Second Presbyterian Church may refer to:

Northern Ireland

* Second Ballyeaston Presbyterian Church, a congregation of the Presbyterian Church in Ireland

United States

* Second Presbyterian Church (Guilford, Baltimore, Maryland), church of Franklin L. Sheppard * Second Presbyterian Church (Birmingham, Alabama), listed on the NRHP in Alabama *

Second Presbyterian Church (Chicago, Illinois) Second Presbyterian Church is a landmark Gothic Revival church located on South Michigan Avenue in Chicago, Illinois, United States. In the late nineteenth and early twentieth centuries, some of Chicago's most prominent families attended this ...

, listed on the NRHP in Illinois *

Second Presbyterian Church (Indianapolis, Indiana) Second Presbyterian Church is a historic congregation located at 7700 North Meridian Street (Indianapolis), Meridian Street in Indianapolis, Indiana. With 4,049 members as of 2013, it is one of the largest congregations in the Presbyterian Church ...

* Second Presbyterian Church (Lexington, Kentucky), listed on the NRHP in Kentucky * Second Presbyterian Church (St. Louis, Missouri), listed on the NRHP in Missouri * Second Presbyterian Church (Princeton, New Jersey), merged with

Nassau Presbyterian Church The Nassau Presbyterian Church is a historic congregation located at 61 Nassau Street in Princeton, New Jersey, United States. It has been the home of many important figures in the history of Presbyterianism in the United States as a result of its ...

* Second Presbyterian Church (Columbus, Ohio), listed on the NRHP in Ohio * Second Presbyterian Church (Portsmouth, Ohio), listed on the NRHP in Ohio * Second Presbyterian Church (Chattanooga, Tennessee), listed on the NRHP in Tennessee * Second Presbyterian Church (Memphis, Tennessee) (1891), listed on the NRHP in Tennessee * Second Presbyterian Church (Memphis, Tennessee) (1952) * Second Presbyterian Church (Petersburg, Virginia), listed on the NRHP in Virginia * Second Presbyterian Church (Richmond, Virginia), listed on the NRHP in Virginia {{disambiguation, church