virology Virology is the scientific study of biological viruses. It is a subfield of microbiology that focuses on their detection, structure, classification and evolution, their methods of infection and exploitation of host cells for reproduction, th ...

, the tombusvirus internal replication element (IRE) is a segment of

RNA Ribonucleic acid (RNA) is a polymeric molecule essential in various biological roles in coding, decoding, regulation and expression of genes. RNA and deoxyribonucleic acid ( DNA) are nucleic acids. Along with lipids, proteins, and carbohydra ...

located within the region coding for

p92 polymerase P9 or P-9 may refer to: * Planet Nine, a hypothetical new planet in the far outer solar system * Boeing XP-9, a prototype fighter aircraft from the 1930s * Heckler & Koch P9, a semi-automatic pistol * Springfield Armory P9, a semi-automatic pistol ...

. This element is essential for

viral replication Viral replication is the formation of biological viruses during the infection process in the target host cells. Viruses must first get into the cell before viral replication can occur. Through the generation of abundant copies of its genome a ...

; specifically, it is thought to be required at an early stage of replication, such as template recruitment and/or replicase complex assembly. Other

non-coding RNA A non-coding RNA (ncRNA) is a functional RNA molecule that is not translated into a protein. The DNA sequence from which a functional non-coding RNA is transcribed is often called an RNA gene. Abundant and functionally important types of non- ...

structures in Tombusvirus include the 3' UTR region IV and

5' UTR The 5′ untranslated region (also known as 5′ UTR, leader sequence, transcript leader, or leader RNA) is the region of a messenger RNA (mRNA) that is directly upstream from the initiation codon. This region is important for the regulation o ...

References

External links

* Cis-regulatory RNA elements {{molecular-cell-biology-stub