Sheffer is a surname, and may refer to:
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Alla Sheffer, Israeli-Canadian computer scientist
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Craig Sheffer (born 1960), American actor
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Daniel Sheffer (1783–1880), U.S. congressman
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Doron Sheffer (born 1972), Israeli basketball player
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Henry M. Sheffer (1882–1964), American logician
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Hogan Sheffer (born 1958), American screenwriter
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Isador M. Sheffer (1901–1992), American mathematician
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Walter Sheffer (1918–2002), American photographer
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