Sarolaner, sold under the brand name Simparica, is an

ectoparasiticide An ectoparasiticide is an antiparasitic drug used in the treatment of ectoparasitic infestations. These drugs are used to kill the parasites that live on the body surface. Permethrin, sulfur, lindane, dicophane, benzyl benzoate, ivermectin ...

veterinary

medication A medication (also called medicament, medicine, pharmaceutical drug, medicinal drug or simply drug) is a drug used to diagnose, cure, treat, or prevent disease. Drug therapy ( pharmacotherapy) is an important part of the medical field an ...

for the treatment of

flea Flea, the common name for the order Siphonaptera, includes 2,500 species of small flightless insects that live as external parasites of mammals and birds. Fleas live by ingesting the blood of their hosts. Adult fleas grow to about long, a ...

and

tick Ticks (order Ixodida) are parasitic arachnids that are part of the mite superorder Parasitiformes. Adult ticks are approximately 3 to 5 mm in length depending on age, sex, species, and "fullness". Ticks are external parasites, living by ...

infestations in dogs. It is also used off-label to control

sarcoptic mange Mange is a type of skin disease caused by parasitic mites. Because various species of mites also infect plants, birds and reptiles, the term "mange", or colloquially "the mange", suggesting poor condition of the skin and fur due to the infection ...

and

demodectic mange Demodicosis , also called Demodex folliculitis in humans and demodectic mange () or red mange in animals, is caused by a sensitivity to and overpopulation of ''Demodex, Demodex spp.'' as the host's immune system is unable to keep the mites under ...

. Sarolaner is also a component of the

combination drug A combination drug or a fixed-dose combination (FDC) is a medicine that includes two or more active ingredients combined in a single dosage form. Terms like "combination drug" or "combination drug product" can be common shorthand for a FDC pr ...

Simparica Trio, which contains sarolaner,

moxidectin Moxidectin is an anthelmintic drug used in animals to prevent or control parasitic worms (helminths), such as heartworm and intestinal worms, in dogs, cats, horses, cattle and sheep. Moxidectin kills some of the most common internal and external ...

, and

pyrantel Pyrantel is a medication used to treat a number of parasitic worm infections. This includes ascariasis, hookworm infections, enterobiasis (pinworm infection), trichostrongyliasis, and trichinellosis. It is taken by mouth. Side effects inclu ...

. It is used for prevention of heartworm disease caused by ''

Dirofilaria immitis ''Dirofilaria immitis'', also known as heartworm or dog heartworm, is a Parasitism, parasitic Nematode, roundworm that is a type of Filarioidea, filarial worm, a small thread-like worm, that causes dirofilariasis. It is spread from host (biolog ...

''; treat and prevent flea infestations; treat and control tick infestations with the

lone star tick ''Amblyomma americanum'', also known as the lone star tick, the northeastern water tick, or the turkey tick, or the "Cricker Tick", is a type of tick indigenous to much of the eastern United States and Mexico, that bites painlessly and common ...

, Gulf Coast tick, American dog tick,

black-legged tick Black-legged tick may refer to either of two species of ticks found in North America: *''Ixodes scapularis'', also known as the "deer tick" or "bear tick," found in eastern North America *''Ixodes pacificus ''Ixodes pacificus'', the western blac ...

, and

brown dog tick ''Rhipicephalus sanguineus'', commonly called the brown dog tick, kennel tick, or pantropical dog tick, is a species of tick found worldwide, but more commonly in warmer climates. This species is unusual among ticks in that its entire lifecycle ...

; and treat and control

roundworm The nematodes ( or grc-gre, Νηματώδη; la, Nematoda) or roundworms constitute the phylum Nematoda (also called Nemathelminthes), with plant-parasitic nematodes also known as eelworms. They are a diverse animal phylum inhabiting a broa ...

and adult

hookworm Hookworms are intestinal, blood-feeding, parasitic roundworms that cause types of infection known as helminthiases. Hookworm infection is found in many parts of the world, and is common in areas with poor access to adequate water, sanitation ...

infections. Sarolaner is also an ingredient in feline

combination In mathematics, a combination is a selection of items from a set that has distinct members, such that the order of selection does not matter (unlike permutations). For example, given three fruits, say an apple, an orange and a pear, there are th ...

antiparasitic Antiparasitics are a class of medications which are indicated for the treatment of parasitic diseases, such as those caused by helminths, amoeba, ectoparasites, parasitic fungi, and protozoa, among others. Antiparasitics target the parasitic ag ...

Revolution Plus (or Stronghold Plus), which contains sarolaner and

selamectin Selamectin (trade names Revolution and Stronghold manufactured by Zoetis, and Revolt manufactured by Aurora Pharmaceuticals, among others) is a topical parasiticide and anthelminthic used on dogs and cats. It treats and prevents infections of ...

and is used for prevention of

, feline

hookworms Hookworms are intestinal, blood-feeding, parasitic roundworms that cause types of infection known as helminthiases. Hookworm infection is found in many parts of the world, and is common in areas with poor access to adequate water, sanitation ...

, feline

roundworms The nematodes ( or grc-gre, Νηματώδη; la, Nematoda) or roundworms constitute the phylum Nematoda (also called Nemathelminthes), with plant-parasitic nematodes also known as eelworms. They are a diverse animal phylum inhabiting a broa ...

, ear mites, and

heartworms ''Dirofilaria immitis'', also known as heartworm or dog heartworm, is a parasitic roundworm that is a type of filarial worm, a small thread-like worm, that causes dirofilariasis. It is spread from host to host through the bites of mosquitoes. ...

, as well as treating and preventing

fleas Flea, the common name for the order Siphonaptera, includes 2,500 species of small flightless insects that live as external parasites of mammals and birds. Fleas live by ingesting the blood of their hosts. Adult fleas grow to about long, a ...

and

ticks Ticks (order Ixodida) are parasitic arachnids that are part of the mite superorder Parasitiformes. Adult ticks are approximately 3 to 5 mm in length depending on age, sex, species, and "fullness". Ticks are external parasites, living by ...

References

External links

* Cat medications Dog medications Insecticides Acaricides Spiro compounds Azetidines Trifluoromethyl compounds Chloroarenes Fluoroarenes Isoxazolines Sulfones {{antiinfective-drug-stub