Sir Henry Hallett Dale (9 June 1875 – 23 July 1968) was an English

pharmacologist Pharmacology is the science of drugs and medications, including a substance's origin, composition, pharmacokinetics, pharmacodynamics, therapeutic use, and toxicology. More specifically, it is the study of the interactions that occur between ...

and

physiologist Physiology (; ) is the scientific study of functions and mechanisms in a living system. As a subdiscipline of biology, physiology focuses on how organisms, organ systems, individual organs, cells, and biomolecules carry out chemical and ...

. For his study of

acetylcholine Acetylcholine (ACh) is an organic compound that functions in the brain and body of many types of animals (including humans) as a neurotransmitter. Its name is derived from its chemical structure: it is an ester of acetic acid and choline. Par ...

as agent in the chemical transmission of nerve pulses (

neurotransmission Neurotransmission (Latin: ''transmissio'' "passage, crossing" from ''transmittere'' "send, let through") is the process by which signaling molecules called neurotransmitters are released by the axon terminal of a neuron (the presynaptic neuron ...

) he shared the 1936

Nobel Prize in Physiology or Medicine The Nobel Prize in Physiology or Medicine () is awarded yearly by the Nobel Assembly at the Karolinska Institute for outstanding discoveries in physiology or medicine. The Nobel Prize is not a single prize, but five separate prizes that, acco ...

with

Otto Loewi Otto Loewi (; 3 June 1873 – 25 December 1961) was a Germany, German-born pharmacology, pharmacologist and psychobiologist who discovered the role of acetylcholine as an endogenous neurotransmitter. For this discovery, he was awarded the Nobel ...

Early life and education

Henry Hallett Dale was born in

Islington Islington ( ) is an inner-city area of north London, England, within the wider London Borough of Islington. It is a mainly residential district of Inner London, extending from Islington's #Islington High Street, High Street to Highbury Fields ...

London London is the Capital city, capital and List of urban areas in the United Kingdom, largest city of both England and the United Kingdom, with a population of in . London metropolitan area, Its wider metropolitan area is the largest in Wester ...

, to Charles James Dale, a pottery manufacturer from

Staffordshire Staffordshire (; postal abbreviation ''Staffs''.) is a Ceremonial counties of England, ceremonial county in the West Midlands (region), West Midlands of England. It borders Cheshire to the north-west, Derbyshire and Leicestershire to the east, ...

, and his wife, Frances Anne Hallett, daughter of a furniture manufacturer, from South Devon.Feldberg W, rev. Tansey EM (2004–2011)
Dale, Sir Henry Hallett (1875–1968)
''Oxford Dictionary of National Biography'', Oxford University Press, 2004; online edn, Jan 2011. Retrieved 2011-07-08. Henry was the third of seven children, one of whom (his younger brother, Benjamin Dale) became an accomplished composer and warden of the

Royal Academy of Music The Royal Academy of Music (RAM) in London, England, is one of the oldest music schools in the UK, founded in 1822 by John Fane and Nicolas-Charles Bochsa. It received its royal charter in 1830 from King George IV with the support of the firs ...

. Henry was educated at the local Tollington Park College and then

The Leys School The Leys School is a co-educational private school in Cambridge, England. It is a boarding and day school for about 565 pupils between the ages of eleven and eighteen. The head is a member of the Headmasters' and Headmistresses' Conference. ...

Cambridge (one of the school's houses is named after him) and in 1894 entered

Trinity College, Cambridge Trinity College is a Colleges of the University of Cambridge, constituent college of the University of Cambridge. Founded in 1546 by King Henry VIII, Trinity is one of the largest Cambridge colleges, with the largest financial endowment of any ...

, working under the physiologist John Langley. For a few months in 1903 he also studied under

Paul Ehrlich Paul Ehrlich (; 14 March 1854 – 20 August 1915) was a Nobel Prize-winning German physician and scientist who worked in the fields of hematology, immunology and antimicrobial chemotherapy. Among his foremost achievements were finding a cure fo ...

Frankfurt Frankfurt am Main () is the most populous city in the States of Germany, German state of Hesse. Its 773,068 inhabitants as of 2022 make it the List of cities in Germany by population, fifth-most populous city in Germany. Located in the forela ...

, Germany. Also in 1903, Dale assisted

Ernest Starling Ernest Henry Starling (17 April 1866 – 2 May 1927) was a British physiologist who contributed many fundamental ideas to this subject. These ideas were important parts of the British contribution to physiology, which at that time led the world. ...

and

William Bayliss Sir William Maddock Bayliss (2 May 1860 – 27 August 1924) was an English physiologist. Life He was born in Wednesbury, Staffordshire but shortly thereafter his father, a successful merchant of ornamental ironwork, moved his family to a ...

in the

vivisection Vivisection () is surgery conducted for experimental purposes on a living organism, typically animals with a central nervous system, to view living internal structure. The word is, more broadly, used as a pejorative catch-all term for Animal test ...

of a dog, by removing the dog's pancreas and then killing the dog with a knife, which ultimately led to the events of the

Brown Dog affair The Brown Dog affair was a political controversy about vivisection that raged in Britain from 1903 until 1910. It involved the infiltration of University of London medical lectures by Swedish feminists, battles between medical students and the ...

. Dale received his

Doctor of Medicine A Doctor of Medicine (abbreviated MD, from the Latin language, Latin ) is a medical degree, the meaning of which varies between different jurisdictions. In the United States, and some other countries, the ''MD'' denotes a professional degree of ph ...

degree from Cambridge in 1909.

Career and research

While working at the

University College London University College London (Trade name, branded as UCL) is a Public university, public research university in London, England. It is a Member institutions of the University of London, member institution of the Federal university, federal Uni ...

, he met and became friends with

. Dale became the director of the Department of

Biochemistry Biochemistry, or biological chemistry, is the study of chemical processes within and relating to living organisms. A sub-discipline of both chemistry and biology, biochemistry may be divided into three fields: structural biology, enzymology, a ...

and

Pharmacology Pharmacology is the science of drugs and medications, including a substance's origin, composition, pharmacokinetics, pharmacodynamics, therapeutic use, and toxicology. More specifically, it is the study of the interactions that occur betwee ...

at the

National Institute for Medical Research The National Institute for Medical Research (NIMR), was a medical research institute based in Mill Hill, on the outskirts of north London, England. It was funded by the Medical Research Council (MRC); In 2016, the NIMR became part of the new F ...

in London in 1914. He became a Fullerian Professor of Chemistry at the

Royal Institution The Royal Institution of Great Britain (often the Royal Institution, Ri or RI) is an organisation for scientific education and research, based in the City of Westminster. It was founded in 1799 by the leading British scientists of the age, inc ...

in 1942. During

World War II World War II or the Second World War (1 September 1939 – 2 September 1945) was a World war, global conflict between two coalitions: the Allies of World War II, Allies and the Axis powers. World War II by country, Nearly all of the wo ...

he served on the scientific advisory panel to the Cabinet. Although Dale and his colleagues first identified acetylcholine in 1914 as a possible

neurotransmitter A neurotransmitter is a signaling molecule secreted by a neuron to affect another cell across a Chemical synapse, synapse. The cell receiving the signal, or target cell, may be another neuron, but could also be a gland or muscle cell. Neurotra ...

, Loewi showed its importance in the

nervous system In biology, the nervous system is the complex system, highly complex part of an animal that coordinates its behavior, actions and sense, sensory information by transmitting action potential, signals to and from different parts of its body. Th ...

. The two men shared the 1936 Nobel Prize for Medicine. During the 1940s Dale was embroiled in the scientific debate over the nature of signaling at the

synapse In the nervous system, a synapse is a structure that allows a neuron (or nerve cell) to pass an electrical or chemical signal to another neuron or a target effector cell. Synapses can be classified as either chemical or electrical, depending o ...

. Dale and others believed that signaling at the synapse was chemical, while

John Carew Eccles Sir John Carew Eccles (27 January 1903 – 2 May 1997) was an Australian neurophysiologist and philosopher who won the 1963 Nobel Prize in Physiology or Medicine for his work on the synapse. He shared the prize with Andrew Huxley and Alan Lloy ...

and others believed that the synapse was electrical. It was later found that most synaptic signalling is chemical, but there are some synapses that are electrical. Dale also originated the scheme used to differentiate

neuron A neuron (American English), neurone (British English), or nerve cell, is an membrane potential#Cell excitability, excitable cell (biology), cell that fires electric signals called action potentials across a neural network (biology), neural net ...

s according to the neurotransmitters they release. Thus, neurons releasing

noradrenaline Norepinephrine (NE), also called noradrenaline (NA) or noradrenalin, is an organic chemical in the catecholamine family that functions in the brain and body as a hormone, neurotransmitter and neuromodulator. The name "noradrenaline" (from ...

(known in the United States as

norepinephrine Norepinephrine (NE), also called noradrenaline (NA) or noradrenalin, is an organic compound, organic chemical in the catecholamine family that functions in the brain and human body, body as a hormone, neurotransmitter and neuromodulator. The ...

) are called noradrenergic, neurons releasing

GABA GABA (gamma-aminobutyric acid, γ-aminobutyric acid) is the chief inhibitory neurotransmitter in the developmentally mature mammalian central nervous system. Its principal role is reducing neuronal excitability throughout the nervous system. GA ...

are

GABAergic In molecular biology and physiology, something is GABAergic or GABAnergic if it pertains to or affects the neurotransmitter gamma-aminobutyric acid (GABA). For example, a synapse is GABAergic if it uses GABA as its neurotransmitter, and a GABAergic ...

, and so on. This is called '' Dale's principle'' (sometimes erroneously referred to as ''Dale's Law''), one interpretation of which holds that each neuron releases only one type of neurotransmitter. This particular interpretation of Dale's principle has been shown to be false, as many neurons release

neuropeptides Neuropeptides are chemical messengers made up of small chains of amino acids that are synthesized and released by neurons. Neuropeptides typically bind to G protein-coupled receptors (GPCRs) to modulate neural activity and other tissues like the ...

and

amino acid Amino acids are organic compounds that contain both amino and carboxylic acid functional groups. Although over 500 amino acids exist in nature, by far the most important are the 22 α-amino acids incorporated into proteins. Only these 22 a ...

s in addition to classical neurotransmitters such as acetylcholine or biogenic amines (see

cotransmission Neurotransmission (Latin: ''transmissio'' "passage, crossing" from ''transmittere'' "send, let through") is the process by which signaling molecules called neurotransmitters are released by the axon terminal of a neuron (the presynaptic neuron) ...

) (Bear, et al. 2001). This finding, that numerous neurotransmitters can be released by the same neuron, is referred to as the "coexistence principle." This phenomenon was most popularized by the Swedish neuroanatomist and neuropharmacologist Tomas Hökfelt, who is considered to be the "Father of the Coexistence Principle." Between 1938 and 1960 Dale served as

chairman The chair, also chairman, chairwoman, or chairperson, is the presiding officer of an organized group such as a board, committee, or deliberative assembly. The person holding the office, who is typically elected or appointed by members of the gro ...

of the

Wellcome Trust The Wellcome Trust is a charitable foundation focused on health research based in London, United Kingdom. It was established in 1936 with legacies from the pharmaceutical magnate Henry Wellcome (founder of Burroughs Wellcome, one of the predec ...

Awards and honours

Dale was elected a Fellow of the Royal Society (FRS) in 1914. In 1926, he was awarded the

Cameron Prize for Therapeutics of the University of Edinburgh The Cameron Prize for Therapeutics of the University of Edinburgh is awarded by the University of Edinburgh College of Medicine and Veterinary Medicine, College of Medicine and Veterinary Medicine to a person who has made any highly important and v ...

. He was elected to the

American Academy of Arts and Sciences The American Academy of Arts and Sciences (The Academy) is one of the oldest learned societies in the United States. It was founded in 1780 during the American Revolution by John Adams, John Hancock, James Bowdoin, Andrew Oliver, and other ...

in 1927, the

American Philosophical Society The American Philosophical Society (APS) is an American scholarly organization and learned society founded in 1743 in Philadelphia that promotes knowledge in the humanities and natural sciences through research, professional meetings, publicat ...

in 1939, and the United States

National Academy of Sciences The National Academy of Sciences (NAS) is a United States nonprofit, NGO, non-governmental organization. NAS is part of the National Academies of Sciences, Engineering, and Medicine, along with the National Academy of Engineering (NAE) and the ...

in 1940. He was

knight A knight is a person granted an honorary title of a knighthood by a head of state (including the pope) or representative for service to the monarch, the church, or the country, especially in a military capacity. The concept of a knighthood ...

ed in 1932, receiving the Knight Grand Cross of the

Order of the British Empire The Most Excellent Order of the British Empire is a British order of chivalry, rewarding valuable service in a wide range of useful activities. It comprises five classes of awards across both civil and military divisions, the most senior two o ...

in 1943 and the

Order of Merit The Order of Merit () is an order of merit for the Commonwealth realms, recognising distinguished service in the armed forces, science, art, literature, or the promotion of culture. Established in 1902 by Edward VII, admission into the order r ...

in 1944. He served as

president President most commonly refers to: *President (corporate title) * President (education), a leader of a college or university *President (government title) President may also refer to: Arts and entertainment Film and television *'' Præsident ...

of the

Royal Society The Royal Society, formally The Royal Society of London for Improving Natural Knowledge, is a learned society and the United Kingdom's national academy of sciences. The society fulfils a number of roles: promoting science and its benefits, re ...

from 1940 to 1945 and president of the

Royal Society of Medicine The Royal Society of Medicine (RSM) is a medical society based at 1 Wimpole Street, London, UK. It is a registered charity, with admission through membership. Its Chief Executive is Michele Acton. History The Royal Society of Medicine (R ...

from 1948 to 1950. The Sir Henry Dale

Fellow A fellow is a title and form of address for distinguished, learned, or skilled individuals in academia, medicine, research, and industry. The exact meaning of the term differs in each field. In learned society, learned or professional society, p ...

ships of the

are named in his honour and the

Society for Endocrinology The Society for Endocrinology is an international membership organisation and registered charity representing scientists, clinicians and nurses who work with hormones. The Society was established in 1946, and currently has approximately 3,000 mem ...

awards the Dale Medal annually in his honour.

Personal life

In 1904, Dale had married his first cousin Ellen Harriett Hallett and had a son and two daughters. One of their daughters, Alison Sarah Dale, married

Alexander R. Todd Alexander Robertus Todd, Baron Todd (2 October 1907 – 10 January 1997) was a British biochemist whose research on the structure and synthesis of nucleotides, nucleosides, and nucleotide coenzymes gained him the Nobel Prize for Chemistry in 195 ...

, who won the 1957 Nobel Prize in Chemistry and served as

President of the Royal Society The president of the Royal Society (PRS), also known as the Royal Society of London, is the elected Head of the Royal Society who presides over meetings of the society's council. After an informal meeting (a lecture) by Christopher Wren at Gres ...

from 1975 to 1980. The Dales lived at Mount Vernon House from 1919 to 1942. Dales's residency at the house is marked by a

Greater London Council The Greater London Council (GLC) was the top-tier local government administrative body for Greater London from 1965 to 1986. It replaced the earlier London County Council (LCC) which had covered a much smaller area. The GLC was dissolved in 198 ...

blue plaque erected in 1981 on the garden wall of the house. Henry Hallett Dale as child.jpg, Dale as a child Henry Hallett Dale 1904.jpg, Dale in 1904 Henry Hallett Dale 1918.jpg, Dale in 1918 Henry Dale and wife.jpg, Dale with wife Son of Henry Hallett Dale.jpg, Son of Henry Hallett Dale DaleNobel20040420.jpg, The Nobel Prize diploma of Dale, displayed in the Royal Society, London. Dale-Schuster pump.jpg, Dale-Schuster blood pump

References

External links