''Schumanniophyton problematicum'' is a species of plant in the family Rubiaceae. It is found in

Ivory Coast Ivory Coast, also known as Côte d'Ivoire, officially the Republic of Côte d'Ivoire, is a country on the southern coast of West Africa. Its capital is Yamoussoukro, in the centre of the country, while its largest city and economic centre is ...

, Ghana, and Sierra Leone. It is threatened by habitat loss.

Chemistry

The plant has been found to contain the alkaloids rohitukine and rohitukine ''N''-oxide, and the iridoid

glycosides In chemistry, a glycoside is a molecule in which a sugar is bound to another functional group via a glycosidic bond. Glycosides play numerous important roles in living organisms. Many plants store chemicals in the form of inactive glycosides. ...

scyphiphorin A1–A2 and scyphiphorin B1–B2.

Alvocidib Alvocidib (INN; also known as flavopiridol) is a flavonoid alkaloid CDK9 kinase inhibitor under clinical development by Tolero Pharmaceuticals for the treatment of acute myeloid leukemia. It has been studied also for the treatment of arthritis a ...

is a synthetic

analog Analog or analogue may refer to: Computing and electronics * Analog signal, in which information is encoded in a continuous variable ** Analog device, an apparatus that operates on analog signals *** Analog electronics, circuits which use analo ...

of rohitukine that acts as a CDK9

kinase inhibitor A protein kinase inhibitor is a type of enzyme inhibitor that blocks the action of one or more protein kinases. Protein kinases are enzymes that phosphorylate (add a phosphate, or PO4, group) to a protein and can modulate its function. The phospha ...

and is under clinical development for the treatment of acute myeloid leukemia. It has also been studied for the treatment of

arthritis Arthritis is a term often used to mean any disorder that affects joints. Symptoms generally include joint pain and stiffness. Other symptoms may include redness, warmth, swelling, and decreased range of motion of the affected joints. In som ...

and atherosclerotic plaque formation Rohitukine was initially extracted from ''

Aphanamixis polystachya ''Aphanamixis polystachya'', the pithraj tree, is a species of tree in the family Meliaceae. It is native to India, Pakistan, Nepal, Bhutan, Bangladesh, Myanmar and Sri Lanka. It is a widely used as a medicinal plant in Ayurveda. Description Th ...

'' (the alkaloid name being derived from the synonym ''Amoora rohituka'') and later from ''

Dysoxylum binectariferum ''Dysoxylum gotadhora'' is a tree in the family Meliaceae. It is native to Bhutan, India, Laos, Nepal, Thailand, and Vietnam. The name ''Dysoxylum ficiforme'' (Wight) Gamble in India and Sri Lanka Sri Lanka (, ; si, ශ්‍රී � ...

''. - both of which plant species belong to the family Meliaceae. The scyphiphorins were first isolated from (and subsequently named for) '' Scyphiphora hydrophylacea'', which, like ''Schumanniophyton'', belongs to the plant family Rubiaceae.

References

{{Taxonbar, from=Q5464443 problematicum Vulnerable plants Taxonomy articles created by Polbot Taxa named by André Aubréville Taxa named by Auguste Chevalier