Tabtoxinine β-lactam is a

monobactam Monobactams are bacterially-produced monocyclic β-lactam antibiotics. The β-lactam ring is not fused to another ring, in contrast to most other β-lactams. Monobactams are narrow-spectrum antibiotics effective only against (strictly or fa ...

antibiotic An antibiotic is a type of antimicrobial substance active against bacteria. It is the most important type of antibacterial agent for fighting pathogenic bacteria, bacterial infections, and antibiotic medications are widely used in the therapy ...

derived from

tabtoxin Tabtoxin, also known as wildfire toxin, is a simple monobactam phytotoxin produced by ''Pseudomonas syringae''. It is the precursor to the antibiotic tabtoxinine β-lactam (TBL). It is produced by: * Pseudomonas syringae pv. tabaci, the causal ag ...

. Unlike other β-lactam antibiotics, which inhibit

penicillin-binding proteins Penicillin-binding proteins (PBPs) are a group of proteins that are characterized by their affinity for and binding of penicillin. They are a normal constituent of many bacteria; the name just reflects the way by which the protein was discov ...

, tabtoxinine β-lactam inhibits

glutamine synthetase Glutamine synthetase (GS) () is an enzyme that catalyzes the condensation of glutamate and ammonia to form glutamine: Glutamate + ATP + NH3 → Glutamine + ADP + phosphate Glutamine synthetase uses ammonia produced by nitrate reduction ...

References

Lactams Alpha-Amino acids Amino acid derivatives Beta-lactam antibiotics Monobactam antibiotics {{heterocyclic-stub