Thomas C. Peebles
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Thomas Chalmers Peebles (June 5, 1921 – July 8, 2010) was an American
physician A physician, medical practitioner (British English), medical doctor, or simply doctor is a health professional who practices medicine, which is concerned with promoting, maintaining or restoring health through the Medical education, study, Med ...
who made multiple discoveries in the field of medicine, including being the first to isolate the
measles Measles (probably from Middle Dutch or Middle High German ''masel(e)'', meaning "blemish, blood blister") is a highly contagious, Vaccine-preventable diseases, vaccine-preventable infectious disease caused by Measles morbillivirus, measles v ...
virus A virus is a submicroscopic infectious agent that replicates only inside the living Cell (biology), cells of an organism. Viruses infect all life forms, from animals and plants to microorganisms, including bacteria and archaea. Viruses are ...
. Peebles also did research that led to the development of fluoridated vitamins and did research that showed that
tetanus vaccine Tetanus vaccine, also known as tetanus toxoid (TT), is a toxoid vaccine used to prevent tetanus. During childhood, five doses are recommended, with a sixth given during adolescence. After three doses, almost everyone is initially immune, but ...
could be given once every ten years, rather than annually as had been the widespread practice.


Early life

Peebles was born on June 5, 1921, in
Newton, Massachusetts Newton is a city in Middlesex County, Massachusetts, United States. It is located roughly west of Downtown Boston, and comprises a patchwork of thirteen villages. The city borders Boston to the northeast and southeast (via the neighborhoods of ...
, and graduated from
Harvard University Harvard University is a Private university, private Ivy League research university in Cambridge, Massachusetts, United States. Founded in 1636 and named for its first benefactor, the History of the Puritans in North America, Puritan clergyma ...
in 1942 with a major in
French language French ( or ) is a Romance languages, Romance language of the Indo-European languages, Indo-European family. Like all other Romance languages, it descended from the Vulgar Latin of the Roman Empire. French evolved from Northern Old Gallo-R ...
. He enlisted in the
United States Navy The United States Navy (USN) is the naval warfare, maritime military branch, service branch of the United States Department of Defense. It is the world's most powerful navy with the largest Displacement (ship), displacement, at 4.5 millio ...
and served as a bomber pilot in the Pacific Theater of Operations, earning the Distinguished Flying Cross. He had been recruited by
KLM KLM Royal Dutch Airlines, or simply KLM (an abbreviation for their official name Koninklijke Luchtvaart Maatschappij N.V. , ),
as a pilot after completing his military service but chose to apply to
Harvard Medical School Harvard Medical School (HMS) is the medical school of Harvard University and is located in the Longwood Medical and Academic Area, Longwood Medical Area in Boston, Massachusetts. Founded in 1782, HMS is the third oldest medical school in the Un ...
, which rejected him because he had received a D in college biology. He attended
Boston University Boston University (BU) is a Private university, private research university in Boston, Massachusetts, United States. BU was founded in 1839 by a group of Boston Methodism, Methodists with its original campus in Newbury (town), Vermont, Newbur ...
for a year, taking the
pre-med Pre-medical (often referred to as pre-med) is an educational track that undergraduate students mostly in the United States pursue prior to becoming medical students. It involves activities that prepare a student for medical school, such as pre-med ...
courses he had not taken as an undergraduate. He was finally accepted by Harvard Medical School but spent an intervening year teaching at an elementary school in
South Carolina South Carolina ( ) is a U.S. state, state in the Southeastern United States, Southeastern region of the United States. It borders North Carolina to the north and northeast, the Atlantic Ocean to the southeast, and Georgia (U.S. state), Georg ...
. He worked at a laundry to help pay for those medical school costs not covered by the
G.I. Bill The G.I. Bill, formally the Servicemen's Readjustment Act of 1944, was a law that provided a range of benefits for some of the returning World War II veterans (commonly referred to as G.I. (military), G.I.s). The original G.I. Bill expired in ...
.Martin, Douglas
"Dr. Thomas C. Peebles, Who Identified Measles Virus, Dies at 89"
''
The New York Times ''The New York Times'' (''NYT'') is an American daily newspaper based in New York City. ''The New York Times'' covers domestic, national, and international news, and publishes opinion pieces, investigative reports, and reviews. As one of ...
'', August 4, 2010. Accessed August 4, 2010.


Career

After completing medical school he did an
internship An internship is a period of work experience offered by an organization for a limited period of time. Once confined to medical graduates, internship is used to practice for a wide range of placements in businesses, non-profit organizations and g ...
and
residency Residency may refer to: * Artist-in-residence, a program to sponsor the residence and work of visual artists, writers, musicians, etc. * Concert residency, a series of concerts performed at one venue * Domicile (law), the act of establishing or m ...
in pediatrics at
Massachusetts General Hospital Massachusetts General Hospital (Mass General or MGH) is a teaching hospital located in the West End neighborhood of Boston, Massachusetts. It is the original and largest clinical education and research facility of Harvard Medical School/Harvar ...
, where he later became a Chief Resident of Pediatrics. He was also a Fellow at
Children's Hospital Boston Boston Children's Hospital (formerly known as Children's Hospital Boston until 2013) is the main pediatric training and research hospital of Harvard Medical School, Harvard University. It is a nationally ranked, freestanding acute care children ...
, where he worked with Dr.
John Franklin Enders John Franklin Enders (February 10, 1897 – September 8, 1985) was an American biomedical scientist and Nobel Laureate. Enders has been called "The Father of Modern Vaccines." Life and education Enders was born in West Hartford, Connecticut on Fe ...
, known as "The Father of Modern Vaccines", who earned the Nobel Prize in 1954 for his research on cultivating the
polio virus Poliovirus, the causative agent of polio (also known as poliomyelitis), is a serotype of the species '' Enterovirus C'', in the family of '' Picornaviridae''. There are three poliovirus serotypes, numbered 1, 2, and 3. Poliovirus is composed ...
that led to the development of a vaccination for the disease. Switching to study measles, Peebles was sent to a
Fay School Fay School, founded in 1866 by the Fay sisters, is an independent, coeducational day and boarding school located in Southborough, Massachusetts. History Founding and early years Fay School was founded in 1866 by sisters Eliza Burnett Fay ...
where an outbreak of the disease was underway and was able to isolate the virus from some of the blood samples and throat swabs he took from students. Even after Enders had taken him off the study team, Peebles was able to cultivate the virus and show that the disease could be passed on to monkeys inoculated with the material he had collected. Enders was able to use the cultivated virus to develop a
measles vaccine Measles vaccine protects against becoming infected with measles. Nearly all of those who do not develop immunity after a single dose develop it after a second dose. When the rate of vaccination within a population is greater than 92%, outbreaks ...
in 1963 based on the material isolated by Peebles. In the late 1950s and early 1960s, nearly twice as many children died from measles as from polio.Staff
"The Measles Vaccine"
''
The New York Times ''The New York Times'' (''NYT'') is an American daily newspaper based in New York City. ''The New York Times'' covers domestic, national, and international news, and publishes opinion pieces, investigative reports, and reviews. As one of ...
'', March 28, 1963. Accessed August 4, 2010.
The vaccine for measles has led to the near-complete elimination of the disease in the United States and other developed countries. In a study he performed on the tetanus vaccine, he found that people were getting as much as 2,500 times the amount needed to provide protection, showing that the
booster dose A booster dose is an extra administration of a vaccine after an earlier ( primer) dose. After initial immunization, a booster provides a re-exposure to the immunizing antigen. It is intended to increase immunity against that antigen back to prote ...
s could be given once every ten years, rather than yearly, while substantially reducing the risk of allergic reactions caused by the higher dosages in common use. In his private practice, he noticed that patients from towns where the water was fluoridated had fewer cavities. He conducted research and determined a dosage that was included as part of a regular vitamin.


Personal life

Peebles died at age 89 on July 8, 2010, in his home in
Port Charlotte, Florida Port Charlotte is a census-designated place and unincorporated community in Charlotte County, Florida, United States. The population was 60,625 at the 2020 census, up from 54,392 at the 2010 census. It is part of the Punta Gorda, FL Metropolitan ...
. He was survived by his wife, the former Annie Diffley, as well as by a daughter, two sons, and five grandchildren.


References

{{DEFAULTSORT:Peebles, Thomas C. 1921 births 2010 deaths United States Navy personnel of World War II American pediatricians Harvard Medical School alumni Harvard University alumni People from Newton, Massachusetts People from Port Charlotte, Florida Recipients of the Distinguished Flying Cross (United States) United States Navy officers American virologists Military personnel from Massachusetts