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Tropatepine (brand name Lepticur) is an
anticholinergic
Anticholinergics (anticholinergic agents) are substances that block the action of the acetylcholine (ACh) neurotransmitter at synapses in the central nervous system, central and peripheral nervous system.
These agents inhibit the parasympatheti ...
used as an antiparkinsonian
In the management of Parkinson's disease, due to the chronic nature of Parkinson's disease (PD), a broad-based program is needed that includes patient and family education, support-group services, general wellness maintenance, exercise, and nutr ...
agent.
Synthesis
Tropatepine can be synthesized from 3-chlorotropane (1).DE1952206 idem J Boissier, R Ratouis, (1973 to Ind Pour La Fab Antibiotiques). A Grignard reaction between 3-chlorotropane and dibenzo 'b,e''hiepin-11(6''H'')-one (2) followed bydehydration
In physiology, dehydration is a lack of total body water that disrupts metabolic processes. It occurs when free water loss exceeds intake, often resulting from excessive sweating, health conditions, or inadequate consumption of water. Mild deh ...
to the olefin produces tropatepine (3).
See also
*Muscarinic antagonist
A muscarinic acetylcholine receptor antagonist, also simply known as a muscarinic antagonist or as an antimuscarinic agent, is a type of anticholinergic drug that blocks the activity of the muscarinic acetylcholine receptors (mAChRs). The muscarin ...
References
{{Tricyclics Dibenzothiepines M1 receptor antagonists M2 receptor antagonists M3 receptor antagonists M4 receptor antagonists M5 receptor antagonists Tropanes