Tulathromycin, sold under the brand name Draxxin among others, is a

macrolide antibiotic Macrolides are a class of mostly natural products with a large macrocyclic lactone ring to which one or more deoxy sugars, usually cladinose and desosamine, may be attached. Macrolides belong to the polyketide class of natural products. Some ...

used to treat

bovine respiratory disease Bovine respiratory disease (BRD) is the most common and economically devastating infectious disease affecting beef cattle in the world. It is a complex, bacterial or viral infection that causes pneumonia in calves which can be fatal. It also aff ...

in cattle and swine respiratory disease in pigs.

Medical uses

Tulathromycin is indicated for: Cattle: Treatment and metaphylaxis of bovine respiratory disease (BRD) associated with ''

Mannheimia haemolytica ''Mannheimia haemolytica'' is a species of Gram-negative bacteria belonging to the family Pasteurellaceae. It is a facultatively anaerobic, non-spore-forming, and non-motile coccobacillus. ''M. haemolytica'' is a primary bacterial pathogen implic ...

'', ''

Pasteurella multocida ''Pasteurella multocida'' is a Gram-negative, nonmotile, penicillin-sensitive coccobacillus of the family Pasteurellaceae. Strains of the species are currently classified into five serogroups (A, B, D, E, F) based on capsular composition and 16 ...

'', ''

Histophilus somni ''Histophilus somni'' is a non-motile, gram-negative, rod or coccobacillus shaped, facultative anaerobe bacterial species belonging to the family Pasteurellaceae. Prior to 2003, it was thought ''Haemophilus somnus'', ''Histophilus ovis'', and ''H ...

'', and ''

Mycoplasma bovis ''Mycoplasma bovis'' is one of 126 species of genus ''Mycoplasma''. It is the smallest living cell and anaerobic organism in nature. It does not contain any cell wall and is therefore resistant to penicillin and other β-lactam antibiotic, beta ...

'' sensitive to tulathromycin. Treatment of infectious bovine keratoconjunctivitis (IBK) associated with ''

Moraxella bovis ''Moraxella bovis'' is a Gram-negative, aerobic, oxidase-positive rod-shaped bacterium. It is the cause of infectious bovine keratoconjunctivitis, a contagious ocular disease of cattle,George M. Garrity: ''Bergey's Manual of Systematic Bacteriol ...

'' sensitive to tulathromycin. Pigs: Treatment and metaphylaxis of swine respiratory disease (SRD) associated with ''

Actinobacillus pleuropneumoniae ''Actinobacillus pleuropneumoniae'' (previously ''Haemophilus pleuropneumoniae''), is a Gram-negative, facultative anaerobic, respiratory pathogen found in pigs. It was first reported in 1957, and was formally declared to be the causative agent o ...

'', ''

'', '' Mycoplasma hyopneumoniae'', '' Haemophilus parasuis'', and ''

Bordetella bronchiseptica ''Bordetella bronchiseptica'' is a small, gram-negative, rod-shaped bacterium of the genus ''Bordetella''. It can cause infectious bronchitis in dogs and other animals, but rarely infects humans. Closely related to '' B. pertussis''—the obl ...

'' sensitive to tulathromycin. Sheep: Treatment of the early stages of infectious pododermatitis (foot rot) associated with virulent ''Dichelobacter nodosus'' requiring systemic treatment.

Society and culture

Legal status

Tulathromycin (brand name Draxxin) was approved for medical use in the European Union in November 2003. Text was copied from this source which is copyright European Medicines Agency. Reproduction is authorized provided the source is acknowledged. Tulathromycin (brand names Tulissin and Tulaven) was approved for medical use in the European Union in April 2020. In July 2020, the

Committee for Medicinal Products for Veterinary Use The Committee for Veterinary Medicinal Products (CVMP) is the European Medicines Agency's committee responsible for elaborating the agency's opinions on all issues regarding veterinary medicines. Text was copied from this source which is copyrigh ...

(CVMP) adopted positive opinions, recommending the granting of marketing authorizations for the veterinary medicinal products Increxxa and Tulinovet solutions for injection for cattle, pigs and sheep. Text was copied from this source which is copyright European Medicines Agency. Reproduction is authorized provided the source is acknowledged. Text was copied from this source which is copyright European Medicines Agency. Reproduction is authorized provided the source is acknowledged. The applicant for Increxxa is Elanco GmbH. The applicant for Tulinovet is VMD N.V. Increxxa was approved for veterinary use in the European Union in September 2020.

Brand names

It is marketed by

Zoetis Zoetis Inc. (/zō-EH-tis/) is an American drug company, the world's largest producer of medicine and vaccinations for pets and livestock. The company was a subsidiary of Pfizer, the world's largest drug maker, but with Pfizer's spinoff of its ...

under the brand name Draxxin. It is marketed by Bimeda Inc. under the brand name Macrosyn, and by Merck & Co. under the brand name Arovyn. It is also sold under the brand name Increxxa. by

Elanco Elanco Animal Health Incorporated is an American pharmaceutical company which produces medicines and vaccinations for pets and livestock. Until 2019, the company was a subsidiary of Eli Lilly and Company, before being divested. It is the third-l ...

References

{{GlycopeptideAntiBio Macrolide antibiotics Drugs developed by Pfizer Drugs developed by Merck & Co. Veterinary drugs