Tribendimidine is a broad-spectrum

anthelmintic Anthelmintics or antihelminthics are a group of antiparasitic drugs that expel parasitic worms (helminths) and other internal parasites from the body by either stunning or killing them without causing significant damage to the host. They may also ...

agent developed in

China China, officially the People's Republic of China (PRC), is a country in East Asia. With population of China, a population exceeding 1.4 billion, it is the list of countries by population (United Nations), second-most populous country after ...

, at the National Institute of Parasitic Diseases in

Shanghai Shanghai, Shanghainese: , Standard Chinese pronunciation: is a direct-administered municipality and the most populous urban area in China. The city is located on the Chinese shoreline on the southern estuary of the Yangtze River, with the ...

. It is a derivative of amidantel.Free full text
In

clinical trial Clinical trials are prospective biomedical or behavioral research studies on human subject research, human participants designed to answer specific questions about biomedical or behavioral interventions, including new treatments (such as novel v ...

s, it was highly effective in treating ankylostomiasis,

ascariasis Ascariasis is a disease caused by the parasitic roundworm ''Ascaris lumbricoides''. Infections have no symptoms in more than 85% of cases, especially if the number of worms is small. Symptoms increase with the number of worms present and may in ...

and

enterobiasis Pinworm infection (threadworm infection in the UK), also known as enterobiasis, is a human parasitic disease caused by the pinworm (parasite), pinworm, ''Enterobius vermicularis''. The most common symptom is pruritus ani, or itching in the Human ...

. It is also effective against

clonorchiasis Clonorchiasis is an infectious disease caused by the Chinese liver fluke (''Clonorchis sinensis'') and two related species. Clonorchiasis is a known risk factor for the development of cholangiocarcinoma, a neoplasm of the biliary system. Symp ...

. However, animal studies suggest it is ineffective in treating ''

Schistosoma mansoni A paired couple of ''Schistosoma mansoni''. ''Schistosoma mansoni'' is a water-borne parasite of humans, and belongs to the group of blood flukes (''Schistosoma''). The adult lives in the blood vessels ( mesenteric veins) near the human inte ...

'' or ''

Fasciola hepatica ''Fasciola hepatica'', also known as the common liver fluke or sheep liver fluke, is a parasitism, parasitic trematode (fluke (flatworm), fluke or flatworm, a type of helminth) of the class (biology), class Trematoda, phylum Platyhelminthes. It ...

'' disease. The drug has also performed well in trials against

opisthorchiasis Opisthorchiasis is a parasitic disease caused by certain species of genus '' Opisthorchis'' (specifically, '' Opisthorchis viverrini'' and '' Opisthorchis felineus''). Chronic infection may lead to cholangiocarcinoma, a cancer of the bile ducts. M ...

, curing about 70% of cases. Tribendimidine is manufactured by Shandong Xinhua Pharmaceutical Company Limited in

Zibo Zibo () is a prefecture-level city in central Shandong province of China, province, China. It borders the provincial capital Jinan to the west, Tai'an to the southwest, Linyi to the south, Weifang to the east, Dongying to the northeast, and Bi ...

Shandong Shandong is a coastal Provinces of China, province in East China. Shandong has played a major role in Chinese history since the beginning of Chinese civilization along the lower reaches of the Yellow River. It has served as a pivotal cultural ...

. It was approved by the China Food and Drug Administration in 2007.

References

Anthelmintics Amidines Imines Nicotinic agonists {{antimicrobial-stub