line. Since then, US 61 has been moved to a shorter route between
Jackson
Jackson may refer to:
Places Australia
* Jackson, Queensland, a town in the Maranoa Region
* Jackson North, Queensland, a locality in the Maranoa Region
* Jackson South, Queensland, a locality in the Maranoa Region
* Jackson oil field in Durham, ...
and
Festus
Festus may refer to:
People Ancient world
*Porcius Festus, Roman governor of Judea from approximately 58 to 62 AD
*Sextus Pompeius Festus (later 2nd century), Roman grammarian
*Festus (died 305), martyr along with Proculus of Pozzuoli
*Festus (h ...
, replacing much of
Route 25; the old alignment is now
Route 72 and
US 67.
Iowa
Prior to 1958, US 61 followed the route now known as
Iowa 22 between
Davenport
Davenport may refer to:
Places Australia
*Davenport, Northern Territory, a locality
*Hundred of Davenport, cadastral unit in South Australia
**Davenport, South Australia, suburb of Port Augusta
**District Council of Davenport, former local govern ...
and
Muscatine. US 61 was then rerouted onto the old Iowa 22 which passed through
Blue Grass.
Starting in the early 1980s, US 61 between Davenport and
Dubuque
Dubuque (, ) is a city in Dubuque County, Iowa, United States, and its county seat. The population was 59,667 at the 2020 United States census. The city lies along the Mississippi River at the junction of Iowa, Illinois, and Wisconsin, a region ...
was rebuilt as a four-lane highway. The first link, a stretch between Davenport and
De Witt, was finished in 1982; a bypass around De Witt, which overlapped US 30, was in use starting in November 1975. Subsequent links were completed to
Maquoketa (in 1996) and finally to Dubuque in 1999. When the final link was completed, Dubuque finally had a direct four-lane connection to
Interstate 80
Interstate 80 (I-80) is an east–west transcontinental freeway that crosses the United States from San Francisco, California, to Teaneck, New Jersey, in the New York metropolitan area. The highway was designated in 1956 as one of the ori ...
.
In 1983, two multi-lane one-way routes were designated through Davenport starting at the northern city limits. Southbound traffic used the newly constructed Welcome Way until it merges with Harrison Street just north of 35th Street; northbound traffic use Brady Street (which had been a two-way, four-lane street). Other two-way stretches of the highway through Davenport have four (or more) lanes. In 2010, in large part due to a railroad bridge with a low clearance in downtown Davenport, US 61 through Davenport was moved to Interstates 80 and 280, with signing taking place in the fall of 2011; the highway through Davenport was redesignated as "US 61 Business."
A bypass around
Muscatine was opened in 1984, but other changes on the stretch south of Davenport would not happen for another decade. The changes came as follows:
*1996 – The completion of a , four-lane stretch between Blue Grass and
I-280
Interstate 280 may refer to multiple highways, all of which are or were related to Interstate 80:
* Interstate 280 (California), a north–south freeway running from San Jose to San Francisco
* Interstate 280 (Iowa–Illinois), part of the beltwa ...
in Davenport.
*November 2000 — A stretch between Blue Grass and the Muscatine bypass was opened.
*May 2001 — A bypass around Blue Grass.
*July 2002 — A stretch, from the Muscatine bypass to the southern tip of
Muscatine County, just north of
Letts.
*December 2017 — A new stretch of divided highway from the Muscatine-
Louisa county line to near
Grandview was opened to traffic, including an interchange with
Iowa 92
Iowa Highway 92 (Iowa 92) is a state highway that runs from east to west across the state of Iowa. Iowa 92 is long and is part of a continuous four-state "Highway 92" which begins in Torrington, Wyoming, goes through Nebraska and Iowa an ...
and County Highway G48.
The final stretch completed a continuous multi-laned link between
Dickeyville,
Wisconsin
Wisconsin ( ) is a U.S. state, state in the Great Lakes region, Great Lakes region of the Upper Midwest of the United States. It borders Minnesota to the west, Iowa to the southwest, Illinois to the south, Lake Michigan to the east, Michig ...
south to Grandview.
Illinois
Prior to the construction of the
Dubuque-Wisconsin Bridge, US 61 passed through a short distance through
Jo Daviess County between Dubuque and Wisconsin, concurrent with
US 151. Now both highways cross the Mississippi on the Dubuque-Wisconsin Bridge, which directly connects Wisconsin and Iowa, with neither US 61 nor US 151 passing through
Illinois
Illinois ( ) is a U.S. state, state in the Midwestern United States, Midwestern United States. It borders on Lake Michigan to its northeast, the Mississippi River to its west, and the Wabash River, Wabash and Ohio River, Ohio rivers to its ...
.
Minnesota
US 61 follows the west bank of the
Mississippi River
The Mississippi River is the main stem, primary river of the largest drainage basin in the United States. It is the second-longest river in the United States, behind only the Missouri River, Missouri. From its traditional source of Lake Ita ...
from the Wisconsin border through
Hastings
Hastings ( ) is a seaside town and Borough status in the United Kingdom, borough in East Sussex on the south coast of England,
east of Lewes and south east of London. The town gives its name to the Battle of Hastings, which took place to th ...
where it crosses the river and proceeds to
St. Paul
Paul, also named Saul of Tarsus, commonly known as Paul the Apostle and Saint Paul, was a Christian apostle ( AD) who spread the teachings of Jesus in the first-century world. For his contributions towards the New Testament, he is generally ...
. North from the city of Wyoming, Old US 61 continues as "Forest Boulevard" in
Chisago County, and then as "County 61" through
Pine
A pine is any conifer tree or shrub in the genus ''Pinus'' () of the family Pinaceae. ''Pinus'' is the sole genus in the subfamily Pinoideae.
''World Flora Online'' accepts 134 species-rank taxa (119 species and 15 nothospecies) of pines as cu ...
and
Carlton counties before ending at
MN 210. The original US 61 had continued east along MN 210 to
Carlton and north on present-day
MN 45 to
Scanlon Scanlon is an Anglicized form of the Irish Gaelic name Ó Scannláin, meaning "descendant of Scannlán", and is a variant of the name Ó Scannail derived from the Irish word ''scannal'', originally meaning quarrel, contention, fight, and later, scan ...
before turning northeast on what is now "County 61 / Old US 61" through
Esko.
I-35
Interstate 35 (I-35) is a major Interstate Highway in the central United States. As with most primary Interstates that end in a five, it is a major cross-country, north–south route. It stretches from Laredo, Texas, near the Mexico–Uni ...
has replaced the original US 61 descending Thompson Hill into
West Duluth
West Duluth refers to an official neighborhood district in the west–central part of Duluth, Minnesota, United States.
Grand Avenue, Central Avenue, Cody Street, and Interstate Highway 35 are four of the main routes in West Duluth. Other main ...
, from which most of the city of
Duluth
Duluth ( ) is a Port, port city in the U.S. state of Minnesota and the county seat of St. Louis County, Minnesota, St. Louis County. Located on Lake Superior in Minnesota's Arrowhead Region, the city is a hub for cargo shipping. The population ...
can be seen entering town, including the
Aerial Lift Bridge
The Aerial Lift Bridge, earlier known as the Aerial Bridge or Aerial Ferry Bridge, is a landmark in the port city of Duluth, Minnesota. The span began life in 1905 as the United States' first transporter bridge: Only one other was ever construc ...
and the waterfront. The original US 61 in the city of Duluth had previously followed Cody Street, Grand Avenue, Superior Street, Second Street, Third Street, and London Road.
The original US 61 between
Duluth
Duluth ( ) is a Port, port city in the U.S. state of Minnesota and the county seat of St. Louis County, Minnesota, St. Louis County. Located on Lake Superior in Minnesota's Arrowhead Region, the city is a hub for cargo shipping. The population ...
and Canada was designated as
MN 61 in 1991. MN 61, part of the ''Lake Superior Circle Tour'' route, follows the
North Shore of
Lake Superior
Lake Superior is the largest freshwater lake in the world by surface areaThe Caspian Sea is the largest lake, but is saline, not freshwater. Lake Michigan–Huron has a larger combined surface area than Superior, but is normally considered tw ...
, where it becomes Ontario
Highway 61 upon entering Canada. Highway 61 continues to the city of
Thunder Bay
Thunder Bay is a city in and the seat of Thunder Bay District, Ontario, Canada. It is the most populous municipality in Northwestern Ontario and the second most populous (after Greater Sudbury) municipality in Northern Ontario. Its population i ...
, where it ends at an intersection with the
Trans-Canada Highway
The Trans-Canada Highway (Canadian French, French: ; abbreviated as the TCH or T-Can) is a transcontinental federal–provincial highway system that travels through all ten provinces of Canada, from the Pacific Ocean on the west coast to the A ...
.
Starting in 2012
Chisago,
Carlton and
Pine
A pine is any conifer tree or shrub in the genus ''Pinus'' () of the family Pinaceae. ''Pinus'' is the sole genus in the subfamily Pinoideae.
''World Flora Online'' accepts 134 species-rank taxa (119 species and 15 nothospecies) of pines as cu ...
Counties began placing "OLD US 61" markers along the former routing of US 61 through their respective counties.
Major intersections
;Louisiana
: in
New Orleans
New Orleans (commonly known as NOLA or The Big Easy among other nicknames) is a Consolidated city-county, consolidated city-parish located along the Mississippi River in the U.S. state of Louisiana. With a population of 383,997 at the 2020 ...
: in New Orleans
: in
St. Rose
: in
LaPlace
Pierre-Simon, Marquis de Laplace (; ; 23 March 1749 – 5 March 1827) was a French polymath, a scholar whose work has been instrumental in the fields of physics, astronomy, mathematics, engineering, statistics, and philosophy. He summariz ...
: southeast of
Sorrento
Sorrento ( , ; ; ) is a City status in Italy, city and overlooking the Gulf of Naples, Bay of Naples in Southern Italy. A popular tourist destination, Sorrento is located on the Sorrentine Peninsula at the southern terminus of a main branch o ...
: in
Baton Rouge
Baton Rouge ( ; , ) is the List of capitals in the United States, capital city of the U.S. state of Louisiana. It had a population of 227,470 at the 2020 United States census, making it List of municipalities in Louisiana, Louisiana's second-m ...
: in Baton Rouge. The highways travel concurrently through the city.
: in Baton Rouge
: in Baton Rouge
;Mississippi
: in
Natchez Natchez may refer to:
Places
* Natchez, Alabama, United States
* Natchez, Indiana, United States
* Natchez, Louisiana, United States
* Natchez, Mississippi, a city in southwestern Mississippi, United States
** Natchez slave market, Mississippi
* ...
. US 61/US 84 travels concurrently to west-southwest of
Washington
Washington most commonly refers to:
* George Washington (1732–1799), the first president of the United States
* Washington (state), a state in the Pacific Northwest of the United States
* Washington, D.C., the capital of the United States
** A ...
.
: west-southwest of Washington
: in
Vicksburg. The highways travel concurrently through the city.
: east of
Leland. US 61/US 278 travels concurrently to
Clarksdale.
: near
Merigold. I-69/US 61 will travel concurrently to near
Tunica.
: in Clarksdale. The highways travel concurrently to west-northwest of
Rich
Rich may refer to:
Common uses
* Rich, an entity possessing wealth
* Rich, an intense taste, flavor, color, sound, texture, or feeling
**Rich (wine), a descriptor in wine tasting
Places United States
* Rich, Mississippi, an unincorporated c ...
.
;Tennessee
: in
Memphis
Memphis most commonly refers to:
* Memphis, Egypt, a former capital of ancient Egypt
* Memphis, Tennessee, a major American city
Memphis may also refer to:
Places United States
* Memphis, Alabama
* Memphis, Florida
* Memphis, Indiana
* Mem ...
: in Memphis. US 61/US 64 travels concurrently to
Marion, Arkansas
Marion is a city in and the county seat of Crittenden County, Arkansas, United States. The population was 12,345 at the 2010 census, a 38.7% increase since 2000. The city is part of the Memphis metropolitan area. It is the second largest city ...
. US 61/US 70/US 79 travels concurrently to
West Memphis, Arkansas
West Memphis is the largest city in Crittenden County, Arkansas, United States. The population was 24,520 at the 2020 United States census, 2020 census, ranking it as the state's 20th largest city. It is part of the Memphis metropolitan area, an ...
.
: in Memphis. The highways travel concurrently to
Turrell.
;Arkansas
: in West Memphis. The highways travel concurrently through the city.
: in West Memphis.
: in
Turrell
: in
Blytheville
: in Blytheville
;Missouri
: east of
Steele. The highways travel concurrently to
Portageville.
: in
Hayti
: southwest of
Howardville. The highways travel concurrently to
Sikeston
Sikeston () is a city located both in southern Scott County, Missouri, Scott County and northern New Madrid County, Missouri, New Madrid County, in the state of Missouri, United States. It is situated just north of the "Missouri Bootheel", althou ...
.
: in
New Madrid
: north of New Madrid
: in Sikeston
: in
Scott City. The highways travel concurrently to
Cape Girardeau
Cape Girardeau ( , ; colloquially referred to as "Cape") is a city in Cape Girardeau and Scott Counties in the U.S. state of Missouri. At the 2020 census, the population was 39,540, making it the 17th-largest in the state. The city is one o ...
.
: in Cape Girardeau
: north-northeast of
Jackson
Jackson may refer to:
Places Australia
* Jackson, Queensland, a town in the Maranoa Region
* Jackson North, Queensland, a locality in the Maranoa Region
* Jackson South, Queensland, a locality in the Maranoa Region
* Jackson oil field in Durham, ...
: south-southeast of
Festus
Festus may refer to:
People Ancient world
*Porcius Festus, Roman governor of Judea from approximately 58 to 62 AD
*Sextus Pompeius Festus (later 2nd century), Roman grammarian
*Festus (died 305), martyr along with Proculus of Pozzuoli
*Festus (h ...
: in
Crystal City. The highways travel concurrently to the
Frontenac–
Ladue
Ladue is an inner-ring suburb of St. Louis, located in St. Louis County, Missouri. As of the 2020 census, the city had a population of 8,989.
Ladue has the highest median household income of any city in Missouri with a population over 1,000.
Ge ...
city line.
: in
Mehlville
: in Mehlville. The highways travel concurrently to the
Sunset Hills–
Kirkwood city line.
: on the
Concord
Concord may refer to:
Meaning "agreement"
* Harmony, in music
* Agreement (linguistics), a change in the form of a word depending on grammatical features of other words
Arts and media
* ''Concord'' (video game), a defunct 2024 first-person sh ...
–Mehlville–
Green Park
The Green Park, one of the Royal Parks of London, is in the City of Westminster, Central London. Green Park is to the north of the gardens and semi-circular forecourt of Buckingham Palace, across Constitution Hill road. The park is in the m ...
line
: on the Sunset Hills–Kirkwood city line
: on the Frontenac–Ladue city line. The highways travel concurrently to
Wentzville
Wentzville is an exurb of St. Louis that is located in western St. Charles County, Missouri, United States. As of the 2023 U.S. Census Bureau estimates, the city had a total population of 47,497, making it the 15th largest city in Missouri. Wentz ...
.
: in
Town and Country
: in Wentzville
: north of
Bowling Green
A bowling green is a finely laid, close-mown and rolled stretch of turf for playing the game of bowls.
Before 1830, when Edwin Beard Budding of Thrupp, near Stroud, UK, invented the lawnmower, lawns were often kept cropped by grazing sheep ...
: in
Hannibal
Hannibal (; ; 247 – between 183 and 181 BC) was a Punic people, Carthaginian general and statesman who commanded the forces of Ancient Carthage, Carthage in their battle against the Roman Republic during the Second Punic War.
Hannibal's fat ...
: south of
Palmyra
Palmyra ( ; Palmyrene dialect, Palmyrene: (), romanized: ''Tadmor''; ) is an ancient city in central Syria. It is located in the eastern part of the Levant, and archaeological finds date back to the Neolithic period, and documents first menti ...
. The highways travel concurrently to
Taylor
Taylor, Taylors or Taylor's may refer to:
People
* Taylor (surname)
** List of people with surname Taylor
* Taylor (given name), including Tayla and Taylah
* Taylor sept, a branch of Scottish clan Cameron
* Justice Taylor (disambiguation)
...
.
: west-northwest of
Alexandria
Alexandria ( ; ) is the List of cities and towns in Egypt#Largest cities, second largest city in Egypt and the List of coastal settlements of the Mediterranean Sea, largest city on the Mediterranean coast. It lies at the western edge of the Nile ...
. The highways travel concurrently to
Keokuk, Iowa
Keokuk is a city in and a county seat of Lee County, Iowa, United States. It is Iowa's southernmost city. The population was 9,900 at the time of the United States Census, 2020, 2020 census. The city is named after the Sauk people, Sauk chief K ...
.
;Iowa
: in Keokuk. The highways travel concurrently to southwest of
Montrose.
: in
Burlington
: in
Davenport
Davenport may refer to:
Places Australia
*Davenport, Northern Territory, a locality
*Hundred of Davenport, cadastral unit in South Australia
**Davenport, South Australia, suburb of Port Augusta
**District Council of Davenport, former local govern ...
. The highways travel concurrently through the city.
: in Davenport. The highways travel concurrently through the city.
: in Davenport. I-80/US 61 travels concurrently through the city.
: southwest of
DeWitt. The highways travel concurrently to DeWitt.
: south of
Dubuque
Dubuque (, ) is a city in Dubuque County, Iowa, United States, and its county seat. The population was 59,667 at the 2020 United States census. The city lies along the Mississippi River at the junction of Iowa, Illinois, and Wisconsin, a region ...
. The highways travel concurrently to south of
Dickeyville, Wisconsin
Dickeyville is a village in Grant County, Wisconsin, United States. The population was 1,015 at the 2020 census.
The Dickeyville Grotto is located in the heart of the village.
History
Dickeyville was not formally platted. The village was nam ...
.
: in
Dubuque County
Dubuque County is a County (United States), county located in the U.S. state of Iowa. As of the 2020 United States census, 2020 census, the population was 99,266, making it the eighth-most populous county in Iowa. The county seat is Dubuque, Io ...
. The highways travel concurrently for a short distance south of Dubuque .
;Wisconsin
: in
Fennimore. The highways travel concurrently through the city.
: in
Readstown
Readstown is a village in Vernon County, Wisconsin, Vernon County, Wisconsin, United States. The population was 376 at the 2020 United States census, 2020 census.
Geography
Readstown is located at (43.448544, -90.760708).
According to the Uni ...
. The highways travel concurrently to
Winona, Minnesota
Winona ( ) is a city in and the county seat of Winona County, Minnesota, United States. Located in bluff country on the Mississippi River, its most noticeable physical landmark is Sugar Loaf (Winona, Minnesota), Sugar Loaf. The population was 2 ...
.
: in
La Crosse, Wisconsin
La Crosse ( ) is a city in La Crosse County, Wisconsin, United States, and its county seat. Positioned alongside the Mississippi River, La Crosse is the largest city on Wisconsin's western border. La Crosse's population was 52,680 as of the 202 ...

;Minnesota
: north of
La Crescent. The highways travel concurrently to
Dakota
Dakota may refer to:
* Dakota people, a sub-tribe of the Sioux
** Dakota language, their language
Dakota may also refer to:
Places United States
* Dakota, Georgia, an unincorporated community
* Dakota, Illinois, a town
* Dakota, Minnesota ...
.
: in
Lake City
Lake City may refer to:
Places
*Lake City, Arkansas
* Lake City, California (disambiguation)
*Lake City, Modoc County, California
* Lake City, Nevada County, California
*Lake City, Colorado
*Lake City, Florida
* Lake City, Georgia
* Lake City, I ...
. The highways travel concurrently to
Red Wing.
: north of
Hastings
Hastings ( ) is a seaside town and Borough status in the United Kingdom, borough in East Sussex on the south coast of England,
east of Lewes and south east of London. The town gives its name to the Battle of Hastings, which took place to th ...
. The highways travel concurrently to
Saint Paul
Paul, also named Saul of Tarsus, commonly known as Paul the Apostle and Saint Paul, was a Christian apostle ( AD) who spread the teachings of Jesus in the first-century world. For his contributions towards the New Testament, he is generally ...
.
: in
Newport
Newport most commonly refers to:
*Newport, Wales
*Newport, Rhode Island, US
Newport or New Port may also refer to:
Places Asia
*Newport City, Metro Manila, a Philippine district in Pasay
* Newport (Vietnam), a United States Army and Army of t ...
: in Saint Paul. The highways travel concurrently through the city.
: in Saint Paul
: in
Vadnais Heights
Vadnais Heights ( ) is a city in Ramsey County, Minnesota, United States. The population was 12,912 at the 2020 census.
Geography
According to the United States Census Bureau, the city has a total area of , of which is land and is water. It ...
: in
Forest Lake
: in
Wyoming
Wyoming ( ) is a landlocked U.S. state, state in the Mountain states, Mountain West subregion of the Western United States, Western United States. It borders Montana to the north and northwest, South Dakota and Nebraska to the east, Idaho t ...
See also
*
Avenue of the Saints
The Avenue of the Saints is a highway in the Midwestern United States that connects St. Louis, Missouri, and St. Paul, Minnesota.
__TOC__ Route description
Missouri
The southern end of the Avenue of the Saints is at exit 28A on Interstate ...
* ''
Highway 61'', a 1991 film
Special routes
*
Special routes of U.S. Route 61
*
U.S. Route 61 Business (Keokuk, Iowa)
*
U.S. Route 61 Business (Muscatine, Iowa)
*
U.S. Route 61 Business (Davenport, Iowa)
*
U.S. Route 61 Business (St. Francisville, Louisiana)
*
U.S. Route 61 Business (Vicksburg, Mississippi)
*
U.S. Route 61 Business (Natchez, Mississippi)
Related routes
*
U.S. Route 161
References
Notes
Sources
Endpoints of US highwaysMN Highway Endings. Accessed August 27, 2004.
Unofficial Minnesota Highways Page. Accessed August 27, 2004.
The Iowa Highways Pageby Scott Stanton
External links
The Blues Highway Association at The Delta Center for Culture and Learning at Delta State University
Missouri Department of Natural Resources
Ste. Genevieve TourismLa Maison de Guibourd Historical House
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Mississippi Blues Trail