Tom Jefferson is a British epidemiologist, based in

Rome Rome (Italian language, Italian and , ) is the capital city and most populated (municipality) of Italy. It is also the administrative centre of the Lazio Regions of Italy, region and of the Metropolitan City of Rome. A special named with 2, ...

, Italy, who works for the

Cochrane Collaboration Cochrane is a British international charitable organisation formed to synthesize medical research findings to facilitate evidence-based choices about health interventions involving health professionals, patients and policy makers. It includes ...

. Jefferson is an author and editor of the Cochrane Collaboration's acute respiratory infections group, as well as part of four other Cochrane groups. He was also an advisor to the Italian National Agency for Regional Health Services. In 1999, Jefferson was one of the founding members of the Brighton Collaboration along with Harald Heijbel, Ulrich Heininger, Robert Chen, and Elisabeth Loupi. He has worked on Cochrane reviews examining the effectiveness of the anti-viral

oseltamivir Oseltamivir, sold under the brand name Tamiflu among others, is an antiviral medication used to treat and prevent influenza A and influenza B, viruses that cause the flu. Many medical organizations recommend it in people who have complicati ...

and the

influenza vaccine Influenza vaccines, colloquially known as flu shots or the flu jab, are vaccines that protect against infection by influenza viruses. New versions of the vaccines are developed twice a year, as the influenza virus rapidly changes. While their ...

Notable work

In 2009, Jefferson was hired by the governments of Britain and Australia to update a

systematic review A systematic review is a scholarly synthesis of the evidence on a clearly presented topic using critical methods to identify, define and assess research on the topic. A systematic review extracts and interprets data from published studies on ...

. Initially he had a great deal of trouble getting results of the original trials. Previous researchers had published trials without seeing the underlying data and it appeared that some of the published papers used

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. As the company,

Roche F. Hoffmann-La Roche AG, commonly known as Roche (), is a Switzerland, Swiss multinational corporation, multinational holding healthcare company that operates worldwide under two divisions: Pharmaceuticals and Diagnostics. Its holding company, ...

, that did the trials refused to provide data for independent analysis, their conclusions in 2009 were that benefits could not be shown. In 2011, Jefferson's team was provided 22,000 pages of data from the

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and Roche eventually provided 3,000 pages of data. In 2012, Jefferson was the lead author of another Cochrane review of this data which concluded that oseltamivir did not reduce the number of hospitalizations caused by influenza. Jefferson said that this review also found no evidence that oseltamivir stopped complications from the disease. The review is considered a landmark and is posted on the James Lind Library website which illustrates the development of fair tests of healthcare. Jefferson is the lead author of a suite of Cochrane reviews on antivirals, influenza vaccines and physical interventions to interrupt the spread of acute respiratory infections. The reviews are either kept up to date or stabilized, meaning no new evidence is likely to become available. The earliest review date from 1996 and the latest is the fourth update of the physical interventions review (2020, currently undergoing its fifth update). Jefferson has also reviewed the evidence of effects of editorial and grant giving peer review and co-written several reviews and topics on this subject. Currently he is assessing the evidence of transmission of SARS-CoV-2 and other respiratory pathogens and is co-editor of the

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publication website ''Trust The Evidence''. In his latest publication Jefferson and his fellows have concluded the presence of replication-competent SARS-CoV-2 on

fomites A fomite () or fomes () is any inanimate object that, when contaminated with or exposed to infectious agents (such as pathogenic bacteria, viruses or fungi), can transfer disease to a new host. Transfer of pathogens by fomites A fomite is any ...

, using evidence from viral culture studies. A list of his publications and contributions is available on his personal website.

Publications

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References

External links

Official website
{{DEFAULTSORT:Jefferson, Tom British epidemiologists 20th-century births Year of birth missing (living people) Living people Cochrane Collaboration people