Sputnik Light (russian: Спутник Лайт, Sputnik Layt or Lajt) is a single dose
COVID-19 vaccine
A COVID19 vaccine is a vaccine intended to provide acquired immunity against severe acute respiratory syndrome coronavirus 2 (SARS‑CoV‑2), the virus that causes coronavirus disease 2019 (COVID19).
Prior to the COVID19 pandemic, an est ...
developed by the
. It consists of the first dose of the
Sputnik V vaccine, which is based on the
Ad26
Adenoviruses (members of the family ''Adenoviridae'') are medium-sized (90–100 nm), nonenveloped (without an outer lipid bilayer) viruses with an icosahedral nucleocapsid containing a double-stranded DNA genome. Their name derives from ...
vector, and it can be stored at a normal refrigerator temperature of . The institute says this version would be ideally suited for areas with acute outbreaks, allowing more people to be vaccinated quickly. It will also be used as a third (
booster
Booster may refer to:
Amusement rides
* Booster (Fabbri ride), a pendulum ride
* Booster (HUSS ride), an evolution of the Breakdance ride
* Booster (KMG ride), a pendulum ride
Arts, entertainment, and media Fictional characters
* Booster, a cha ...
) dose for those who received Sputnik V at least 6 months earlier.
Effectiveness
A vaccine is generally considered effective if the estimate is ≥50% with a >30% lower limit of the 95%
confidence interval
In frequentist statistics, a confidence interval (CI) is a range of estimates for an unknown parameter. A confidence interval is computed at a designated ''confidence level''; the 95% confidence level is most common, but other levels, such as ...
.
As of September 2021, no study on Sputnik Light reported confidence intervals, so it is not possible to know the accuracy of the estimates. Effectiveness is generally expected to slowly decrease over time.
A
real-world study with participants aged 60–79 years in Argentina found that the single-injection vaccine is
effective
Effectiveness is the capability of producing a desired result or the ability to produce desired output. When something is deemed effective, it means it has an intended or expected outcome, or produces a deep, vivid impression.
Etymology
The ori ...
in preventing infections, effective against hospitalization, and against death.
A
phase III clinical trial in Russia also found an efficacy of 79%.
According to
Nextstrain
Nextstrain is a collaboration between researchers in Seattle, United States and Basel, Switzerland which provides a collection of open-source tools for visualising the genetics behind the spread of viral outbreaks.
Its aim is to support public he ...
, lineage B.1.1.317 was the dominant
variant in Russia during the study period (5 December 2020 to 15 April 2021),
while in Argentina (29 December 2020 to 21 March 2021)
lineage N.5 dominated at first, but soon many lineages coexisted in similar proportions.
Preliminary data from a study in Moscow in July 2021 indicate that the vaccine is effective against symptomatic disease from the
Delta variant
The Delta variant (B.1.617.2) was a variant of SARS-CoV-2, the virus that causes COVID-19. It was first detected in India in late 2020. The Delta variant was named on 31 May 2021 and had spread to over 179 countries by 22 November 2021. The ...
for three months after vaccination.
Composition
Composition, manufacturing sites and procedures, logistics and concerns about adverse effects and quality control are the same as the first dose of the
Sputnik V vaccine. As a result, issues related to the second dose, such as the possible presence of replication-competent particles, do not apply to Sputnik Light.
Clinical trials
In January 2021, Sputnik Light commenced phase I/II trials.
In February, Sputnik Light commenced phase III trials.
Heterologous prime-boost vaccination
In August 2021,
RDIF
The Russian Direct Investment Fund (RDIF) is Russia's sovereign wealth fund established in 2011 by the Russian government to make investments in companies of high-growth sectors of the Russian economy. Its mandate is to co-invest alongside the wo ...
announced that preliminary results from a study on
heterologous prime-boost vaccination indicate that it is safe to administer Sputnik Light as the first dose, then the
Oxford–AstraZeneca,
Moderna
Moderna, Inc. ( ) is an American pharmaceutical and biotechnology company based in Cambridge, Massachusetts that focuses on RNA therapeutics, primarily mRNA vaccines. These vaccines use a copy of a molecule called messenger RNA (mRNA) to pro ...
or
Sinopharm BIBP vaccine as the second dose, as well as the homologous course consisting of Sputnik Light as the second dose.
Authorizations
Although Sputnik Light was not authorized by Ukraine or international organizations, tens of thousands of doses were shipped by Russia for use in
non-government controlled parts of the eastern
Donbas
The Donbas or Donbass (, ; uk, Донба́с ; russian: Донба́сс ) is a historical, cultural, and economic region in eastern Ukraine. Parts of the Donbas are controlled by Russian separatist groups as a result of the Russo-Ukrai ...
region from January 2021. Ukrainian officials criticized the move.
References
{{Portal bar , Medicine , Viruses , COVID-19
Clinical trials
Russian COVID-19 vaccines
Science and technology in Russia
Viral vector vaccines
Gamaleya Research Institute of Epidemiology and Microbiology